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Referencias:

• Van Kooyk, Y., Rabinovich, G.A., Protein-glycan interactions in the control of innate and adaptive immune responses (2008) Nature Immunology, 9 (6), pp. 593-601. , DOI 10.1038/ni.f.203, PII NI.F.203
• Sharon, N., Lectins: Past, present and future (2008) Biochem. Soc. Trans., 36 (PART 6), pp. 1457-1460
• Sharon, N., Lis, H., History of lectins: From hemagglutinins to biological recognition molecules (2004) Glycobiology, 14 (11), pp. 53R-62R. , DOI 10.1093/glycob/cwh122
• Sharon, N., Lis, H., Lectins: Cell-agglutinating and sugar-specific proteins (1972) Science, 177 (53), pp. 949-959
• Rabinovich, G.A., Toscano, M.A., Jackson, S.S., Vasta, G.R., Functions of cell surface galectin-glycoprotein lattices (2007) Current Opinion in Structural Biology, 17 (5), pp. 513-520. , DOI 10.1016/j.sbi.2007.09.002, PII S0959440X07001303, Carbohydrates and glycoconjugates / Biophysical methods
• Dam, T.K., Brewer, F.C., Maintenance of cell surface glycan density by lectin-glycan interactions: A homeostatic and innate immune regulatory mechanism (2010) Glycobiology, 20 (9), pp. 1061-1064
• Rabinovich, G.A., Toscano, M., Turning "sweet" on immunity: Galectin-glycan interactions in immune tolerance and inflammation (2009) Nat. Rev. Immunol., 9 (5), pp. 338-352
• Liu, F.T., Rabinovich, G.A., Galectins: Regulators of acute and chronic inflammation (2010) Ann. N.Y. Acad. Sci., 1183, pp. 158-182
• Sacchettini, J.C., Baum, L.G., Brewer, C.F., Multivalent protein - Carbohydrate interactions. A new paradigm for supermolecular assembly and signal transduction (2001) Biochemistry, 40 (10), pp. 3009-3015. , DOI 10.1021/bi002544j
• Barondes, S.H., Castronovo, V., Cooper, D.N.W., Cummings, R.D., Drickamer, K., Feizi, T., Gitt, M.A., Rigby, P.W.J., Galectins: A family of animal β-galactoside-binding lectins (1994) Cell, 76 (4), pp. 597-598. , DOI 10.1016/0092-8674(94)90498-7
• Iglesias, M.M., Elola, M.T., Martinez, V., Fink, N., Wolfenstein-Todel, C., Identification of an equilibrium intermediate in the unfolding process of galectin-1, which retains its carbohydrate-binding specificity (2003) Biochimica et Biophysica Acta - Proteins and Proteomics, 1648 (1-2), pp. 164-173. , DOI 10.1016/S1570-9639(03)00119-5
• Liao, D.I., Kapadia, G., Ahmed, H., Vasta, G.R., Herzberg, O., Structure of S-lectin, a developmentally regulated vertebrate β-galactoside-binding protein (1994) Proc. Natl. Acad. Sci. U.S.A., 91 (4), pp. 1428-1432
• Hirabayashi, J., Kasai, K.-I., The family of metazoan metal-independent β-galactoside-binding lectins: Structure, function and molecular evolution (1993) Glycobiology, 3 (4), pp. 297-304
• Houzelstein, D., Goncalves, I.R., Fadden, A.J., Sidhu, S.S., Cooper, D.N.W., Drickamer, K., Leffler, H., Poirier, F., Phylogenetic analysis of the vertebrate galectin family (2004) Molecular Biology and Evolution, 21 (7), pp. 1177-1187. , DOI 10.1093/molbev/msh082
• Zhou, D., Ge, H., Sun, J., Gao, Y., Teng, M., Niu, L., Crystal structure of the C-terminal conserved domain of human GRP, a galectin-related protein, reveals a function mode different from those of galectins (2008) Proteins: Structure, Function and Genetics, 71 (3), pp. 1582-1588. , DOI 10.1002/prot.22003
• Ogden, A.T., Nunes, I., Ko, K., Wu, S., Hines, C.S., Wang, A.-F., Hegde, R.S., Lang, R.A., GRIFIN, a novel lens-specific protein related to the galectin family (1998) Journal of Biological Chemistry, 273 (44), pp. 28889-28896. , DOI 10.1074/jbc.273.44.28889
• Swaminathan, G.J., Leonidas, D.D., Savage, M.P., Ackerman, S.J., Acharya, K.R., Selective recognition of mannose by the human eosinophil Charcot-Leyden crystal protein (galectin-10): A crystallographic study at 1.8 A resolution (1999) Biochemistry, 38 (42), pp. 13837-13843. , DOI 10.1021/bi990756e
• Dam, T.K., Gerken, T.A., Brewer, C.F., Thermodynamics of multivalent carbohydrate-lectin cross-linking interactions: Importance of entropy in the bind and jump mechanism (2009) Biochemistry, 48 (18), pp. 3822-3827
• Guardia, C.M.A., Gauto, D.F., Di Lella, S., Rabinovich, G.A., Marti, M.A., Estrin, D.A., An integrated computational analysis of the structure, dynamics and ligand binding interactions of the human galectin network (2011) J. Chem. Inf. Model., 51, pp. 1918-1930
• Camby, I., Le Mercier, M., Lefranc, F., Kiss, R., Galectin-1: A small protein with major functions (2006) Glycobiology, 16 (11), pp. 137R-157R. , DOI 10.1093/glycob/cwl025
• Dumic, J., Dabelic, S., Flogel, M., Galectin-3: An open-ended story (2006) Biochimica et Biophysica Acta - General Subjects, 1760 (4), pp. 616-635. , DOI 10.1016/j.bbagen.2005.12.020, PII S0304416505004083
• Bernerd, F., Sarasin, A., Magnaldo, T., Galectin-7 overexpression is associated the apoptotic process in UVB- induced sunburn keratinocytes (1999) Proceedings of the National Academy of Sciences of the United States of America, 96 (20), pp. 11329-11334. , DOI 10.1073/pnas.96.20.11329
• Gendronneau, G., Sidhu, S.S., Delacour, D., Dang, T., Calonne, C., Houzelstein, D., Magnaldo, T., Poirier, F., Galectin-7 in the control of epidermal homeostasis after injury (2008) Mol. Biol. Cell, 19 (12), pp. 5541-5549
• Sato, M., Nishi, N., Shoji, H., Kumagai, M., Imaizumi, T., Hata, Y., Hirashima, M., Nakamura, T., Quantification of galectin-7 and its localization in adult mouse tissues (2002) Journal of Biochemistry, 131 (2), pp. 255-260
• Hotta, K., Funahashi, T., Matsukawa, Y., Takahashi, M., Nishizawa, H., Kishida, K., Matsuda, M., Matsuzawa, Y., Galectin-12, an adipose-expressed galectin-like molecule possessing apoptosis-inducing activity (2001) J. Biol. Chem., 276 (36), pp. 34089-34097
• Yang, R.-Y., Hsu, D.K., Yu, L., Chen, H.-Y., Liu, F.-T., Galectin-12 is required for adipogenic signaling and adipocyte differentation (2004) Journal of Biological Chemistry, 279 (28), pp. 29761-29766. , DOI 10.1074/jbc.M401303200
• Barres, C., Blanc, L., Bette-Bobillo, P., Andre, S., Mamoun, R., Gabius, H.J., Vidal, M., Galectin-5 is bound onto the surface of rat reticulocyte exosomes and modulates vesicle uptake by macrophages (2010) Blood, 115 (3), pp. 696-705
• Gitt, M.A., Wiser, M.F., Leffler, H., Herrmann, J., Xia, Y.R., Massa, S.M., Cooper, D.N., Barondes, S.H., Sequence and mapping of galectin-5, a β-galactoside-binding lectin, found in rat erythrocytes (1995) J. Biol. Chem., 270 (10), pp. 5032-5038
• Hernandez, J.D., Baum, L.G., Ah, sweet mystery of death! Galectins and control of cell fate (2002) Glycobiology, 12 (10), pp. 127R-136R
