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cytokine production

"Vasoactive intestinal peptide shapes first-trimester placenta trophoblast, vascular, and immune cell cooperation" (2019) Paparini, D.E.;Choudhury, R.H.;Vota, D.M. (...)Aplin, J.D. British Journal of Pharmacology. 176(7):964-980

"IRE1α–XBP1 controls T cell function in ovarian cancer by regulating mitochondrial activity" (2018) Song, M.;Sandoval, T.A.;Chae, C.-S. (...)Cubillos-Ruiz, J.R. Nature. 562(7727):423-428

"Elevated cyclic AMP inhibits mycobacterium tuberculosis-stimulated T-cell IFN-γ secretion through type I protein kinase A" (2018) Chung, Y.-T.;Pasquinelli, V.;Jurado, J.O. (...)Samten, B. Journal of Infectious Diseases. 217(11):1821-1831

"Peripheral neuroimmunoendocrine interactions: Contribution of TNFRp55 to the circadian synchronization of progesterone and cytokine production in joints of mice in late pregnancy" (2018) Arias, J.L.;Mayordomo, A.C.;Silva, J.E. (...)Di Genaro, M.S. NeuroImmunoModulation. 25(3):153-162

"Galectin-1 as an Emerging Mediator of Cardiovascular Inflammation: Mechanisms and Therapeutic Opportunities" (2018) Seropian, I.M.;González, G.E.;Maller, S.M. (...)Rabinovich, G.A. Mediators of Inflammation. 2018

"Primary immunodeficiencies unravel the role of IL-2/CD25/STAT5b in human natural killer cell maturation" (2018) Caldirola, M.S.;Broggi, M.G.R.;Gaillard, M.I. (...)Zwirner, N.W. Frontiers in Immunology. 9(JUN)

"Virucidal, antiviral and immunomodulatory activities of β-escin and Aesculus hippocastanum extract" (2018) Michelini, F.M.; Alché, L.E.; Bueno, C.A. Journal of Pharmacy and Pharmacology. 70(11):1561-1571

"Restimulation-induced T-cell death through NTB-A/SAP signaling pathway is impaired in tuberculosis patients with depressed immune responses" (2017) Hernández Del Pino, R.E.;Pellegrini, J.M.;Rovetta, A.I. (...)Garciá, V.E. Immunology and Cell Biology. 95(8):716-728

"Shaping the Immune Landscape in Cancer by Galectin-Driven Regulatory Pathways" (2016) Rabinovich, G.A.; Conejo-García, J.R. Journal of Molecular Biology. 428(16):3266-3281

"Synthetic stigmastanes with dual antiherpetic and immunomodulating activities inhibit ERK and Akt signaling pathways without binding to glucocorticoid receptors" (2016) Michelini, F.M.;Bueno, C.A.;Molinari, A.M. (...)Ramírez, J.A. Biochimica et Biophysica Acta - General Subjects. 1860(1):129-139

"Lack of galectin-3 increases Jagged1/Notch activation in bone marrow-derived dendritic cells and promotes dysregulation of T helper cell polarization" (2016) Fermino, M.L.;Dylon, L.S.D.;Cecílio, N.T. (...)Bernardes, E.S. Molecular Immunology. 76:22-34

"Expression and functional role of α7 nicotinic receptor in human cytokine-stimulated natural killer (NK) cells" (2016) Zanetti, S.R.;Ziblat, A.;Torres, N.I. (...)Bouzat, C. Journal of Biological Chemistry. 291(32):16541-16552

"Galectin-8 promotes regulatory T-cell differentiation by modulating IL-2 and TGFβ signaling" (2016) Sampson, J.F.;Suryawanshi, A.;Chen, W.-S. (...)Panjwani, N. Immunology and Cell Biology. 94(2):213-219

"Conventional Dendritic Cells Confer Protection against Mouse Cytomegalovirus Infection via TLR9 and MyD88 Signaling" (2016) Puttur, F.;Francozo, M.;Solmaz, G. (...)Sparwasser, T. Cell Reports. 17(4):1113-1127

