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Enzyme Inhibitors
94
"Studies of 4-arylthiazolylhydrazones derived from 1-indanones as Trypanosoma cruzi squalene epoxidase inhibitors by molecular simulations"
(2018) Noguera, G.J.; Fabian, L.E.; Lombardo, E.; Finkielsztein, L.M. Organic and Biomolecular Chemistry. 16(44):8525-8536
"Leptin alters somatosensory thalamic networks by decreasing gaba release from reticular thalamic nucleus and action potential frequency at ventrobasal neurons"
(2018) Perissinotti, P.P.;Rivero-Echeto, M.C.;Garcia-Rill, E. (
...
)Urbano, F.J. Brain Structure and Function. 223(5):2499-2514
"Role of the ERK1/2 signaling pathway in the replication of junín and tacaribe viruses"
(2018) Brunetti, J.E.;Foscaldi, S.;Quintana, V.M. (
...
)Castilla, V. Viruses. 10(4)
"Effects of Hippocampal LIMK Inhibition on Memory Acquisition, Consolidation, Retrieval, Reconsolidation, and Extinction"
(2018) Lunardi, P.;Sachser, R.M.;Sierra, R.O. (
...
)de Oliveira Alvares, L. Molecular Neurobiology. 55(2):958-967
"In Vitro and in Vivo activities of sulfur-containing linear bisphosphonates against apicomplexan parasites"
(2017) Szajnman, S.H.;Galaka, T.;Li, Z.-H. (
...
)Rodriguez, J.B. Antimicrobial Agents and Chemotherapy. 61(2)
"Nitric oxide reduces paracellular resistance in rat thick ascending limbs by increasing Na+ and Cl- permeabilities"
(2017) Monzon, C.M.; Occhipinti, R.; Pignataro, O.P.; Garvin, J.L. American Journal of Physiology - Renal Physiology. 312(6):F1035-F1043
"Antiparasitic activity of sulfur- and fluorine-containing bisphosphonates against trypanosomatids and apicomplexan parasites"
(2017) Galaka, T.;Casal, M.F.;Storey, M. (
...
)Rodriguez, J.B. Molecules. 22(1)
"Approaches for Designing new Potent Inhibitors of Farnesyl Pyrophosphate Synthase"
(2016) Rodriguez, J.B.; Falcone, B.N.; Szajnman, S.H. Expert Opinion on Drug Discovery. 11(3):307-320
"Synthesis of Enantiomeric Polyhydroxyalkylpyrrolidines from 1,3-Dipolar Cycloadducts. Evaluation as Inhibitors of a β-Galactofuranosidase"
(2016) Oliveira Udry, G.A.; Repetto, E.; Vega, D.R.; Varela, O. Journal of Organic Chemistry. 81(10):4179-4189
"Phosphatidylinositol kinase activities in Trypanosoma cruzi epimastigotes"
(2015) Gimenez, A.M.;Gesumaría, M.C.;Schoijet, A.C. (
...
)Machado, E.E. Molecular and Biochemical Parasitology. 203(1-2):14-24
"Oxidative effects and toxin bioaccumulation after dietary microcystin intoxication in the hepatopancreas of the crab Neohelice (Chasmagnathus) granulata"
(2015) Sabatini, S.E.;Brena, B.M.;Pirez, M. (
...
)Luquet, C.M. Ecotoxicology and Environmental Safety. 120:136-141
"Involvement of PI3K/Akt and p38 MAPK in the induction of COX-2 expression by bacterial lipopolysaccharide in murine adrenocortical cells"
(2014) Mercau, M.E.;Astort, F.;Giordanino, E.F. (
...
)Cymeryng, C.B. Molecular and Cellular Endocrinology. 384(1-2):43-51
"Solanesyl diphosphate synthase, an enzyme of the ubiquinone synthetic pathway, is required throughout the life cycle of Trypanosoma brucei"
(2014) Lai, D.-H.;Poropat, E.;Pravia, C. (
...
)Lukeš, J. Eukaryotic Cell. 13(2):320-328
"Inhibition of the PI3K/Akt pathway by Ly294002 does not prevent establishment of persistent Junín virus infection in Vero cells"
(2014) Linero, F.N.;Fernández Bell-Fano, P.M.;Cuervo, E. (
...
