Artículo

Refojo, D.; Liberman, A.C.; Giacomini, D.; Nagashima, A.C.; Graciarena, M.; Echenique, C.; Paez Pereda, M.; Stalla, G.; Holsboer, F.; Arzt, E. "Integrating systemic information at the molecular level: Cross-talk between steroid receptors and cytokine signaling on different target cells" (2003) Annals of the New York Academy of Sciences. 992:196-204
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Abstract:

An essential event in immune activation is the increase of cytokines in both plasma and immune tissues. Steroid hormones influence several adaptive responses in both health and disease. Cytokines and steroids have an intimate cross-communication in many systems, making possible a satisfactory adaptive response to environmental changes. The ultimate level of integration of the cytokine-steroids cross-talk is the molecular level. We have demonstrated this in four types of cross-talk mechanisms on different cells in which steroids have major roles: (1) The tumor necrosis factor (TNF)-glucocorticoid receptor (GR) transcriptional interaction in cellular targets of TNF-induced cytotoxicity. TNF potentiates the transactivation activity of GR and the priming with TNF increases the protective action of GR on TNF-induced cytotoxicity. (2) The GR-T cell receptor (TCR) antagonism in GR-TCR-induced T cell apoptosis and its modulation by cAMP. cAMP inhibits the TCR-induced apoptosis through a PKA-CREB-dependent mechanism and potentiates glucocorticoid-induced apoptosis by means of a CREB-independent mechanism. (3) The GR influence on Th1-Th2 cytokine expression and differentiation. Glucocorticoids inhibit the induction of GATA-3 and T-bet transcription factors. (4) The influence of ER/Smad-4 signaling cross-communication on prolactinoma pathogenesis. Physical and functional interactions between Smad-4 and estrogen receptors take place in prolactinoma cells, providing a molecular explanation to link the tumorigenic action of these two important players of prolactinoma pathogenesis. The molecular cross-talk between steroids and transcription factors is the mechanism that provides the basis for the outcome of adaptive responses integrating the systemic information provided by hormones and cytokines.

Registro:

Documento: Artículo
Título:Integrating systemic information at the molecular level: Cross-talk between steroid receptors and cytokine signaling on different target cells
Autor:Refojo, D.; Liberman, A.C.; Giacomini, D.; Nagashima, A.C.; Graciarena, M.; Echenique, C.; Paez Pereda, M.; Stalla, G.; Holsboer, F.; Arzt, E.
Filiación:Lab. de Fisiol. y Biol. Molecular, Depto. Fisiol. y Biol. Molec. y Cel., C1428EHA, Buenos Aires, Argentina
Max-Planck Institute of Psychiatry, 80804 Munich, Germany
Lab. Fisiol. y Biol. Molecular, FCEN-Universidad de Buenos Aires, Pabellón II (C1428EHA), Buenos Aires, Argentina
Palabras clave:Apoptosis; BMP-4; cAMP; Estrogen; GATA-3; Glucocorticoid; Prolactinoma; T cell receptor (TCR); T-bet; Th1-Th2 differentiation; Tumor necrosis factor (TNF); cyclic AMP; cyclic AMP dependent protein kinase; cyclic AMP responsive element binding protein; cytokine; estrogen; estrogen receptor; glucocorticoid receptor; Smad4 protein; steroid hormone; steroid receptor; T lymphocyte receptor; transcription factor; transcription factor GATA 3; tumor necrosis factor; adaptation; apoptosis; carcinogenesis; conference paper; cytokine production; cytotoxicity; genetic transcription; immune response; lymphocyte differentiation; prolactinoma; protein protein interaction; signal transduction; T lymphocyte; target cell; Th1 cell; Th2 cell; transactivation
Año:2003
Volumen:992
Página de inicio:196
Página de fin:204
DOI: http://dx.doi.org/10.1111/j.1749-6632.2003.tb03150.x
Título revista:Annals of the New York Academy of Sciences
Título revista abreviado:Ann. New York Acad. Sci.
ISSN:00778923
CODEN:ANYAA
CAS:cyclic AMP, 60-92-4; cyclic AMP dependent protein kinase; cyclic AMP responsive element binding protein, 130428-87-4, 130939-96-7; Smad4 protein, 282562-18-9; transcription factor GATA 3, 137878-55-8
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00778923_v992_n_p196_Refojo

