Artículo

Bello, E.P.; Mateo, Y.; Gelman, D.M.; Noaín, D.; Shin, J.H.; Low, M.J.; Alvarez, V.A.; Lovinger, D.M.; Rubinstein, M. "Cocaine supersensitivity and enhanced motivation for reward in mice lacking dopamine D2 autoreceptors" (2011) Nature Neuroscience. 14(8):1033-1038
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Abstract:

Dopamine (DA) D2 receptors expressed in DA neurons (D 2 autoreceptors) exert a negative feedback regulation that reduces DA neuron firing, DA synthesis and DA release. As D2 receptors are mostly expressed in postsynaptic neurons, pharmacological and genetic approaches have been unable to definitively address the in vivo contribution of D 2 autoreceptors to DA-mediated behaviors. We found that midbrain DA neurons from mice deficient in D2 autoreceptors (Drd2 loxP/loxP; Dat+/IREScre, referred to as autoDrd2KO mice) lacked DA-mediated somatodendritic synaptic responses and inhibition of DA release. AutoDrd2KO mice displayed elevated DA synthesis and release, hyperlocomotion and supersensitivity to the psychomotor effects of cocaine. The mice also exhibited increased place preference for cocaine and enhanced motivation for food reward. Our results highlight the importance of D 2 autoreceptors in the regulation of DA neurotransmission and demonstrate that D2 autoreceptors are important for normal motor function, food-seeking behavior, and sensitivity to the locomotor and rewarding properties of cocaine. © 2011 Nature America, Inc. All rights reserved.

Registro:

Documento: Artículo
Título:Cocaine supersensitivity and enhanced motivation for reward in mice lacking dopamine D2 autoreceptors
Autor:Bello, E.P.; Mateo, Y.; Gelman, D.M.; Noaín, D.; Shin, J.H.; Low, M.J.; Alvarez, V.A.; Lovinger, D.M.; Rubinstein, M.
Filiación:Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina
Section on Synaptic Pharmacology, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, United States
Section on Neuronal Structure, Laboratory for Integrative Neuroscience, US National Institutes of Health, Bethesda, MD, United States
Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, United States
Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
Palabras clave:cocaine; dopamine 2 receptor; dopamine autoreceptor; article; dopaminergic nerve cell; feeding behavior; motivation; motor performance; nerve cell inhibition; neurotransmission; priority journal; psychomotor activity; supersensitivity; synapse; Analysis of Variance; Animals; Autoradiography; Baclofen; Choice Behavior; Cocaine; Conditioning, Operant; Dihydroxyphenylalanine; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dopamine Uptake Inhibitors; Drug Interactions; Enzyme Inhibitors; Exploratory Behavior; Food; GABA-B Receptor Agonists; Hydrazines; Hyperkinesis; Maze Learning; Membrane Potentials; Mesencephalon; Mice; Mice, Knockout; Motivation; Motor Activity; Neurons; Quinpirole; Receptors, Dopamine D2; Reinforcement Schedule; Reward; Sulpiride
Año:2011
Volumen:14
Número:8
Página de inicio:1033
Página de fin:1038
DOI: http://dx.doi.org/10.1038/nn.2862
Título revista:Nature Neuroscience
Título revista abreviado:Nat. Neurosci.