)Scolaro, L.A. Archives of Virology. 160(2):469-475
"Aryl hydrocarbon receptor activation leads to impairment of estrogen-driven chicken vitellogenin promoter activity in LMH cells"
(2013) Bussmann, U.A.; Pérez Sáez, J.M.; Bussmann, L.E.; Barañao, J.L. Comparative Biochemistry and Physiology - C Toxicology and Pharmacology. 157(2):111-118
"Design, synthesis, calorimetry, and crystallographic analysis of 2-alkylaminoethyl-1,1-bisphosphonates as inhibitors of trypanosoma cruzi farnesyl diphosphate synthase"
(2012) Aripirala, S.;Szajnman, S.H.;Jakoncic, J. (
...
)Amzel, L.M. Journal of Medicinal Chemistry. 55(14):6445-6454
"1-(Fluoroalkylidene)-1,1-bisphosphonic acids are potent and selective inhibitors of the enzymatic activity of Toxoplasma gondii farnesyl pyrophosphate synthase"
(2012) Szajnman, S.H.;Rosso, V.S.;Malayil, L. (
...
)Rodriguez, J.B. Organic and Biomolecular Chemistry. 10(7):1424-1433
"Improved bioavailability of inhibitors of Trypanosoma cruzi trans-sialidase: PEGylation of lactose analogs with multiarm polyethyleneglycol"
(2012) Giorgi, M.E.;Ratier, L.;Agusti, R. (
...
)De Lederkremer, R.M. Glycobiology. 22(10):1363-1373
"Discovery of a β-glucosidase inhibitor from a chemically engineered extract prepared through sulfonylation"
(2011) Salazar, M.O.; Micheloni, O.; Escalante, A.M.; Furlan, R.L.E. Molecular Diversity. 15(3):713-719
"Synthesis of multivalent glycoclusters from 1-thio-β-D-galactose and their inhibitory activity against the β-galactosidase from E. coli"
(2011) Cagnoni, A.J.;Varela, O.;Gouin, S.G. (
...
)Uhrig, M.L. Journal of Organic Chemistry. 76(9):3064-3077
"Identification of transmitter systems and learning tag molecules involved in behavioral tagging during memory formation"
(2011) Moncada, D.;Ballarini, F.;Martinez, M.C. (
...
)Viola, H. Proceedings of the National Academy of Sciences of the United States of America. 108(31):12931-12936
"Trans-sialidase and mucins of Trypanosoma cruzi: An important interplay for the parasite"
(2011) Eugenia Giorgi, M.; De Lederkremer, R.M. Carbohydrate Research. 346(12):1389-1393
"Cocaine supersensitivity and enhanced motivation for reward in mice lacking dopamine D2 autoreceptors"
(2011) Bello, E.P.;Mateo, Y.;Gelman, D.M. (
...
)Rubinstein, M. Nature Neuroscience. 14(8):1033-1038
"Synthesis and biological evaluation of new 2-alkylaminoethyl-1,1- bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl diphosphate synthase"
(2011) Rosso, V.S.;Szajnman, S.H.;Malayil, L. (
...
)Rodriguez, J.B. Bioorganic and Medicinal Chemistry. 19(7):2211-2217
"Defining the role of a FYVE domain in the localization and activity of a cAMP phosphodiesterase implicated in osmoregulation in Trypanosoma cruzi"
(2011) Schoijet, A.C.;Miranda, K.;Medeiros, L.C.S. (
...
)Alonso, G.D. Molecular Microbiology. 79(1):50-62
"Continuous nonradioactive method for screening trypanosomal transsialidase activity and its inhibitors"
(2010) Sartor, P.A.;Agusti, R.;Leguizamón, M.S. (
...
)de Lederkremer, R.M. Glycobiology. 20(8):982-990
"Inhibition of cholinesterases and carboxylesterases of two invertebrate species, Biomphalaria glabrata and Lumbriculus variegatus, by the carbamate pesticide carbaryl"
(2010) Kristoff, G.; Guerrero, N.R.V.; Cochón, A.C. Aquatic Toxicology. 96(2):115-123
"Inhibitory effect of quercetin on matrix metalloproteinase 9 activity Molecular mechanism and structure-activity relationship of the flavonoid-enzyme interaction"
(2010) Saragusti, A.C.;Ortega, M.G.;Cabrera, J.L. (
...
