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Substrate Specificity

"CDK and MAPK Synergistically Regulate Signaling Dynamics via a Shared Multi-site Phosphorylation Region on the Scaffold Protein Ste5" (2018) Repetto, M.V.;Winters, M.J.;Bush, A. (...)Colman-Lerner, A. Molecular Cell. 69(6):938-952.e6

"Short linear motif core and flanking regions modulate retinoblastoma protein binding affinity and specificity" (2018) Palopoli, N.; Foutel, N.S.G.; Gibson, T.J.; Chemes, L.B. Protein Engineering, Design and Selection. 31(3):69-77

"PrxQ B from Mycobacterium tuberculosis is a monomeric, thioredoxin-dependent and highly efficient fatty acid hydroperoxide reductase" (2016) Reyes, A.M.;Vazquez, D.S.;Zeida, A. (...)Trujillo, M. Free Radical Biology and Medicine. 101:249-260

"In vitro and in vivo studies of cholinesterases and carboxylesterases in Planorbarius corneus exposed to a phosphorodithioate insecticide: Finding the most sensitive combination of enzymes, substrates, tissues and recovery capacity" (2016) Otero, S.; Kristoff, G. Aquatic Toxicology. 180:186-195

"Steered Molecular Dynamics Methods Applied to Enzyme Mechanism and Energetics" (2016) Ramírez, C.L.; Martí, M.A.; Roitberg, A.E. Methods in Enzymology. 578:123-143

"Conformational Heterogeneity Determined by Folding and Oligomer Assembly Routes of the Interferon Response Inhibitor NS1 Protein, Unique to Human Respiratory Syncytial Virus" (2015) Pretel, E.;Sánchez, I.E.;Fassolari, M. (...)De Prat-Gay, G. Biochemistry. 54(33):5136-5146

"Molecular Basis of Hydroperoxide Specificity in Peroxiredoxins: The Case of AhpE from Mycobacterium tuberculosis" (2015) Zeida, A.;Reyes, A.M.;Lichtig, P. (...)Trujillo, M. Biochemistry. 54(49):7237-7247

"Enzymatic synthesis of bile acid derivatives and biological evaluation against Trypanosoma cruzi" (2015) García Liñares, G.;Antonela Zígolo, M.;Simonetti, L. (...)Baldessari, A. Bioorganic and Medicinal Chemistry. 23(15):4804-4814

"Functional studies of p.R132C, p.R149C, p.M283V, p.E431K, and a novel c.652-2A>G mutations of the CYP21A2 gene" (2014) Taboas, M.;Gómez Acuña, L.;Scaia, M.F. (...)Dain, L. PLoS ONE. 9(3)

"Differential O-3/O-4 selectivity in the glycosylation of N-dimethylmaleoyl-protected hexosamine acceptors: Effect of a conformationally armed (superarmed) glycosyl donor" (2013) Della Felice, F.; Rúveda, E.A.; Stortz, C.A.; Colombo, M.I. Carbohydrate Research. 380:167-173

"Functional Analysis Of A Mosquito Short-Chain Dehydrogenase Cluster" (2013) Mayoral, J.G.;Leonard, K.T.;Nouzova, M. (...)Turjanski, A.G. Archives of Insect Biochemistry and Physiology. 82(2):96-115

"Electron transfer properties of dual self-assembled architectures based on specific recognition and electrostatic driving forces: Its application to control substrate inhibition in horseradish peroxidase-based sensors" (2013) Cortez, M.L.;Pallarola, D.;Ceolín, M. (...)Battaglini, F. Analytical Chemistry. 85(4):2414-2422

"Oligomerization studies show that the kinase domain of the tomato pollen receptor kinase LePRK2 is necessary for interaction with LePRK1" (2012) Salem, T.M.;Barberini, M.L.;Wengier, D.L. (...)Muschietti, J. Plant Physiology and Biochemistry. 53:40-45

"Transglycosylation specificity of Acremonium sp. α-rhamnosyl-β- glucosidase and its application to the synthesis of the new fluorogenic substrate 4-methylumbelliferyl-rutinoside" (2012) Mazzaferro, L.S.;Piñuel, L.;Erra-Balsells, R. (...)Breccia, J.D. Carbohydrate Research. 347(1):69-75

