Artículo

Hernández Del Pino, R.E.; Pellegrini, J.M.; Rovetta, A.I.; Penã, D.; Álvarez, G.I.; Rolandelli, A.; Musella, R.M.; Palmero, D.J.; Malbran, A.; Pasquinelli, V.; Garciá, V.E. "Restimulation-induced T-cell death through NTB-A/SAP signaling pathway is impaired in tuberculosis patients with depressed immune responses" (2017) Immunology and Cell Biology. 95(8):716-728
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Abstract:

Production of IFN-γ3 contributes to host defense against Mycobacterium tuberculosis (Mtb) infection. We previously demonstrated that Signaling lymphocytic activation molecule-associated protein (SAP) expression on cells from tuberculosis (TB) patients was inversely correlated with IFN-γ3 production. Here we first investigated the role of NK, T- A nd B-cell antigen (NTB-A)/SAP pathway in the regulation of Th1 response against Mtb. Upon antigen stimulation, NTB-A phosphorylation rapidly increases and afterwards modulates IFN-γ3 and IL-17 secretion. To sustain a healthy immune system, controlled expansion and contraction of lymphocytes, both during and after an adaptive immune response, is essential. Besides, restimulation-induced cell death (RICD) results in an essential homeostatic mechanism for precluding excess T-cell accumulation and associated immunopathology during the course of certain infections. Accordingly, we found that the NTB-A/SAP pathway was required for RICD during active tuberculosis. In low responder (LR) TB patients, impaired RICD was associated with diminished FASL levels, IL-2 production and CD25high expression after cell-restimulation. Interestingly, we next observed that SAP mediated the recruitment of the Src-related kinase FYNT, only in T cells from LR TB patients that were resistant to RICD. Together, we showed that the NTB-A/SAP pathway regulates T-cell activation and RICD during human TB. Moreover, the NTB-A/SAP/FYNT axis promotes polarization to an unfavorable Th2-phenotype.

Registro:

Documento: Artículo
Título:Restimulation-induced T-cell death through NTB-A/SAP signaling pathway is impaired in tuberculosis patients with depressed immune responses
Autor:Hernández Del Pino, R.E.; Pellegrini, J.M.; Rovetta, A.I.; Penã, D.; Álvarez, G.I.; Rolandelli, A.; Musella, R.M.; Palmero, D.J.; Malbran, A.; Pasquinelli, V.; Garciá, V.E.
Filiación:Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Ciudad Universitaria, Buenos Aires, Argentina
Centro de Investigaciones y Transferencia Del Noroeste de la Provincia de Buenos Aires, Universidad Nacional Del Noroeste de la Provincia de Buenos, Newbery 261, Buenos Aires, Argentina
Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales, Facultad de Ciencias Exactas, Pabellón II, 4, Buenos Aires, Argentina
División Tisioneumonologiá Hospital F.J. Muñiz, Uspallata, 2272, Argentina
Unidad de Alergia, Asma e Inmunologiá Clínica, Hospital Británico de Buenos Aires, Av. Roque Saenz Penã 1160, Piso, Buenos Aires, Argentina
Palabras clave:B lymphocyte antigen; blame protein; CD3 antigen; CD3 epsilon antigen; cracc protein; Fas ligand; FLICE inhibitory protein; gamma interferon; interleukin 17; interleukin 2; interleukin 2 receptor alpha; interleukin 4; lymphocyte antigen; Mycobacterium tuberculosis antigen; natural killer cell antigen; protein; signaling lymphocyte activation molecule associated protein; signaling lymphocytic activation molecule; silver; slamf7 protein; slamf8 protein; T lymphocyte antigen; unclassified drug; FRK protein, human; gamma interferon; interleukin 17; protein tyrosine kinase; signaling lymphocytic activation molecule; SLAMF6 protein, human; tumor protein; 3' untranslated region; adaptive immunity; adult; apoptosis; Article; CD4+ T lymphocyte; cell differentiation; cell expansion; cell proliferation; cellular immunity; controlled study; cytokine production; cytokine release; disease severity; down regulation; female; flow cytometry; homeostasis; human; human cell; immunopathology; immunoprecipitation; immunostimulation; in vitro study; leukocyte count; major clinical study; male; peripheral blood mononuclear cell; protein phosphorylation; quantitative analysis; restimulation induced cell death; signal transduction; T lymphocyte; T lymphocyte activation; tuberculosis; cell culture; cell death; immunity; immunology; immunosuppressive treatment; lymphocyte activation; metabolism; Mycobacterium tuberculosis; signal transduction; Th2 cell; tuberculosis; Adult; Cell Death; Cell Differentiation; Cells, Cultured; Female; Homeostasis; Humans; Immunity; Immunosuppression; Interferon-gamma; Interleukin-17; Lymphocyte Activation; Male; Mycobacterium tuberculosis; Neoplasm Proteins; Protein-Tyrosine Kinases; Signal Transduction; Signaling Lymphocytic Activation Molecule Family; Th2 Cells; Tuberculosis
Año:2017
Volumen:95
Número:8
Página de inicio:716
Página de fin:728
DOI: http://dx.doi.org/10.1038/icb.2017.42
Título revista:Immunology and Cell Biology
Título revista abreviado:Immunol. Cell Biol.
ISSN:08189641
CODEN:ICBIE
CAS:gamma interferon, 82115-62-6; interleukin 2, 85898-30-2; protein, 67254-75-5; silver, 7440-22-4; protein tyrosine kinase, 80449-02-1; FRK protein, human; Interferon-gamma; Interleukin-17; Neoplasm Proteins; Protein-Tyrosine Kinases; Signaling Lymphocytic Activation Molecule Family; SLAMF6 protein, human
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08189641_v95_n8_p716_HernandezDelPino

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Citas:

---------- APA ----------
Hernández Del Pino, R.E., Pellegrini, J.M., Rovetta, A.I., Penã, D., Álvarez, G.I., Rolandelli, A., Musella, R.M.,..., Garciá, V.E. (2017) . Restimulation-induced T-cell death through NTB-A/SAP signaling pathway is impaired in tuberculosis patients with depressed immune responses. Immunology and Cell Biology, 95(8), 716-728.
http://dx.doi.org/10.1038/icb.2017.42
---------- CHICAGO ----------
Hernández Del Pino, R.E., Pellegrini, J.M., Rovetta, A.I., Penã, D., Álvarez, G.I., Rolandelli, A., et al. "Restimulation-induced T-cell death through NTB-A/SAP signaling pathway is impaired in tuberculosis patients with depressed immune responses" . Immunology and Cell Biology 95, no. 8 (2017) : 716-728.
http://dx.doi.org/10.1038/icb.2017.42
---------- MLA ----------
Hernández Del Pino, R.E., Pellegrini, J.M., Rovetta, A.I., Penã, D., Álvarez, G.I., Rolandelli, A., et al. "Restimulation-induced T-cell death through NTB-A/SAP signaling pathway is impaired in tuberculosis patients with depressed immune responses" . Immunology and Cell Biology, vol. 95, no. 8, 2017, pp. 716-728.
http://dx.doi.org/10.1038/icb.2017.42
---------- VANCOUVER ----------
Hernández Del Pino, R.E., Pellegrini, J.M., Rovetta, A.I., Penã, D., Álvarez, G.I., Rolandelli, A., et al. Restimulation-induced T-cell death through NTB-A/SAP signaling pathway is impaired in tuberculosis patients with depressed immune responses. Immunol. Cell Biol. 2017;95(8):716-728.
http://dx.doi.org/10.1038/icb.2017.42