Artículo
Vazquez, E.; Gerez, E.; Caballero, F.; Polo, C.; Batlle, A. "Drug metabolizing enzyme system and heme pathway in hepatocarcinogenesis" (1999) Cancer Biochemistry Biophysics. 17(1-2):25-34
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Abstract:
Chemically induced and spontaneous liver tumors share some metabolic alterations. The decline in hemoprotein levels during hepatocarcinogenesis may result from a diminution of the intracellular heme pool. To elucidate if the onset of the pre-initiation stage alters the natural regulation mechanism of heme pathway, animals were fed with p-dimethylaminoazobenzene (DAB) and treated or not with 2-allylisopropylacetamide (AIA). The induction of 6-Aminolevulinic acid synthase (ALA-S) activity and the diminution in microsomal heme oxygenase (MHO) did not change when DAB fed animals were treated with AIA. Cytochrome P-450 (P-450) levels and glutathione S-transferase activity were increased in all the groups tested. Tryptophan pyrrolase, sulphatase and β-glucuronidase activities were altered in DAB fed animals but AIA treatment did not produce any effect. Changes in drug metabolizing enzymes in livers of DAB fed animals could be the result of a primary deregulation of heme metabolism. These results give additional support to our hypothesis about a mechanism for the onset of hepatocarcinogenesis.
Registro:
| Documento: | Artículo |
| Título: | Drug metabolizing enzyme system and heme pathway in hepatocarcinogenesis |
| Autor: | Vazquez, E.; Gerez, E.; Caballero, F.; Polo, C.; Batlle, A. |
| Filiación: | Ctro. Invest. Porfirinas y Porfirias, Ciudad Universitaria, Pabellón II, (1428) Buenos Aires, Argentina Viamonte 1881 10o, A 1056 - Buenos Aires, Argentina |
| Palabras clave: | δ-Aminolevulinic acid synthase; 2-allylisopropyl-acetamide; Cytochrome P-450; Gluthatione S-transferase; Hepatocarcinogenesis; Microsomal heme oxygenase; 4 dimethylaminoazobenzene; 5 aminolevulinate synthase; allylisopropylacetamide; beta glucuronidase; carcinogen; cytochrome P450; enzyme inhibitor; glutathione transferase; heme; heme oxygenase; hemoprotein; prodrug; sulfatase; tryptophan 2,3 dioxygenase; animal; article; biological model; biotransformation; cell transformation; chemically induced disorder; comparative study; drug antagonism; drug effect; drug resistance; enzyme induction; enzymology; liver microsome; liver tumor; male; metabolism; mouse; oxidation reduction reaction; physiology; precancer; 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Biotransformation; Carcinogens; Cell Transformation, Neoplastic; Cytochrome P-450 Enzyme System; Drug Resistance; Enzyme Induction; Enzyme Inhibitors; Glucuronidase; Glutathione Transferase; Heme; Heme Oxygenase (Decyclizing); Hemeproteins; Liver Neoplasms, Experimental; Male; Mice; Microsomes, Liver; Models, Biological; Oxidation-Reduction; p-Dimethylaminoazobenzene; Precancerous Conditions; Prodrugs; Sulfatases; Tryptophan Oxygenase |
| Año: | 1999 |
| Volumen: | 17 |
| Número: | 1-2 |
| Página de inicio: | 25 |
| Página de fin: | 34 |
| Título revista: | Cancer Biochemistry Biophysics |
| Título revista abreviado: | Cancer Biochem. Biophys. |
| ISSN: | 03057232 |
| CODEN: | CABCD |
| CAS: | 5-Aminolevulinate Synthetase, EC 2.3.1.37; Allylisopropylacetamide, 299-78-5; Carcinogens; Cytochrome P-450 Enzyme System, 9035-51-2; Enzyme Inhibitors; Glucuronidase, EC 3.2.1.31; Glutathione Transferase, EC 2.5.1.18; Heme Oxygenase (Decyclizing), EC 1.14.99.3; Heme, 14875-96-8; Hemeproteins; p-Dimethylaminoazobenzene, 60-11-7; Prodrugs; Sulfatases, EC 3.1.6.-; Tryptophan Oxygenase, EC 1.13.11.11 |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03057232_v17_n1-2_p25_Vazquez |
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Citas:
---------- APA ----------
Vazquez, E., Gerez, E., Caballero, F., Polo, C. & Batlle, A. (1999) . Drug metabolizing enzyme system and heme pathway in hepatocarcinogenesis. Cancer Biochemistry Biophysics, 17(1-2), 25-34.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03057232_v17_n1-2_p25_Vazquez [ ]
---------- CHICAGO ----------
Vazquez, E., Gerez, E., Caballero, F., Polo, C., Batlle, A. "Drug metabolizing enzyme system and heme pathway in hepatocarcinogenesis" . Cancer Biochemistry Biophysics 17, no. 1-2 (1999) : 25-34.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03057232_v17_n1-2_p25_Vazquez [ ]
---------- MLA ----------
Vazquez, E., Gerez, E., Caballero, F., Polo, C., Batlle, A. "Drug metabolizing enzyme system and heme pathway in hepatocarcinogenesis" . Cancer Biochemistry Biophysics, vol. 17, no. 1-2, 1999, pp. 25-34.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03057232_v17_n1-2_p25_Vazquez [ ]
---------- VANCOUVER ----------
Vazquez, E., Gerez, E., Caballero, F., Polo, C., Batlle, A. Drug metabolizing enzyme system and heme pathway in hepatocarcinogenesis. Cancer Biochem. Biophys. 1999;17(1-2):25-34.Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03057232_v17_n1-2_p25_Vazquez [ ]
