Abstract:
A dense glycocalix covers the surface of Trypanosoma cruzi, the agent of Chagas disease. Sialic acid in the surface of the parasite plays an important role in the infectious process, however, T. cruzi is unable to synthesize sialic acid or the usual donor CMP-sialic acid. Instead, T. cruzi expresses a unique enzyme, the trans-sialidase (TcTS) involved in the transfer of sialic acid from host glycoconjugates to mucins of the parasite. The mucins are the major glycoproteins in the insect stage epimastigotes and in the infective trypomastigotes. Both, the mucins and the TcTS are anchored to the plasma membrane by a glycosylphosphatidylinositol anchor. Thus, TcTS may be shed into the bloodstream of the mammal host by the action of a parasite phosphatidylinositol-phospholipase C, affecting the immune system. The composition and structure of the sugars in the parasite mucins is characteristic of each differentiation stage, also, interstrain variations were described for epimastigote mucins. This review focus on the characteristics of the interplay between the trans-sialidase and the mucins of T. cruzi and summarizes the known carbohydrate structures of the mucins. © 2011 Elsevier Ltd. All rights reserved.
Registro:
Documento: |
Artículo
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Título: | Trans-sialidase and mucins of Trypanosoma cruzi: An important interplay for the parasite |
Autor: | Eugenia Giorgi, M.; De Lederkremer, R.M. |
Filiación: | CIHIDECAR, Departamento de Química Orgánica, Ciudad Universitaria, Pabellón II, 1428 Buenos Aires, Argentina
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Palabras clave: | Chagas disease; Mucins; Trans-sialidase; Trypanosoma cruzi; Chagas disease; Epimastigotes; Glycoconjugates; Glycosylphosphatidylinositol anchors; Immune systems; Mucins; Parasite-; Sialic acids; Trans-sialidases; Trypanosoma cruzi; Cell membranes; Sugars; Carboxylic acids; glycoconjugate; glycosylphosphatidylinositol; mucin; oligosaccharide; sialidase; article; carbohydrate analysis; enzyme activity; epimastigote; nonhuman; priority journal; sialylation; Trypanosoma cruzi; trypomastigote; Animals; Carbohydrate Sequence; Chagas Disease; Enzyme Inhibitors; Glycoconjugates; Glycoproteins; Glycosylphosphatidylinositols; Humans; Life Cycle Stages; Molecular Sequence Data; Mucins; Neuraminidase; Protein Binding; Sialic Acids; Species Specificity; Trypanosoma cruzi; Type C Phospholipases; Hexapoda; Mammalia; Trypanosoma cruzi |
Año: | 2011
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Volumen: | 346
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Número: | 12
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Página de inicio: | 1389
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Página de fin: | 1393
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DOI: |
http://dx.doi.org/10.1016/j.carres.2011.04.006 |
Título revista: | Carbohydrate Research
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Título revista abreviado: | Carbohydr. Res.
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ISSN: | 00086215
