Artículo

Frick, L.R.; Barreiro Arcos, M.L.; Rapanelli, M.; Zappia, M.P.; Brocco, M.; Mongini, C.; Genaro, A.M.; Cremaschi, G.A. "Chronic restraint stress impairs T-cell immunity and promotes tumor progression in mice" (2009) Stress. 12(2):134-143
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Abstract:

Long-term exposure to stressful situations can affect the immune system. The T-cell response is an important component of anti-tumoral immunity. Hence, impairment of the immune function induced by a chronic stressor has been postulated to alter the immunosurveillance of tumors, thus leading to a worse neoplastic prognosis. Here, we show that chronic restraint stress affects T-cell mediated immunity in mice. This was evidenced by a decrease of mitogen-induced T-cell proliferation, a reduction in CD4+T lymphocyte number and a decrease of tumor necrosis factor-alpha (TNF-α) and Interferon-gamma (IFN-γ) production in stressed mice. Additionally, mice subjected to chronic restraint stress displayed an enhancement of tumor growth in a syngeneic lymphoma model, i.e. an increase of tumor proliferation and a reduction of animal survival. Finally, stressed mice had a reduced specific cytotoxic response against these tumor cells. These results suggest that chronic exposure to stress promotes cancer establishment and subsequent progression, probably by depressing T-cell mediated immunity. The T-cell immunity impairment as well as the tumor progression enhancement emphasize the importance of the therapeutic management of stress to improve the prognosis of cancer patients. © Informa Healthcare USA, Inc.

Registro:

Documento: Artículo
Título:Chronic restraint stress impairs T-cell immunity and promotes tumor progression in mice
Autor:Frick, L.R.; Barreiro Arcos, M.L.; Rapanelli, M.; Zappia, M.P.; Brocco, M.; Mongini, C.; Genaro, A.M.; Cremaschi, G.A.
Filiación:Centro de Estudios Farmacológicos Y Botánicos, Consejo Nacional de Investigaciones Científicas Y Técnicas, Universidad de Buenos Aires, Paraguay 2155, Buenos Aires 1121, Argentina
Instituto de Biología Y Medicina Experimental, Consejo Nacional de Investigaciones Científicas Y Técnicas, Vuelta de Obligado 2490, Buenos Aires, 1428, Argentina
Instituto de Investigaciones Biotecnológicas, Instituto Tecnológico de Chascomús, Edificio 24, Av. Gral. Paz 5445, Buenos Aires 1650, Argentina
Palabras clave:Cancer; CD4/CD8; Chronic stress; Cytokines; T-cell immunity; Tumor growth; gamma interferon; tumor necrosis factor alpha; animal cell; animal experiment; animal model; article; behavior change; CD4+ T lymphocyte; CD8+ T lymphocyte; cellular immunity; chronic stress; controlled study; cytokine production; cytotoxicity; female; immobilization stress; lymphocyte proliferation; mouse; natural killer cell; nonhuman; priority journal; spleen cell; T cell lymphoma; tumor growth; Animals; Behavior, Animal; CD4-Positive T-Lymphocytes; Cell Proliferation; Female; Interferon-gamma; Killer Cells, Natural; Lymphoma, T-Cell; Mice; Mice, Inbred BALB C; Restraint, Physical; Stress, Psychological; T-Lymphocytes; Tumor Necrosis Factor-alpha
Año:2009
Volumen:12
Número:2
Página de inicio:134
Página de fin:143
DOI: http://dx.doi.org/10.1080/10253890802137437
Título revista:Stress
Título revista abreviado:Stress
ISSN:10253890
CODEN:STREF
CAS:gamma interferon, 82115-62-6; Interferon-gamma, 82115-62-6; Tumor Necrosis Factor-alpha
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10253890_v12_n2_p134_Frick

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Citas:

---------- APA ----------
Frick, L.R., Barreiro Arcos, M.L., Rapanelli, M., Zappia, M.P., Brocco, M., Mongini, C., Genaro, A.M.,..., Cremaschi, G.A. (2009) . Chronic restraint stress impairs T-cell immunity and promotes tumor progression in mice. Stress, 12(2), 134-143.
http://dx.doi.org/10.1080/10253890802137437
---------- CHICAGO ----------
Frick, L.R., Barreiro Arcos, M.L., Rapanelli, M., Zappia, M.P., Brocco, M., Mongini, C., et al. "Chronic restraint stress impairs T-cell immunity and promotes tumor progression in mice" . Stress 12, no. 2 (2009) : 134-143.
http://dx.doi.org/10.1080/10253890802137437
---------- MLA ----------
Frick, L.R., Barreiro Arcos, M.L., Rapanelli, M., Zappia, M.P., Brocco, M., Mongini, C., et al. "Chronic restraint stress impairs T-cell immunity and promotes tumor progression in mice" . Stress, vol. 12, no. 2, 2009, pp. 134-143.
http://dx.doi.org/10.1080/10253890802137437
---------- VANCOUVER ----------
Frick, L.R., Barreiro Arcos, M.L., Rapanelli, M., Zappia, M.P., Brocco, M., Mongini, C., et al. Chronic restraint stress impairs T-cell immunity and promotes tumor progression in mice. Stress. 2009;12(2):134-143.
http://dx.doi.org/10.1080/10253890802137437