"Functional characterization of residues involved in redox modulation of maize photosynthetic NADP-Malic enzyme activity" (2012) Alvarez, C.E.;Detarsio, E.;Moreno, S. (...)Drincovich, M.F. Plant and Cell Physiology. 53(6):1144-1153

"Topology and dynamics of the zebrafish segmentation clock core circuit" (2012) Schröter, C.;Ares, S.;Morelli, L.G. (...)Oates, A.C. PLoS Biology. 10(7):11

"Oxidizing substrate specificity of Mycobacterium tuberculosis alkyl hydroperoxide reductase E: Kinetics and mechanisms of oxidation and overoxidation" (2011) Reyes, A.M.;Hugo, M.;Trostchansky, A. (...)Trujillo, M. Free Radical Biology and Medicine. 51(2):464-473

"Juvenile hormone synthesis: "esterify then epoxidize" or " epoxidize then esterify" ? Insights from the structural characterization of juvenile hormone acid methyltransferase" (2011) Defelipe, L.A.;Dolghih, E.;Roitberg, A.E. (...)Turjanski, A.G. Insect Biochemistry and Molecular Biology. 41(4):228-235

"Molecular basis for the substrate stereoselectivity in tryptophan dioxygenase" (2011) Capece, L.;Lewis-Ballester, A.;Marti, M.A. (...)Yeh, S.-R. Biochemistry. 50(50):10910-10918

"New human papilloma virus E2 transcription factor mimics: A tripyrrole-peptide conjugate with tight and specific DNA-recognition" (2011) Wetzler, D.E.; Comin, M.J.; Krajewski, K.; Gallo, M. PLoS ONE. 6(7)

"Characterization of substrates that have a differential effect on Saccharomyces cerevisiae protein kinase A holoenzyme activation" (2010) Galello, F.; Portela, P.; Moreno, S.; Rossi, S. Journal of Biological Chemistry. 285(39):29770-29779

"Substrate stereo-specificity in tryptophan dioxygenase and indoleamine 2,3-dioxygenase" (2010) Capece, L.;Arrar, M.;Roitberg, A.E. (...)Estrin, D.A. Proteins: Structure, Function and Bioinformatics. 78(14):2961-2972

"Genomic affinities in Turnera (subseries Turnera, Turneraceae) inferred by in situ hybridization techniques" (2010) López, A.; Fernández, A.; Poggio, L. Genome. 53(8):594-598

"Synthesis of 5-deoxy-β-d-galactofuranosides as tools for the characterization of β-d-galactofuranosidases" (2010) Bordoni, A.; De Lederkremer, R.M.; Marino, C. Bioorganic and Medicinal Chemistry. 18(14):5339-5345

"The serine/arginine-rich protein SF2/ASF regulates protein sumoylation" (2010) Pelisch, F.;Gerez, J.;Druker, J. (...)Srebrow, A. Proceedings of the National Academy of Sciences of the United States of America. 107(37):16119-16124

"Molecular basis of coupled protein and electron transfer dynamics of cytochrome c in biomimetic complexes" (2010) Alvarez-Paggi, D.;Martín, D.F.;Debiase, P.M. (...)Murgida, D.H. Journal of the American Chemical Society. 132(16):5769-5778

"Conformational and electronic effects on the regioselectivity of the glycosylation of different anomers of N-dimethylmaleoyl-protected glucosamine acceptors" (2008) Bohn, M.L.; Colombo, M.I.; Rúveda, E.A.; Stortz, C.A. Organic and Biomolecular Chemistry. 6(3):554-561

"The catalytic domain of insulin-degrading enzyme forms a denaturant-resistant complex with amyloid β peptide: Implications for Alzheimer disease pathogenesis" (2008) Llovera, R.E.;De Tullio, M.;Alonso, L.G. (...)Castaño, E.M. Journal of Biological Chemistry. 283(25):17039-17048

"Nitric Oxide Reactivity with Globins as Investigated Through Computer Simulation" (2008) Marti, M.A.;Capece, L.;Bidon-Chanal, A. (...)Estrin, D.A. Methods in Enzymology. 437:477-498

"Optimal conditions for the fruit body production of natural occurring strains of Lentinus tigrinus" (2007) Lechner, B.E.; Albertó, E. Bioresource Technology. 98(9):1866-1869