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CODEN: | CRBRA
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CAS: | sialidase, 9001-67-6; Enzyme Inhibitors; Glycoconjugates; Glycoproteins; Glycosylphosphatidylinositols; Mucins; Neuraminidase, 3.2.1.18; Sialic Acids; Type C Phospholipases, 3.1.4.-; trans-sialidase, 3.2.1.-
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00086215_v346_n12_p1389_EugeniaGiorgi |
Referencias:
- Brener, Z., (1973) Ann. Rev. Microbiol., 27, pp. 347-382
- Moncayo, A., (2003) Mem. Inst. Oswaldo Cruz., 98, pp. 577-591
- Anonymous, (1999) Mem. Inst. Oswaldo Cruz., 429, p. 432
- Zingales, B., Andrade, S.G., Briones, M.R., Campbell, D.A., Chiari, E., Fernandes, O., Guhl, F., Schijman, A.G., (2009) Mem. Inst. Oswaldo Cruz., 104, pp. 1051-1054
- Lederkremer, R.M., Agustí, R., (2009) Adv. Carbohydr. Chem. Biochem., 62, pp. 311-366
- Lederkremer, R.M., Bertello, L.E., (2001) Curr. Pharm. Des., 7, pp. 1165-1179
- Previato, J.O., Wait, R., Jones, C., Dosreis, G.A., Todeschini, A.R., Heise, N., Previato, L.M., (2004) Adv. Parasitol., 56, pp. 1-41
- Schenkman, S., Jiang, M.S., Hart, G.W., Nussenzweig, V., (1991) Cell, 65, pp. 1117-1125
- Frasch, A.C.C., (2000) Parasitol. Today, 16, pp. 282-286
- Ferrero-Garcia, M.A., Trombetta, S.E., Sanchez, D.O., Reglero, A., Frasch, A.C.C., Parodi, A.J., (1993) Eur. J. Biochem., 213, pp. 765-771
- Schenkman, S., Eichinger, D., Pereira, M.E., Nussenzweig, V., (1994) Annu. Rev. Microbiol., 48, pp. 499-523
- Buschiazzo, A., Alzari, P.M., (2008) Curr. Opin. Chem. Biol., 12, pp. 565-572
- Agusti, R., Giorgi, M.E., Lederkremer, R.M., (2007) Carbohydr. Res., 342, pp. 2465-2469
- Schroven, A., Meinke, S., Ziegelmuller, P., Thiem, J., (2007) Chem. Eur. J., 13, pp. 9012-9021
- Zingales, B., Carniol, C., Lederkremer, R.M., Colli, W., (1987) Mol. Biochem. Parasitol., 26, pp. 135-144
- Chaves, L.B., Briones, M.R., Schenkman, S., (1993) Mol. Biochem. Parasitol., 61, pp. 97-106
- Amino, R., Acosta-Serrano, A., Morita, O.M., Pereira-Chioccola, V.L., Schenkman, S., (1995) Glycobiology, 5, pp. 625-631
- Buschiazzo, A., Frasch, A.C.C., Campetella, O., (1996) Cell. Mol. Biol., 42, pp. 703-710
- Paris, G., Cremona, M.L., Amaya, M.F., Buschiazzo, A., Giambiagi, S., Frasch, A.C.C., Alzari, P.M., (2001) Glycobiology, 11, pp. 305-311
- Agusti, R., Paris, G., Ratier, L., Frasch, A.C.C., Lederkremer, R.M., (2004) Glycobiology, 14, pp. 659-670
- Buschiazzo, A., Amaya, M.F., Cremona, M.L., Frasch, A.C.C., Alzari, P.M., (2002) Mol. Cell, 10, pp. 575-768
- Amaya, M.F., Buschiazzo, A., Nguyen, T., Alzari, P.M., (2003) J. Mol. Biol., 325, pp. 773-784
- Amaya, M.F., Watts, A.G., Damager, I., Wehenkel, A., Nguyen, T., Buschiazzo, A., Paris, G., Alzari, P.M., (2004) Structure, 12, pp. 775-784
- Todeschini, A.R., Dias, W.B., Girard, M.F., Wieruszeski, J.M., Mendona-Previato, L., Previato, J.O., (2004) J. Biol. Chem., 279, pp. 5323-5328
- Magdesian, M.H., Tonelli, R.R., Fessel, M.R., Silveira, M.S., Schumacher, R.I., Linden, R., Colli, W., Alves, M.J., (2006) Exp. Cell Res., 313, pp. 210-218
