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Abstract:

Objective. To summarize current knowledge of the immunological mechanisms involved in the pathogenesis of multiple sclerosis and its implications in the development of new therapeutic options. Development. The aetiology of multiple sclerosis is still not completely clear. Nevertheless there is much evidence in favor of the possibility that autoimmune phenomena play an important part in the development and course of the disorder. Knowledge of the immunological phenomena involved determines the possibility of modifying the immune response at different levels. Thus it is possible to act on: 1. The trimolecular complex during lymphocyte activation. 2. To block the passage of activated cells across the blood-brain barrier. 3. To modify the effector action of specific antigen cells, and 4. Induce populations of regulator cells. Similarly, immunological phenomena which develop during pregnancy and the postpartum period are an interesting physiological model which permit identification of the mechanisms by which autoimmune disorders are modified Amongst the factors affecting the immune response during pregnancy and the postpartum period the various maternal and foeto-placental hormones should be considered. Their actions may be due to their effects on the secretion of different groups of cytokines. Better understanding of the factors regulating the immune response during pregnancy and the postpartum period permits definition of new potential sites for therapeutic action. Conclusions. Current knowledge of the many physiopathological mechanisms involved in the development of multiple sclerosis allows rational development of new alterative treatments for this condition.

Registro:

Documento: Artículo
Título:Immunological mechanisms involved in the pathogenesis of multiple sclerosis
Autor:Correale, J.
Filiación:Seccion de Neuroimmunologia, Enfermedades Desmielinizantes, Instituto de Investigaciones, Montaneses 2325, 1428 Buenos Aires, Argentina
Palabras clave:Autoimmunity; Immunology; Lymphocytes; Multiple sclerosis; Pregnancy; alpha interferon; antibody; beta1 integrin; CD4 antigen derivative; glatiramer; HLA antibody; hormone; intercellular adhesion molecule 1 antibody; interleukin 4; peptide derivative; phosphodiesterase inhibitor; vascular cell adhesion molecule 1; cytokine; autoimmunity; blood brain barrier; conference paper; cytokine production; desensitization; hormone action; human; immunopathogenesis; immunotherapy; lymphocyte activation; lymphocyte migration; multiple sclerosis; pregnancy; puerperium; vaccination; article; female; immunology; pathophysiology; physiology; T lymphocyte; Blood-Brain Barrier; Cytokines; Female; Humans; Lymphocyte Activation; Multiple Sclerosis; Pregnancy; T-Lymphocytes
Año:2000
Volumen:31
Número:5
Página de inicio:471
Página de fin:476
Título revista:Revista de Neurologia
Título revista abreviado:Rev. Neurol.
ISSN:02100010
CODEN:RVNRA
CAS:Cytokines
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02100010_v31_n5_p471_Correale

Referencias:

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Citas:

---------- APA ----------
(2000) . Immunological mechanisms involved in the pathogenesis of multiple sclerosis . Revista de Neurologia, 31(5), 471-476.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02100010_v31_n5_p471_Correale [ ]
---------- CHICAGO ----------
Correale, J. "Immunological mechanisms involved in the pathogenesis of multiple sclerosis " . Revista de Neurologia 31, no. 5 (2000) : 471-476.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02100010_v31_n5_p471_Correale [ ]
---------- MLA ----------
Correale, J. "Immunological mechanisms involved in the pathogenesis of multiple sclerosis " . Revista de Neurologia, vol. 31, no. 5, 2000, pp. 471-476.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02100010_v31_n5_p471_Correale [ ]
---------- VANCOUVER ----------
Correale, J. Immunological mechanisms involved in the pathogenesis of multiple sclerosis . Rev. Neurol. 2000;31(5):471-476.
Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02100010_v31_n5_p471_Correale [ ]