• Vasta, G.R., Ahmed, H., (2009) Animal Lectins, , CRC Press, Boca Raton, FL
• Cho, M., Cummings, R.D., Galectin-1, a β-galactoside-binding lectin in Chinese hamster ovary cells. I. Physical and chemical characterization (1995) J. Biol. Chem., 270 (10), pp. 5198-5206
• Lopez-Lucendo, M.F., Solis, D., Andre, S., Hirabayashi, J., Kasai, K.-I., Kaltner, H., Gabius, H.-J., Romero, A., Growth-regulatory human galectin-1: Crystallographic characterisation of the structural changes induced by single-site mutations and their impact on the thermodynamics of ligand binding (2004) Journal of Molecular Biology, 343 (4), pp. 957-970. , DOI 10.1016/j.jmb.2004.08.078, PII S0022283604010782
• Seetharaman, J., Kfanigsberg, A., Slaaby, R., Leffler, H., Barondes, S.H., Rini, J.M., X-ray crystal structure of the human galectin-3 carbohydrate recognition domain at 2.1-A resolution (1998) Journal of Biological Chemistry, 273 (21), pp. 13047-13052. , DOI 10.1074/jbc.273.21.13047
• Nagae, M., Nishi, N., Murata, T., Usui, T., Nakamura, T., Wakatsuki, S., Kato, R., Structural analysis of the recognition mechanism of poly-N- acetyllactosamine by the human galectin-9 N-terminal carbohydrate recognition domain (2009) Glycobiology, 19 (2), pp. 112-117
• Cho, M., Cummings, R.D., Characterization of monomeric forms of galectin-1 generated by site- directed mutagenesis (1996) Biochemistry, 35 (40), pp. 13081-13088. , DOI 10.1021/bi961181d
• Ford, M.G., Weimar, T., Kohli, T., Woods, R.J., Molecular dynamics simulations of galectin-1-oligosaccharide complexes reveal the molecular basis for ligand diversity (2003) Proteins: Structure, Function and Genetics, 53 (2), pp. 229-240. , DOI 10.1002/prot.10428
• Di Lella, S., Ma, L., Rabinovich, G.A., Díaz Ricci, J.C., Asher, S., Alvarez, R.M.S., Critical role of water molecules in galectin-1 binding to the disaccharide lactose (2009) Biochemistry, 48 (4), pp. 786-791
• Lella, S.D., Marti, M.A., Alvarez, R.M.S., Estrin, D.A., Diaz Ricci, J.C., Characterization of the galectin-1 carbohydrate recognition domain in terms of solvent occupancy (2007) Journal of Physical Chemistry B, 111 (25), pp. 7360-7366. , DOI 10.1021/jp068989k
• Ahmad, N., Gabius, H.-J., Kaltner, H., Andre, S., Kuwabara, I., Liu, F.-T., Oscarson, S., Brewer, C.F., Thermodynamic binding studies of cell surface carbohydrate epitopes to galectins-1, -3, and -7: Evidence for differential binding specificities (2002) Canadian Journal of Chemistry, 80 (8), pp. 1096-1104. , DOI 10.1139/v02-162
• Echeverria, I., Amzel, L.M., Disaccharide binding to galectin-1: Free energy calculations and molecular recognition mechanism (2011) Biophys. J., 100 (9), pp. 2283-2292
• Miller, M.C., Nesmelova, I.V., Platt, D., Klyosov, A., Mayo, K.H., The carbohydrate-binding domain on galectin-1 is more extensive for a complex glycan than for simple saccharides: Implications for galectin-glycan interactions at the cell surface (2009) Biochem. J., 421 (2), pp. 211-221
• Meynier, C., Feracci, M., Espeli, M., Chaspoul, F., Gallice, P., Schiff, C., Guerlesquin, F., Roche, P., NMR and MD investigations of human galectin-1/oligosaccharide complexes (2009) Biophys. J., 97 (12), pp. 3168-3177
• Meynier, R., Guerlesquin, F., Roche, P., Computational studies of human galectin-1: Role of conserved tryptophan residue in stacking interaction with carbohydrate ligands (2009) J. Biomol. Struct. Dyn., 27 (1), pp. 49-57
• Hirabayashi, J., Kasai, K.-I., Effect of amino acid substitution by site-directed mutagenesis on the carbohydrate recognition and stability of human 14-kDa β-galactoside- binding lectin (1991) Journal of Biological Chemistry, 266 (35), pp. 23648-23653
• Di Lella, S., Marti, M.A., Croci, D.O., Guardia, C.M.A., Díaz Ricci, J.C., Rabinovich, G.A., Caramelo, J.J., Estrin, D.A., Linking the structure and thermal stability of β-galactoside-binding protein galectin-1 to ligand binding and dimerization equilibria (2010) Biochemistry, 49 (35), pp. 7652-7658
• Stowell, S.R., Cho, M., Feasley, C.L., Arthur, C.M., Song, X., Colucci, J.K., Karmakar, S., Cummings, R.D., Ligand reduces galectin-1 sensitivity to oxidative inactivation by enhancing dimer formation (2009) J. Biol. Chem., 284 (8), pp. 4989-4999
• Nishi, N., Abe, A., Iwaki, J., Yoshida, H., Itoh, A., Shoji, H., Kamitori, S., Nakamura, T., Functional and structural bases of a cysteine-less mutant as a long-lasting substitute for galectin-1 (2008) Glycobiology, 18 (12), pp. 1065-1073. , DOI 10.1093/glycob/cwn089
• Ilarregui, J.M., Rabinovich, G.A., Tolerogenic dendritic cells in the control of autoimmune neuroinflammation: An emerging role of protein-glycan interactions (2010) Neuroimmunomodulation, 17 (3), pp. 157-160
• Lobsanov, Y.D., Gitt, M.A., Leffler, H., Barondes, S.H., Rini, J.M., X-ray crystal structure of the human dimeric S-Lac lectin, L-14-II, in complex with lactose at 2.9-A resolution (1993) Journal of Biological Chemistry, 268 (36), pp. 27034-27038
• Leonidas, D.D., Vatzaki, E.H., Vorum, H., Celis, J.E., Madsen, P., Acharya, K.R., Structural basis for the recognition of carbohydrates by human galectin- 7 (1998) Biochemistry, 37 (40), pp. 13930-13940. , DOI 10.1021/bi981056x
• Nieminen, J., Kuno, A., Hirabayashi, J., Sato, S., Visualization of galectin-3 oligomerization on the surface of neutrophils and endothelial cells using fluorescence resonance energy transfer (2007) Journal of Biological Chemistry, 282 (2), pp. 1374-1383. , http://www.jbc.org/cgi/reprint/282/2/1374, DOI 10.1074/jbc.M604506200
• Krejcirikova, V., Pachl, P., Fabry, M., Maly, P., Rezacova, P., Brynda, J., Structure of the mouse galectin-4 N-terminal carbohydrate-recognition domain reveals the mechanism of oligosaccharide recognition (2011) Acta Crystallogr., 67 (3), pp. 204-211
• Tomizawa, T., Kigawa, T., Saito, K., Koshiba, S., Inoue, M., Yokoyama, S., Solution structure of the C-terminal gal-bind lectin domain from human galectin-4 (2005) Structural Genomics and Proteomics Initiative (RSGI), , Riken
• Ideo, H., Matsuzaka, T., Nonaka, T., Seko, A., Yamashita, K., Galectin-8-N-domain recognition mechanism for sialylated and sulfated glycans (2011) J. Biol. Chem., 286 (13), pp. 11346-11355
• Tomizawa, T., Koshiba, S., Inoue, M., Kigawa, T., Yokoyama, S., Solution structure of the C-terminal gal-bind lectin protein from human galectin-8 (2007) Structural Genomics and Proteomics Initiative (RSGI), , Riken
