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Abstract:

Recent reports have given a central role to environmental factors in the etiology of autism spectrum disorders (ASD). However, most proposed perinatal factors seem to converge into the activation of the immune system, suggesting that an early inflammatory response could be a unifying factor in the etiology ASD. Here I review the evidence of early immune activation in individuals with ASD, and the chronic peripheral and central alterations observed in the inflammatory response in ASD. This evidence shows that ASD is associated with altered neuroinflammatory processes and abnormal immune responses in adulthood. How these immune alterations can affect developmental programming of adult behavior or directly affect behavior later in life is discussed in the context of both clinical and animal models of research. Recent studies in rodents clearly support a role of elevated cytokines in the behavioral symptoms of ASD, both during development and in adulthood. This article is part of a Special Issue entitled 'Neuroinflammation in neurodegeneration and neurodysfunction'. © 2012 Elsevier Inc.

Registro:

Documento: Artículo
Título:Peripheral and central inflammation in autism spectrum disorders
Autor:Depino, A.M.
Filiación:Instituto de Fisiología, Biología Molecular y Neurociencias, CONICET-UBA, C1428EHA Buenos Aires, Argentina
Departamento de Fisiología y Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, C1428EHA Buenos Aires, Argentina
Palabras clave:Animal model; Autism spectrum disorders; Behavior; Cytokines; Immune activation; Inflammation; alpha interferon; autoantibody; chemokine; cytokine; gamma interferon; interleukin 1; interleukin 1 receptor; interleukin 10; interleukin 1beta; interleukin 2; interleukin 4; interleukin 6; interleukin 8; monocyte chemotactic protein 1; myelin; transforming growth factor beta1; tumor necrosis factor alpha; adulthood; article; astrocytosis; autism; autoimmune disease; bacterial infection; behavior; brain development; cell migration; central nervous system; chronic inflammation; cytokine production; cytokine response; disease association; environmental factor; epigenetic repression; fetus development; gestational age; glia cell; heredity; hippocampus; human; immune response; immunity; immunocompetent cell; molecular mechanics; nerve cell; nerve cell differentiation; nerve degeneration; nervous system inflammation; neuropsychiatry; nonhuman; pathophysiology; perinatal period; peripheral nervous system; postnatal development; prenatal period; priority journal; protein expression; Streptococcus infection; systemic lupus erythematosus; virus infection; Animals; Child; Child Development Disorders, Pervasive; Cytokines; Humans; Immunity, Maternally-Acquired; Inflammation; Animalia; Rodentia
Año:2013
Volumen:53
Página de inicio:69
Página de fin:76
DOI: http://dx.doi.org/10.1016/j.mcn.2012.10.003
Título revista:Molecular and Cellular Neuroscience
Título revista abreviado:Mol. Cell. Neurosci.
ISSN:10447431
CODEN:MOCNE
CAS:gamma interferon, 82115-62-6; interleukin 2, 85898-30-2; interleukin 8, 114308-91-7; Cytokines
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10447431_v53_n_p69_Depino

Referencias:

  • Abbott, N.J., Patabendige, A.A., Dolman, D.E., Yusof, S.R., Begley, D.J., Structure and function of the blood-brain barrier (2010) Neurobiol. Dis., 37, pp. 13-25
  • Abdallah, M.W., Larsen, N., Grove, J., Norgaard-Pedersen, B., Thorsen, P., Mortensen, E.L., Hougaard, D.M., Amniotic fluid chemokines and autism spectrum disorders: an exploratory study utilizing a Danish Historic Birth Cohort (2012) Brain Behav. Immun., 26, pp. 170-176
