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Abstract:

Since antiretroviral therapy suppresses but does not eradicate HIV-1 infection, methods to purge viral reservoirs are required. Many strategies involve the reactivation of chronically HIV infected cells to induce the expression of integrated viral genome. In this study, five bioactive compounds, the plant derivatives 1-cinnamoyl-3,11-dihydroxymeliacarpin (CDM), nordihydroguaiaretic acid (NDGA), and curcumin (Cur) and the synthetic stigmasterol analogs (22S,23S)-22,23-dihydroxystigmast-4-en-3-one (compound 1) and (22S,23S)-3β-bromo-5α,22,23-trihydroxystigmastan-6-one (compound 2), were evaluated for their ability to elicit HIV replication in promonocytic (U1) and lymphocytic (H9+) HIV-1 chronically infected cells. The results revealed that natural compounds CDM, NDGA, and Cur were able to increase HIV-1 p24 antigen, determined by ELISA, only in latently infected promonocytic cells. CDM would reactivate HIV from latency by modulating the release of IL-6 and TNF-α, since the amount of both cytokines measured through ELISA significantly increased in U1 treated cells. Besides, NDGA increased ROS production, which might be related to the increase on p24 level observed in NDGA treated U1. These findings suggest that CDM, NDGA, and Cur might be candidates for further studies on latency-reversing therapeutics to eliminate latently HIV-1 reservoirs. © 2014 Andrea Alejandra Barquero et al.

Registro:

Documento: Artículo
Título:Naturally occurring compounds elicit hiv-1 replication in chronically infected promonocytic cells
Autor:Barquero, A.A.; Dávola, M.E.; Riva, D.A.; Mersich, S.E.; Alché, L.E.
Filiación:Department of Biological Chemistry, School of Science, University of Buenos Aires, Pabellón 2, 4to. Piso, Intendente Güiraldes 2160, C1428EGA Buenos Aires, Argentina
Palabras clave:1 cinnamoyl 3,11 dihydroxymeliacarpin; 22,23 dihydroxystigmast 4 en 3 one; 3beta bromo 5alpha,22,23 trihydroxystigmastan 6 one; antigen p24; antiretrovirus agent; curcumin; interleukin 2; interleukin 6; interleukin 7; nordihydroguaiaretic acid; plant medicinal product; reactive oxygen metabolite; stigmasterol; tumor necrosis factor alpha; unclassified drug; 1-cinnamoyl-3,11-dihydroxymeliacarpin; 22,23-dihydroxystigmast-4-en-3-one; 3-bromo-5,22,23-trihydroxystigmastan-6-one; biological factor; cholestane derivative; interleukin 6; limonoid; plant extract; reactive oxygen metabolite; stigmasterol; tumor necrosis factor alpha; article; cell viability; controlled study; cytokine production; cytokine release; drug mechanism; human; human cell; Human immunodeficiency virus 1 infection; lymphocyte; monocyte macrophage precursor cell; oxidation reduction state; protein expression; virus reactivation; virus replication; analogs and derivatives; cell line; DNA replication; drug effects; Human immunodeficiency virus 1; Human immunodeficiency virus infection; metabolism; monocyte; tumor cell line; U937 cell line; virology; virus replication; Biological Factors; Cell Line; Cell Line, Tumor; Cholestanones; Curcumin; DNA Replication; HIV Infections; HIV-1; Humans; Interleukin-6; Limonins; Masoprocol; Monocytes; Plant Extracts; Reactive Oxygen Species; Stigmasterol; Tumor Necrosis Factor-alpha; U937 Cells; Virus Replication
Año:2014
Volumen:2014
DOI: http://dx.doi.org/10.1155/2014/989101
Título revista:BioMed Research International
Título revista abreviado:BioMed Res. Int.
ISSN:23146133
CAS:curcumin, 458-37-7; interleukin 2, 85898-30-2; nordihydroguaiaretic acid, 500-38-9; stigmasterol, 83-48-7; 1-cinnamoyl-3,11-dihydroxymeliacarpin; 22,23-dihydroxystigmast-4-en-3-one; 3-bromo-5,22,23-trihydroxystigmastan-6-one; Biological Factors; Cholestanones; Curcumin; Interleukin-6; Limonins; Masoprocol; Plant Extracts; Reactive Oxygen Species; Stigmasterol; Tumor Necrosis Factor-alpha
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_23146133_v2014_n_p_Barquero

Referencias:

  • Dahl, V., Josefsson, L., Palmer, S., HIV reservoirs, latency, and reactivation: Prospects for eradication (2010) Antiviral Research, 85 (1), pp. 286-294. , 2-s2.0-73549121926 10.1016/j.antiviral.2009.09.016
  • Catalfamo, M., Le Saout, C., Clifford, H., The role of cytokines in the pathogenesis and treatment of HIV infection (2012) Cytokine & Growth Factor Reviews, 23, pp. 207-214
  • Choudhary, S.K., Margolis, D.M., Curing HIV: Pharmacologic approaches to target HIV-1 Latency (2011) Annual Review of Pharmacology and Toxicology, 51, pp. 397-418. , 2-s2.0-79951990287 10.1146/annurev-pharmtox-010510-100237
  • Alche, L.E., Ferek, G.A., Meo, M., Coto, C.E., Maier, M.S., An antiviral meliacarpin from leaves of Melia azedarach L (2003) Zeitschrift fur Naturforschung - Section C Journal of Biosciences, 58 (3-4), pp. 215-219
  • Barquero, A.A., Alche, L.E., Coto, C.E., Block of vesicular stomatitis virus endocytic and exocytic pathways by 1-cinnamoyl-3,11-dihydroxymeliacarpin, a tetranortriterpenoid of natural origin (2004) Journal of General Virology, 85 (2), pp. 483-493. , DOI 10.1099/vir.0.19343-0
  • Bueno, C.A., Barquero, A.A., Di Cónsoli, H., Maier, M.S., Alché, L.E., A natural tetranortriterpenoid with immunomodulating properties as a potential anti-HSV agent (2009) Virus Research, 141 (1), pp. 47-54. , 2-s2.0-61749086046 10.1016/j.virusres.2008.12.013
  • Lü, J.-M., Nurko, J., Weakley, S.M., Jiang, J., Kougias, P., Lin, P.H., Yao, Q., Chen, C., Molecular mechanisms and clinical applications of nordihydroguaiaretic acid (NDGA) and its derivatives: An update (2010) Medical Science Monitor, 16 (5), pp. RA93-RA100. , 2-s2.0-77954288819
  • Aggarwal, B.B., Harikumar, K.B., Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases (2009) International Journal of Biochemistry and Cell Biology, 41 (1), pp. 40-59. , 2-s2.0-55949117806 10.1016/j.biocel.2008.06.010
  • Michelini, F.M., Ramirez, J.A., Berra, A., Galagovsky, L.R., Alche, L.E., In vitro and in vivo antiherpetic activity of three new synthetic brassinosteroid analogues (2004) Steroids, 69 (11-12), pp. 713-720. , DOI 10.1016/j.steroids.2004.04.011, PII S0039128X04001412
  • Michelini, F.M., Berra, A., Alche, L.E., The in vitro immunomodulatory activity of a synthetic brassinosteroid analogue would account for the improvement of herpetic stromal keratitis in mice (2008) Journal of Steroid Biochemistry and Molecular Biology, 108 (1-2), pp. 164-170. , DOI 10.1016/j.jsbmb.2007.10.002, PII S0960076007002671
  • Michelini, F.M., Ramírez, J.A., Berra, A., Galagovsky, L.R., Alché, L.E., Anti-herpetic and anti-inflammatory activities of two new synthetic 22,23-dihydroxylated stigmastane derivatives (2008) Journal of Steroid Biochemistry and Molecular Biology, 111 (1-2), pp. 111-116. , 2-s2.0-48049083074 10.1016/j.jsbmb.2008.05.005
  • Shishodia, S., Molecular mechanisms of curcumin action: Gene expression (2013) Biofactors, 39, pp. 37-55
  • Chun, T.-W., Engel, D., Mizell, S.B., Ehler, L.A., Fauci, A.S., Induction of HIV-1 replication in latently infected CD4+ T cells using a combination of cytokines (1998) Journal of Experimental Medicine, 188 (1), pp. 83-91. , DOI 10.1084/jem.188.1.83
  • Oguariri, R.M., Brann, T.W., Imamichi, T., Hydroxyurea and interleukin-6 synergistically reactivate HIV-1 replication in a latently infected promonocytic cell line via SP1/SP3 transcription factors (2007) Journal of Biological Chemistry, 282 (6), pp. 3594-3604. , http://www.jbc.org/cgi/reprint/282/6/3594, DOI 10.1074/jbc.M608150200
  • Imamichi, H., Degray, G., Asmuth, D.M., Fischl, M.A., Landay, A.L., Lederman, M.M., Sereti, I., HIV-1 viruses detected during episodic blips following interleukin-7 administration are similar to the viruses present before and after interleukin-7 therapy (2011) AIDS, 25 (2), pp. 159-164. , 2-s2.0-78650903022 10.1097/QAD.0b013e328340a270
  • Pyo, C.-W., Yang, Y.L., Yoo, N.-K., Choi, S.-Y., Reactive oxygen species activate HIV long terminal repeat via post-translational control of NF- B (2008) Biochemical and Biophysical Research Communications, 376 (1), pp. 180-185. , 2-s2.0-52349112869 10.1016/j.bbrc.2008.08.114
  • Durand, C.M., Blankson, J.N., Siliciano, R.F., Developing strategies for HIV-1 eradication (2012) Trends in Immunology, 33, pp. 554-562
  • Murakami, T., Harada, H., Suico, M.A., Shuto, T., Suzu, S., Kai, H., Okada, S., Ephedrae herba, a component of Japanese herbal medicine Mao-to, efficiently activates the replication of latent human immunodeficiency virus type 1 (HIV-1) in a monocytic cell line (2008) Biological and Pharmaceutical Bulletin, 31 (12), pp. 2334-2337. , 2-s2.0-57349142006 10.1248/bpb.31.2334
  • Krishnan, V., Zeichner, S.L., Host cell gene expression during human immunodeficiency virus type 1 latency and reactivation and effects of targeting genes that are differentially expressed in viral latency (2004) Journal of Virology, 78 (17), pp. 9458-9473. , DOI 10.1128/JVI.78.17.9458-9473.2004
  • Riva, D.A., Fernández-Larrosa, P.N., Dolcini, G.L., Martínez- Peralta, L.A., Coulombié, F.C., Mersich, S.E., Two immunomodulators, curcumin and sulfasalazine, enhance IDV antiretroviral activity in HIV-1 persistently infected cells (2008) Archives of Virology, 153 (3), pp. 561-565. , 2-s2.0-39749151689 10.1007/s00705-007-0023-4
  • Hwu, J.R., Hsu, M.-H., Huang, R.C.C., New nordihydroguaiaretic acid derivatives as anti-HIV agents (2008) Bioorganic and Medicinal Chemistry Letters, 18 (6), pp. 1884-1888. , DOI 10.1016/j.bmcl.2008.02.018, PII S0960894X08001984
  • Olivares, I., Ballester, A., Lombardia, L., Dominguez, O., López- Galíndez, C., Human immunodeficiency virus type 1 chronic infection is associated with different gene expression in MT-4, H9 and U937 cell lines (2009) Virus Research, 139 (1), pp. 22-31. , 2-s2.0-57749102540 10.1016/j.virusres.2008.09.010
  • Folks, T.M., Justement, J., Kinter, A., Dinarello, C.A., Fauci, A.S., Cytokine-induced expression of HIV-1 in a chronically infected promonocyte cell line (1987) Science, 238 (4828), pp. 800-802. , 2-s2.0-0023508507
  • Sharma, R.A., Gescher, A.J., Steward, W.P., Curcumin: The story so far (2005) European Journal of Cancer, 41 (13), pp. 1955-1968. , DOI 10.1016/j.ejca.2005.05.009
  • Galati, G., Sabzevari, O., Wilson, J.X., O'Brien, P.J., Prooxidant activity and cellular effects of the phenoxyl radicals of dietary flavonoids and other polyphenolics (2002) Toxicology, 177 (1), pp. 91-104. , DOI 10.1016/S0300-483X(02)00198-1, PII S0300483X02001981
  • Gloire, G., Legrand-Poels, S., Piette, J., NF-κB activation by reactive oxygen species: Fifteen years later (2006) Biochemical Pharmacology, 72 (11), pp. 1493-1505. , DOI 10.1016/j.bcp.2006.04.011, PII S0006295206002255, Cell Signalling, Transcription and Translation as Therapeutic Tergets