• Ideo, H., Seko, A., Ishizuka, I., Yamashita, K., The N-terminal carbohydrate recognition domain of galectin-8 recognizes specific glycosphingolipids with high affinity (2003) Glycobiology, 13 (10), pp. 713-723. , DOI 10.1093/glycob/cwg094
• Ahmad, N., Gabius, H.-J., Andre, S., Kaltner, H., Sabesan, S., Roy, R., Liu, B., Brewer, C.F., Galectin-3 Precipitates as a Pentamer with Synthetic Multivalent Carbohydrates and Forms Heterogeneous Cross-linked Complexes (2004) Journal of Biological Chemistry, 279 (12), pp. 10841-10847. , DOI 10.1074/jbc.M312834200
• Garner, O.B., Baum, L.G., Galectin-glycan lattices regulate cell-surface glycoprotein organization and signalling (2008) Biochem. Soc. Trans., 36 (6), pp. 1472-1477
• Brewer, C.F., Miceli, M.C., Baum, L.G., Clusters, bundles, arrays and lattices: Novel mechanisms for lectin-saccharide-mediated cellular interactions (2002) Current Opinion in Structural Biology, 12 (5), pp. 616-623. , DOI 10.1016/S0959-440X(02)00364-0
• Surolia, A., Swaminathan, C.P., Ramkumar, R., Podder, S.K., Unusual structural stability and ligand induced alterations in oligomerization of a galectin (1997) FEBS Letters, 409 (3), pp. 417-420. , DOI 10.1016/S0014-5793(97)00432-8, PII S0014579397004328
• Than, N.G., Romero, R., Erez, O., Weckle, A., Tarca, A.L., Hotra, J., Abbas, A., Wildman, D.E., Emergence of hormonal and redox regulation of galectin-1 in placental mammals: Implication in maternal-fetal immune tolerance (2008) Proc. Natl. Acad. Sci. U.S.A., 105 (41), pp. 15819-15824
• Battig, P., Saudan, P., Gunde, T., Bachmann, M.F., Enhanced apoptotic activity of a structurally optimized form of galectin-1 (2004) Molecular Immunology, 41 (1), pp. 9-18. , DOI 10.1016/j.molimm.2004.02.004, PII S0161589004000495
• Nesmelova, I.V., Ermakova, E., Daragan, V.A., Pang, M., Menendez, M., Lagartera, L., Solis, D., Mayo, K.H., Lactose binding to galectin-1 modulates structural dynamics, increases conformational entropy, and occurs with apparent negative cooperativity (2010) J. Mol. Biol., 397 (5), pp. 1209-1230
• Schwarz, F.P., Ahmed, H., Bianchet, M.A., Amzel, L.M., Vasta, G.R., Thermodynamics of bovine spleen galectin-1 binding to disaccharides: Correlation with structure and its effect on oligomerization at the denaturation temperature (1998) Biochemistry, 37 (17), pp. 5867-5877. , DOI 10.1021/bi9716478
• Cerliani, J.P., Stowell, S.R., Mascanfroni, I.D., Arthur, C.M., Cummings, R.D., Rabinovich, G.A., Expanding the universe of cytokines and pattern recognition receptors: Galectins and glycans in innate immunity (2011) J. Clin. Immunol., 31 (1), pp. 10-21
• Laderach, D.J., Compagno, D., Toscano, M.A., Croci, D.O., Dergan-Dylon, S., Salatino, M., Rabinovich, G.A., Dissecting the signal transduction pathways triggered by galectin-glycan interactions in physiological and pathological settings (2010) IUBMB Life, 62 (1), pp. 1-13
• Iurisci, I., Cumashi, A., Sherman, A.A., Tsvetkov, Y.E., Tinari, N., Piccolo, E., D'Egidio, M., Nifantiev, N., Synthetic inhibitors of galectin-1 and -3 selectively modulate homotypic cell aggregation and tumor cell apoptosis (2009) Anticancer Res., 29 (1), pp. 403-410
• Ingrassia, L., Camby, I., Lefranc, F., Mathieu, V., Nshimyumukiza, P., Darro, F., Kiss, R., Anti-galectin compounds as potential anti-cancer drugs (2006) Current Medicinal Chemistry, 13 (29), pp. 3513-3527. , http://www.ingentaconnect.com/content/ben/cmc/2006/00000013/00000029/ art00003, DOI 10.2174/092986706779026219
• Barchi, J.J.J., Emerging roles of carbohydrates and glycomimetics in anticancer drug design (2000) Curr. Pharm. Des., 6 (4), pp. 485-501
• Sirois, S., Giguere, D., Roy, R., A first QSAR model for galectin-3 glycomimetic inhibitors based on 3D docked structures (2006) Medicinal Chemistry, 2 (5), pp. 481-489. , http://www.ingentaconnect.com/content/ben/mc/2006/00000002/00000005/ art00006, DOI 10.2174/157340606778250252
• Rabinovich, G.A., Ilarregui, J.M., Conveying glycan information into T-cell homeostatic programs: A challenging role for galectin-1 in inflammatory and tumor microenvironments (2009) Immunol. Rev., 230 (1), pp. 144-159
• Bi, S., Hong, P.W., Lee, B., Baum, L.G., Galectin-9 binding to cell surface protein disulfide isomerase regulates the redox environment to enhance T-cell migration and HIV entry (2011) Proc. Natl. Acad. Sci. U.S.A., 108 (26), pp. 10650-10655
• Vasta, G.R., Roles of galectins in infection (2009) Nat. Rev. Microbiol., 7 (6), pp. 424-438
• Garner, O.B., Aguilar, H.C., Fulcher, J.A., Levroney, E.L., Harrison, R., Wright, L., Robinson, L.R., Baum, L.G., Endothelial galectin-1 binds to specific glycans on nipah virus fusion protein and inhibits maturation, mobility, and function to block syncytia formation (2011) PLoS Pathog., 6 (7), p. 1000993
• Davicino, R.C., Elicabe, R.J., Di Genaro, M.S., Rabinovich, G.A., Coupling pathogen recognition to innate immunity through glycan-dependent mechanisms (2011) Int. Immunopharmacol., , doi: 10.1016/j.intimp.2011.05.002
• La, M., Cao, T.V., Cerchiaro, G., Chilton, K., Hirabayashi, J., Kasai, K.-I., Oliani, S.M., Perretti, M., A novel biological activity for galectin-1: Inhibition of leukocyte-endothelial cell interactions in experimental inflammation (2003) American Journal of Pathology, 163 (4), pp. 1505-1515
• Cooper, D., Norling, L.V., Perretti, M., Novel insights into the inhibitory effects of Galectin-1 on neutrophil recruitment under flow (2008) Journal of Leukocyte Biology, 83 (6), pp. 1459-1466. , http://www.jleukbio.org/cgi/reprint/83/6/1459, DOI 10.1189/jlb.1207831
• Stowell, S.R., Karmakar, S., Stowell, C.J., Dias-Baruffi, M., McEver, R.P., Cummings, R.D., Human galectin-1, -2, and -4 induce surface exposure of phosphatidylserine in activated human neutrophils but not in activated T cells (2007) Blood, 109 (1), pp. 219-227. , http://www.bloodjournal.org/cgi/reprint/109/1/219, DOI 10.1182/blood-2006-03-007153
• Stowell, S.R., Karmakar, S., Arthur, C.M., Ju, T., Rodrigues, L.C., Riul, T.B., Dias-Baruffi, M., Cummings, R.D., Galectin-1 induces reversible phosphatidylserine exposure at the plasma membrane (2009) Mol. Biol. Cell, 20 (5), pp. 1408-1418
• Karmakar, S., Stowell, S.R., Cummings, R.D., McEver, R.P., Galectin-1 signaling in leukocytes requires expression of complex-type N-glycans (2008) Glycobiology, 18 (10), pp. 770-778
• Almkvist, J., Dahlgren, C., Leffler, H., Karlsson, A., Activation of the neutrophil nicotinamide adenine dinucleotide phosphate oxidase by galectin-1 (2002) Journal of Immunology, 168 (8), pp. 4034-4041