  • Abrahams, B.S., Geschwind, D.H., Advances in autism genetics: on the threshold of a new neurobiology (2008) Nat. Rev. Genet., 9, pp. 341-355
  • Adams-Chapman, I., Stoll, B.J., Neonatal infection and long-term neurodevelopmental outcome in the preterm infant (2006) Curr. Opin. Infect. Dis., 19, pp. 290-297
  • Aly, H., Khashaba, M.T., El-Ayouty, M., El-Sayed, O., Hasanein, B.M., IL-1beta, IL-6 and TNF-alpha and outcomes of neonatal hypoxic ischemic encephalopathy (2006) Brain Dev., 28, pp. 178-182
  • Amaral, D.G., Schumann, C.M., Nordahl, C.W., Neuroanatomy of autism (2008) Trends Neurosci., 31, pp. 137-145
  • (2000) Diagnostic and Statistical Manual of Mental Disorders, , American Psychiatric Association, Text Revision, American Psychiatric Publishing, Inc., Washington, DC
  • Anderson, G.M., Jacobs-Stannard, A., Chawarska, K., Volkmar, F.R., Kliman, H.J., Placental trophoblast inclusions in autism spectrum disorder (2007) Biol. Psychiatry, 61, pp. 487-491
  • Ashdown, H., Dumont, Y., Ng, M., Poole, S., Boksa, P., Luheshi, G.N., The role of cytokines in mediating effects of prenatal infection on the fetus: implications for schizophrenia (2006) Mol. Psychiatry, 11, pp. 47-55
  • Atladottir, H.O., Pedersen, M.G., Thorsen, P., Mortensen, P.B., Deleuran, B., Eaton, W.W., Parner, E.T., Association of family history of autoimmune diseases and autism spectrum disorders (2009) Pediatrics, 124, pp. 687-694
  • Atladottir, H.O., Thorsen, P., Ostergaard, L., Schendel, D.E., Lemcke, S., Abdallah, M., Parner, E.T., Maternal infection requiring hospitalization during pregnancy and autism spectrum disorders (2010) J. Autism Dev. Disord., 40, pp. 1423-1430
  • Atladottir, H.O., Henriksen, T.B., Schendel, D.E., Parner, E.T., Using maternally reported data to investigate the association between early childhood infection and autism spectrum disorder: the importance of data source (2012) Paediatr. Perinat. Epidemiol., 26, pp. 373-385
  • Barak, Y., Kimhi, R., Stein, D., Gutman, J., Weizman, A., Autistic subjects with comorbid epilepsy: a possible association with viral infections (1999) Child Psychiatry Hum. Dev., 29, pp. 245-251
  • Baron-Cohen, S., Scott, F.J., Allison, C., Williams, J., Bolton, P., Matthews, F.E., Brayne, C., Prevalence of autism-spectrum conditions: UK school-based population study (2009) Br. J. Psychiatry, 194, pp. 500-509
  • Becker, K.G., Autism, asthma, inflammation, and the hygiene hypothesis (2007) Med. Hypotheses, 69, pp. 731-740
  • Berg, R., Autism-an environmental health issue after all? (2009) J. Environ. Health, 71, pp. 14-18
  • Besedovsky, H.O., Rey, A.D., Physiology of psychoneuroimmunology: a personal view (2007) Brain Behav. Immun., 21, pp. 34-44
  • Bilbo, S.D., Biedenkapp, J.C., Der-Avakian, A., Watkins, L.R., Rudy, J.W., Maier, S.F., Neonatal infection-induced memory impairment after lipopolysaccharide in adulthood is prevented via caspase-1 inhibition (2005) J. Neurosci., 25, pp. 8000-8009
  • Bilousova, T.V., Dansie, L., Ngo, M., Aye, J., Charles, J.R., Ethell, D.W., Ethell, I.M., Minocycline promotes dendritic spine maturation and improves behavioural performance in the fragile X mouse model (2009) J. Med. Genet., 46, pp. 94-102
  • Bluthe, R.M., Walter, V., Parnet, P., Laye, S., Lestage, J., Verrier, D., Poole, S., Dantzer, R., Lipopolysaccharide induces sickness behaviour in rats by a vagal mediated mechanism (1994) C. R. Acad. Sci. III, 317, pp. 499-503
  • Bluthe, R.M., Michaud, B., Poli, V., Dantzer, R., Role of IL-6 in cytokine-induced sickness behavior: a study with IL-6 deficient mice (2000) Physiol. Behav., 70, pp. 367-373
  • Bluthe, R.M., Lestage, J., Rees, G., Bristow, A., Dantzer, R., Dual effect of central injection of recombinant rat interleukin-4 on lipopolysaccharide-induced sickness behavior in rats (2002) Neuropsychopharmacology, 26, pp. 86-93