"NK cells restrain spontaneous antitumor CD8+ T cell priming through pd-1/pd-l1 interactions with dendritic cells" (2016) Raffo Iraolagoitia, X.L.;Spallanzani, R.G.;Torres, N.I. (...)Fuertes, M.B. Journal of Immunology. 197(3):953-961

"RSUME is implicated in tumorigenesis and metastasis of pancreatic neuroendocrine tumors" (2016) Wu, Y.;Tedesco, L.;Lucia, K. (...)Stalla, G.K. Oncotarget. 7(36):57878-57893

"Deletion of A44L, A46R and C12L vaccinia virus genes from the MVA genome improved the vector immunogenicity by modifying the innate immune response generating enhanced and optimized specific T-cell responses" (2016) Holgado, M.P.;Falivene, J.;Maeto, C. (...)Gherardi, M.M. Viruses. 8(5)

"VIP boosts regulatory T cell induction by trophoblast cells in an in vitro model of trophoblast–maternal leukocyte interaction" (2015) Fraccaroli, L.;Grasso, E.;Hauk, V. (...)Ramhorst, R. Journal of Leukocyte Biology. 98(1):49-58

"Small molecules as anti-TNF drugs" (2015) Richmond, V.;Michelini, F.M.;Bueno, C.A. (...)Ramírez, J.A. Current Medicinal Chemistry. 22(25):2920-2942

"Trypanosoma cruzi infection imparts a regulatory program in dendritic cells and T cells via galectin-1-dependent mechanisms" (2015) Poncini, C.V.;Ilarregui, J.M.;Batalla, E.I. (...)Rabinovich, G.A. Journal of Immunology. 195(7):3311-3324

"Natural and semisynthetic diterpenoids with antiviral and immunomodulatory activities block the ERK signaling pathway" (2015) Bueno, C.A.;Michelini, F.M.;Pertino, M.W. (...)Alché, L.E. Medical Microbiology and Immunology. 204(5):575-584

"Trypanosoma cruzi trans-sialidase prevents elicitation of Th1 cell response via interleukin 10 and downregulates Th1 effector cells" (2015) Díaz, P.R.;Mucci, J.;Meira, M.A. (...)Campetella, O. Infection and Immunity. 83(5):2099-2108

"Lactate and short chain fatty acids produced by microbial fermentation downregulate proinflammatory responses in intestinal epithelial cells and myeloid cells" (2015) Iraporda, C.;Errea, A.;Romanin, D.E. (...)Rumbo, M. Immunobiology. 220(10):1161-1169

"Acetylcholine contributes to control the physiological inflammatory response during the peri-implantation period" (2015) Paparini, D.;Gori, S.;Grasso, E. (...)Salamone, G. Acta Physiologica. 214(2):237-247

"Antitumor responses stimulated by dendritic cells are improved by triiodothyronine binding to the thyroid hormone receptor β" (2015) Alamino, V.A.;Mascanfroni, I.D.;Montesinos, M.M. (...)Pellizas, C.G. Cancer Research. 75(7):1265-1274

"Regulatory dendritic cells restrain NK cell IFN-γ production through mechanisms involving NKp46, IL-10, and MHC class I-specific inhibitory receptors" (2015) Spallanzani, R.G.;Torres, N.I.;Avila, D.E. (...)Zwirner, N.W. Journal of Immunology. 195(5):2141-2148

"Effect of the potent antiviral 1-cinnamoyl-3,11-dihydroxymeliacarpin on cytokine production by murine macrophages stimulated with HSV-2" (2014) Petrera, E.; Coto, C.E. Phytotherapy Research. 28(1):104-109

"In vitro and in vivo immunomodulatory activity of sulfated polysaccharides from red seaweed Nemalion helminthoides" (2014) Pérez-Recalde, M.; Matulewicz, M.C.; Pujol, C.A.; Carlucci, M.J. International Journal of Biological Macromolecules. 63:38-42

"IFNG-mediated immune responses enhance autophagy against Mycobacterium tuberculosis antigens in patients with active tuberculosis" (2014) Rovetta, A.I.;Peña, D.;Hernández Del Pino, R.E. (...)García, V.E. Autophagy. 10(12):2109-2121