ISSN:10976256
CODEN:NANEF
CAS:cocaine, 50-36-2, 53-21-4, 5937-29-1; 3-hydroxybenzylhydrazine, 637-33-2; Baclofen, 1134-47-0; Cocaine, 50-36-2; Dihydroxyphenylalanine, 63-84-3; Dopamine Agonists; Dopamine Antagonists; Dopamine Uptake Inhibitors; Enzyme Inhibitors; GABA-B Receptor Agonists; Hydrazines; Quinpirole, 85760-74-3; Receptors, Dopamine D2; Sulpiride, 15676-16-1
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10976256_v14_n8_p1033_Bello

Referencias:

  • Schultz, W., Dopamine signals for reward value and risk: Basic and recent data (2010) Behav. Brain Funct., 6, p. 24
  • Goto, Y., Otani, S., Grace, A.A., The Yin and Yang of dopamine release: A new perspective (2007) Neuropharmacology, 53 (5), pp. 583-587. , DOI 10.1016/j.neuropharm.2007.07.007, PII S0028390807002171
  • Volkow, N.D., Fowler, J.S., Wang, G.J., Baler, R., Telang, F., Imaging dopamine's role in drug abuse and addiction (2009) Neuropharmacology, 56 (SUPPL. 1), pp. 3-8
  • Kenny, P.J., Reward mechanisms in obesity: New insights and future directions (2011) Neuron, 69, pp. 664-679
  • Sulzer, D., How addictive drugs disrupt presynaptic dopamine neurotransmission (2011) Neuron, 69, pp. 628-649
  • Morgan, D., Grant, K.A., Gage, H.D., Mach, R.H., Kaplan, J.R., Prioleau, O., Nader, S.H., Nader, M.A., Social dominance in monkeys: Dopamine D2 receptors and cocaine self-administration (2002) Nature Neuroscience, 5 (2), pp. 169-174. , DOI 10.1038/nn798
  • Thanos, P.K., Volkow, N.D., Freimuth, P., Umegaki, H., Ikari, H., Roth, G., Ingram, D.K., Hitzemann, R., Overexpression of dopamine D2 receptors reduces alcohol self-administration (2001) Journal of Neurochemistry, 78 (5), pp. 1094-1103. , DOI 10.1046/j.1471-4159.2001.00492.x
  • Volkow, N.D., Wang, G.-J., Fowler, J.S., Logan, J., Gatley, S.J., Gifford, A., Hitzemann, R., Pappas, N., Prediction of reinforcing responses to psychostimulants in humans by brain dopamine D2 receptor levels (1999) American Journal of Psychiatry, 156 (9), pp. 1440-1443
  • Volkow, N.D., Brain da D2 receptors predict reinforcing effects of stimulants in humans: Replication study (2002) Synapse, 46, pp. 79-82
  • Chausmer, A.L., Elmer, G.I., Rubinstein, M., Low, M.J., Grandy, D.K., Katz, J.L., Cocaine-induced locomotor activity and cocaine discrimination in dopamine D2 receptor mutant mice (2002) Psychopharmacology, 163 (1), pp. 54-61. , DOI 10.1007/s00213-002-1142-y
  • Maldonado, R., Saiardi, A., Valverde, O., Samad, T.A., Roques, B.P., Borrelli, E., Absence of opiate, rewarding effects in mice lacking dopamine D2 receptors (1997) Nature, 388 (6642), pp. 586-589. , DOI 10.1038/41567
  • Phillips, T.J., Alcohol preference and sensitivity are markedly reduced in mice lacking dopamine D2 receptors (1998) Nat. Neurosci., 1, pp. 610-615
  • Welter, M., Vallone, D., Samad, T.A., Meziane, H., Usiello, A., Borrelli, E., Absence of dopamine D2 receptors unmasks an inhibitory control over the brain circuitries activated by cocaine (2007) Proceedings of the National Academy of Sciences of the United States of America, 104 (16), pp. 6840-6845. , DOI 10.1073/pnas.0610790104
  • Cunningham, C.L., Howard, M.A., Gill, S.J., Rubinstein, M., Low, M.J., Grandy, D.K., Ethanol-conditioned place preference is reduced in dopamine D2 receptor-deficient mice (2000) Pharmacology Biochemistry and Behavior, 67 (4), pp. 693-699. , DOI 10.1016/S0091-3057(00)00414-7, PII S0091305700004147