  • Boisse, L., Mouihate, A., Ellis, S., Pittman, Q.J., Long-term alterations in neuroimmune responses after neonatal exposure to lipopolysaccharide (2004) J. Neurosci., 24, pp. 4928-4934
  • Braunschweig, D., Ashwood, P., Krakowiak, P., Hertz-Picciotto, I., Hansen, R., Croen, L.A., Pessah, I.N., Van de Water, J., Autism: maternally derived antibodies specific for fetal brain proteins (2008) Neurotoxicology, 29, pp. 226-231
  • Cai, Z., Pan, Z.L., Pang, Y., Evans, O.B., Rhodes, P.G., Cytokine induction in fetal rat brains and brain injury in neonatal rats after maternal lipopolysaccharide administration (2000) Pediatr. Res., 47, pp. 64-72
  • (2009) Prevalence of Autism Spectrum Disorders-Autism and Developmental Disabilities Monitoring Network, United States, 2006, , Surveillance Summaries, MMWR, Centers for Disease Control and Prevention
  • Chess, S., Autism in children with congenital rubella (1971) J. Autism Child. Schizophr., 1, pp. 33-47
  • Chess, S., Follow-up report on autism in congenital rubella (1977) J. Autism Child. Schizophr., 7, pp. 69-81
  • Chez, M.G., Guido-Estrada, N., Immune therapy in autism: historical experience and future directions with immunomodulatory therapy (2010) Neurotherapeutics, 7, pp. 293-301
  • Chez, M.G., Dowling, T., Patel, P.B., Khanna, P., Kominsky, M., Elevation of tumor necrosis factor-alpha in cerebrospinal fluid of autistic children (2007) Pediatr. Neurol., 36, pp. 361-365
  • Ciaranello, A.L., Ciaranello, R.D., The neurobiology of infantile autism (1995) Annu. Rev. Neurosci., 18, pp. 101-128
  • Comi, A.M., Zimmerman, A.W., Frye, V.H., Law, P.A., Peeden, J.N., Familial clustering of autoimmune disorders and evaluation of medical risk factors in autism (1999) J. Child Neurol., 14, pp. 388-394
  • Crawley, J.N., Mouse behavioral assays relevant to the symptoms of autism (2007) Brain Pathol., 17, pp. 448-459
  • Croen, L.A., Braunschweig, D., Haapanen, L., Yoshida, C.K., Fireman, B., Grether, J.K., Kharrazi, M., Van de Water, J., Maternal mid-pregnancy autoantibodies to fetal brain protein: the early markers for autism study (2008) Biol. Psychiatry, 64, pp. 583-588
  • Croonenberghs, J., Bosmans, E., Deboutte, D., Kenis, G., Maes, M., Activation of the inflammatory response system in autism (2002) Neuropsychobiology, 45, pp. 1-6
  • Curran, L.K., Newschaffer, C.J., Lee, L.C., Crawford, S.O., Johnston, M.V., Zimmerman, A.W., Behaviors associated with fever in children with autism spectrum disorders (2007) Pediatrics, 120, pp. e1386-e1392
  • Dalton, P., Deacon, R., Blamire, A., Pike, M., McKinlay, I., Stein, J., Styles, P., Vincent, A., Maternal neuronal antibodies associated with autism and a language disorder (2003) Ann. Neurol., 53, pp. 533-537
  • DeLong, G.R., Bean, S.C., Brown, F.R., Acquired reversible autistic syndrome in acute encephalopathic illness in children (1981) Arch. Neurol., 38, pp. 191-194
  • Depino, A.M., Maternal infection and the offspring brain (2006) J. Neurosci., 26, pp. 7777-7778
  • Depino, A.M., Lucchina, L., Pitossi, F., Early and adult hippocampal TGF-beta1 overexpression have opposite effects on behavior (2011) Brain Behav. Immun., 25, pp. 1582-1591
  • D'Souza, Y., Dionne, S., Seidman, E.G., Bitton, A., Ward, B.J., No evidence of persisting measles virus in the intestinal tissues of patients with inflammatory bowel disease (2007) Gut, 56, pp. 886-888
  • Emanuele, E., Orsi, P., Boso, M., Broglia, D., Brondino, N., Barale, F., di Nemi, S.U., Politi, P., Low-grade endotoxemia in patients with severe autism (2010) Neurosci. Lett., 471, pp. 162-165