Referencias:

  • Schöbitz, B., De Kloet, E.R., Holsboer, F., Gene expression and function of interleukin 1, interlukin 6 and tumor necrosis factor in the brain (1994) Prog. Neurobiol., 44, pp. 397-432
  • Arzt, E., Paez Pereda, M.P., Perez Castro, C., Pathophysiological role of the cytokine network in the anterior pituitary gland (1999) Front. Neuroendocrinol., 20, pp. 71-95
  • Besedovsky, H.O., Del Rey, A., Immune-neuro-endocrine interactions: Facts and hypotheses (1996) Endocr. Rev., 17, pp. 64-102
  • McEwen, B., Biron, C., Brunson, K.W., The role of adrenocorticoids as modulators of immune function in health and disease: Neural, endocrine and immune interactions (1997) Brain Res. Rev., 23, pp. 79-133
  • McKay, L.I., Cidlowski, J.A., Molecular control of immune/inflammatory responses: Interactions between nuclear factor-kappa B and steroid receptor-signaling pathways (1999) Endocr. Rev., 20, pp. 435-459
  • Refojo, D., Liberman, A.C., Holsboer, F., Transcription factor-mediated molecular mechanisms involved in the functional cross-talk between cytokines and glucocorticoids (2001) Immunol. Cell. Biol., 79, pp. 385-394
  • Costas, M., Trapp, T., Paez Pereda, M., Molecular and functional evidence for in vitro cytokine enhancement of human and murine target cell sensitivity to glucocorticoids: TNF-α priming increases glucocorticoid inhibition of TNF-α-induced cytotoxicity/apoptosis (1996) J. Clin. Invest., 98, pp. 1409-1416
  • Chen, G., Goeddel, D.V., TNF-R1 signaling: A beautiful pathway (2002) Science, 296, pp. 1634-1635
  • Hsu, H., Shu, H.B., Pan, M.G., TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways (1996) Cell, 84, pp. 299-308
  • Costas, M.A., Muller Igaz, L., Holsboer, F., Transrepression of NF-kappaB is not required for glucocorticoid-mediated protection of TNF-alpha-induced apoptosis on fibroblasts (2000) Biochim. Biophys. Acta, 1499, pp. 122-129
  • Zacharchuk, C.M., Mercep, M., Chakraborti, P., Programmed T lymphocyte death: Cell activation and steroid-induced pathways are mutually antagonistic (1990) J. Immunol., 145, pp. 4037-4045
  • Ashwell, J.D., Lu, F.W.M., Vacchio, M.S., Glucocorticoids in T-cell development and function (2000) Ann. Rev. Immunol., 18, pp. 309-345
  • Krammer, P.H., CD95'S deadly mission in the immune system (2000) Nature, 407, pp. 789-795
  • Hakem, R., Hakem, A., Duncan, G.S., Differential requirement for caspase 9 in apoptotic pathways in vivo (1998) Cell, 94, pp. 339-352
  • Kasibhatla, S., Genestier, L., Green, D.R., Regulation of fas-ligand expression during activation-induced cell death in T lymphocytes via nuclear factor kappaB (1999) J. Biol. Chem., 274, pp. 987-992
  • Müller-Igaz, L., Refojo, D., Costas, M., CRE-mediated transcriptional activation is involved in cAMP protection of T-cell receptor-induced apoptosis but not in cAMP potentiation of glucocorticoid-mediated programmed cell death (2002) Biochim. Biophys. Acta, 1542, pp. 139-148
  • Glimcher, L.H., Murphy, K.M., Lineage commitment in the immune system: The T helper lymphocyte grows up (2000) Genes Dev., 14, pp. 1693-1711
  • Reiner, S.L., Helper T cell differetiation, inside and out (2001) Curr. Opin. Immunol., 13, pp. 351-355
  • Zheng, W., Flavell, R.A., The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells (1997) Cell, 89, pp. 587-596
  • Szabo, S.J., Kim, S.T., Costa, G.L., A novel transcription factor, T-bet, direct Th1 lineage commitment (2000) Cell, 100, pp. 655-669
  • Grogan, J.L., Locksley, R.M., T helper cell differentiation: On again, off again (2002) Curr. Opin. Immunol., 14, pp. 366-372
  • Ramirez, F., Fowell, D.J., Puklavec, M., Glucocorticoids promote a Th2 cytokine response by CD4 T cells in vitro (1996) J. Immunol., 156, pp. 2406-2412
  • Garcia, M.M., Kapcala, L.P., Growth of a microprolactinoma to a macroprolactinoma during estrogen therapy (1995) J. Endocrinol. Invest., 18, pp. 450-455
  • Stefaneanu, L., Kovacs, K., Horvath, E., In situ hybridization study of estrogen receptor messenger ribonucleic acid in human adenohypophysial cells and pituitary adenomas (1994) J. Clin. Endocrinol. Metab., 78, pp. 83-88
  • Lee, E.J., Duan, W.R., Jakacka, M., Dominant negative ER induces apoptosis in GH(4) pituitary lactotrope cells and inhibits tumor growth in nude mice (2001) Endocrinology, 142, pp. 3756-3763
  • Ramsdell, J.S., Transforming growth factor-alpha and -beta are potent and effective inhibitors of GH4 pituitary tumor cell proliferation (1991) Endocrinology, 128, pp. 1981-1990
  • Paez Pereda, M., Giacomini, D., Refojo, D., Involvement of bone morphogenetic protein Y (BMP-Y) in pituitary prolactinoma pathogenesis through a SMAD/estrogen receptor crosstalk (2003) Proc. Natl. Acad. Sci. USA, 100, pp. 1034-1039

