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Gompel, M.; Leost, M.; Bal De Kier Joffe, E.; Puricelli, L.; Hernandez Franco, L.; Palermo, J.; Meijer, L. "Meridianins, a new family of protein kinase inhibitors isolated from the Ascidian Aplidium meridianum" (2004) Bioorganic and Medicinal Chemistry Letters. 14(7):1703-1707
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Abstract:

Meridianins are brominated 3-(2-aminopyrimidine)-indoles which are purified from Aplidium meridianum, an Ascidian from the South Atlantic (South Georgia Islands). We here show that meridianins inhibit various protein kinases such as cyclin-dependent kinases, glycogen synthase kinase-3, cyclic nucleotide-dependent kinases and casein kinase 1. Meridianins prevent cell proliferation and induce apoptosis, a demonstration of their ability to enter cells and to interfere with the activity of kinases important for cell division and cell death. These results suggest that meridianins constitute a promising scaffold from which more potent and selective protein kinase inhibitors could be designed. © 2004 Elsevier Ltd. All rights reserved.

Registro:

Documento: Artículo
Título:Meridianins, a new family of protein kinase inhibitors isolated from the Ascidian Aplidium meridianum
Autor:Gompel, M.; Leost, M.; Bal De Kier Joffe, E.; Puricelli, L.; Hernandez Franco, L.; Palermo, J.; Meijer, L.
Filiación:C.N.R.S., Cell Cycle Group, Station Biologique, B.P. 74, 29682 Roscoff Cedex, Bretagne, France
Angel H. Roffo Institute of Oncology, Research Area, University of Buenos Aires, Av. San Martín 5481, 1417 Buenos Aires, Argentina
Universidad de Buenos Aires, Depto. de Quim. Orgánica, Pabellón 2, (1428) Buenos Aires, Argentina
Palabras clave:Cancer; CDK; Cyclin-dependent kinase; Glycogen synthase kinase; Glycogen synthase kinase-3; GSK-3; Kinase inhibitor; MEM; Meridianin; Modified Eagle Medium; MTT; Neurodegenerative diseases; Protein kinase; casein kinase I; cyclic nucleotide dependent protein kinase; cyclin dependent kinase; discodermindol; glycogen synthase kinase 3; isomeridianin c; isomeridianin g; meridianin; meridianin a; meridianin b; meridianin c; meridianin d; meridianin e; meridianin f; meridianin g; protein kinase inhibitor; psammopemmin a; psammopemmin b; psammopemmin c; unclassified drug; variolin b; Aplidium meridianum; apoptosis; article; Ascidiacea; cell death; cell division; cell proliferation; controlled study; drug mechanism; enzyme activity; enzyme inhibition; human; human cell; nonhuman; pharmacodynamics; Aminopyridines; Animals; Cell Division; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Indole Alkaloids; Mice; Protein Kinase Inhibitors; Urochordata; Aplidium; Aplidium meridianum; Ascidia; Ciconiiformes
Año:2004
Volumen:14
Número:7
Página de inicio:1703
Página de fin:1707
DOI: http://dx.doi.org/10.1016/j.bmcl.2004.01.050
Título revista:Bioorganic and Medicinal Chemistry Letters
Título revista abreviado:Bioorg. Med. Chem. Lett.
ISSN:0960894X
CODEN:BMCLE
CAS:cyclin dependent kinase, 150428-23-2; Aminopyridines; Enzyme Inhibitors; Indole Alkaloids; Protein Kinase Inhibitors
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0960894X_v14_n7_p1703_Gompel

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Citas:

---------- APA ----------
Gompel, M., Leost, M., Bal De Kier Joffe, E., Puricelli, L., Hernandez Franco, L., Palermo, J. & Meijer, L. (2004) . Meridianins, a new family of protein kinase inhibitors isolated from the Ascidian Aplidium meridianum. Bioorganic and Medicinal Chemistry Letters, 14(7), 1703-1707.
http://dx.doi.org/10.1016/j.bmcl.2004.01.050
---------- CHICAGO ----------
Gompel, M., Leost, M., Bal De Kier Joffe, E., Puricelli, L., Hernandez Franco, L., Palermo, J., et al. "Meridianins, a new family of protein kinase inhibitors isolated from the Ascidian Aplidium meridianum" . Bioorganic and Medicinal Chemistry Letters 14, no. 7 (2004) : 1703-1707.
http://dx.doi.org/10.1016/j.bmcl.2004.01.050
---------- MLA ----------
Gompel, M., Leost, M., Bal De Kier Joffe, E., Puricelli, L., Hernandez Franco, L., Palermo, J., et al. "Meridianins, a new family of protein kinase inhibitors isolated from the Ascidian Aplidium meridianum" . Bioorganic and Medicinal Chemistry Letters, vol. 14, no. 7, 2004, pp. 1703-1707.
http://dx.doi.org/10.1016/j.bmcl.2004.01.050
---------- VANCOUVER ----------
Gompel, M., Leost, M., Bal De Kier Joffe, E., Puricelli, L., Hernandez Franco, L., Palermo, J., et al. Meridianins, a new family of protein kinase inhibitors isolated from the Ascidian Aplidium meridianum. Bioorg. Med. Chem. Lett. 2004;14(7):1703-1707.
http://dx.doi.org/10.1016/j.bmcl.2004.01.050