• Giudicelli, V., Lutomski, D., Levi-Strauss, M., Bladier, D., Joubert-Caron, R., Caron, M., Is human galectin-1 activity modulated by monomer/dimer equilibrium? (1997) Glycobiology, 7 (3)
• Levroney, E.L., Aguilar, H.C., Fulcher, J.A., Kohatsu, L., Pace, K.E., Pang, M., Gurney, K.B., Lee, B., Novel innate immune functions for galectin-1: Galectin-1 inhibits cell fusion by Nipah virus envelope glycoproteins and augments dendritic cell secretion of proinflammatory cytokines (2005) Journal of Immunology, 175 (1), pp. 413-420
• Leppanen, A., Stowell, S., Blixt, O., Cummings, R.D., Dimeric galectin-1 binds with high affinity to α2,3-sialylated and non-sialylated terminal N-acetyllactosamine units on surface-bound extended glycans (2005) Journal of Biological Chemistry, 280 (7), pp. 5549-5562. , DOI 10.1074/jbc.M412019200
• Dias-Baruffi, M., Zhu, H., Cho, M., Karmakar, S., McEver, R.P., Cummings, R.D., Dimeric Galectin-1 Induces Surface Exposure of Phosphatidylserine and Phagocytic Recognition of Leukocytes without Inducing Apoptosis (2003) Journal of Biological Chemistry, 278 (42), pp. 41282-41293. , DOI 10.1074/jbc.M306624200
• Correa, S.G., Sotomayor, C.E., Aoki, M.P., Maldonado, C.A., Rabinovich, G.A., Opposite effects of galectin-1 on alternative metabolic pathways of L-arginine in resident, inflammatory, and activated macrophages (2003) Glycobiology, 13 (2), pp. 119-128. , DOI 10.1093/glycob/cwg010
• Barrionuevo, P., Beigier-Bompadre, M., Ilarregui, J.M., Toscano, M.A., Bianco, G.A., Isturiz, M.A., Rabinovich, G.A., A novel function for galectin-1 at the crossroad of innate and adaptive immunity: Galectin-1 regulates monocyte/macrophage physiology through a nonapoptotic EMK-dependent pathway (2007) Journal of Immunology, 178 (1), pp. 436-445
• Malik, R.K., Ghurye, R.R., Lawrence-Watt, D.J., Stewart, H.J., Galectin-1 stimulates monocyte chemotaxis via the p44/42 MAP kinase pathway and a pertussis toxin-sensitive pathway (2009) Glycobiology, 19 (12), pp. 1402-1407
• Rabinovich, G.A., Sotomayor, C.E., Riera, C.M., Bianco, I., Correa, S.G., Evidence of a role for galectin-1 in acute inflammation (2000) European Journal of Immunology, 30 (5), pp. 1331-1339
• Fulcher, J.A., Hashimi, S.T., Levroney, E.L., Pang, M., Gurney, K.B., Baum, L.G., Lee, B., Galectin-1-matured human monocyte-derived dendritic cells have enhanced migration through extracellular matrix (2006) Journal of Immunology, 177 (1), pp. 216-226
• Fulcher, J.A., Chang, M.H., Wang, S., Almazan, T., Hashimi, S.T., Eriksson, A.U., Wen, X., Lee, B., Galectin-1 co-clusters CD43/CD45 on dendritic cells and induces cell activation and migration through Syk and protein kinase C signaling (2009) J. Biol. Chem., 284 (39), pp. 26860-26870
• Blois, S.M., Ilarregui, J.M., Tometten, M., Garcia, M., Orsal, A.S., Cordo-Russo, R., Toscano, M.A., Arck, P.C., A pivotal role for galectin-1 in fetomaternal tolerance (2007) Nature Medicine, 13 (12), pp. 1450-1457. , DOI 10.1038/nm1680, PII NM1680
• Perone, M.J., Bertera, S., Tawadrous, Z.S., Shufesky, W.J., Piganelli, J.D., Baum, L.G., Trucco, M., Morelli, A.E., Dendritic cells expressing transgenic galectin-1 delay onset of autoimmune diabetes in mice (2006) Journal of Immunology, 177 (8), pp. 5278-5289
• Ilarregui, J.M., Croci, D.O., Bianco, G.A., Toscano, M., Salatino, M., Vermeulen, M.E., Greffner, J.R., Rabinovich, G.A., Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1 driven immunoregulatory circuit involving interleukin 27 and interleukin 10 (2009) Nat. Immunol., 10 (9), pp. 981-991
• Suzuki, Y., Inoue, T., Yoshimaru, T., Ra, C., Galectin-3 but not galectin-1 induces mast cell death by oxidative stress and mitochondrial permeability transition (2008) Biochim. Biophys. Acta, 1783 (5), pp. 924-934
• Hughes, R.C., Galectins as modulators of cell adhesion (2001) Biochimie, 83 (7), pp. 667-676. , DOI 10.1016/S0300-9084(01)01289-5
• Ahmad, N., Gabius, H.-J., Sabesan, S., Oscarson, S., Brewer, C.F., Thermodynamic binding studies of bivalent oligosaccharides to galectin-1, galectin-3, and the carbohydrate recognition domain of galectin-3 (2004) Glycobiology, 14 (9), pp. 817-825. , DOI 10.1093/glycob/cwh095
• Kuwabara, I., Liu, F.-T., Galectin-3 promotes adhesion of human neutrophils to laminin (1996) Journal of Immunology, 156 (10), pp. 3939-3944
• Sato, S., Ouellet, N., Pelletier, I., Simard, M., Rancourt, A., Bergeron, M.G., Role of galectin-3 as an adhesion molecule for neutrophil extravasation during streptococcal pneumonia (2002) Journal of Immunology, 168 (4), pp. 1813-1822
• Nieminen, J., St.-Pierre, C., Sato, S., Galectin-3 interacts with naïve and primed neutrophils, inducing innate immune responses (2005) Journal of Leukocyte Biology, 78 (5), pp. 1127-1135. , DOI 10.1189/jlb.1204702
• Fernandez, G.C., Ilarregui, J.M., Rubel, C.J., Toscano, M.A., Gomez, S.A., Bompadre, M.B., Isturiz, M.A., Palermo, M.S., Galectin-3 and soluble fibrinogen act in concert to modulate neutrophil activation and survival: Involvement of alternative MAPK pathways (2005) Glycobiology, 15 (5), pp. 519-527. , DOI 10.1093/glycob/cwi026
• Yamaoka, A., Kuwabara, I., Frigeri, L.G., Liu, F.T., A human lectin, galectin-3 (εbp/Mac-2), stimulates superoxide production by neutrophils (1995) J. Immunol., 154 (7), pp. 3479-3487
• Almkvist, J., Faldt, J., Dahlgren, C., Leffler, H., Karlsson, A., Lipopolysaccharide-induced gelatinase granule mobilization primes neutrophils for activation by galectin-3 and formylmethionyl-Leu-Phe (2001) Infection and Immunity, 69 (2), pp. 832-837. , DOI 10.1128/IAI.69.2.832-837.2001
• Swarte, V.V.R., Mebius, R.E., Joziasse, D.H., Van Den Eijnden, D.H., Kraal, G., Lymphocyte triggering via L-selectin leads to enhanced galectin-3-mediated binding to dendritic cells (1998) European Journal of Immunology, 28 (9), pp. 2864-2871. , DOI 10.1002/(SICI)1521-4141(199809)28:09<2864::AID-IMMU2864>3.0. CO;2-U
• Mina-Osorio, P., Soto-Cruz, I., Ortega, E., A role for galectin-3 in CD13-mediated homotypic aggregation of monocytes (2007) Biochemical and Biophysical Research Communications, 353 (3), pp. 605-610. , DOI 10.1016/j.bbrc.2006.12.081, PII S0006291X0602715X
• Sano, H., Hsu, D.K., Yu, L., Apgar, J.R., Kuwabara, I., Yamanaka, T., Hirashima, M., Liu, F.-T., Human galectin-3 is a novel chemoattractant for monocytes and macrophages (2000) Journal of Immunology, 165 (4), pp. 2156-2164
• Liu, F.T., Hsu, D.K., Zuberi, R.I., Kuwabara, I., Chi, E.Y., Henderson Jr., W.R., Expression and function of galectin-3, a β-galactoside-binding lectin, in human monocytes and macrophages (1995) Am. J. Pathol., 147 (4), pp. 1016-1028