Citas:

---------- APA ----------
Barquero, A.A., Dávola, M.E., Riva, D.A., Mersich, S.E. & Alché, L.E. (2014) . Naturally occurring compounds elicit hiv-1 replication in chronically infected promonocytic cells. BioMed Research International, 2014.
http://dx.doi.org/10.1155/2014/989101
---------- CHICAGO ----------
Barquero, A.A., Dávola, M.E., Riva, D.A., Mersich, S.E., Alché, L.E. "Naturally occurring compounds elicit hiv-1 replication in chronically infected promonocytic cells" . BioMed Research International 2014 (2014).
http://dx.doi.org/10.1155/2014/989101
---------- MLA ----------
Barquero, A.A., Dávola, M.E., Riva, D.A., Mersich, S.E., Alché, L.E. "Naturally occurring compounds elicit hiv-1 replication in chronically infected promonocytic cells" . BioMed Research International, vol. 2014, 2014.
http://dx.doi.org/10.1155/2014/989101
---------- VANCOUVER ----------
Barquero, A.A., Dávola, M.E., Riva, D.A., Mersich, S.E., Alché, L.E. Naturally occurring compounds elicit hiv-1 replication in chronically infected promonocytic cells. BioMed Res. Int. 2014;2014.
http://dx.doi.org/10.1155/2014/989101