"Identification of regions critically affecting kinetics and allosteric regulation of the Escherichia coli ADP-glucose pyrophosphorylase by modeling and pentapeptide-scanning mutagenesis" (2007) Ballicora, M.A.;Erben, E.D.;Yazaki, T. (...)Preiss, J. Journal of Bacteriology. 189(14):5325-5333

"TcrPDEA1, a cAMP-specific phosphodiesterase with atypical pharmacological properties from Trypanosoma cruzi" (2007) Alonso, G.D.; Schoijet, A.C.; Torres, H.N.; Flawiá, M.M. Molecular and Biochemical Parasitology. 152(1):72-79

"Two new dialkoxycarbonylated nucleosides obtained through a regioselective enzymatic alcoholysis" (2007) Capello, M.; Imanishi, L.; Iglesias, L.E.; Iribarren, A.M. Biotechnology Letters. 29(8):1217-1220

"Quantitative single particle tracking of NGF-receptor complexes: Transport is bidirectional but biased by longer retrograde run lengths" (2007) Echarte, M.M.;Bruno, L.;Arndt-Jovin, D.J. (...)Pietrasanta, L.I. FEBS Letters. 581(16):2905-2913

"Characterization of yeast pyruvate kinase 1 as a protein kinase A substrate, and specificity of the phosphorylation site sequence in the whole protein" (2006) Portela, P.; Moreno, S.; Rossi, S. Biochemical Journal. 396(1):117-126

"Characterization and in vitro expression patterns of extracellular degradative enzymes from non-pathogenic binucleate Rhizoctonia AG-G" (2005) MacHinandiarena, M.F.;Wolski, E.A.;Barrera, V. (...)Andreu, A.B. Mycopathologia. 159(3):441-448

"Glycosphingolipids in Plasmodium falciparum: Presence of an active glucosylceramide synthase" (2004) Couto, A.S.;Caffaro, C.;Uhrig, M.L. (...)Erra-Balsells, R. European Journal of Biochemistry. 271(11):2204-2214

"Lactose derivatives are inhibitors of Trypanosoma cruzi trans-sialidase activity toward conventional substrates in vitro and in vivo" (2004) Agustí, R.;París, G.;Ratier, L. (...)de Lederkremer, R.M. Glycobiology. 14(7):659-670

"Activation state of protein kinase A as measured in permeabilised Saccharomyces cerevisiae cells correlates with PKA-controlled phenotypes in vivo" (2003) Portela, P.; Van Dijck, P.; Thevelein, J.M.; Moreno, S. FEMS Yeast Research. 3(1):119-126

"Regulation of CDPK isoforms during tuber development" (2003) Raíces, M.;Gargantini, P.R.;Chinchilla, D. (...)Ulloa, R.M. Plant Molecular Biology. 52(5):1011-1024

"Rat kidney porphobilinogen deaminase kinetics: Detection of enzyme-substrate complexes" (2002) Noriega, G.; Mattei, G.; Batlle, A.; Juknat, A.A. International Journal of Biochemistry and Cell Biology. 34(10):1230-1240

"The phosphatidylinositol-phospholipase C from Trypanosoma cruzi is active on inositolphosphoceramide" (2002) Salto, M.L.;Furuya, T.;Moreno, S.N. (...)De Lederkremer, R.M. Molecular and Biochemical Parasitology. 119(1):131-133

"Rapeseed chloroplast thioredoxin-m modulation of the affinity for target proteins" (2001) Duek, P.D.; Wolosiuk, R.A. Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology. 1546(2):299-311

"Evidence for phospholipases from Trypanosoma cruzi active on phosphatidylinositol and inositolphosphoceramide" (2000) Bertello, L.E.; Alves, M.J.M.; Colli, W.; De Lederkremer, R.M. Biochemical Journal. 345(1):77-84

"Participation of Rel/NF-κB transcription factors in long-term memory in the crab Chasmagnathus" (2000) Freudenthal, R.; Romano, A. Brain Research. 855(2):274-281

"Covalent attachment of osmium complexes to glucose oxidase and the application off the resulting modified enzyme in an enzyme switch responsive to glucose" (2000) Battaglini, F.; Bartlett, P.N.; Wang, J.H. Analytical Chemistry. 72(3):502-509