• Sano, H., Hsu, D.K., Apgar, J.R., Yu, L., Sharma, B.B., Kuwabara, I., Izui, S., Liu, F.-T., Critical role of galectin-3 in phagocytosis by macrophages (2003) Journal of Clinical Investigation, 112 (3), pp. 389-397. , DOI 10.1172/JCI200317592
• Hsu, D.K., Yang, R.-Y., Pan, Z., Yu, L., Salomon, D.R., Fung-Leung, W.-P., Liu, F.-T., Targeted disruption of the Galectin-3 gene results in attenuated peritoneal inflammatory responses (2000) American Journal of Pathology, 156 (3), pp. 1073-1083
• Bernardes, E.S., Silva, N.M., Ruas, L.P., Mineo, J.R., Loyola, A.M., Hsu, D.K., Liu, F.-T., Roque-Barreira, M.C., Toxoplasma gondii infection reveals a novel regulatory role for galectin-3 in the interface of innate and adaptive immunity (2006) American Journal of Pathology, 168 (6), pp. 1910-1920. , DOI 10.2353/ajpath.2006.050636
• Chen, H.-Y., Sharma, B.B., Yu, L., Zuberi, R., Weng, I.-C., Kawakami, Y., Kawakami, T., Liu, F.-T., Role of galectin-3 in mast cell functions: Galectin-3-deficient mast cells exhibit impaired mediator release and defective JNK expression (2006) Journal of Immunology, 177 (8), pp. 4991-4997
• Stowell, S.R., Arthur, C.M., Slanina, K.A., Horton, J.R., Smith, D.F., Cummings, R.D., Dimeric galectin-8 induces phosphatidylserine exposure in leukocytes through polylactosamine recognition by the C-terminal domain (2008) J. Biol. Chem., 283 (29), pp. 20547-20559
• Nishi, N., Shoji, H., Seki, M., Itoh, A., Miyanaka, H., Yuube, K., Hirashima, M., Nakamura, T., Galectin-8 modulates neutrophil function via interaction with integrin αM (2003) Glycobiology, 13 (11), pp. 755-763. , DOI 10.1093/glycob/cwg102
• Kashio, Y., Nakamura, K., Abedin, M.J., Seki, M., Nishi, N., Yoshida, N., Nakamura, T., Hirashima, M., Galectin-9 induces apoptosis through the calcium-calpain-caspase-1 pathway (2003) Journal of Immunology, 170 (7), pp. 3631-3636
• Matsuura, A., Tsukada, J., Mizobe, T., Higashi, T., Mouri, F., Tanikawa, R., Yamauchi, A., Tanaka, Y., Intracellular galectin-9 activates inflammatory cytokines in monocytes (2009) Genes Cells, 14 (4), pp. 511-521
• Dai, S.-Y., Nakagawa, R., Itoh, A., Murakami, H., Kashio, Y., Abe, H., Katoh, S., Hirashima, M., Galectin-9 induces maturation of human monocyte-derived dendritic cells (2005) Journal of Immunology, 175 (5), pp. 2974-2981
• Anderson, A.C., Anderson, D.E., Bregoli, L., Hastings, W.D., Kassam, N., Lei, C., Chandwaskar, R., Hafler, D.A., Promotion of tissue inflammation by the immune receptor Tim-3 expressed on innate immune cells (2007) Science, 318 (5853), pp. 1141-1143. , DOI 10.1126/science.1148536
• Matsumoto, R., Hirashima, M., Kita, H., Gleich, G.J., Biological activities of ecalectin: A novel eosinophil-activating factor (2002) Journal of Immunology, 168 (4), pp. 1961-1967
• Matsumoto, R., Matsumoto, H., Seki, M., Hata, M., Asano, Y., Kanegasaki, S., Stevens, R.L., Hirashima, M., Human ecalectin, a variant of human galectin-9, is a novel eosinophil chemoattractant produced by T lymphocytes (1998) Journal of Biological Chemistry, 273 (27), pp. 16976-16984. , DOI 10.1074/jbc.273.27.16976
• Matsushita, N., Nishi, N., Seki, M., Matsumoto, R., Kuwabara, I., Liu, F.-T., Hata, Y., Hirashima, M., Requirement of divalent galactoside-binding activity of ecalectin/galectin-9 for eosinophil chemoattraction (2000) Journal of Biological Chemistry, 275 (12), pp. 8355-8360. , DOI 10.1074/jbc.275.12.8355
• Sato, M., Nishi, N., Shoji, H., Seki, M., Hashidate, T., Hirabayashi, J., Kasai, K.-I., Nakamura, T., Functional analysis of the carbohydrate recognition domains and a linker peptide of galectin-9 as to eosinophil chemoattractant activity (2002) Glycobiology, 12 (3), pp. 191-197
• Saita, N., Goto, E., Yamamoto, T., Cho, I., Tsumori, K., Kohrogi, H., Maruo, K., Hirashima, M., Association of galectin-9 with eosinophil apoptosis (2002) International Archives of Allergy and Immunology, 128 (1), pp. 42-50. , DOI 10.1159/000058002
• Asakura, H., Kashio, Y., Nakamura, K., Seki, M., Dai, S., Shirato, Y., Abedin, M.J., Hirashima, M., Selective eosinophil adhesion to fibroblast via IFN-γ-induced galectin-9 (2002) Journal of Immunology, 169 (10), pp. 5912-5918
• Abedin, M.J., Kashio, Y., Seki, M., Nakamura, K., Hirashima, M., Potential roles of galectins in myeloid differentiation into three different lineages (2003) Journal of Leukocyte Biology, 73 (5), pp. 650-656. , DOI 10.1189/jlb.0402163
• Rabinovich, G.A., Iglesias, M.M., Modesti, N.M., Castagna, L.F., Wolfenstein-Todel, C., Riera, C.M., Sotomayor, C.E., Activated rat macrophages produce a galectin-1-like protein that induces apoptosis of T cells: Biochemical and functional characterization (1998) Journal of Immunology, 160 (10), pp. 4831-4840
• Blaser, C., Kaufmann, M., Muller, C., Zimmermann, C., Wells, V., Mallucci, L., Pircher, H., β-galactoside-binding protein secreted by activated T cells inhibits antigen-induced proliferation of T cells (1998) European Journal of Immunology, 28 (8), pp. 2311-2319. , DOI 10.1002/(SICI)1521-4141(199808)28:08<2311::AID-IMMU2311>3.0. CO;2-G
• Perillo, N.L., Uittenbogaart, C.H., Nguyen, J.T., Baum, L.G., Galectin-1, an endogenous lectin produced by thymic epithelial cells, induces apoptosis of human thymocytes (1997) Journal of Experimental Medicine, 185 (10), pp. 1851-1858. , DOI 10.1084/jem.185.10.1851
• Perillo, N.L., Pace, K.E., Seilhamer, J.J., Baum, L.G., Apoptosis of T cells mediated by galectin-1 (1995) Nature, 378 (6558), pp. 736-739
• Rabinovich, G.A., Modesti, N.M., Castagna, L.F., Landa, C.A., Riera, C.M., Sotomayor, C.E., Specific inhibition of lymphocyte proliferation and induction of apoptosis by CLL-I, a β-galactoside-binding lectin (1997) Journal of Biochemistry, 122 (2), pp. 365-373
• Rabinovich, G.A., Ramhorst, R.E., Rubinstein, N., Corigliano, A., Daroqui, M.C., Kier-Joffe, E.B., Fainboim, L., Induction of allogenic T-cell hyporesponsiveness by galectin-1-mediated apoptotic and non-apoptotic mechanisms (2002) Cell Death and Differentiation, 9 (6), pp. 661-670. , DOI 10.1038/sj/cdd/4401009
• Matarrese, P., Tinari, A., Mormone, E., Bianco, G.A., Toscano, M.A., Ascione, B., Rabinovich, G.A., Malorni, W., Galectin-1 sensitizes resting human T lymphocytes to Fas (CD95)-mediated cell death via mitochondrial hyperpolarization, budding, and fission (2005) Journal of Biological Chemistry, 280 (8), pp. 6969-6985. , DOI 10.1074/jbc.M409752200