- Tonelli, R.R., Giordano, R.J., Barbu, E.M., Torrecilhas, A.C., Kobayashi, G.S., Langley, R.R., Arap, W., Alves, M.J., (2010) PloS Negl. Trop. Dis., 4, p. 864
- Santos, M.A., Garg, N., Tarleton, R.L., (1997) Mol. Biochem. Parasitol., 86, pp. 1-11
- Agusti, R., Couto, A.S., Campetella, O., Frasch, A.C.C., Lederkremer, R.M., (1997) Glycobiology, 7, pp. 731-735
- Agusti, R., Couto, A.S., Campetella, O., Frasch, A.C.C., Lederkremer, R.M., (1998) Mol. Biochem. Parasitol., 97, pp. 123-131
- Leguizamón, M.S., Mocetti, E., Garcia Rivello, H., Argibay, P., Campetella, O., (1999) J. Infect. Dis., 180, pp. 1398-1402
- Risso, M.G., Pitcovsky, T.A., Caccuri, R.L., Campetella, O., Leguizamón, M.S., (2007) Parasitology, 134, pp. 503-510
- Mucci, J., Hidalgo, A., Mocetti, E., Argibay, P.F., Leguizamón, M.S., Campetella, O., (2002) Proc. Natl. Acad. Sci. USA, 99, pp. 3896-3901
- Mucci, J., Mocetti, E., Leguizamón, M.S., Campetella, O., (2005) J. Immunol., 174, pp. 4545-4550
- Mucci, J., Risso, M.G., Leguizamón, M.S., Frasch, A.C., Campetell, O., (2006) Cell. Microbiol., 8, pp. 1086-1095
- Rubin-De-Celis, S.S., Uemura, H., Yoshida, N., Schenkman, S., (2006) Cell. Microbiol., 8, pp. 1888-1898
- Risso, M.G., Garbarino, G.B., Mocetti, E., Campetella, O., Gonzalez Cappa, S.M., Buscaglia, C.A., Leguizamon, M.S., (2004) J. Infect. Dis., 189, pp. 2250-2259
- Erdmann, H., Steeg, C., Koch-Nolte, F., Fleischer, B., Jacobs, T., (2009) Cell. Microbiol., 11, pp. 1600-1611
- Jacobs, T., Erdmann, H., Fleischer, B., (2010) Eur. J. Cell Biol., 89, pp. 113-116
- Muiá, R.P., Yu, H., Prescher, J.A., Hellman, U., Chen, X., Bertozzi, C.R., Campetella, O., (2010) Glycobiology, 20, pp. 833-842
- Neres, J., Bryce, R.J., Douglas, K.T., (2008) Drug Discovery Today, 13, pp. 110-117
- Buchini, S., Buschiazzo, A., Withers, S.G., (2008) Angew. Chem., Int. Ed., 47, pp. 2700-2703
- Carvalho, S.T., Sola-Penna, M., Oliveira, I.A., Pita, S., Gonalves, A.S., Neves, B.C., Sousa, F.R., Todeschini, A.R., (2010) Glycobiology, 20, pp. 1034-1045
- Kim, J.H., Ryu, H.W., Shim, J.H., Park, K.H., Withers, S.G., (2009) Chembiochem, 10, p. 2475
- Arioka, S., Sakagami, M., Uematsu, R., Yamaguchi, H., Togame, H., Takemoto, H., Hinou, H., Nishimura, S., (2010) Bioorg. Med. Chem., 18, p. 1633
- Giorgi, M.E., Ratier, L., Agusti, R., Frasch, A.C.C., Lederkremer, R.M., (2010) Glycoconjugate J., 27, pp. 549-559
- Buscaglia, A.C., Campo, V.A., Frasch, A.C.C., Di Noia, J.M., (2006) Nat. Rev. Microbiol., 4, pp. 229-236
- Pereira-Chioccola, V.L., Acosta-Serrano, A., Correira De Almeida, I., Ferguson, M.A.J., Souto-Padron, T., Rodrigues, M.M., Travassos, L.R., Schenkman, S., (2000) J. Cell Sci., 113, pp. 1299-1307
- Almeida, I.C., Ferguson, M.A.J., Schenkman, S., Travassos, L.R., (1994) Biochem. J., 304, pp. 793-802
- Couto, A.S., Gonalves, M.F., Colli, W., Lederkremer, R.M., (1990) Mol. Biochem. Parasitol., 39, pp. 101-107
- Acosta-Serrano, A., Schenkman, S., Yoshida, N., Mehlert, A., Richardson, J., Ferguson, M.A.J., (1995) J. Biol. Chem., 270, pp. 27244-27253
- Previato, J.O., Jones, C., Gonalves, L.B.P., Wait, R., Travassos, L.R., Mendona-Previato, L., (1994) Biochem. J., 301, pp. 151-159