)Chiabrando, G.A. European Journal of Pharmacology. 644(1-3):138-145
"Quaternary benzyltriethylammonium ion binding to the Na,K-ATPase: A tool to investigate extracellular K+ binding reactions"
(2009) Peluffo, R.D.;González-Lebrero, R.M.;Kaufman, S.B. (
...
)Berlin, J.R. Biochemistry. 48(34):8105-8119
"Mammalian Staufen 1 is recruited to stress granules and impairs their assembly"
(2009) Thomas, M.G.;Martinez Tosar, L.J.;Desbats, M.A. (
...
)Boccaccio, G.L. Journal of Cell Science. 122(4):563-573
"Participation of the phosphatidylinositol 3-kinase/Akt pathway in Junín virus replication in vitro"
(2009) Linero, F.N.; Scolaro, L.A. Virus Research. 145(1):166-170
"Thiodisaccharides with galactofuranose or arabinofuranose as terminal units: Synthesis and inhibitory activity of an exo β-d-galactofuranosidase"
(2009) Repetto, E.; Marino, C.; Laura Uhrig, M.; Varela, O. Bioorganic and Medicinal Chemistry. 17(7):2703-2711
"In vitro effect of a new cinnamic acid derivative against the epimastigote form of Trypanosoma cruzi"
(2009) Andreu, G.L.P.;Inada, N.M.;Pellón, R.F. (
...
)Vercesi, A.E. Arzneimittel-Forschung/Drug Research. 59(4):207-211
"Synthesis of pentopyranosyl-containing thiodisaccharides. Inhibitory activity against β-glycosidases"
(2009) Cagnoni, A.J.; Uhrig, M.L.; Varela, O. Bioorganic and Medicinal Chemistry. 17(17):6203-6212
"Regulation of ion transport by pH and [HCO3 -] in isolated gills of the crab Neohelice (Chasmagnathus) granulata"
(2008) Tresguerres, M.;Parks, S.K.;Sabatini, S.E. (
...
)Luquet, C.M. American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 294(3):R1033-R1043
"Synthesis and biological evaluation of 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl diphosphate synthase"
(2008) Szajnman, S.H.;García Liñares, G.E.;Li, Z.-H. (
...
)Rodriguez, J.B. Bioorganic and Medicinal Chemistry. 16(6):3283-3290
"Two immunomodulators, curcumin and sulfasalazine, enhance IDV antiretroviral activity in HIV-1 persistently infected cells"
(2008) Riva, D.A.;Fernández-Larrosa, P.N.;Dolcini, G.L. (
...
)Mersich, S.E. Archives of Virology. 153(3):561-565
"PKMζ inactivation induces spatial familiarity"
(2008) Moncada, D.; Viola, H. Learning and Memory. 15(11):810-814
"Programmed cell death and differential JNK, p38 and ERK response in a prenatal acute hypoxic hypoxia model"
(2008) Vacotto, M.; Coso, O.; Fiszer de Plazas, S. Neurochemistry International. 52(4-5):857-863
"Periconceptional alcohol consumption-induced changes in embryonic prostaglandin E levels in mouse organogenesis: Modulation by nitric oxide"
(2007) Cebral, E.; Faletti, A.; Jawerbaum, A.; Paz, D. Prostaglandins Leukotrienes and Essential Fatty Acids. 76(3):141-151
"Induction of nitric oxide synthase and heme oxygenase activities by endotoxin in the rat adrenal cortex: Involvement of both signaling systems in the modulation of ACTH-dependent steroid production"
(2007) Grion, N.;Repetto, E.M.;Pomeraniec, Y. (
...