• Hahn, H.P., Pang, M., He, J., Hernandez, J.D., Yang, R.-Y., Li, L.Y., Wang, X., Baum, L.G., Galectin-1 induces nuclear translocation of endonuclease G in caspase- and cytochrome c-independent T cell death (2004) Cell Death and Differentiation, 11 (12), pp. 1277-1286. , DOI 10.1038/sj.cdd.4401485
• Pace, K.E., Hahn, H.P., Pang, M., Nguyen, J.T., Baum, L.G., Cutting edge: CD7 delivers a pro-apoptotic signal during galectin-1-induced T cell death (2000) Journal of Immunology, 165 (5), pp. 2331-2334
• Liu, S.D., Whiting, C.C., Tomassian, T., Pang, M., Bissel, S.J., Baum, L.G., Mossine, V.V., Miceli, M.C., Endogenous galectin-1 enforces class I-restricted TCR functional fate decisions in thymocytes (2008) Blood, 112 (1), pp. 120-130
• Chung, C.D., Patel, V.P., Moran, M., Lewis, L.A., Miceli, M.C., Galectin-1 induces partial TCR ζ-chain phosphorylation and antagonizes processive TCR signal transduction (2000) Journal of Immunology, 165 (7), pp. 3722-3729
• Endharti, A.T., Zhou, Y.W., Nakashima, I., Suzuki, H., Galectin-1 supports survival of naive T cells without promoting cell proliferation (2005) European Journal of Immunology, 35 (1), pp. 86-97. , DOI 10.1002/eji.200425340
• Silva-Monteiro, E., Lorenzato, L.R., Nihei, O.K., Junqueira, M., Rabinovich, G.A., Hsu, D.K., Liu, F.-T., Villa-Verde, D.M.S., Altered expression of galectin-3 induces cortical thymocyte depletion and premature exit of immature thymocytes during Trypanosoma cruzi infection (2007) American Journal of Pathology, 170 (2), pp. 546-556. , DOI 10.2353/ajpath.2007.060389
• Rabinovich, G.A., Liu, F.-T., Hirashima, M., Anderson, A., An emerging role for galectins in tuning the immune response: Lessons from experimental models of inflammatory disease, autoimmunity and cancer (2007) Scandinavian Journal of Immunology, 66 (2-3), pp. 143-158. , DOI 10.1111/j.1365-3083.2007.01986.x
• Pace, K.E., Lee, C., Stewart, P.L., Baum, L.G., Restricted receptor segregation into membrane microdomains occurs on human T cells during apoptosis induced by galectin-1 (1999) Journal of Immunology, 163 (7), pp. 3801-3811
• Stillman, B.N., Hsu, D.K., Pang, M., Brewer, C.F., Johnson, P., Liu, F.-T., Baum, L.G., Galectin-3 and galectin-1 bind distinct cell surface glycoprotein receptors to induce T cell death (2006) Journal of Immunology, 176 (2), pp. 778-789
• Nguyen, J.T., Evans, D.P., Galvan, M., Pace, K.E., Leitenberg, D., Bui, T.N., Baum, L.G., CD45 modulates galectin-1-induced T cell death: Regulation by expression of core 2 O-glycans (2001) Journal of Immunology, 167 (10), pp. 5697-5707
• Walzel, H., Blach, M., Hirabayashi, J., Kasai, K.-I., Brock, J., Involvement of CD2 and CD3 in galectin-1 induced signaling in human Jurkat T-cells (2000) Glycobiology, 10 (2), pp. 131-140
• Toscano, M.A., Bianco, G.A., Ilarregui, J.M., Croci, D.O., Correale, J., Hernandez, J.D., Zwirner, N.W., Rabinovich, G.A., Differential glycosylation of T H1, T H2 and T H-17 effector cells selectively regulates susceptibility to cell death (2007) Nature Immunology, 8 (8), pp. 825-834. , DOI 10.1038/ni1482, PII NI1482
• Amano, M., Galvan, M., He, J., Baum, L.G., The ST6Gal I sialyltransferase selectively modifies N-glycans on CD45 to negatively regulate galectin-1-induced CD45 clustering, phosphatase modulation, and T cell death (2003) Journal of Biological Chemistry, 278 (9), pp. 7469-7475. , DOI 10.1074/jbc.M209595200
• Hernandez, J.D., Nguyen, J.T., He, J., Wang, W., Ardman, B., Green, J.M., Fukuda, M., Baum, L.G., Galectin-1 binds different CD43 glycoforms to cluster CD43 and regulate T cell death (2006) Journal of Immunology, 177 (8), pp. 5328-5336
• Ion, G., Fajka-Boja, R., Toth, G.K., Caron, M., Monostori, E., Role of p56 lck and ZAP70-mediated tyrosine phosphorylation in galectin-1-induced cell death [2] (2005) Cell Death and Differentiation, 12 (8), pp. 1145-1147. , DOI 10.1038/sj.cdd.4401628
• Rabinovich, G.A., Alonso, C.R., Sotomayor, C.E., Durand, S., Bocco, J.L., Riera, C.M., Molecular mechanisms implicated in galectin-1-induced apoptosis: Activation of the AP-1 transcription factor and downregulation of Bcl-2 (2000) Cell Death and Differentiation, 7 (8), pp. 747-753
• Brandt, B., Buchse, T., Abou-Eladab, E.F., Tiedge, M., Krause, E., Jeschke, U., Walzel, H., Galectin-1 induced activation of the apoptotic death-receptor pathway in human Jurkat T lymphocytes (2008) Histochem. Cell Biol., 129 (5), pp. 599-609
• Stowell, S.R., Qian, Y., Karmakar, S., Koyama, N.S., Dias-Baruffi, M., Leffler, H., McEver, R.P., Cummings, R.D., Differential roles of galectin-1 and galectin-3 in regulating leukocyte viability and cytokine secretion (2008) J. Immunol., 180 (5), pp. 3091-3102
• Rabinovich, G.A., Ariel, A., Hershkoviz, R., Hirabayashi, J., Kasai, K.-I., Lider, O., Specific inhibition of T-cell adhesion to extracellular matrix and proinflammatory cytokine secretion by human recombinant galectin-1 (1999) Immunology, 97 (1), pp. 100-106. , DOI 10.1046/j.1365-2567.1999.00746.x
• Van Der Leij, J., Van Den Berg, A., Harms, G., Eschbach, H., Vos, H., Zwiers, P., Van Weeghel, R., Visser, L., Strongly enhanced IL-10 production using stable galectin-1 homodimers (2007) Molecular Immunology, 44 (4), pp. 506-513. , DOI 10.1016/j.molimm.2006.02.011, PII S016158900600037X
• Motran, C.C., Molinder, K.M., Liu, S.D., Poirier, F., Miceli, M.C., Galectin-1 functions as a Th2 cytokine that selectively induces Th1 apoptosis and promotes Th2 function (2008) Eur. J. Immunol., 38 (11), pp. 3015-3027
• Juszczynski, P., Ouyang, J., Monti, S., Rodig, S.J., Takeyama, K., Abramson, J., Chen, W., Shipp, M.A., The AP1-dependent secretion of galectin-1 by Reed-Sternberg cells fosters immune privilege in classical Hodgkin lymphoma (2007) Proceedings of the National Academy of Sciences of the United States of America, 104 (32), pp. 13134-13139. , http://www.pnas.org/cgi/reprint/104/32/13134, DOI 10.1073/pnas.0706017104
• Gandhi, M.K., Moll, G., Smith, C., Dua, U., Lambley, E., Ramuz, O., Gill, D., Khanna, R., Galectin-1 mediated suppression of Epstein-Barr virus-specific T-cell immunity in classic Hodgkin lymphoma (2007) Blood, 110 (4), pp. 1326-1329. , http://bloodjournal.hematologylibrary.org/cgi/reprint/110/4/1326, DOI 10.1182/blood-2007-01-066100
• Sugimoto, N., Oida, T., Hirota, K., Nakamura, K., Nomura, T., Uchiyama, T., Sakaguchi, S., Foxp3-dependent and -independent molecules specific for CD25 + CD4 + natural regulatory T cells revealed by DNA microarray analysis (2006) International Immunology, 18 (8), pp. 1197-1209. , DOI 10.1093/intimm/dxl060