  • Bunney, B.S., Aghajanian, G.K., Roth, R.H., Comparison of effects of L-DOPA, amphetamine and apomorphine on firing rate of rat dopaminergic neurones (1973) Nat. New Biol., 245, pp. 123-125
  • Cubeddu, L.X., Hoffmann, I.S., Operational characteristics of the inhibitory feedback mechanism for regulation of dopamine release via presynaptic receptors (1982) Journal of Pharmacology and Experimental Therapeutics, 223 (2), pp. 497-501
  • Ford, C.P., Gantz, S.C., Phillips, P.E., Williams, J.T., Control of extracellular dopamine at dendrite and axon terminals (2010) J. Neurosci., 30, pp. 6975-6983
  • Paladini, C.A., Robinson, S., Morikawa, H., Williams, J.T., Palmiter, R.D., Dopamine controls the firing pattern of dopamine neurons via a network feedback mechanism (2003) Proceedings of the National Academy of Sciences of the United States of America, 100 (5), pp. 2866-2871. , DOI 10.1073/pnas.0138018100
  • Wolf, M.E., Roth, R.H., Autoreceptor regulation of dopamine synthesis (1990) Ann. NY Acad. Sci., 604, pp. 323-343
  • Schmitz, Y., Benoit-Marand, M., Gonon, F., Sulzer, D., Presynaptic regulation of dopaminergic neurotransmission (2003) Journal of Neurochemistry, 87 (2), pp. 273-289. , DOI 10.1046/j.1471-4159.2003.02050.x
  • Buckholtz, J.W., Dopaminergic network differences in human impulsivity (2010) Science, 329, p. 532
  • Koeltzow, T.E., Xu, M., Cooper, D.C., Hu, X.-T., Tonegawa, S., Wolf, M.E., White, F.J., Alterations in dopamine release but not dopamine autoreceptor function in dopamine D3 receptor mutant mice (1998) Journal of Neuroscience, 18 (6), pp. 2231-2238
  • Mercuri, N.B., Saiardi, A., Bonci, A., Picetti, R., Calabresi, P., Bernardi, G., Borrelli, E., Loss of auroreceptor function in dopaminergic neurons from dopamine D2 receptor deficient mice (1997) Neuroscience, 79 (2), pp. 323-327. , DOI 10.1016/S0306-4522(97)00135-8
  • Diaz-Torga, G., Feierstein, C., Libertun, C., Gelman, D., Kelly, M.A., Low, M.J., Rubinstein, M., Becu-Villalobos, D., Disruption of the D2 dopamine receptor alters GH and IGF-I secretion and causes dwarfism in male mice (2002) Endocrinology, 143 (4), pp. 1270-1279. , DOI 10.1210/en.143.4.1270
  • Backman, C.M., Malik, N., Zhang, Y., Shan, L., Grinberg, A., Hoffer, B.J., Westphal, H., Tomac, A.C., Characterization of a mouse strain expressing Cre recombinase from the 3′ untranslated region of the dopamine transporter locus (2006) Genesis, 44 (8), pp. 383-390. , DOI 10.1002/dvg.20228
  • Kennedy, R.T., Jones, S.R., Wightman, R.M., Dynamic observation of dopamine autoreceptor effects in rat striatal slices (1992) J. Neurochem., 59, pp. 449-455
  • Phillips, P.E.M., Hancock, P.J., Stamford, J.A., Time window of autoreceptor-mediated inhibition of limbic and striatal dopamine release (2002) Synapse, 44 (1), pp. 15-22. , DOI 10.1002/syn.10049
  • Kehr, W., Carlsson, A., Lindqvist, M., Magnusson, T., Atack, C., Evidence for a receptor-mediated feedback control of striatal tyrosine hydroxylase activity (1972) J. Pharm. Pharmacol., 24, pp. 744-747