)Cymeryng, C.B. Journal of Endocrinology. 194(1):11-20
"An insight on targets and patented drugs for chemotherapy of chagas disease"
(2007) Duschak, V.G.; Couto, A.S. Recent Patents on Anti-Infective Drug Discovery. 2(1):19-51
"Effect of erythropoietin on staurosporine-induced apoptosis and differentiation of SH-SY5Y neuroblastoma cells"
(2006) Pregi, N.;Vittori, D.;Pérez, G. (
...
)Nesse, A. Biochimica et Biophysica Acta - Molecular Cell Research. 1763(2):238-246
"Inhibition of heme oxygenase-1 interferes with the transforming activity of the Kaposi sarcoma herpesvirus-encoded G protein-coupled receptor"
(2006) Marinissen, M.J.;Tanos, T.;Bolós, M. (
...
)Cuadrado, A. Journal of Biological Chemistry. 281(16):11332-11346
"Different signaling pathways are involved in cardiomyocyte survival induced by a Trypanosoma cruzi glycoprotein"
(2006) Aoki, M.d.P.;Cano, R.C.;Pellegrini, A.V. (
...
)Gea, S. Microbes and Infection. 8(7):1723-1731
"Regulation of aryl hydrocarbon receptor expression in rat granulosa cells"
(2006) Bussmann, U.A.; Barañao, J.L. Biology of Reproduction. 75(3):360-369
"Calcium signaling pathways mediating synaptic potentiation triggered by amyotrophic lateral sclerosis IgG in motor nerve terminals"
(2006) Pagani, M.R.; Reisin, R.C.; Uchitel, O.D. Journal of Neuroscience. 26(10):2661-2672
"Phosphorylation of c-Fos by members of the p38 MAPK family: Role in the AP-1 response to UV light"
(2005) Tanos, T.;Marinissen, M.J.;Leskow, F.C. (
...
)Coso, O.A. Journal of Biological Chemistry. 280(19):18842-18852
"Evidence of the presence of calcium/calmodulin-dependent protein kinase IV in human sperm and its involvement in motility regulation"
(2005) Marín-Briggiler, C.I.;Jha, K.N.;Chertihin, O. (
...
)Visconti, P.E. Journal of Cell Science. 118(9):2013-2022
"Glycosphingolipids in Plasmodium falciparum: Presence of an active glucosylceramide synthase"
(2004) Couto, A.S.;Caffaro, C.;Uhrig, M.L. (
...
)Erra-Balsells, R. European Journal of Biochemistry. 271(11):2204-2214
"Hepatic nuclear factor 3 and nuclear factor 1 regulate 5-aminolevulinate synthase gene expression and are involved in insulin repression"
(2004) Scassa, M.E.; Guberman, A.S.; Ceruti, J.M.; Cánepa, E.T. Journal of Biological Chemistry. 279(27):28082-28092
"ACTH stimulates the release of alkaline phosphatase through Gi-mediated activation of a phospholipase C and the release of inositolphosphoglycan"
(2004) Martini, C.N.; Vaena de Avalos, S.G.; del Carmen Vila, M. Molecular and Cellular Biochemistry. 258(1-2):191-199
"Hexachlorobenzene impairs glucose metabolism in a rat model of porphyria cutanea tarda: A mechanistic approach"
(2004) Mazzetti, M.B.;Taira, M.C.;Lelli, S.M. (
...
)De Viale, L.C.S.M. Archives of Toxicology. 78(1):25-33
"Meridianins, a new family of protein kinase inhibitors isolated from the Ascidian Aplidium meridianum"
(2004) Gompel, M.;Leost, M.;Bal De Kier Joffe, E. (
...
)Meijer, L. Bioorganic and Medicinal Chemistry Letters. 14(7):1703-1707
"Inhibition of serum-stimulated mitogen activated protein kinase by 1α,25(OH)2-vitamin D3 in MCF-7 breast cancer cells"
(2004) Capiati, D.A.;Rossi, A.M.;Picotto, G. (
...
)Boland, R.L. Journal of Cellular Biochemistry. 93(2):384-397
"Heterologous expression of a plant arginine decarboxylase gene in Trypanosoma cruzi"
(2004) Carrillo, C.;Serra, M.P.;Pereira, C.A. (
...