• Garin, M.I., Chu, N.-C., Golshayan, D., Cernuda-Morollon, E., Wait, R., Lechler, R.I., Galectin-1: A key effector of regulation mediated by CD4 +CD25 + T cells (2007) Blood, 109 (5), pp. 2058-2065. , http://bloodjournal.hematologylibrary.org/cgi/reprint/109/5/2058, DOI 10.1182/blood-2006-04-016451
• He, J., Baum, L.G., Endothelial cell expression of galectin-1 induced by prostate cancer cells inhibits T-cell transendothelial migration (2006) Laboratory Investigation, 86 (6), pp. 578-590. , DOI 10.1038/labinvest.3700420, PII 3700420
• Norling, L.V., Sampaio, A.L.F., Cooper, D., Perretti, M., Inhibitory control of endothelial galectin-1 on in vitro and in vivo lymphocyte trafficking (2008) FASEB Journal, 22 (3), pp. 682-690. , http://www.fasebj.org/cgi/reprint/22/3/682, DOI 10.1096/fj.07-9268com
• Rubinstein, N., Alvarez, M., Zwirner, N.W., Toscano, M.A., Ilarregui, J.M., Bravo, A., Mordoh, J., Rabinovich, G.A., Targeted inhibition of galectin-1 gene expression in tumor cells results in heightened T cell-mediated rejection: A potential mechanism of tumor-immune privilege (2004) Cancer Cell, 5 (3), pp. 241-251. , DOI 10.1016/S1535-6108(04)00024-8, PII S1535610804000248
• Gauthier, L., Rossi, B., Roux, F., Termine, E., Schiff, C., Galectin-1 is a stromal cell ligand of the pre-B cell receptor (BCR) implicated in synapse formation between pre-B and stromal cells and in pre-BCR triggering (2002) Proc. Natl. Acad. Sci. U.S.A., 99 (20), pp. 13014-13019
• Rossi, B., Espeli, M., Schiff, C., Gauthier, L., Clustering of pre-B cell integrals induces galectin-1-dependent pre-B cell receptor relocalization and activation (2006) Journal of Immunology, 177 (2), pp. 796-803
• Espeli, M., Mancini, S.J., Breton, C., Poirier, F., Schiff, C., Impaired B-cell development at the pre-BII-cell stage in galectin-1-deficient mice due to inefficient pre-BII/stromal cell interactions (2009) Blood, 113 (23), pp. 5878-5886
• Zuniga, E., Rabinovich, G.A., Iglesias, M.M., Gruppi, A., Regulated expression of galectin-1 during B-cell activation and implications for T-cell apoptosis (2001) Journal of Leukocyte Biology, 70 (1), pp. 73-79
• Tsai, C.M., Chiu, Y.K., Hsu, T.L., Lin, I.Y., Hsieh, S.L., Lin, K.I., Galectin-1 promotes immunoglobulin production during plasma cell differentiation (2008) J. Immunol., 181 (7), pp. 4570-4579
• Yu, X., Siegel, R., Roeder, R.G., Interaction of the B cell-specific transcriptional coactivator OCA-B and galectin-1 and a possible role in regulating BCR-mediated B cell proliferation (2006) Journal of Biological Chemistry, 281 (22), pp. 15505-15516. , http://www.jbc.org/cgi/reprint/281/22/15505.pdf, DOI 10.1074/jbc.M509041200
• Tabrizi, S.J., Niiro, H., Masui, M., Yoshimoto, G., Iino, T., Kikushige, Y., Wakasaki, T., Akashi, K., T cell leukemia/lymphoma 1 and galectin-1 regulate survival/cell death pathways in human naive and IgM + memory B cells through altering balances in Bcl-2 family proteins (2009) J. Immunol., 182 (3), pp. 1490-1499
• Sturm, A., Lensch, M., Andre, S., Kaltner, H., Wiedenmann, B., Rosewicz, S., Dignass, A.U., Gabius, H.-J., Human galectin-2: Novel inducer of T cell apoptosis with distinct profile of caspase activation (2004) Journal of Immunology, 173 (6), pp. 3825-3837
• Paclik, D., Berndt, U., Guzy, C., Dankof, A., Danese, S., Holzloehner, P., Rosewicz, S., Sturm, A., Galectin-2 induces apoptosis of lamina propria T lymphocytes and ameliorates acute and chronic experimental colitis in mice (2008) J. Mol. Med., 86 (12), pp. 1395-1406
• Ozaki, K., Inoue, K., Sato, H., Iida, A., Ohnishi, Y., Sekine, A., Sato, H., Tanaka, T., Functional variation in LGALS2 confers risk of myocardial infarction and regulates lymphotoxin-α secretion in vitro (2004) Nature, 429 (6987), pp. 72-75. , DOI 10.1038/nature02502
• Yang, R.-Y., Hsu, D.K., Liu, F.-T., Expression of galectin-3 modulates T-cell growth and apoptosis (1996) Proceedings of the National Academy of Sciences of the United States of America, 93 (13), pp. 6737-6742. , DOI 10.1073/pnas.93.13.6737
• Fukumori, T., Takenaka, Y., Yoshii, T., Kim, H.-R.C., Hogan, V., Inohara, H., Kagawa, S., Raz, A., CD29 and CD7 Mediate Galectin-3-Induced Type II T-Cell Apoptosis (2003) Cancer Research, 63 (23), pp. 8302-8311
• Liu, F.-T., Patterson, R.J., Wang, J.L., Intracellular functions of galectins (2002) Biochimica et Biophysica Acta - General Subjects, 1572 (2-3), pp. 263-273. , DOI 10.1016/S0304-4165(02)00313-6, PII S0304416502003136
• Hsu, D.K., Yang, R., Liu, F., Galectins in Apoptosis (2006) Methods in Enzymology, 417, pp. 256-273. , DOI 10.1016/S0076-6879(06)17018-4, PII S0076687906170184, Functional Glycomics
• Matarrese, P., Tinari, N., Semeraro, M.L., Natoli, C., Iacobelli, S., Malorni, W., Galectin-3 overexpression protects from cell damage and death by influencing mitochondrial homeostasis (2000) FEBS Letters, 473 (3), pp. 311-315. , DOI 10.1016/S0014-5793(00)01547-7, PII S0014579300015477
• Joo, H.-G., Goedegebuure, P.S., Sadanaga, N., Nagoshi, M., Von Bernstorff, W., Eberlein, T.J., Expression and function of galectin-3, a β-galactoside-binding protein in activated T lymphocytes (2001) Journal of Leukocyte Biology, 69 (4), pp. 555-564
• Muller, S., Schaffer, T., Flogerzi, B., Fleetwood, A., Weimann, R., Schoepfer, A.M., Seibold, F., Galectin-3 modulates T cell activity and is reduced in the inflamed intestinal epithelium in IBD (2006) Inflammatory Bowel Diseases, 12 (7), pp. 588-597. , DOI 10.1097/01.MIB.0000225341.37226.7c, PII 0005472520060700000008
• Demetriou, M., Granovsky, M., Quaggin, S., Dennis, J.W., Negative regulation of T-cell activation and autoimmunity by Mgat5 N-glycosylation (2001) Nature, 409 (6821), pp. 733-739. , DOI 10.1038/35055582
• Grigorian, A., Lee, S.-U., Tian, W., Chen, I.-J., Gao, G., Mendelsohn, R., Dennis, J.W., Demetriou, M., Control of T cell-mediated autoimmunity by metabolite flux to N-glycan biosynthesis (2007) Journal of Biological Chemistry, 282 (27), pp. 20027-20035. , http://www.jbc.org/cgi/reprint/282/27/20027, DOI 10.1074/jbc.M701890200
• Chen, H.Y., Fermin, A., Vardhana, S., Weng, I.C., Lo, K.F., Chang, E.Y., Maverakis, E., Liu, F.T., Galectin-3 negatively regulates TCR-mediated CD4 + T-cell activation at the immunological synapse (2009) Proc. Natl. Acad. Sci. U.S.A., 106 (34), pp. 14496-14501