  • Enstrom, A.M., Onore, C.E., Van de Water, J.A., Ashwood, P., Differential monocyte responses to TLR ligands in children with autism spectrum disorders (2010) Brain Behav. Immun., 24, pp. 64-71
  • Fatemi, S.H., Emamian, E.S., Kist, D., Sidwell, R.W., Nakajima, K., Akhter, P., Shier, A., Bailey, K., Defective corticogenesis and reduction in Reelin immunoreactivity in cortex and hippocampus of prenatally infected neonatal mice (1999) Mol. Psychiatry, 4, pp. 145-154
  • Fatemi, S.H., Emamian, E.S., Sidwell, R.W., Kist, D.A., Stary, J.M., Earle, J.A., Thuras, P., Human influenza viral infection in utero alters glial fibrillary acidic protein immunoreactivity in the developing brains of neonatal mice (2002) Mol. Psychiatry, 7, pp. 633-640
  • Fatemi, S.H., Reutiman, T.J., Folsom, T.D., Huang, H., Oishi, K., Mori, S., Smee, D.F., Juckel, G., Maternal infection leads to abnormal gene regulation and brain atrophy in mouse offspring: implications for genesis of neurodevelopmental disorders (2008) Schizophr. Res., 99, pp. 56-70
  • Flaherty, D.K., The vaccine-autism connection: a public health crisis caused by unethical medical practices and fraudulent science (2011) Ann. Pharmacother., 45, pp. 1302-1304
  • Garbett, K., Ebert, P.J., Mitchell, A., Lintas, C., Manzi, B., Mirnics, K., Persico, A.M., Immune transcriptome alterations in the temporal cortex of subjects with autism (2008) Neurobiol. Dis., 30, pp. 303-311
  • Ghaziuddin, M., Tsai, L.Y., Eilers, L., Ghaziuddin, N., Brief report: autism and herpes simplex encephalitis (1992) J. Autism Dev. Disord., 22, pp. 107-113
  • Gillberg, C., Onset at age 14 of a typical autistic syndrome. A case report of a girl with herpes simplex encephalitis (1986) J. Autism Dev. Disord., 16, pp. 369-375
  • Golan, H.M., Lev, V., Hallak, M., Sorokin, Y., Huleihel, M., Specific neurodevelopmental damage in mice offspring following maternal inflammation during pregnancy (2005) Neuropharmacology, 48, pp. 903-917
  • Graciarena, M., Depino, A.M., Pitossi, F.J., Prenatal inflammation impairs adult neurogenesis and memory related behavior through persistent hippocampal TGFbeta(1) downregulation (2010) Brain Behav. Immun., 24, pp. 1301-1309
  • Granger, D.A., Hood, K.E., Ikeda, S.C., Reed, C.L., Block, M.L., Neonatal endotoxin exposure alters the development of social behavior and the hypothalamic-pituitary-adrenal axis in selectively bred mice (1996) Brain Behav. Immun., 10, pp. 249-259
  • Greer, M.K., Lyons-Crews, M., Mauldin, L.B., Brown, F.R., A case study of the cognitive and behavioral deficits of temporal lobe damage in herpes simplex encephalitis (1989) J. Autism Dev. Disord., 19, pp. 317-326
  • Hallmayer, J., Cleveland, S., Torres, A., Phillips, J., Cohen, B., Torigoe, T., Miller, J., Risch, N., Genetic heritability and shared environmental factors among twin pairs with autism (2011) Arch. Gen. Psychiatry, 68, pp. 1095-1102
  • Heo, Y., Zhang, Y., Gao, D., Miller, V.M., Lawrence, D.A., Aberrant immune responses in a mouse with behavioral disorders (2011) PLoS One, 6, pp. e20912
  • Hertz-Picciotto, I., Delwiche, L., The rise in autism and the role of age at diagnosis (2009) Epidemiology, 20, pp. 84-90
  • Hood, K.E., Dreschel, N.A., Granger, D.A., Maternal behavior changes after immune challenge of neonates with developmental effects on adult social behavior (2003) Dev. Psychobiol., 42, pp. 17-34
  • Hornig, M., Briese, T., Buie, T., Bauman, M.L., Lauwers, G., Siemetzki, U., Hummel, K., Lipkin, W.I., Lack of association between measles virus vaccine and autism with enteropathy: a case-control study (2008) PLoS One, 3, pp. e3140
  • Hsiao, E.Y., McBride, S.W., Chow, J., Mazmanian, S.K., Patterson, P.H., Modeling an autism risk factor in mice leads to permanent immune dysregulation (2012) Proc. Natl. Acad. Sci. U. S. A., 109, pp. 12776-12781
