Artículo
Abstract:
Since the appearance of resistance to antiretroviral treatment is unavoidable, the host cell's transcription factor NF-kappaB is a novel HIV target. The goal of this study was to characterize the effect of two immunomodulators, curcumin (Cur) and sulfasalazine (Sul), with a protease inhibitor, indinavir (IDV), on HIV-1 persistently infected CD4+ T-cells. Viral p24 antigen production, viral infectivity (tested on MAGI cells) and viral relative infectivity (viral infectivity/p24) were analysed. When used alone, both immunomodulators were able to reduce viral infectivity. When in combination, both 10 μM IDV plus 10 μM Cur and 10 μM IDV plus 250 μM Sul showed a significant reduction in viral infectivity and viral relative infectivity when compared to the reduction produced by IDV alone. Thus, the use of immunomodulators with IDV could help to reduce HIV-1 production in persistently infected cells. © 2008 Springer-Verlag.
Registro:
| Documento: | Artículo |
| Título: | Two immunomodulators, curcumin and sulfasalazine, enhance IDV antiretroviral activity in HIV-1 persistently infected cells |
| Autor: | Riva, D.A.; Fernández-Larrosa, P.N.; Dolcini, G.L.; Martínez-Peralta, L.A.; Coulombié, F.C.; Mersich, S.E. |
| Filiación: | Department of Biochemistry, School of Science, University of Buenos Aires, Int. Güiraldes 2160, C1428EGA, Buenos Aires, Argentina Department of Microbiology, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina |
| Palabras clave: | anti human immunodeficiency virus agent; curcumin; enzyme inhibitor; Gag protein; indinavir; NF kappa B kinase; NF-kappa B kinase; protein serine threonine kinase; proteinase inhibitor; salazosulfapyridine; unclassified drug; article; CD4+ T lymphocyte; cell line; cell survival; drug effect; drug potentiation; human; Human immunodeficiency virus 1; metabolism; physiology; virology; Anti-HIV Agents; CD4-Positive T-Lymphocytes; Cell Line; Cell Survival; Curcumin; Drug Synergism; Enzyme Inhibitors; HIV Core Protein p24; HIV Protease Inhibitors; HIV-1; Humans; Indinavir; Protein-Serine-Threonine Kinases; Sulfasalazine; Human immunodeficiency virus; Human immunodeficiency virus 1 |
| Año: | 2008 |
| Volumen: | 153 |
| Número: | 3 |
| Página de inicio: | 561 |
| Página de fin: | 565 |
| DOI: | http://dx.doi.org/10.1007/s00705-007-0023-4 |
| Título revista: | Archives of Virology |
| Título revista abreviado: | Arch. Virol. |
| ISSN: | 03048608 |
| CODEN: | ARVID |
| CAS: | curcumin, 458-37-7; indinavir, 150378-17-9, 157810-81-6, 180683-37-8; proteinase inhibitor, 37205-61-1; salazosulfapyridine, 599-79-1; Anti-HIV Agents; Curcumin, 458-37-7; Enzyme Inhibitors; HIV Core Protein p24; HIV Protease Inhibitors; Indinavir, 150378-17-9; NF-kappa B kinase, 2.7.1.37; Protein-Serine-Threonine Kinases, 2.7.11.1; Sulfasalazine, 599-79-1 |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03048608_v153_n3_p561_Riva |
Citas:
---------- APA ----------
Riva, D.A., Fernández-Larrosa, P.N., Dolcini, G.L., Martínez-Peralta, L.A., Coulombié, F.C. & Mersich, S.E. (2008) . Two immunomodulators, curcumin and sulfasalazine, enhance IDV antiretroviral activity in HIV-1 persistently infected cells. Archives of Virology, 153(3), 561-565.http://dx.doi.org/10.1007/s00705-007-0023-4
---------- CHICAGO ----------
Riva, D.A., Fernández-Larrosa, P.N., Dolcini, G.L., Martínez-Peralta, L.A., Coulombié, F.C., Mersich, S.E. "Two immunomodulators, curcumin and sulfasalazine, enhance IDV antiretroviral activity in HIV-1 persistently infected cells" . Archives of Virology 153, no. 3 (2008) : 561-565.http://dx.doi.org/10.1007/s00705-007-0023-4
---------- MLA ----------
Riva, D.A., Fernández-Larrosa, P.N., Dolcini, G.L., Martínez-Peralta, L.A., Coulombié, F.C., Mersich, S.E. "Two immunomodulators, curcumin and sulfasalazine, enhance IDV antiretroviral activity in HIV-1 persistently infected cells" . Archives of Virology, vol. 153, no. 3, 2008, pp. 561-565.http://dx.doi.org/10.1007/s00705-007-0023-4
---------- VANCOUVER ----------
Riva, D.A., Fernández-Larrosa, P.N., Dolcini, G.L., Martínez-Peralta, L.A., Coulombié, F.C., Mersich, S.E. Two immunomodulators, curcumin and sulfasalazine, enhance IDV antiretroviral activity in HIV-1 persistently infected cells. Arch. Virol. 2008;153(3):561-565.http://dx.doi.org/10.1007/s00705-007-0023-4