)Algranati, I.D. Biochimica et Biophysica Acta - General Subjects. 1674(3):223-230
"The small GTP-binding protein RhoA regulates c-jun by a ROCK-JNK signaling axis"
(2004) Marinissen, M.J.;Chiariello, M.;Tanos, T. (
...
)Gutkind, J.S. Molecular Cell. 14(1):29-41
"Lactose derivatives are inhibitors of Trypanosoma cruzi trans-sialidase activity toward conventional substrates in vitro and in vivo"
(2004) Agustí, R.;París, G.;Ratier, L. (
...
)de Lederkremer, R.M. Glycobiology. 14(7):659-670
"Formation and remodeling of inositolphosphoceramide during differentiation of Trypanosoma cruzi from trypomastigote to amastigote"
(2003) Salto, M.L.;Bertello, L.E.;Vieira, M. (
...
)De Lederkremer, R.M. Eukaryotic Cell. 2(4):756-768
"Heregulin induces transcriptional activation of the progesterone receptor by a mechanism that requires functional ErbB-2 and mitogen-activated protein kinase activation in breast cancer cells"
(2003) Labriola, L.;Salatino, M.;Proietti, C.J. (
...
)Elizalde, P.V. Molecular and Cellular Biology. 23(3):1095-1111
"Nitric oxide induces gelatinase A (matrix metalloproteinase 2) during rat embryo implantation"
(2002) Novaro, V.;Pustovrh, C.;Colman-Lerner, A. (
...
)González, E. Fertility and Sterility. 78(6):1278-1287
"Influence of exo β-D-galactofuranosidase inhibitors in cultures of Penicillium fellutanum and modifications in hyphal cell structure"
(2002) Mariño, K.;Lima, C.;Maldonado, S. (
...
)De Lederkremer, R.M. Carbohydrate Research. 337(10):891-897
"Contribution of Ca2+ calmodulin-dependent protein kinase II and mitogen-activated protein kinase kinase to neural activity-induced neurite outgrowth and survival of cerebellar granule cells"
(2002) Borodinsky, L.N.; Coso, O.A.; Fiszman, M.L. Journal of Neurochemistry. 80(6):1062-1070
"Activation of nitric oxide synthase through muscarinic receptors in rat parotid gland"
(2002) Rosignoli, F.; Pérez Leirós, C. European Journal of Pharmacology. 439(1-3):27-33
"Myosin light chain kinase inhibitors induce retraction of mature oligodendrocyte processes"
(2002) Thomas, M.G.; Santa Coloma, T.A.; Correale, J.; Boccaccio, G.L. Neurochemical Research. 27(11):1305-1312
"Roscovitine inhibits ongoing DNA synthesis in human cervical cancer"
(2002) Vitali, L.;Yakisich, J.Sebastian;Vita, M.F. (
...
)Idoyaga Vargas, V. Cancer Letters. 180(1):7-12
"Impairment of mineralocorticoid receptor (MR)-dependent biological response by oxidative stress and aging: Correlation with post-translational modification of MR and decreased ADP-ribosylatable level of elongation factor 2 in kidney cells"
(2002) Piwien-Pilipuk, G.; Ayala, A.; Machado, A.; Galigniana, M.D. Journal of Biological Chemistry. 277(14):11896-11903
"Osmotic stress sensitizes naturally resistant cells to TNF-α-induced apoptosis"
(2002) Franco, D.L.;Nojek, I.M.;Molinero, L. (
...
)Costas, M.A. Cell Death and Differentiation. 9(10):1090-1098
"Glutathione-like tripeptides as inhibitors of glutathionylspermidine synthetase. Part 1: Substitution of the glycine carboxylic acid group"
(2002) Amssoms, K.;Oza, S.L.;Ravaschino, E. (
...
)Haemers, A. Bioorganic and Medicinal Chemistry Letters. 12(18):2553-2556
"Interaction of cimetidine with P450 in a mouse model of hepatocarcinogenesis initiation"
(2002) Caballero, F.; Gerez, E.; Batlle, A.; Vazquez, E. British Journal of Cancer. 86(4):630-635
"Evidence for CRK3 participation in the cell division cycle of Trypanosoma cruzi"
(2002) Santori, M.I.;Laría, S.;Gómez, E.B. (
...