"Expression and biochemical characterisation of recombinant AceA, a bacterial α-mannosyltransferase" (1999) Geremia, R.A.;Roux, M.;Ferreiro, D.U. (...)Ielpi, L. Molecular and General Genetics. 261(6):933-940

"Synthesis of 4-nitrophenyl β-D-fucofuranoside and β-D-fucofuranosyl-(1 → 3)-D-mannopyranose: Modified substrates for studies on catalytic requirements of β-D-galactofuranosidase" (1999) Chiocconi, A.; Marino, C.; De Lederkremer, R.M. Carbohydrate Research. 323(1-4):7-13

"Lysosomal glycerophosphocholine phosphodiesterase in Tetrahymena" (1999) Florin-Christensen, J.; Florin-Christensen, M. Biochemistry and Molecular Biology International. 47(2):283-292

"The glycosyl-aldonolactone approach for the synthesis of β-d-Galf-(1→3)-d-Manp and 3-deoxy-β-d-xylo-hexofuranosyl-(1→3)-d-Manp" (1998) Marino, C.; Chiocconi, A.; Varela, O.; De Lederkremer, R.M. Carbohydrate Research. 311(4):183-189

"The trans-sialidase of Trypanosoma cruzi is anchored by two different lipids" (1997) Agusti, R.;Couto, A.S.;Campetella, O.E. (...)De Lederkremer, R.M. Glycobiology. 7(6):731-735

"Regulation of Ca2+/calmodulin-dependent protein kinase from" (1996) Cruzi, T.; Ogueta, S.; Intosh, G.M.; Téllez-Iñon, Ma.T. Molecular and Biochemical Parasitology. 78(1-2):171-183

"delta-Aminolevulinic acid uptake is mediated by the gamma-aminobutyric acid-specific permease UGA4." (1996) Bermúdez Moretti, M.; Correa García, S.; Ramos, E.; Batlle, A. Cellular and molecular biology (Noisy-le-Grand, France). 42(4):519-523

"Purification and partial characterization of the cytosolic malate dehydrogenase from protoscolices of Echinococcus granulosus" (1995) Agüero, F.; Repetto, Y.; Hellman, U.; Cazzulo, J.J. Molecular and Biochemical Parasitology. 72(1-2):247-251

"Phosphoenolpyruvate carboxykinase from Trypanosoma cruzi. Purification and physicochemical and kinetic properties" (1995) Cymeryng, C.; Cazzulo, J.J.; Cannata, J.J.B. Molecular and Biochemical Parasitology. 73(1-2):91-101

"Purification and characterization of a soluble nucleoside diphosphate kinase in Trypanosoma cruzi" (1995) Ulloa, R.M.;Muschietti, J.P.;Veron, M. (...)Tellez-Iñón, M.T. Molecular and Biochemical Parasitology. 70(1-2):119-129

"Purification and partial structural and kinetic characterization of an aromatic L-α-hydroxy acid dehydrogenase from epimastigotes of Trypanosoma cruzi" (1994) Montemartini, M.; Santomé, JosA.; Cazzulo, J.J.; Nowicki, C. Molecular and Biochemical Parasitology. 68(1):15-23

"Uroporhyrinogen decarboxylase from mouse mammary carcinoma and liver of normal and tumor-bearing mouse" (1992) Navone, N.M.; Afonso, S.G.; Polo, C.F.; del C. Battle, A.M. Comparative Biochemistry and Physiology -- Part B: Biochemistry and. 102(1):87-92

"Involvement of free and enzyme‐bound intermediates in the reaction mechanism catalyzed by the bovine liver immobilized porphobilinogen deaminase. Proof that they are substrates for cosynthetase in uroporphyrinogen III biosynthesis" (1991) Kotler, M.L.; Juknat, A.A.; Fumagalli, S.A.; Batlle, A.M. Biotechnology and Applied Biochemistry. 13(2):173-180

"Characteristics of an inulinase produced by Bacillus subtilis 430A, a strain isolated from the rhizosphere of Vernonia herbacea (Vell Rusby)" (1991) Vullo, D.L.; Coto, C.E.; Sineriz, F. Applied and Environmental Microbiology. 57(8):2392-2394

"Isolation and characterization of a dimeric cAMP-dependent protein kinase from the fungus Saccobolus platensis" (1990) Silberstein, S.; Cantore, M.L.; Galvagno, M.A.; Passeron, S. Archives of Biochemistry and Biophysics. 282(1):132-140