"Integration of lectin-glycan recognition systems and immune cell networks in CNS inflammation" (2014) Mendez-Huergo, S.P.;Maller, S.M.;Farez, M.F. (...)Rabinovich, G.A. Cytokine and Growth Factor Reviews. 25(3):247-255

"Differential migration and activation profile of monocytes after trophoblast interaction" (2014) Grasso, E.;Paparini, D.;Hauk, V. (...)Ramhorst, R. PLoS ONE. 9(5)

"Curcumin ameliorates autoimmune diabetes. Evidence in accelerated murine models of type 1 diabetes" (2014) Castro, C.N.;Barcala Tabarrozzi, A.E.;Winnewisser, J. (...)Perone, M.J. Clinical and Experimental Immunology. 177(1):149-160

"Antiviral Action of Synthetic Stigmasterol Derivatives on Herpes Simplex Virus Replication in Nervous Cells in Vitro" (2014) Petrera, E.; Níttolo, A.G.; Alché, L.E. BioMed Research International. 2014

"Naturally occurring compounds elicit hiv-1 replication in chronically infected promonocytic cells" (2014) Barquero, A.A.;Dávola, M.E.;Riva, D.A. (...)Alché, L.E. BioMed Research International. 2014

"Bayesian Approach to Model CD137 Signaling in Human M. tuberculosis In Vitro Responses" (2013) Fernández Do Porto, D.A.;Auzmendi, J.;Peña, D. (...)Moffatt, L. PLoS ONE. 8(2)

"Mesenchymal stem cells and their use in therapy: What has been achieved?" (2013) Fernández Vallone, V.B.;Romaniuk, M.A.;Choi, H. (...)Chasseing, N.A. Differentiation. 85(1-2):1-10

"Contribution of vasoactive intestinal peptide to immune homeostasis in trophoblast-maternal leukocyte interaction under LPS stimulation" (2013) Fraccaroli, L.;Grasso, E.;Hauk, V. (...)Ramhorst, R. NeuroImmunoModulation. 21(1):21-30

"Peripheral and central inflammation in autism spectrum disorders" (2013) Depino, A.M. Molecular and Cellular Neuroscience. 53:69-76

"Parasite infections in multiple sclerosis modulate immune responses through a retinoic acid-dependent pathway" (2013) Correale, J.; Farez, M.F. Journal of Immunology. 191(7):3827-3837

"CD137 differentially regulates innate and adaptive immunity against Mycobacterium tuberculosis" (2012) Fernández Do Porto, D.A.;Jurado, J.O.;Pasquinelli, V. (...)García, V.E. Immunology and Cell Biology. 90(4):449-456

"A natural antiviral and immunomodulatory compound with antiangiogenic properties" (2012) Bueno, C.A.; Lombardi, M.G.; Sales, M.E.; Alché, L.E. Microvascular Research. 84(3):235-241

"Compound a, a dissociated glucocorticoid receptor modulator, inhibits t-bet (th1) and induces gata-3 (th2) activity in immune cells" (2012) Liberman, A.C.;Antunica-Noguerol, M.;Ferraz-de-Paula, V. (...)Arzt, E. PLoS ONE. 7(4)

"Regulatory Circuits Mediated by Lectin-Glycan Interactions in Autoimmunity and Cancer" (2012) Rabinovich, G.; Croci, D.O. Immunity. 36(3):322-335

"Dexamethasone counteracts the immunostimulatory effects of triiodothyronine (T3) on dendritic cells" (2012) Montesinos, M.M.;Alamino, V.A.;Mascanfroni, I.D. (...)Pellizas, C.G. Steroids. 77(1-2):67-76

"Serine leucocyte proteinase inhibitor-treated monocyte inhibits human CD4+ lymphocyte proliferation" (2011) Guerrieri, D.;Tateosian, N.L.;Maffía, P.C. (...)Chuluyan, H.E. Immunology. 133(4):434-441

"When galectins recognize glycans: From biochemistry to physiology and back again" (2011) Di Lella, S.;Sundblad, V.;Cerliani, J.P. (...)Rabinovich, G.A. Biochemistry. 50(37):7842-7857

"A sweet path toward tolerance in the gut" (2010) Rabinovich, G.A. Nature Medicine. 16(10):1076-1077

