Artículo

Onofri, C.; Carbia Nagashima, A.; Schaaf, L.; Feirer, M.; Lohrer, P.; Stummer, W.; Berner, S.; Chervin, A.; Goldberg, V.; Stalla, G.K.; Renner, U.; Arzt, E. "Estradiol Stimulates Vascular Endothelial Growth Factor and Interleukin-6 in Human Lactotroph and Lactosomatotroph Pituitary Adenomas" (2004) Experimental and Clinical Endocrinology and Diabetes. 112(1):18-23
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Abstract:

Estrogens are considered to be critically involved in lactotroph and lactosomatotroph pituitary tumor development. In addition to direct effects, estradiol-induced tumor formation may involve alterations in growth factor and cytokine production. We have studied whether estradiol stimulates the production of the angiogenic vascular endothelial growth factor and the potential tumor progression factor interleukin-6 in 5 lactotroph (LA) and 5 lactosomatotroph (LSA) human pituitary adenoma cell cultures. All tumors secreted heterogenous basal amounts of VEGF (18.0 ± 1.4 to 425 ± 26 pg/ml per 24h) and IL-6 (18.1 ± 1.5 to 604 ± 17 pg/ml per 24h). Estradiol (100nM) significantly enhanced VEGF release in all LA and LSA cell cultures (47 to 168% above basal). IL-6 secretion was stimulated in 3 out of 5 LA and in all LSA cell cultures (31 to 287% above basal). In cell cultures obtained from tumors from which sufficient cells could be isolated, a dose-dependent effect of estradiol (1 to 100 nM) on VEGF and IL-6 production was observed. Stimulation of IL-6 and/or VEGF secretion by estradiol in the majority of human lactotroph and lactosomatotroph adenoma cell cultures studied, suggests that estrogens may contribute to adenoma expansion through the stimulation of these auto-/paracrine-acting adenoma progression factors.

Registro:

Documento: Artículo
Título:Estradiol Stimulates Vascular Endothelial Growth Factor and Interleukin-6 in Human Lactotroph and Lactosomatotroph Pituitary Adenomas
Autor:Onofri, C.; Carbia Nagashima, A.; Schaaf, L.; Feirer, M.; Lohrer, P.; Stummer, W.; Berner, S.; Chervin, A.; Goldberg, V.; Stalla, G.K.; Renner, U.; Arzt, E.
Filiación:Max Planck Institute of Psychiatry, Department of Endocrinology, Munich, Germany
Lab. de Fisiol. y Biologia Molecular, Dept. Fisiol. y Biologia Molecular, FCEN - Universidad de Buenos Aires, Buenos Aires, Argentina
Department of Neurosurgery, University of Munich, Munich, Germany
Hospital Santa Lucia, Buenos Aires, Argentina
Instituto de Investigaciones Medicas, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina
Department of Endocrinology, Max Planck Institute of Psychiatry, Kraepelinstraße 10, 80804 Munich, Germany
Palabras clave:Estrogens; Interleukin-6; Lactotroph/lactosomatotroph adenomas; Vascular endothelial growth factor; estradiol; interleukin 6; vasculotropin; adult; article; clinical article; cytokine production; female; hormonal regulation; human; human tissue; hypophysis adenoma; male; neuroendocrinology; priority journal; protein expression; Adult; Enzyme-Linked Immunosorbent Assay; Estradiol; Female; Humans; Interleukin-6; Male; Middle Aged; Pituitary Neoplasms; Prolactinoma; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A
Año:2004
Volumen:112
Número:1
Página de inicio:18
Página de fin:23
DOI: http://dx.doi.org/10.1055/s-2004-815722
Título revista:Experimental and Clinical Endocrinology and Diabetes
Título revista abreviado:Exp. Clin. Endocrinol. Diabetes
ISSN:09477349
CODEN:ECEDF
CAS:estradiol, 50-28-2; vasculotropin, 127464-60-2; Estradiol, 50-28-2; Interleukin-6; Vascular Endothelial Growth Factor A
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09477349_v112_n1_p18_Onofri

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Citas:

---------- APA ----------
Onofri, C., Carbia Nagashima, A., Schaaf, L., Feirer, M., Lohrer, P., Stummer, W., Berner, S.,..., Arzt, E. (2004) . Estradiol Stimulates Vascular Endothelial Growth Factor and Interleukin-6 in Human Lactotroph and Lactosomatotroph Pituitary Adenomas. Experimental and Clinical Endocrinology and Diabetes, 112(1), 18-23.
http://dx.doi.org/10.1055/s-2004-815722
---------- CHICAGO ----------
Onofri, C., Carbia Nagashima, A., Schaaf, L., Feirer, M., Lohrer, P., Stummer, W., et al. "Estradiol Stimulates Vascular Endothelial Growth Factor and Interleukin-6 in Human Lactotroph and Lactosomatotroph Pituitary Adenomas" . Experimental and Clinical Endocrinology and Diabetes 112, no. 1 (2004) : 18-23.
http://dx.doi.org/10.1055/s-2004-815722
---------- MLA ----------
Onofri, C., Carbia Nagashima, A., Schaaf, L., Feirer, M., Lohrer, P., Stummer, W., et al. "Estradiol Stimulates Vascular Endothelial Growth Factor and Interleukin-6 in Human Lactotroph and Lactosomatotroph Pituitary Adenomas" . Experimental and Clinical Endocrinology and Diabetes, vol. 112, no. 1, 2004, pp. 18-23.
http://dx.doi.org/10.1055/s-2004-815722
---------- VANCOUVER ----------
Onofri, C., Carbia Nagashima, A., Schaaf, L., Feirer, M., Lohrer, P., Stummer, W., et al. Estradiol Stimulates Vascular Endothelial Growth Factor and Interleukin-6 in Human Lactotroph and Lactosomatotroph Pituitary Adenomas. Exp. Clin. Endocrinol. Diabetes. 2004;112(1):18-23.
http://dx.doi.org/10.1055/s-2004-815722