- Agrellos, O.A., Jones, C., Todeschini, A.R., Previato, J.O., Mendona-Previato, L., (2003) Mol. Biochem. Parasitol., 126, pp. 93-96
- Todeschini, A.R., Almeida, E.G., Agrellos, O.A., Jones, C., Previato, J.O., Mendona-Previato, L., (2009) Mem. Inst. Oswaldo Cruz., 104, pp. 270-274
- Previato, J.O., Jones, C., Gonalves, P.B., Wait, R., Travassos, L.R., Parodi, A.J., Mendona-Previato, L., (1995) J. Biol. Chem., 270, pp. 7241-7250
- Salto, M.L., Gallo-Rodriguez, C., Lima, C., Lederkremer, R.M., (2000) Anal. Biochem., 279, pp. 79-84
- Pollevick, G.D., Di Noia, J.M., Salto, M.L., Lima, C., Leguizamon, M.S., Lederkremer, R.M., Frasch, A.C.C., (2000) J. Biol. Chem., 275, pp. 27671-27680
- Todeschini, A.R., Da Silveira, E.X., Jones, C., Wait, R., Previato, J.O., Mendona-Previato, L., (2001) Glycobiology, 11, pp. 47-55
- Jones, C., Todeschini, A.R., Agrellos, O.A., Previato, J.O., Mendona-Previato, L., (2004) Biochemistry, 43, pp. 11889-11897
- De Arruda, M.V., Colli, W., Zingales, B., (1989) Eur. J. Biochem., 182, pp. 413-421
- Tetaud, E., Barret, M.P., Bringaud, F., Baltz, T., (1997) Biochem. J., 325, pp. 569-580
- Roper, J.R., Ferguson, M.A.J., (2003) Mol. Biochem. Parasitol., 132, pp. 47-53
- Beverley, S.M., Owens, K.L., Showalter, M., Griffith, C.L., Doering, T.L., Jones, V.C., Mc Neil, M.R., (2005) Eukariot. Cell, 4, pp. 1147-1154
- Bakker, H., Kleczka, B., Gerardy-Schahn, R., Routier, F.H., (2005) Biol. Chem., 386, pp. 657-661
- Previato, J.O., Sola-Penna, M., Agrellos, O.A., Jones, C., Oekmann, T., Travassos, L.R., Mendona-Previato, L., (1998) J. Biol. Chem., 273, pp. 14982-14988
- Campo, V.A., Buscaglia, C.A., Di Noia, J.M., Frasch, A.C.C., (2006) Microbes Infect., 2, pp. 401-409
- Mendoza, V.M., Kashiwagi, G.A., Lederkremer, R.M., Gallo-Rodriguez, C., (2010) Carbohydr. Res., 345, pp. 385-396
- Mendoza, V.M., Agusti, R., Gallo-Rodriguez, C., Lederkremer, R.M., (2006) Carbohydr. Res., 341, pp. 1488-1497
- Agusti, R., Giorgi, M.E., Mendoza, V.M., Gallo-Rodriguez, C., Lederkremer, R.M., (2007) Bioorg. Med. Chem., 15, pp. 2611-2617
Citas:
---------- APA ----------
Eugenia Giorgi, M. & De Lederkremer, R.M.
(2011)
. Trans-sialidase and mucins of Trypanosoma cruzi: An important interplay for the parasite. Carbohydrate Research, 346(12), 1389-1393.
http://dx.doi.org/10.1016/j.carres.2011.04.006---------- CHICAGO ----------
Eugenia Giorgi, M., De Lederkremer, R.M.
"Trans-sialidase and mucins of Trypanosoma cruzi: An important interplay for the parasite"
. Carbohydrate Research 346, no. 12
(2011) : 1389-1393.
http://dx.doi.org/10.1016/j.carres.2011.04.006---------- MLA ----------
Eugenia Giorgi, M., De Lederkremer, R.M.
"Trans-sialidase and mucins of Trypanosoma cruzi: An important interplay for the parasite"
. Carbohydrate Research, vol. 346, no. 12, 2011, pp. 1389-1393.
http://dx.doi.org/10.1016/j.carres.2011.04.006---------- VANCOUVER ----------
Eugenia Giorgi, M., De Lederkremer, R.M. Trans-sialidase and mucins of Trypanosoma cruzi: An important interplay for the parasite. Carbohydr. Res. 2011;346(12):1389-1393.
http://dx.doi.org/10.1016/j.carres.2011.04.006