• Del Pozo, V., Rojo, M., Rubio, M.L., Cortegano, I., Cardaba, B., Gallardo, S., Ortega, M., Lahoz, C., Gene therapy with galectin-3 inhibits bronchial obstruction and inflammation in antigen-challenged rats through interleukin-5 gene downregulation (2002) American Journal of Respiratory and Critical Care Medicine, 166 (5), pp. 732-737. , DOI 10.1164/rccm.2111031
• Zuberi, R.I., Hsu, D.K., Kalayci, O., Chen, H.-Y., Sheldon, H.K., Yu, L., Apgar, J.R., Liu, F.-T., Critical role for galectin-3 in airway inflammation and bronchial hyperresponsiveness in a murine model of asthma (2004) American Journal of Pathology, 165 (6), pp. 2045-2053
• Breuilh, L., Vanhoutte, F., Fontaine, J., Van Stijn, C.M.W., Tillie-Leblond, I., Capron, M., Faveeuw, C., Trottein, F., Galectin-3 modulates immune and inflammatory responses during helminthic infection: Impact of galectin-3 deficiency on the functions of dendritic cells (2007) Infection and Immunity, 75 (11), pp. 5148-5157. , DOI 10.1128/IAI.02006-06
• Jiang, H.R., Al Rasebi, Z., Mensah-Brown, E., Shahin, A., Xu, D., Goodyear, C.S., Fukada, S.Y., Lukic, M.L., Galectin-3 deficiency reduces the severity of experimental autoimmune encephalomyelitis (2009) J. Immunol., 182 (2), pp. 1167-1173
• Hokama, A., Mizoguchi, E., Sugimoto, K., Shimomura, Y., Tanaka, Y., Yoshida, M., Rietdijk, S.T., Mizoguchi, A., Induced reactivity of intestinal CD4 + T cells with an epithelial cell lectin, galectin-4, contributes to exacerbation of intestinal inflammation (2004) Immunity, 20 (6), pp. 681-693. , DOI 10.1016/j.immuni.2004.05.009, PII S1074761304001414
• Paclik, D., Danese, S., Berndt, U., Wiedenmann, B., Dignass, A., Sturm, A., Galectin-4 controls intestinal inflammation by selective regulation of peripheral and mucosal T cell apoptosis and cell cycle (2008) PLoS One, 3 (7), p. 2629
• Tribulatti, M.V., Mucci, J., Cattaneo, V., Agucero, F., Gilmartin, T., Head, S.R., Campetella, O., Galectin-8 Induces apoptosis in the CD4 highCD8 high thymocyte subpopulation (2007) Glycobiology, 17 (12), pp. 1404-1412. , DOI 10.1093/glycob/cwm104
• Norambuena, A., Metz, C., Vicuna, L., Silva, A., Pardo, E., Oyanadel, C., Massardo, L., Soza, A., Galectin-8 induces apoptosis in Jurkat T cells by phosphatidic acid-mediated ERK1/2 activation supported by protein kinase A down-regulation (2009) J. Biol. Chem., 284 (19), pp. 12670-12679
• Tribulatti, M.V., Cattaneo, V., Hellman, U., Mucci, J., Campetella, O., Galectin-8 provides costimulatory and proliferative signals to T lymphocytes (2009) J. Leukocyte Biol., 86 (2), pp. 371-380
• Yamamoto, H., Nishi, N., Shoji, H., Itoh, A., Lu, L.-H., Hirashima, M., Nakamura, T., Induction of cell adhesion by galectin-8 and its target molecules in Jurkat T-cells (2008) Journal of Biochemistry, 143 (3), pp. 311-324. , DOI 10.1093/jb/mvm223
• Wada, J., Ota, K., Kumar, A., Wallner, E.I., Kanwar, Y.S., Developmental regulation, expression, and apoptotic potential of galectin-9, a β-galactoside binding lectin (1997) Journal of Clinical Investigation, 99 (10), pp. 2452-2461
• Zhu, C., Anderson, A.C., Schubart, A., Xiong, H., Imitola, J., Khoury, S.J., Zheng, X.X., Kuchroo, V.K., The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity (2005) Nature Immunology, 6 (12), pp. 1245-1252. , DOI 10.1038/ni1271, PII N1271
• Wang, F., He, W., Yuan, J., Wu, K., Zhou, H., Zhang, W., Chen, Z.K., Activation of Tim-3-Galectin-9 pathway improves survival of fully allogeneic skin grafts (2008) Transplant Immunol., 19 (1), pp. 12-19
• Seki, M., Oomizu, S., Sakata, K.M., Sakata, A., Arikawa, T., Watanabe, K., Ito, K., Hirashima, M., Galectin-9 suppresses the generation of Th17, promotes the induction of regulatory T cells, and regulates experimental autoimmune arthritis (2008) Clin. Immunol., 127 (1), pp. 78-88
• Kubach, J., Lutter, P., Bopp, T., Stoll, S., Becker, C., Huter, E., Richter, C., Jonuleit, H., Human CD4 +CD25 + regulatory T cells: Proteome analysis identifies galectin-10 as a novel marker essential for their anergy and suppressive function (2007) Blood, 110 (5), pp. 1550-1558. , http://bloodjournal.hematologylibrary.org/cgi/reprint/110/5/1550, DOI 10.1182/blood-2007-01-069229
• Lu, L.-H., Nakagawa, R., Kashio, Y., Ito, A., Shoji, H., Nishi, N., Hirashima, M., Nakamura, T., Characterization of galectin-9-induced death of Jurkat T cells (2007) Journal of Biochemistry, 141 (2), pp. 157-172. , DOI 10.1093/jb/mvm019
• Levy, Y., Auslender, S., Eisenstein, M., Vidavski, R.R., Ronen, D., Bershadsky, A.D., Zick, Y., It depends on the hinge: A structure-functional analysis of galectin-8, a tandem-repeat type lectin (2006) Glycobiology, 16 (6), pp. 463-476. , DOI 10.1093/glycob/cwj097
• Carlsson, S., Oberg, C.T., Carlsson, M.C., Sundin, A., Nilsson, U.J., Smith, D., Cummings, R.D., Leffler, H., Affinity of galectin-8 and its carbohydrate recognition domains for ligands in solution and at the cell surface (2007) Glycobiology, 17 (6), pp. 663-676. , DOI 10.1093/glycob/cwm026
• Bi, S., Earl, L.A., Jacobs, L., Baum, L.G., Structural features of galectin-9 and galectin-1 that determine distinct T cell death pathways (2008) J. Biol. Chem., 283 (18), pp. 12248-12258
• Earl, L.A., Bi, S., Baum, L.G., Galectin multimerization and lattice formation are regulated by linker region structure (2011) Glycobiology, 21 (1), pp. 6-12
• Tracey, B.M., Feizi, T., Abbott, W.M., Carruthers, R.A., Green, B.N., Lawson, A.M., Subunit molecular mass assignment of 14,654 da to the soluble β-galactoside-binding lectin from bovine heart muscle and demonstration of intramolecular disulfide bonding associated with oxidative inactivation (1992) J. Biol. Chem., 267 (15), pp. 10342-10347
• Inagaki, Y., Sohma, Y., Horie, H., Nozawa, R., Kadoya, T., Oxidized galectin-1 promotes axonal regeneration in peripheral nerves but does not possess lectin properties (2000) European Journal of Biochemistry, 267 (10), pp. 2955-2964. , DOI 10.1046/j.1432-1327.2000.01311.x
• Horie, H., Kadoya, T., Sango, K., Hasegawa, M., Oxidized galectin-1 is an essential factor for peripheral nerve regeneration (2005) Current Drug Targets, 6 (4), pp. 385-394. , DOI 10.2174/1389450054021954
• Yang, R.Y., Rabinovich, G.A., Liu, F.T., Galectins: Structure, function and therapeutic potential (2008) Expert Rev. Mol. Med., 10, p. 17
• Tureci, O., Schmitt, H., Fadle, N., Pfreundschuh, M., Sahin, U., Molecular definition of a novel human galectin which is immunogenic in patients with Hodgkin's disease (1997) Journal of Biological Chemistry, 272 (10), pp. 6416-6422. , DOI 10.1074/jbc.272.10.6416

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