  • Hu, V.W., Sarachana, T., Kim, K.S., Nguyen, A., Kulkarni, S., Steinberg, M.E., Luu, T., Lee, N.H., Gene expression profiling differentiates autism case-controls and phenotypic variants of autism spectrum disorders: evidence for circadian rhythm dysfunction in severe autism (2009) Autism Res., 2, pp. 78-97
  • Ivarsson, S.A., Bjerre, I., Vegfors, P., Ahlfors, K., Autism as one of several disabilities in two children with congenital cytomegalovirus infection (1990) Neuropediatrics, 21, pp. 102-103
  • Jyonouchi, H., Sun, S., Le, H., Proinflammatory and regulatory cytokine production associated with innate and adaptive immune responses in children with autism spectrum disorders and developmental regression (2001) J. Neuroimmunol., 120, pp. 170-179
  • Jyonouchi, H., Sun, S., Itokazu, N., Innate immunity associated with inflammatory responses and cytokine production against common dietary proteins in patients with autism spectrum disorder (2002) Neuropsychobiology, 46, pp. 76-84
  • Khazipov, R., Luhmann, H.J., Early patterns of electrical activity in the developing cerebral cortex of humans and rodents (2006) Trends Neurosci., 29, pp. 414-418
  • Khazipov, R., Sirota, A., Leinekugel, X., Holmes, G.L., Ben-Ari, Y., Buzsaki, G., Early motor activity drives spindle bursts in the developing somatosensory cortex (2004) Nature, 432, pp. 758-761
  • Konsman, J.P., Parnet, P., Dantzer, R., Cytokine-induced sickness behaviour: mechanisms and implications (2002) Trends Neurosci., 25, pp. 154-159
  • Konsman, J.P., Veeneman, J., Combe, C., Poole, S., Luheshi, G.N., Dantzer, R., Central nervous action of interleukin-1 mediates activation of limbic structures and behavioural depression in response to peripheral administration of bacterial lipopolysaccharide (2008) Eur. J. Neurosci., 28, pp. 2499-2510
  • Landrigan, P.J., What causes autism? Exploring the environmental contribution (2010) Curr. Opin. Pediatr., 22, pp. 219-225
  • Larsson, M., Weiss, B., Janson, S., Sundell, J., Bornehag, C.G., Associations between indoor environmental factors and parental-reported autistic spectrum disorders in children 6-8 years of age (2009) Neurotoxicology, 30, pp. 822-831
  • Leinekugel, X., Khazipov, R., Cannon, R., Hirase, H., Ben-Ari, Y., Buzsaki, G., Correlated bursts of activity in the neonatal hippocampus in vivo (2002) Science, 296, pp. 2049-2052
  • Li, X., Chauhan, A., Sheikh, A.M., Patil, S., Chauhan, V., Li, X.M., Ji, L., Malik, M., Elevated immune response in the brain of autistic patients (2009) J. Neuroimmunol., 207, pp. 111-116
  • Libbey, J.E., Fujinami, R.S., Role for antibodies in altering behavior and movement (2010) Autism Res., 3, pp. 147-152
  • Lintas, C., Altieri, L., Lombardi, F., Sacco, R., Persico, A.M., Association of autism with polyomavirus infection in postmortem brains (2010) J. Neurovirol., 16, pp. 141-149
  • Liu, J., Feng, Z.C., Increased umbilical cord plasma interleukin-1 beta levels was correlated with adverse outcomes of neonatal hypoxic-ischemic encephalopathy (2010) J. Trop. Pediatr., 56, pp. 178-182
  • Lucchina, L., Carola, V., Pitossi, F., Depino, A.M., Evaluating the interaction between early postnatal inflammation and maternal care in the programming of adult anxiety and depression-related behaviors (2010) Behav. Brain Res., 213, pp. 56-65
  • MacFabe, D.F., Cain, D.P., Rodriguez-Capote, K., Franklin, A.E., Hoffman, J.E., Boon, F., Taylor, A.R., Ossenkopp, K.P., Neurobiological effects of intraventricular propionic acid in rats: possible role of short chain fatty acids on the pathogenesis and characteristics of autism spectrum disorders (2007) Behav. Brain Res., 176, pp. 149-169
