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Abstract:

Despite their central function in orchestrating immunity, dendritic cells (DCs) can respond to inhibitory signals by becoming tolerogenic. Here we show that galectin-1, an endogenous glycan-binding protein, can endow DCs with tolerogenic potential. After exposure to galectin-1, DCs acquired an interleukin 27 (IL-27)-dependent regulatory function, promoted IL-10-mediated T cell tolerance and suppressed autoimmune neuroinflammation. Consistent with its regulatory function, galectin-1 had its highest expression on DCs exposed to tolerogenic stimuli and was most abundant from the peak through the resolution of autoimmune pathology. DCs lacking galectin-1 had greater immunogenic potential and an impaired ability to halt inflammatory disease. Our findings identify a tolerogenic circuit linking galectin-1 signaling, IL-27-producing DCs and IL-10-secreting T cells, which has broad therapeutic implications in immunopathology.

Registro:

Documento: Artículo
Título:Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10
Autor:Ilarregui, J.M.; Croci, D.O.; Bianco, G.A.; Toscano, M.A.; Salatino, M.; Vermeulen, M.E.; Geffner, J.R.; Rabinovich, G.A.
Filiación:Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina
Hospital de Clínicas 'José de San Martín', Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina
Instituto de Investigaciones Hematológicas, Academia Nacional de Medicina, Buenos Aires, Argentina
Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
Palabras clave:galectin 1; gamma interferon; granulocyte macrophage colony stimulating factor; interleukin 10; interleukin 27; ovalbumin; animal cell; antiinflammatory activity; article; CD4+ T lymphocyte; cell differentiation; cell stimulation; controlled study; cytokine production; cytokine release; dendritic cell; human; human cell; immunological tolerance; immunoregulation; inflammation; mouse; nonhuman; priority journal; protein expression; protein function; protein localization; signal transduction; T lymphocyte; upregulation; Animals; Antigens, CD40; Dendritic Cells; Encephalomyelitis, Autoimmune, Experimental; Female; Galectin 1; Gene Expression Regulation; Glycoproteins; Immune Tolerance; Interleukin-10; Interleukins; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Peptide Fragments; STAT3 Transcription Factor; T-Lymphocytes
Año:2009
Volumen:10
Número:9
Página de inicio:981
Página de fin:991
DOI: http://dx.doi.org/10.1038/ni.1772
Título revista:Nature Immunology
Título revista abreviado:Nat. Immunol.
ISSN:15292908
CODEN:NIAMC
CAS:galectin 1, 258495-34-0; gamma interferon, 82115-62-6; ovalbumin, 77466-29-6; Antigens, CD40; Galectin 1; Glycoproteins; Il27 protein, mouse; Interleukin-10, 130068-27-8; Interleukins; Peptide Fragments; STAT3 Transcription Factor; Stat3 protein, mouse; myelin oligodendrocyte glycoprotein (35-55)
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_15292908_v10_n9_p981_Ilarregui

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Citas:

---------- APA ----------
Ilarregui, J.M., Croci, D.O., Bianco, G.A., Toscano, M.A., Salatino, M., Vermeulen, M.E., Geffner, J.R.,..., Rabinovich, G.A. (2009) . Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10. Nature Immunology, 10(9), 981-991.
http://dx.doi.org/10.1038/ni.1772
---------- CHICAGO ----------
Ilarregui, J.M., Croci, D.O., Bianco, G.A., Toscano, M.A., Salatino, M., Vermeulen, M.E., et al. "Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10" . Nature Immunology 10, no. 9 (2009) : 981-991.
http://dx.doi.org/10.1038/ni.1772
---------- MLA ----------
Ilarregui, J.M., Croci, D.O., Bianco, G.A., Toscano, M.A., Salatino, M., Vermeulen, M.E., et al. "Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10" . Nature Immunology, vol. 10, no. 9, 2009, pp. 981-991.
http://dx.doi.org/10.1038/ni.1772
---------- VANCOUVER ----------
Ilarregui, J.M., Croci, D.O., Bianco, G.A., Toscano, M.A., Salatino, M., Vermeulen, M.E., et al. Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10. Nat. Immunol. 2009;10(9):981-991.
http://dx.doi.org/10.1038/ni.1772