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Abstract:

The molecular interaction between hormonal and cytokine signals is crucial for providing specificity to their actions and represents a key step for understanding, at the molecular level, the ultimate response of physiological neuroendocrine-immune interactions. In this article we will describe new insights into the mechanisms underlying glucocorticoid-mediated anti-inflammatory action, focused on the regulation of immune-cytokine pathways. There are different levels of interaction between intracellular signals elicited by glucocorticoids and cytokines, with the final outcome being regulation of gene expression. One such interaction involves the molecular cross-talk between the activated glucocorticoid receptor (GR) and transcription factors implicated in the regulation of cytokine synthesis and function. This interaction results in the regulation of gene transcription, as we will illustrate with the helper T (Th)1 and Th2 transcription factors T-bet and GATA-3, respectively, implicated in the outcome of specific adaptive immune responses. A further level of mutual regulation is the posttranslational modification of GR by the ubiquitin-proteasome and sumoylation systems. These posttranslational modifications regulate GR activity and will be discussed for the small ubiquitin-related modifier (SUMO) pathway and its enhancer RWD RING finger-containing proteins, WD-repeat-containing proteins, and yeast DEAD (DEXD)-like helicases-containing sumoylation enhancer (RSUME). The impact of posttranslational modifications on inflammatory pathways, such as nuclear factor-κβ and regulated cytokines, will also be discussed. © 2009 New York Academy of Sciences.

Registro:

Documento: Artículo
Título:Intracellular molecular signaling: Basis for specificity to glucocorticoid anti-inflammatory actions
Autor:Liberman, A.C.; Druker, J.; Garcia, F.A.; Holsboer, F.; Arzt, E.
Filiación:Laboratorio de Fisiología Y Biología Molecular, Departamento de Fisiología Y Biología Molecular Y Celular, Universidad de Buenos Aires, Buenos Aires, Argentina
Instituto de Fisologia Y Biologia Molecular Y Neurociencias, Consejo Nacional de Investigaciones Científicas Y Técnicas
Max-Planck Institute of Psychiatry, Munich, Germany
Laboratorio Fisiología Y Biología Molecular, FCEN-Universidad de Buenos Aires, Pabellón II, (C1428EHA), Buenos Aires, Argentina
Palabras clave:GATA-3; Glucocorticoids; RSUME; SUMO; T-bet; cytokine; DEAD box protein; glucocorticoid; glucocorticoid receptor; interleukin 10; interleukin 2; interleukin 4; interleukin 5; proteasome; RING finger protein; SUMO protein; transcription factor GATA 3; transcription factor T bet; ubiquitin; antiinflammatory activity; conference paper; cytokine production; human; immunomodulation; immunoregulation; inflammation; molecular recognition; nonhuman; protein processing; RING finger motif; signal transduction; sumoylation; Th1 cell; Th2 cell; transcription regulation
Año:2009
Volumen:1153
Página de inicio:6
Página de fin:13
DOI: http://dx.doi.org/10.1111/j.1749-6632.2008.03958.x
Título revista:Annals of the New York Academy of Sciences
Título revista abreviado:Ann. New York Acad. Sci.
ISSN:00778923
CODEN:ANYAA
CAS:interleukin 2, 85898-30-2; proteasome, 140879-24-9; transcription factor GATA 3, 137878-55-8; ubiquitin, 60267-61-0
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00778923_v1153_n_p6_Liberman

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Citas:

---------- APA ----------
Liberman, A.C., Druker, J., Garcia, F.A., Holsboer, F. & Arzt, E. (2009) . Intracellular molecular signaling: Basis for specificity to glucocorticoid anti-inflammatory actions. Annals of the New York Academy of Sciences, 1153, 6-13.
http://dx.doi.org/10.1111/j.1749-6632.2008.03958.x
---------- CHICAGO ----------
Liberman, A.C., Druker, J., Garcia, F.A., Holsboer, F., Arzt, E. "Intracellular molecular signaling: Basis for specificity to glucocorticoid anti-inflammatory actions" . Annals of the New York Academy of Sciences 1153 (2009) : 6-13.
http://dx.doi.org/10.1111/j.1749-6632.2008.03958.x
---------- MLA ----------
Liberman, A.C., Druker, J., Garcia, F.A., Holsboer, F., Arzt, E. "Intracellular molecular signaling: Basis for specificity to glucocorticoid anti-inflammatory actions" . Annals of the New York Academy of Sciences, vol. 1153, 2009, pp. 6-13.
http://dx.doi.org/10.1111/j.1749-6632.2008.03958.x
---------- VANCOUVER ----------
Liberman, A.C., Druker, J., Garcia, F.A., Holsboer, F., Arzt, E. Intracellular molecular signaling: Basis for specificity to glucocorticoid anti-inflammatory actions. Ann. New York Acad. Sci. 2009;1153:6-13.
http://dx.doi.org/10.1111/j.1749-6632.2008.03958.x