Citas:

---------- APA ----------
Refojo, D., Liberman, A.C., Giacomini, D., Nagashima, A.C., Graciarena, M., Echenique, C., Paez Pereda, M.,..., Arzt, E. (2003) . Integrating systemic information at the molecular level: Cross-talk between steroid receptors and cytokine signaling on different target cells. Annals of the New York Academy of Sciences, 992, 196-204.
http://dx.doi.org/10.1111/j.1749-6632.2003.tb03150.x
---------- CHICAGO ----------
Refojo, D., Liberman, A.C., Giacomini, D., Nagashima, A.C., Graciarena, M., Echenique, C., et al. "Integrating systemic information at the molecular level: Cross-talk between steroid receptors and cytokine signaling on different target cells" . Annals of the New York Academy of Sciences 992 (2003) : 196-204.
http://dx.doi.org/10.1111/j.1749-6632.2003.tb03150.x
---------- MLA ----------
Refojo, D., Liberman, A.C., Giacomini, D., Nagashima, A.C., Graciarena, M., Echenique, C., et al. "Integrating systemic information at the molecular level: Cross-talk between steroid receptors and cytokine signaling on different target cells" . Annals of the New York Academy of Sciences, vol. 992, 2003, pp. 196-204.
http://dx.doi.org/10.1111/j.1749-6632.2003.tb03150.x
---------- VANCOUVER ----------
Refojo, D., Liberman, A.C., Giacomini, D., Nagashima, A.C., Graciarena, M., Echenique, C., et al. Integrating systemic information at the molecular level: Cross-talk between steroid receptors and cytokine signaling on different target cells. Ann. New York Acad. Sci. 2003;992:196-204.
http://dx.doi.org/10.1111/j.1749-6632.2003.tb03150.x