)Téllez-Iñón, M.T. Molecular and Biochemical Parasitology. 121(2):225-232
"Heregulin inhibits proliferation via ERKs and phosphatidyl-inositol 3-kinase activation but regulates urokinase plasminogen activator independently of these pathways in metastatic mammary tumor cells"
(2002) Puricelli, L.;Proiettii, C.J.;Labriola, L. (
...
)Elizalde, P.V. International Journal of Cancer. 100(6):642-653
"The IκB kinase inhibitor sulfasalazine impairs long-term memory in the crab Chasmagnathus"
(2002) Merlo, E.; Freudenthal, R.; Romano, A. Neuroscience. 112(1):161-172
"Spermidine is essential for normal proliferation of trypanosomatid protozoa"
(2001) González, N.S.; Huber, A.; Algranati, I.D. FEBS Letters. 508(3):323-326
"Coupling of L-type calcium channels to neurotransmitter release at mouse motor nerve terminals"
(2001) Urbano, F.J.; Depetris, R.S.; Uchitel, O.D. Pflugers Archiv European Journal of Physiology. 441(6):824-831
"Characterization of the Trypanosoma cruzi Cdc2p-related protein kinase 1 and identification of three novel associating cyclins"
(2001) Gómez, E.B.;Santori, M.I.;Laría, S. (
...
)Téllez-Ión, M.T. Molecular and Biochemical Parasitology. 113(1):97-108
"Effect of aminoguanidine, a nitric oxide synthase inhibitor, on ocular infection with herpes simplex virus in Balb/c mice"
(2001) Benencia, F.;Courrèges, M.C.;Gamba, G. (
...
)Massouh, E.J. Investigative Ophthalmology and Visual Science. 42(6):1277-1284
"Involvement of vacuolar proton ATPase in Junin virus multiplication"
(2001) Castilla, V.; Palermo, L.M.; Coto, C.E. Archives of Virology. 146(2):251-263
"Preventive aspirin treatment of streptozotocin induced diabetes: Blockage of oxidative status and revertion of heme enzymes inhibition"
(2000) Caballero, F.; Gerez, E.; Batlle, A.; Vazquez, E. Chemico-Biological Interactions. 126(3):215-225
"Evidence for phospholipases from Trypanosoma cruzi active on phosphatidylinositol and inositolphosphoceramide"
(2000) Bertello, L.E.; Alves, M.J.M.; Colli, W.; De Lederkremer, R.M. Biochemical Journal. 345(1):77-84
"Role of protein kinase C in 1,25(OH)2-vitamin D3 modulation of intracellular calcium during development of skeletal muscle cells in culture"
(2000) Capiati, D.A.; Vazquez, G.; Tellez Iñón, M.T.; Boland, R.L. Journal of Cellular Biochemistry. 77(2):200-212
"Drug metabolizing enzyme system and heme pathway in hepatocarcinogenesis"
(1999) Vazquez, E.;Gerez, E.;Caballero, F. (
...
)Batlle, A. Cancer Biochemistry Biophysics. 17(1-2):25-34
"Porphyria-induced hepatic porphyrinogen carboxy-lyase inhibitor and its interaction with the active site(s) of the enzyme"
(1999) De Catabbi, S.B.;De Calmanovici, R.W.;Minutolo, C. (
...
)De Viale, L.C.S.M. Biochemistry and Molecular Biology International. 47(6):945-956
"Participation of protein kinase C α in 1,25-dihydroxy-vitamin D3 regulation of chick myoblast proliferation and differentiation"
(1999) Capiati, D.A.; Téllez-Iñón, M.T.; Boland, R.L. Molecular and Cellular Endocrinology. 153(1-2):39-45
"Identification of a UPTG inhibitor protein from maize endosperm: high homology with sucrose synthase protein."
(1998) Wald, F.A.; Rothschild, A.; Moreno, S.; Tandecarz, J.S. Cellular and molecular biology (Noisy-le-Grand, France). 44(3):397-406
"Extracellular ATP and bradykinin increase cGMP in vascular endothelial cells via activation of PKC"
(1998) Castro, A.F.;Amorena, C.;Müller, A. (
...
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