"Flagellin delays spontaneous human neutrophil apoptosis" (2010) Salamone, G.V.;Petracca, Y.;Bass, J.I.F. (...)Trevani, A.S. Laboratory Investigation. 90(7):1049-1059

"Curcumin inhibits the growth, induces apoptosis and modulates the function of pituitary folliculostellate cells" (2010) Schaaf, C.;Shan, B.;Onofri, C. (...)Renner, U. Neuroendocrinology. 91(2):200-210

"Nuclear factor (NF)-κB-dependent thyroid hormone receptor β 1 expression controls dendritic cell function via Akt signaling" (2010) Mascanfroni, I.D.;Montesinos, M.D.M.;Alamino, V.A. (...)Pellizas, C.G. Journal of Biological Chemistry. 285(13):9569-9582

"Tolerogenic dendritic cells in the control of autoimmune neuroinflammation: An emerging role of protein-glycan interactions" (2010) Ilarregui, J.M.; Rabinovich, G.A. NeuroImmunoModulation. 17(3):157-160

"Intracellular molecular signaling: Basis for specificity to glucocorticoid anti-inflammatory actions" (2009) Liberman, A.C.;Druker, J.;Garcia, F.A. (...)Arzt, E. Annals of the New York Academy of Sciences. 1153:6-13

"Immunology, signal transduction, and behavior in hypothalamic-pituitary- adrenal axis-related genetic mouse models" (2009) Silberstein, S.;Vogl, A.M.;Bonfiglio, J.J. (...)Refojo, D. Annals of the New York Academy of Sciences. 1153:120-130

"Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10" (2009) Ilarregui, J.M.;Croci, D.O.;Bianco, G.A. (...)Rabinovich, G.A. Nature Immunology. 10(9):981-991

"Chronic restraint stress impairs T-cell immunity and promotes tumor progression in mice" (2009) Frick, L.R.;Barreiro Arcos, M.L.;Rapanelli, M. (...)Cremaschi, G.A. Stress. 12(2):134-143

"Dehydroepiandrosterone and metformin modulate progesterone-induced blocking factor (PIBF), cyclooxygenase 2 (COX2) and cytokines in early pregnant mice" (2008) Luchetti, C.G.;Mikó, E.;Szekeres-Bartho, J. (...)Motta, A.B. Journal of Steroid Biochemistry and Molecular Biology. 111(3-5):200-207

"The in vitro immunomodulatory activity of a synthetic brassinosteroid analogue would account for the improvement of herpetic stromal keratitis in mice" (2008) Michelini, F.M.; Berra, A.; Alché, L.E. Journal of Steroid Biochemistry and Molecular Biology. 108(1-2):164-170

"Programmed death (PD)-1:PD-ligand 1/PD-ligand 2 pathway inhibits T cell effector functions during human tuberculosis" (2008) Jurado, J.O.;Alvarez, I.B.;Pasquinelli, V. (...)García, V.E. Journal of Immunology. 181(1):116-125

"A phase I clinical study of vaccination of melanoma patients with dendritic cells loaded with allogeneic apoptotic/necrotic melanoma cells. Analysis of toxicity and immune response to the vaccine and of IL-10-1082 promoter genotype as predictor of disease progression" (2008) von Euw, E.M.;Barrio, M.M.;Furman, D. (...)Mordoh, J. Journal of Translational Medicine. 6

"VIP limits LPS-induced nitric oxide production through IL-10 in NOD mice macrophages" (2007) Larocca, L.;Calafat, M.;Roca, V. (...)Leirós, C.P. International Immunopharmacology. 7(10):1343-1349

"Molecular transduction mechanisms of cytokine-hormone interactions: Role of gp130 cytokines" (2007) Gerez, J.;Bonfiglio, J.;Sosa, S. (...)Arzt, E. Experimental Physiology. 92(5):801-806

"Neutrophil signaling pathways activated by bacterial DNA stimulation" (2006) Alvarez, M.E.;Bass, J.I.F.;Geffner, J.R. (...)Trevani, A.S. Journal of Immunology. 177(6):4037-4046

"Dehydroepiandrosterone (DHEA) modulates GHRH, somatostatin and angiotensin II action at the pituitary level" (2005) Suárez, C.; Vela, J.; García-Tornadú, I.; Becu-Villalobos, D. Journal of Endocrinology. 185(1):165-172