  • Avale, M.E., Falzone, T.L., Gelman, D.M., Low, M.J., Grandy, D.K., Rubinstein, M., The dopamine D4 receptor is essential for hyperactivity and impaired behavioral inhibition in a mouse model of attention deficit/hyperactivity disorder (2004) Molecular Psychiatry, 9 (7), pp. 718-726
  • Giros, B., Jaber, M., Jones, S.R., Wightman, R.M., Caron, M.G., Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter (1996) Nature, 379 (6566), pp. 606-612. , DOI 10.1038/379606a0
  • Zhuang, X., Oosting, R.S., Jones, S.R., Gainetdinov, R.R., Miller, G.W., Caron, M.G., Hen, R., Hyperactivity and impaired response habituation in hyperdopaminergic mice (2001) Proceedings of the National Academy of Sciences of the United States of America, 98 (4), pp. 1982-1987. , DOI 10.1073/pnas.98.4.1982
  • Dickinson, S.D., Sabeti, J., Larson, G.A., Giardina, K., Rubinstein, M., Kelly, M.A., Grandy, D.K., Zahniser, N.R., Dopamine D2 receptor-deficient mice exhibit decreased dopamine transporter function but no changes in dopamine release in dorsal striatum (1999) Journal of Neurochemistry, 72 (1), pp. 148-156. , DOI 10.1046/j.1471-4159.1999.0720148.x
  • Jones, S.R., Gainetdinov, R.R., Hu, X.-T., Cooper, D.C., Wightman, R.M., White, F.J., Caron, M.G., Loss of autoreceptor functions in mice lacking the dopamine transporter (1999) Nature Neuroscience, 2 (7), pp. 649-655. , DOI 10.1038/10204
  • Berridge, K.C., The debate over dopamine's role in reward: The case for incentive salience (2007) Psychopharmacology, 191 (3), pp. 391-431. , DOI 10.1007/s00213-006-0578-x, Dopamine - Revisited
  • Salamone, J.D., Correa, M., Motivational views of reinforcement: Implications for understanding the behavioral functions of nucleus accumbens dopamine (2002) Behavioural Brain Research, 137 (1-2), pp. 3-25. , DOI 10.1016/S0166-4328(02)00282-6, PII S0166432802002826
  • Joseph, J.D., Wang, Y.-M., Miles, P.R., Budygin, E.A., Picetti, R., Gainetdinov, R.R., Caron, M.G., Wightman, R.M., Dopamine autoreceptor regulation of release and uptake in mouse brain slices in the absence of D3 receptors (2002) Neuroscience, 112 (1), pp. 39-49. , DOI 10.1016/S0306-4522(02)00067-2, PII S0306452202000672
  • Maina, F.K., Mathews, T.A., A functional fast scan cyclic voltammetry assay to characterize dopamine D2 and D3 autoreceptors in the mouse striatum (2010) ACS Chem. Neurosci., 1, pp. 450-462
  • Benoit-Marand, M., Borrelli, E., Gonon, F., Inhibition of dopamine release via presynaptic D2 receptors: Time course and functional characteristics in vivo (2001) Journal of Neuroscience, 21 (23), pp. 9134-9141
  • Schmitz, Y., Schmauss, C., Sulzer, D., Altered dopamine release and uptake kinetics in mice lacking D 2 receptors (2002) Journal of Neuroscience, 22 (18), pp. 8002-8009
  • Baik, J.H., Parkinsonian-like locomotor impairment in mice lacking dopamine D2 receptors (1995) Nature, 377, pp. 424-428
  • Kelly, M.A., Rubinstein, M., Phillips, T.J., Lessov, C.N., Burkhart-Kasch, S., Zhang, G., Bunzow, J.R., Low, M.J., Locomotor activity in D2 dopamine receptor-deficient mice is determined by gene dosage, genetic background, and developmental adaptations (1998) Journal of Neuroscience, 18 (9), pp. 3470-3479
  • Sano, H., Yasoshima, Y., Matsushita, N., Kaneko, T., Kohno, K., Pastan, I., Kobayashi, K., Conditional ablation of striatal neuronal types containing dopamine D2 receptor disturbs coordination of basal ganglia function (2003) Journal of Neuroscience, 23 (27), pp. 9078-9088
