Artículo

Chung, Y.-T.; Pasquinelli, V.; Jurado, J.O.; Wang, X.; Yi, N.; Barnes, P.F.; Garcia, V.E.; Samten, B. "Elevated cyclic AMP inhibits mycobacterium tuberculosis-stimulated T-cell IFN-γ secretion through type I protein kinase A" (2018) Journal of Infectious Diseases. 217(11):1821-1831
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Abstract:

Cyclic adenosine monophosphate (cAMP) is critical in immune regulation, and its role in tuberculosis infection remains unclear. We determined the levels of cAMP in peripheral blood mononuclear cells (PBMC) from tuberculosis patients and the mechanisms for cAMP suppression of IFN-γ production. PBMC from tuberculosis patients contained significantly elevated cAMP than latent tuberculosis infected subjects (LTBI), with an inverse correlation with IFN-γ production. Consistent with this, the expression of cAMP response element binding protein (CREB), activating transcription factor (ATF)-2 and c-Jun were reduced in tuberculosis patients compared with LTBI. PKA type I specific cAMP analogs inhibited Mtb-stimulated IFN-g production by PBMC through suppression of Mtb-induced IFN-γ promoter binding activities of CREB, ATF-2, and c-Jun and also miR155, the target miRNA of these transcription factors. Neutralizing both IL-10 and TGF-β1 or supplementation of IL-12 restored cAMP-suppressed IFN-g production. We conclude that increased cAMP inhibits IFN-g production through PKA type I pathway in tuberculosis infection. © The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved.

Registro:

Documento: Artículo
Título:Elevated cyclic AMP inhibits mycobacterium tuberculosis-stimulated T-cell IFN-γ secretion through type I protein kinase A
Autor:Chung, Y.-T.; Pasquinelli, V.; Jurado, J.O.; Wang, X.; Yi, N.; Barnes, P.F.; Garcia, V.E.; Samten, B.
Filiación:Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires, Universidad Nacional del Noroeste de la Provincia de Buenos Aires- Consejo Nacional de Investigaciones Científicas y Técnicas, Junín, Argentina
Departamento de Química Biológica, Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina
Department of Vet Biomedical Sciences, Oregon State University, United States
Department of Pulmonary Immunology, University of Texas Health Science Center, 11937 US Hwy 271, Tyler, TX 75708-3154, United States
Palabras clave:Cyclic adenosine monophosphate; Cytokine; Human; Transcription factor; Tuberculosis; activating transcription factor 2; cyclic AMP; cyclic AMP dependent protein kinase 1; cyclic AMP responsive element binding protein; gamma interferon; interleukin 10; interleukin 12; microRNA 155; protein c jun; transforming growth factor beta1; Article; controlled study; cytokine production; cytokine release; gel mobility shift assay; gene expression; human; human cell; latent tuberculosis; lung tuberculosis; major clinical study; Mycobacterium tuberculosis; nonhuman; peripheral blood mononuclear cell; priority journal; protein expression; Western blotting
Año:2018
Volumen:217
Número:11
Página de inicio:1821
Página de fin:1831
DOI: http://dx.doi.org/10.1093/infdis/jiy079
Título revista:Journal of Infectious Diseases
Título revista abreviado:J. Infect. Dis.
ISSN:00221899
CODEN:JIDIA
CAS:cyclic AMP, 60-92-4; cyclic AMP responsive element binding protein, 130428-87-4, 130939-96-7; gamma interferon, 82115-62-6; interleukin 12, 138415-13-1
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00221899_v217_n11_p1821_Chung

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Citas:

---------- APA ----------
Chung, Y.-T., Pasquinelli, V., Jurado, J.O., Wang, X., Yi, N., Barnes, P.F., Garcia, V.E.,..., Samten, B. (2018) . Elevated cyclic AMP inhibits mycobacterium tuberculosis-stimulated T-cell IFN-γ secretion through type I protein kinase A. Journal of Infectious Diseases, 217(11), 1821-1831.
http://dx.doi.org/10.1093/infdis/jiy079
---------- CHICAGO ----------
Chung, Y.-T., Pasquinelli, V., Jurado, J.O., Wang, X., Yi, N., Barnes, P.F., et al. "Elevated cyclic AMP inhibits mycobacterium tuberculosis-stimulated T-cell IFN-γ secretion through type I protein kinase A" . Journal of Infectious Diseases 217, no. 11 (2018) : 1821-1831.
http://dx.doi.org/10.1093/infdis/jiy079
---------- MLA ----------
Chung, Y.-T., Pasquinelli, V., Jurado, J.O., Wang, X., Yi, N., Barnes, P.F., et al. "Elevated cyclic AMP inhibits mycobacterium tuberculosis-stimulated T-cell IFN-γ secretion through type I protein kinase A" . Journal of Infectious Diseases, vol. 217, no. 11, 2018, pp. 1821-1831.
http://dx.doi.org/10.1093/infdis/jiy079
---------- VANCOUVER ----------
Chung, Y.-T., Pasquinelli, V., Jurado, J.O., Wang, X., Yi, N., Barnes, P.F., et al. Elevated cyclic AMP inhibits mycobacterium tuberculosis-stimulated T-cell IFN-γ secretion through type I protein kinase A. J. Infect. Dis. 2018;217(11):1821-1831.
http://dx.doi.org/10.1093/infdis/jiy079