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Abstract:

The present experiments report the effects of estradiol or of progesterone on the activity of 15-prostaglandin-dehydrogenase (PGDH) in the uterus of spayed rats. When the substrate was PGF2α the treatment with progesterone (4 mg.day-1, two days) or with estradiol-17-beta (0.5 ug + 1 ug) did not show any effect on the activity of the enzyme. On the contrary, uteri from ovariectomized rats injected with a higher dose of estradiol- 17-beta (0.5 ug + 50 ug) exhibited a significant increment. When the substrate was PGE2, progesterone failed again to modify the enzyme activity, whereas estradiol, both at a low and at a high doses, enhanced significantly the uterine PGDH activity. The possibility of two different PGDHs for each PG and the role of estradiol in enhancing PGE2 catabolism into 15-keto- PGE2 as a mechanism subserving the effect of estrogens on the output of this PG in the rat uterus, are discussed. © 1985.

Registro:

Documento: Artículo
Título:Influence of sex hormones on prostaglandin dehydrogenase activity in the rat uterus
Autor:Franchi, A.M.; Faletti, A.; Gimeno, M.F.; Gimeno, A.L.
Filiación:Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), Consejo Nacional de Investigaciones Cientificas y Tecnicas de la Republica Argentina (CONICET). Serr, 1414 Buenos Aires, Argentina
Palabras clave:15 hydroxyprostaglandin dehydrogenase; estradiol; progesterone; prostaglandin e2; prostaglandin f2 alpha; animal cell; animal experiment; dose response; drug comparison; drug interaction; drug mechanism; drug metabolism; drug response; endocrine system; female genital system; nonhuman; ovariectomy; priority journal; rat; subcutaneous drug administration; uterus; Animal; Castration; Dinoprost; Dinoprostone; Estradiol; Female; Hydroxyprostaglandin Dehydrogenases; Ovary; Progesterone; Prostaglandins E; Prostaglandins F; Rats; Rats, Inbred Strains; Substrate Specificity; Support, Non-U.S. Gov't; Uterus
Año:1985
Volumen:29
Número:6
Página de inicio:953
Página de fin:960
DOI: http://dx.doi.org/10.1016/0090-6980(85)90220-5
Título revista:Prostaglandins
Título revista abreviado:Prostaglandins
ISSN:00906980
CODEN:PRGLB
CAS:15 hydroxyprostaglandin dehydrogenase, 9030-87-9; estradiol, 50-28-2; progesterone, 57-83-0; prostaglandin E2, 363-24-6; prostaglandin F2 alpha, 551-11-1; 15-hydroxyprostaglandin dehydrogenase, EC 1.1.1.141; Dinoprost, 551-11-1; Dinoprostone, 363-24-6; Estradiol, 50-28-2; Hydroxyprostaglandin Dehydrogenases, EC 1.1.1.-; Progesterone, 57-83-0; Prostaglandins E; Prostaglandins F
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00906980_v29_n6_p953_Franchi

Referencias:

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Citas:

---------- APA ----------
Franchi, A.M., Faletti, A., Gimeno, M.F. & Gimeno, A.L. (1985) . Influence of sex hormones on prostaglandin dehydrogenase activity in the rat uterus. Prostaglandins, 29(6), 953-960.
http://dx.doi.org/10.1016/0090-6980(85)90220-5
---------- CHICAGO ----------
Franchi, A.M., Faletti, A., Gimeno, M.F., Gimeno, A.L. "Influence of sex hormones on prostaglandin dehydrogenase activity in the rat uterus" . Prostaglandins 29, no. 6 (1985) : 953-960.
http://dx.doi.org/10.1016/0090-6980(85)90220-5
---------- MLA ----------
Franchi, A.M., Faletti, A., Gimeno, M.F., Gimeno, A.L. "Influence of sex hormones on prostaglandin dehydrogenase activity in the rat uterus" . Prostaglandins, vol. 29, no. 6, 1985, pp. 953-960.
http://dx.doi.org/10.1016/0090-6980(85)90220-5
---------- VANCOUVER ----------
Franchi, A.M., Faletti, A., Gimeno, M.F., Gimeno, A.L. Influence of sex hormones on prostaglandin dehydrogenase activity in the rat uterus. Prostaglandins. 1985;29(6):953-960.
http://dx.doi.org/10.1016/0090-6980(85)90220-5