  • Hidalgo-Sanchez, M., Martinez-De-La-Torre, M., Alvarado-Mallart, R.-M., Puelles, L., A distinct preisthmic histogenetic domain is defined by overlap of Otx2 and Pax2 gene expression in the avian caudal midbrain (2005) Journal of Comparative Neurology, 483 (1), pp. 17-29. , DOI 10.1002/cne.20402
  • Schaeren-Wiemers, N., Gerfin-Moser, A., A single protocol to detect transcripts of various types and expression levels in neural tissue and cultured cells: In situ hybridization using digoxigenin-labelled cRNA probes (1993) Histochemistry, 100 (6), pp. 431-440
  • John, C.E., Budygin, E.A., Mateo, Y., Jones, S.R., Neurochemical characterization of the release and uptake of dopamine in ventral tegmental area and serotonin in substantia nigra of the mouse (2006) J. Neurochem., 96, pp. 267-282
  • Pellizzari, E.H., Barontini, M., Figuerola Mde, L., Cigorraga, S.B., Levin, G., Possible autocrine enkephalin regulation of catecholamine release in human pheochromocytoma cells (2008) Life Sci., 83, pp. 413-420
  • Falzone, T.L., Gelman, D.M., Young, J.I., Grandy, D.K., Low, M.J., Rubinstein, M., Absence of dopamine D4 receptors results in enhanced reactivity to unconditioned, but not conditioned, fear (2002) European Journal of Neuroscience, 15 (1), pp. 158-164. , DOI 10.1046/j.0953-816x.2001.01842.x
  • Bevins, R.A., Besheer, J., Object recognition in rats and mice: A one-trial non-matching-to-sample learning task to study'recognition memory' (2006) Nat. Protoc., 1, pp. 1306-1311
  • Cunningham, C.L., Gremel, C.M., Groblewski, P.A., Drug-induced conditioned place preference and aversion in mice (2006) Nature Protocols, 1 (4), pp. 1662-1670. , DOI 10.1038/nprot.2006.279, PII NPROT.2006.279
  • Nemirovsky, S.I., Avale, M.E., Brunner, D., Rubinstein, M., Reward-seeking and discrimination deficits displayed by hypodopaminergic mice are prevented in mice lacking dopamine D4 receptors (2009) Synapse, 63, pp. 991-997

Citas:

---------- APA ----------
Bello, E.P., Mateo, Y., Gelman, D.M., Noaín, D., Shin, J.H., Low, M.J., Alvarez, V.A.,..., Rubinstein, M. (2011) . Cocaine supersensitivity and enhanced motivation for reward in mice lacking dopamine D2 autoreceptors. Nature Neuroscience, 14(8), 1033-1038.
http://dx.doi.org/10.1038/nn.2862
---------- CHICAGO ----------
Bello, E.P., Mateo, Y., Gelman, D.M., Noaín, D., Shin, J.H., Low, M.J., et al. "Cocaine supersensitivity and enhanced motivation for reward in mice lacking dopamine D2 autoreceptors" . Nature Neuroscience 14, no. 8 (2011) : 1033-1038.
http://dx.doi.org/10.1038/nn.2862
---------- MLA ----------
Bello, E.P., Mateo, Y., Gelman, D.M., Noaín, D., Shin, J.H., Low, M.J., et al. "Cocaine supersensitivity and enhanced motivation for reward in mice lacking dopamine D2 autoreceptors" . Nature Neuroscience, vol. 14, no. 8, 2011, pp. 1033-1038.
http://dx.doi.org/10.1038/nn.2862
---------- VANCOUVER ----------
Bello, E.P., Mateo, Y., Gelman, D.M., Noaín, D., Shin, J.H., Low, M.J., et al. Cocaine supersensitivity and enhanced motivation for reward in mice lacking dopamine D2 autoreceptors. Nat. Neurosci. 2011;14(8):1033-1038.
http://dx.doi.org/10.1038/nn.2862