  • MacFabe, D.F., Cain, N.E., Boon, F., Ossenkopp, K.P., Cain, D.P., Effects of the enteric bacterial metabolic product propionic acid on object-directed behavior, social behavior, cognition, and neuroinflammation in adolescent rats: relevance to autism spectrum disorder (2011) Behav. Brain Res., 217, pp. 47-54
  • Malek, A., Sager, R., Lang, A.B., Schneider, H., Protein transport across the in vitro perfused human placenta (1997) Am. J. Reprod. Immunol., 38, pp. 263-271
  • Malik, M., Sheikh, A.M., Wen, G., Spivack, W., Brown, W.T., Li, X., Expression of inflammatory cytokines, Bcl2 and cathepsin D are altered in lymphoblasts of autistic subjects (2011) Immunobiology, 216, pp. 80-85
  • Malkova, N.V., Yu, C.Z., Hsiao, E.Y., Moore, M.J., Patterson, P.H., Maternal immune activation yields offspring displaying mouse versions of the three core symptoms of autism (2012) Brain Behav. Immun., 26, pp. 607-616
  • Mandal, M., Marzouk, A.C., Donnelly, R., Ponzio, N.M., Maternal immune stimulation during pregnancy affects adaptive immunity in offspring to promote development of TH17 cells (2011) Brain Behav. Immun., 25, pp. 863-871
  • Markowitz, P.I., Autism in a child with congenital cytomegalovirus infection (1983) J. Autism Dev. Disord., 13, pp. 249-253
  • Martin, L., Ashwood, P., Braunschweig, D., Cabanlit, M., Van de Water, J., Amaral, D.G., Stereotypies and hyperactivity in rhesus monkeys exposed to IgG from mothers of children with autism (2008) Brain Behav. Immun., 22, pp. 806-816
  • Merrill, J.E., Tumor necrosis factor alpha, interleukin 1 and related cytokines in brain development: normal and pathological (1992) Dev. Neurosci., 14, pp. 1-10
  • Meyer, U., Nyffeler, M., Engler, A., Urwyler, A., Schedlowski, M., Knuesel, I., Yee, B.K., Feldon, J., The time of prenatal immune challenge determines the specificity of inflammation-mediated brain and behavioral pathology (2006) J. Neurosci., 26, pp. 4752-4762
  • Miller, L.C., Isa, S., LoPreste, G., Schaller, J.G., Dinarello, C.A., Neonatal interleukin-1 beta, interleukin-6, and tumor necrosis factor: cord blood levels and cellular production (1990) J. Pediatr., 117, pp. 961-965
  • Moore, S.J., Turnpenny, P., Quinn, A., Glover, S., Lloyd, D.J., Montgomery, T., Dean, J.C., A clinical study of 57 children with fetal anticonvulsant syndromes (2000) J. Med. Genet., 37, pp. 489-497
  • Morgan, J.T., Chana, G., Pardo, C.A., Achim, C., Semendeferi, K., Buckwalter, J., Courchesne, E., Everall, I.P., Microglial activation and increased microglial density observed in the dorsolateral prefrontal cortex in autism (2010) Biol. Psychiatry, 68, pp. 368-376
  • Moy, S.S., Nadler, J.J., Advances in behavioral genetics: mouse models of autism (2008) Mol. Psychiatry, 13, pp. 4-26
  • Moy, S.S., Nadler, J.J., Young, N.B., Perez, A., Holloway, L.P., Barbaro, R.P., Barbaro, J.R., Crawley, J.N., Mouse behavioral tasks relevant to autism: phenotypes of 10 inbred strains (2007) Behav. Brain Res., 176, pp. 4-20
  • Myint, A.M., Schwarz, M.J., Steinbusch, H.W., Leonard, B.E., Neuropsychiatric disorders related to interferon and interleukins treatment (2009) Metab. Brain Dis., 24, pp. 55-68
  • Palmen, S.J., van Engeland, H., Hof, P.R., Schmitz, C., Neuropathological findings in autism (2004) Brain, 127, pp. 2572-2583
  • Paribello, C., Tao, L., Folino, A., Berry-Kravis, E., Tranfaglia, M., Ethell, I.M., Ethell, D.W., Open-label add-on treatment trial of minocycline in fragile X syndrome (2010) BMC Neurol., 10, p. 91
  • Parracho, H.M., Bingham, M.O., Gibson, G.R., McCartney, A.L., Differences between the gut microflora of children with autistic spectrum disorders and that of healthy children (2005) J. Med. Microbiol., 54, pp. 987-991
