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Abstract:

Spatial familiarization consists of a decrease in the exploratory activity over time after exposure to a place. Here, we show that a 30-min exposure to an open field led to a pronounced decrease in the exploratory behavior of rats, generating context familiarity. This behavioral output is associated with a selective decrease in hippocampal PKMζ levels. A short 5-min exposure did not induce spatial familiarity or a decrease in PKMζ, while inactivation of hippocampal PKMζ by the specific inhibitor ZIP was sufficient to induce spatial familiarity, suggesting that the decrease in PKMζ is involved in setting a given context as a familiar place. © 2008 Cold Spring Harbor Laboratory Press.

Registro:

Documento: Artículo
Título:PKMζ inactivation induces spatial familiarity
Autor:Moncada, D.; Viola, H.
Filiación:Instituto de Biología Celular Y Neurociencias, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires 1121, Argentina
Departamento de Fisiología, Biología Molecular Y Celular, Facultad de Ciencias Exactas Y Naturales, Universidad de Buenos Aires, Buenos Aires 1428, Argentina
Palabras clave:protein inhibitor; protein kinase; protein kinase m zeta; unclassified drug; zeta interacting protein; enzyme inhibitor; peptide; protein kinase C; protein kinase M zeta, rat; animal experiment; animal tissue; article; controlled study; exploratory behavior; hippocampus; histology; immunoblotting; male; nonhuman; open field test; priority journal; rat; spatial discrimination; analysis of variance; animal; behavior; drug effect; exploratory behavior; gene expression regulation; hippocampus; metabolism; physiology; recognition; time; Wistar rat; Analysis of Variance; Animals; Enzyme Inhibitors; Exploratory Behavior; Gene Expression Regulation; Hippocampus; Male; Peptides; Protein Kinase C; Rats; Rats, Wistar; Recognition (Psychology); Spatial Behavior; Time Factors
Año:2008
Volumen:15
Número:11
Página de inicio:810
Página de fin:814
DOI: http://dx.doi.org/10.1101/lm.1139508
Título revista:Learning and Memory
Título revista abreviado:Learn. Mem.
ISSN:10720502
CODEN:LEMEF
CAS:protein kinase, 9026-43-1; protein kinase C, 141436-78-4; Enzyme Inhibitors; Peptides; Protein Kinase C, EC 2.7.11.13; protein kinase M zeta, rat, EC 2.7.1.37
PDF:https://bibliotecadigital.exactas.uba.ar/download/paper/paper_10720502_v15_n11_p810_Moncada.pdf
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10720502_v15_n11_p810_Moncada

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Citas:

---------- APA ----------
Moncada, D. & Viola, H. (2008) . PKMζ inactivation induces spatial familiarity. Learning and Memory, 15(11), 810-814.
http://dx.doi.org/10.1101/lm.1139508
---------- CHICAGO ----------
Moncada, D., Viola, H. "PKMζ inactivation induces spatial familiarity" . Learning and Memory 15, no. 11 (2008) : 810-814.
http://dx.doi.org/10.1101/lm.1139508
---------- MLA ----------
Moncada, D., Viola, H. "PKMζ inactivation induces spatial familiarity" . Learning and Memory, vol. 15, no. 11, 2008, pp. 810-814.
http://dx.doi.org/10.1101/lm.1139508
---------- VANCOUVER ----------
Moncada, D., Viola, H. PKMζ inactivation induces spatial familiarity. Learn. Mem. 2008;15(11):810-814.
http://dx.doi.org/10.1101/lm.1139508