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Abstract:

Mature oligodendrocytes emit numerous myelinating processes. Force generating molecules are required for process outgrowth and spreading. We have analyzed the effect of the myosin II light chain kinase inhibitors ML-7 and ML-9 in cultured oligodendrocytes. Both drugs affect oligo-dendrocyte cell shape, provoking a retraction of high order processes. Our results suggest that the adhesion of the myelinating processes to the substrate depends on MLC phosphorylation, thus likely implicating myosin IIA.

Registro:

Documento: Artículo
Título:Myosin light chain kinase inhibitors induce retraction of mature oligodendrocyte processes
Autor:Thomas, M.G.; Santa Coloma, T.A.; Correale, J.; Boccaccio, G.L.
Filiación:IIB Fundación Campomar, IIB FCEyN, University of Buenos Aires, Buenos Aires, Argentina
Inst. Investigaciones Neurologicas, FLENI, Buenos Aires, Argentina
Fundación Instituto Leloir, Av. Patricias Argentinas 435, 1405 Buenos Aires, Argentina
Palabras clave:ML-7; ML-9; MLCK; Myelin; Myosin II; Oligodendrocyte processes; myosin IIA; myosin light chain kinase inhibitor; protein ml 7; protein ml 9; unclassified drug; animal tissue; article; cell activity; cell adhesion; cell culture; cell differentiation; cell growth; cell maturation; cell shape; central nervous system; controlled study; immunohistochemistry; myelination; nonhuman; oligodendroglia; phosphorylation; priority journal; rat; Animals; Azepines; Enzyme Inhibitors; Myosin-Light-Chain Kinase; Naphthalenes; Oligodendroglia; Phosphorylation; Rats; Rats, Wistar; Animalia
Año:2002
Volumen:27
Número:11
Página de inicio:1305
Página de fin:1312
DOI: http://dx.doi.org/10.1023/A:1021615530960
Título revista:Neurochemical Research
Título revista abreviado:Neurochem. Res.
ISSN:03643190
CODEN:NERED
CAS:Azepines; Enzyme Inhibitors; ML 7, 109376-83-2; ML 9, 105637-50-1; Myosin-Light-Chain Kinase, EC 2.7.1.117; Naphthalenes
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03643190_v27_n11_p1305_Thomas

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Citas:

---------- APA ----------
Thomas, M.G., Santa Coloma, T.A., Correale, J. & Boccaccio, G.L. (2002) . Myosin light chain kinase inhibitors induce retraction of mature oligodendrocyte processes. Neurochemical Research, 27(11), 1305-1312.
http://dx.doi.org/10.1023/A:1021615530960
---------- CHICAGO ----------
Thomas, M.G., Santa Coloma, T.A., Correale, J., Boccaccio, G.L. "Myosin light chain kinase inhibitors induce retraction of mature oligodendrocyte processes" . Neurochemical Research 27, no. 11 (2002) : 1305-1312.
http://dx.doi.org/10.1023/A:1021615530960
---------- MLA ----------
Thomas, M.G., Santa Coloma, T.A., Correale, J., Boccaccio, G.L. "Myosin light chain kinase inhibitors induce retraction of mature oligodendrocyte processes" . Neurochemical Research, vol. 27, no. 11, 2002, pp. 1305-1312.
http://dx.doi.org/10.1023/A:1021615530960
---------- VANCOUVER ----------
Thomas, M.G., Santa Coloma, T.A., Correale, J., Boccaccio, G.L. Myosin light chain kinase inhibitors induce retraction of mature oligodendrocyte processes. Neurochem. Res. 2002;27(11):1305-1312.
http://dx.doi.org/10.1023/A:1021615530960