  • Patterson, P.H., Maternal infection: window on neuroimmune interactions in fetal brain development and mental illness (2002) Curr. Opin. Neurobiol., 12, pp. 115-118
  • Ring, A., Barak, Y., Ticher, A., Ashkenazi, I., Elizur, A., Weizman, A., Evidence for an infectious etiology in autism (1997) Pathophysiology, 4, pp. 91-96
  • Roberts, E.M., English, P.B., Grether, J.K., Windham, G.C., Somberg, L., Wolff, C., Maternal residence near agricultural pesticide applications and autism spectrum disorders among children in the California Central Valley (2007) Environ. Health Perspect., 115, pp. 1482-1489
  • Rodier, P.M., Chronology of neuron development: animal studies and their clinical implications (1980) Dev. Med. Child Neurol., 22, pp. 525-545
  • Rosen, N.J., Yoshida, C.K., Croen, L.A., Infection in the first 2 years of life and autism spectrum disorders (2007) Pediatrics, 119, pp. e61-e69
  • Samuelsson, A.M., Jennische, E., Hansson, H.A., Holmang, A., Prenatal exposure to interleukin-6 results in inflammatory neurodegeneration in hippocampus with NMDA/GABA(A) dysregulation and impaired spatial learning (2006) Am. J. Physiol. Regul. Integr. Comp. Physiol., 290, pp. R1345-R1356
  • Saresella, M., Marventano, I., Guerini, F.R., Mancuso, R., Ceresa, L., Zanzottera, M., Rusconi, B., Clerici, M., An autistic endophenotype results in complex immune dysfunction in healthy siblings of autistic children (2009) Biol. Psychiatry, 66, pp. 978-984
  • Saunders, N.R., Knott, G.W., Dziegielewska, K.M., Barriers in the immature brain (2000) Cell. Mol. Neurobiol., 20, pp. 29-40
  • Shanks, N., Windle, R.J., Perks, P.A., Harbuz, M.S., Jessop, D.S., Ingram, C.D., Lightman, S.L., Early-life exposure to endotoxin alters hypothalamic-pituitary-adrenal function and predisposition to inflammation (2000) Proc. Natl. Acad. Sci. U. S. A., 97, pp. 5645-5650
  • Shi, L., Fatemi, S.H., Sidwell, R.W., Patterson, P.H., Maternal influenza infection causes marked behavioral and pharmacological changes in the offspring (2003) J. Neurosci., 23, pp. 297-302
  • Shi, L., Smith, S.E., Malkova, N., Tse, D., Su, Y., Patterson, P.H., Activation of the maternal immune system alters cerebellar development in the offspring (2009) Brain Behav. Immun., 23, pp. 116-123
  • Shultz, S.R., MacFabe, D.F., Ossenkopp, K.P., Scratch, S., Whelan, J., Taylor, R., Cain, D.P., Intracerebroventricular injection of propionic acid, an enteric bacterial metabolic end-product, impairs social behavior in the rat: implications for an animal model of autism (2008) Neuropharmacology, 54, pp. 901-911
  • Shultz, S.R., Macfabe, D.F., Martin, S., Jackson, J., Taylor, R., Boon, F., Ossenkopp, K.P., Cain, D.P., Intracerebroventricular injections of the enteric bacterial metabolic product propionic acid impair cognition and sensorimotor ability in the Long-Evans rat: further development of a rodent model of autism (2009) Behav. Brain Res., 200, pp. 33-41
  • Singh, V.K., Jensen, R.L., Elevated levels of measles antibodies in children with autism (2003) Pediatr. Neurol., 28, pp. 292-294
  • Singh, V.K., Lin, S.X., Yang, V.C., Serological association of measles virus and human herpesvirus-6 with brain autoantibodies in autism (1998) Clin. Immunol. Immunopathol., 89, pp. 105-108
  • Singh, V.K., Lin, S.X., Newell, E., Nelson, C., Abnormal measles-mumps-rubella antibodies and CNS autoimmunity in children with autism (2002) J. Biomed. Sci., 9, pp. 359-364
  • Smith, S.E., Li, J., Garbett, K., Mirnics, K., Patterson, P.H., Maternal immune activation alters fetal brain development through interleukin-6 (2007) J. Neurosci., 27, pp. 10695-10702
  • Stolp, H.B., Dziegielewska, K.M., Review: role of developmental inflammation and blood-brain barrier dysfunction in neurodevelopmental and neurodegenerative diseases (2009) Neuropathol. Appl. Neurobiol., 35, pp. 132-146
