Abstract:
Mature oligodendrocytes emit numerous myelinating processes. Force generating molecules are required for process outgrowth and spreading. We have analyzed the effect of the myosin II light chain kinase inhibitors ML-7 and ML-9 in cultured oligodendrocytes. Both drugs affect oligo-dendrocyte cell shape, provoking a retraction of high order processes. Our results suggest that the adhesion of the myelinating processes to the substrate depends on MLC phosphorylation, thus likely implicating myosin IIA.
Registro:
Documento: |
Artículo
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Título: | Myosin light chain kinase inhibitors induce retraction of mature oligodendrocyte processes |
Autor: | Thomas, M.G.; Santa Coloma, T.A.; Correale, J.; Boccaccio, G.L. |
Filiación: | IIB Fundación Campomar, IIB FCEyN, University of Buenos Aires, Buenos Aires, Argentina Inst. Investigaciones Neurologicas, FLENI, Buenos Aires, Argentina Fundación Instituto Leloir, Av. Patricias Argentinas 435, 1405 Buenos Aires, Argentina
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Palabras clave: | ML-7; ML-9; MLCK; Myelin; Myosin II; Oligodendrocyte processes; myosin IIA; myosin light chain kinase inhibitor; protein ml 7; protein ml 9; unclassified drug; animal tissue; article; cell activity; cell adhesion; cell culture; cell differentiation; cell growth; cell maturation; cell shape; central nervous system; controlled study; immunohistochemistry; myelination; nonhuman; oligodendroglia; phosphorylation; priority journal; rat; Animals; Azepines; Enzyme Inhibitors; Myosin-Light-Chain Kinase; Naphthalenes; Oligodendroglia; Phosphorylation; Rats; Rats, Wistar; Animalia |
Año: | 2002
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Volumen: | 27
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Número: | 11
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Página de inicio: | 1305
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Página de fin: | 1312
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DOI: |
http://dx.doi.org/10.1023/A:1021615530960 |
Título revista: | Neurochemical Research
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Título revista abreviado: | Neurochem. Res.
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ISSN: | 03643190
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CODEN: | NERED
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CAS: | Azepines; Enzyme Inhibitors; ML 7, 109376-83-2; ML 9, 105637-50-1; Myosin-Light-Chain Kinase, EC 2.7.1.117; Naphthalenes
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03643190_v27_n11_p1305_Thomas |
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Citas:
---------- APA ----------
Thomas, M.G., Santa Coloma, T.A., Correale, J. & Boccaccio, G.L.
(2002)
. Myosin light chain kinase inhibitors induce retraction of mature oligodendrocyte processes. Neurochemical Research, 27(11), 1305-1312.
http://dx.doi.org/10.1023/A:1021615530960---------- CHICAGO ----------
Thomas, M.G., Santa Coloma, T.A., Correale, J., Boccaccio, G.L.
"Myosin light chain kinase inhibitors induce retraction of mature oligodendrocyte processes"
. Neurochemical Research 27, no. 11
(2002) : 1305-1312.
http://dx.doi.org/10.1023/A:1021615530960---------- MLA ----------
Thomas, M.G., Santa Coloma, T.A., Correale, J., Boccaccio, G.L.
"Myosin light chain kinase inhibitors induce retraction of mature oligodendrocyte processes"
. Neurochemical Research, vol. 27, no. 11, 2002, pp. 1305-1312.
http://dx.doi.org/10.1023/A:1021615530960---------- VANCOUVER ----------
Thomas, M.G., Santa Coloma, T.A., Correale, J., Boccaccio, G.L. Myosin light chain kinase inhibitors induce retraction of mature oligodendrocyte processes. Neurochem. Res. 2002;27(11):1305-1312.
http://dx.doi.org/10.1023/A:1021615530960