"Polyamines and basic proteins stimulate activation by cAMP and catalytic activity Mucor rouxii" (1990) Guthmann, M.; Pastori, R.; Moreno, S. Cellular Signalling. 2(4):395-402

"Stable ornithine decarboxylase in promastigotes of Leishmania mexicana" (1989) Sanchez, C.P.; Gonzalez, N.S.; Algranati, I.D. Biochemical and Biophysical Research Communications. 161(2):754-761

"Glutamate:4,5‐dioxovaleric acid transaminase from Euglena gracilis Kinetic studies" (1989) LOMBARDO, M.E.; ARAUJO, L.S.; JUKNAT, A.A.; BATLLE, A.M.d.C. European Journal of Biochemistry. 182(3):657-660

"Characterization of two casein kinase activities in the fungus Mucor rouxii" (1988) Pardo, P.; Moreno, S. Second Messengers and Phosphoproteins. 12(4):183-196

"α‐Glucan synthesis on a protein primer, uridine diphosphoglucose: protein transglucosylase I: Separation from starch synthetase and phosphorylase and a study of its properties" (1986) MORENO, S.; CARDINI, C.E.; TANDECARZ, J.S. European Journal of Biochemistry. 157(3):539-545

"Characterization of a sexual steroid binding protein in Bufo arenarum" (1985) Santa-Coloma, T.A.; Fernandez, S.; Charreau, E.H. General and Comparative Endocrinology. 60(2):273-279

"Influence of sex hormones on prostaglandin dehydrogenase activity in the rat uterus" (1985) Franchi, A.M.; Faletti, A.; Gimeno, M.F.; Gimeno, A.L. Prostaglandins. 29(6):953-960

"The separation and properties of two phosphoprotein phosphatases from the dimorphic fungus Mucor rouxii" (1984) Seigelchifer, M.A.; Passeron, S. Archives of Biochemistry and Biophysics. 229(1):403-413

"Some properties of δ-aminolevulinate synthetase of Rhodopseudomonas palustris " (1983) Viale, A.A.; Wider, E.A.; Del Batlle, A.M.C. Revista Argentina de Microbiologia. 15(4):233-238

"Dolichyl‐Phosphate Phosphatase and Dolichyl‐Diphosphate Phosphatase in Rat‐Liver Microsomes" (1982) BELOCOPITOW, E.; BOSCOBOINIK, D. European Journal of Biochemistry. 125(1):167-173

"Studies on potato tuber phosphorylase-catalyzed reaction in the absence of an exogenous acceptor. I. Characterization and properties of the enzyme" (1981) Sivak, M.N.; Tandecarz, J.S.; Cardini, C.E. Archives of Biochemistry and Biophysics. 212(2):525-536

"Further studies on cyclic adenosine 3′:5′-monophosphate protein kinase from dimorphic fungus Mucor rouxii" (1980) Moreno, S.; Passeron, S. Archives of Biochemistry and Biophysics. 199(2):321-330

"A phosphatase acting on dolichyl phosphate in membranes from neuronal perikarya" (1980) Idoyaga-Vargas, V.; Belocopitow, E.; Mentaberry, A.; Carminatti, H. FEBS Letters. 112(1):63-66

"Lipid-bound sugars in Rhizobium meliloti" (1980) Tolmasky, M.E.; Staneloni, R.J.; Ugalde, R.A.; Leloir, L.F. Archives of Biochemistry and Biophysics. 203(1):358-364

"Microsomal glucosidases acting on the saccharide moiety of the glucose-containing dolichyl diphosphate oligosaccharide" (1979) Ugalde, R.A.; Staneloni, R.J.; Leloir, L.F. Biochemical and Biophysical Research Communications. 91(3):1174-1181

"Initiation of glycogen biosynthesis in Escherichia coli studies of the properties of the enzymes involved" (1978) Barengo, R.; Krisman, C.R. BBA - General Subjects. 540(2):190-196

"Tetrapyrroles as substrates and inhibitors of porphyrinogen carboxylyase from rat liver" (1976) San Martin De Viale, L.C.; Aragones, A.; Tomio, J.M. Acta Physiologica Latino-Americana. 26(5):403-414