"Defective signalling in salivary glands precedes the autoimmune response in the non-obese diabetic mouse model of sialadenitis" (2005) Rosignoli, F.;Roca, V.;Meiss, R. (...)Leirós, C.P. Clinical and Experimental Immunology. 142(3):411-418

"Estradiol Stimulates Vascular Endothelial Growth Factor and Interleukin-6 in Human Lactotroph and Lactosomatotroph Pituitary Adenomas" (2004) Onofri, C.;Carbia Nagashima, A.;Schaaf, L. (...)Arzt, E. Experimental and Clinical Endocrinology and Diabetes. 112(1):18-23

"Integrating systemic information at the molecular level: Cross-talk between steroid receptors and cytokine signaling on different target cells" (2003) Refojo, D.;Liberman, A.C.;Giacomini, D. (...)Arzt, E. Annals of the New York Academy of Sciences. 992:196-204

"Functional in vitro studies on the role and regulation of interleukin-6 in human somatotroph pituitary adenomas" (2003) Thiele, J.-O.;Lohrer, P.;Schaaf, L. (...)Renner, U. European Journal of Endocrinology. 149(5):455-461

"Immunostimulatory effects of plasmid DNA and synthetic oligodeoxynucleotides" (2003) Zelenay, S.; Elías, F.; Fló, J. European Journal of Immunology. 33(5):1382-1392

"Brucella lumazine synthase elicits a mixed Th1-Th2 immune response and reduces infection in mice challenged with Brucella abortus 544 independently of the adjuvant formulation used" (2003) Velikovsky, C.A.;Goldbaum, F.A.;Cassataro, J. (...)Giambartolomei, G.H. Infection and Immunity. 71(10):5750-5755

"Increased splenocyte proliferative response and cytokine production in β-endorphin-deficient mice" (2002) Refojo, D.;Kovalovsky, D.;Young, J.I. (...)Arzt, E. Journal of Neuroimmunology. 131(1-2):126-134

"Tumor necrosis factor-alfa production by monocytes from lung and colorectal cancer patients" (2001) Trejo, Y.G.;Bordenave, R.H.;Beviacqua, M. (...)Rumi, L.S. Journal of Experimental and Clinical Cancer Research. 20(1):71-73

"gp130 cytokine signaling in the pituitary gland: A paradigm for cytokine-neuro-endocrine pathways" (2001) Arzt, E. Journal of Clinical Investigation. 108(12):1729-1733

"Bone marrow fibroblasts in patients with advanced lung cancer" (2001) Chasseing, N.A.;Hofer, E.;Bordenave, R.H. (...)Rumi, L.S. Brazilian Journal of Medical and Biological Research. 34(11):1457-1463

"Lipopolysaccharide directly stimulates the intrapituitary interleukin-6 production by folliculostellate cells via specific receptors and the p38α mitogen-activated protein kinase/nuclear factor-κB pathway" (2000) Lohrer, P.;Gloddek, J.;Carbia Nagashima, A. (...)Renner, U. Endocrinology. 141(12):4457-4465

"Immunological mechanisms involved in the pathogenesis of multiple sclerosis " (2000) Correale, J. Revista de Neurologia. 31(5):471-476

"Regulation of HLA-DR antigen in monocytes from colorectal cancer patients by in vitro treatment with human recombinant interferon-γ" (2000) Novellino, P.S.;Trejo, Y.G.;Beviacqua, M. (...)Rumi, L.S. Journal of Investigational Allergology and Clinical Immunology. 10(2):90-93

"Pathophysiological role of the cytokine network in the anterior pituitary gland" (1999) Arzt, E.;Pereda, M.P.;Castro, C.P. (...)Stalla, G.K. Frontiers in Neuroendocrinology. 20(1):71-95

"Differential regulation of interleukin-1 receptor antagonist by proopiomelanocortin peptides adrenocorticotropic hormone and β-endorphin" (1999) Kovalovsky, D.;Pereda, M.P.;Stalla, G.K. (...)Arzt, E. NeuroImmunoModulation. 6(5):367-372