  • Stromland, K., Nordin, V., Miller, M., Akerstrom, B., Gillberg, C., Autism in thalidomide embryopathy: a population study (1994) Dev. Med. Child Neurol., 36, pp. 351-356
  • Stubbs, E.G., Autistic children exhibit undetectable hemagglutination-inhibition antibody titers despite previous rubella vaccination (1976) J. Autism Child. Schizophr., 6, pp. 269-274
  • Stubbs, E.G., Autistic symptoms in a child with congenital cytomegalovirus infection (1978) J. Autism Child. Schizophr., 8, pp. 37-43
  • Suzuki, K., Matsuzaki, H., Iwata, K., Kameno, Y., Shimmura, C., Kawai, S., Yoshihara, Y., Mori, N., Plasma cytokine profiles in subjects with high-functioning autism spectrum disorders (2011) PLoS One, 6, pp. e20470
  • Uhlmann, V., Martin, C.M., Sheils, O., Pilkington, L., Silva, I., Killalea, A., Murch, S.B., O'Leary, J.J., Potential viral pathogenic mechanism for new variant inflammatory bowel disease (2002) Mol. Pathol., 55, pp. 84-90
  • Vargas, D.L., Nascimbene, C., Krishnan, C., Zimmerman, A.W., Pardo, C.A., Neuroglial activation and neuroinflammation in the brain of patients with autism (2005) Ann. Neurol., 57, pp. 67-81
  • Wakefield, A.J., Murch, S.H., Anthony, A., Linnell, J., Casson, D.M., Malik, M., Berelowitz, M., Walker-Smith, J.A., Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children (1998) Lancet, 351, pp. 637-641
  • Wang, L.W., Tancredi, D.J., Thomas, D.W., The prevalence of gastrointestinal problems in children across the United States with autism spectrum disorders from families with multiple affected members (2011) J. Dev. Behav. Pediatr., 32, pp. 351-360
  • Williams, C.L., Teeling, J.L., Perry, V.H., Fleming, T.P., Mouse maternal systemic inflammation at the zygote stage causes blunted cytokine responsiveness in lipopolysaccharide-challenged adult offspring (2011) BMC Biol., 9, p. 49
  • (1994) International Classification of Diseases, , 10th Revision, World Health Organization, Geneva, Switzerland, World Health Organization
  • Yamashita, Y., Fujimoto, C., Nakajima, E., Isagai, T., Matsuishi, T., Possible association between congenital cytomegalovirus infection and autistic disorder (2003) J. Autism Dev. Disord., 33, pp. 455-459
  • Yoon, B.H., Romero, R., Kim, C.J., Jun, J.K., Gomez, R., Choi, J.H., Syn, H.C., Amniotic fluid interleukin-6: a sensitive test for antenatal diagnosis of acute inflammatory lesions of preterm placenta and prediction of perinatal morbidity (1995) Am. J. Obstet. Gynecol., 172, pp. 960-970
  • Ziats, M.N., Rennert, O.M., Expression profiling of autism candidate genes during human brain development implicates central immune signaling pathways (2011) PLoS One, 6, pp. e24691
  • Zimmerman, A.W., Jyonouchi, H., Comi, A.M., Connors, S.L., Milstien, S., Varsou, A., Heyes, M.P., Cerebrospinal fluid and serum markers of inflammation in autism (2005) Pediatr. Neurol., 33, pp. 195-201

Citas:

---------- APA ----------
(2013) . Peripheral and central inflammation in autism spectrum disorders. Molecular and Cellular Neuroscience, 53, 69-76.
http://dx.doi.org/10.1016/j.mcn.2012.10.003
---------- CHICAGO ----------
Depino, A.M. "Peripheral and central inflammation in autism spectrum disorders" . Molecular and Cellular Neuroscience 53 (2013) : 69-76.
http://dx.doi.org/10.1016/j.mcn.2012.10.003
---------- MLA ----------
Depino, A.M. "Peripheral and central inflammation in autism spectrum disorders" . Molecular and Cellular Neuroscience, vol. 53, 2013, pp. 69-76.
http://dx.doi.org/10.1016/j.mcn.2012.10.003
---------- VANCOUVER ----------
Depino, A.M. Peripheral and central inflammation in autism spectrum disorders. Mol. Cell. Neurosci. 2013;53:69-76.
http://dx.doi.org/10.1016/j.mcn.2012.10.003