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Abstract:

Numerous regulatory programs have been identified that contribute to the restoration of homeostasis at the conclusion of immune responses and to safeguarding against the detrimental effects of chronic inflammation and autoimmune pathology. Malignant cells may usurp these pathways to create immunosuppressive networks that thwart antitumor responses. Herein we review the role of endogenous lectins (C-type lectins, siglecs, and galectins) and specific N- and O-glycans generated by the coordinated action of glycosyltransferases and glycosidases that together promote regulatory signals that control immune cell homeostasis. We also discuss the mechanisms by which glycan-dependent regulatory programs integrate into canonical circuits that amplify or silence immune responses related to autoimmunity and neoplastic disease. © 2012 Elsevier Inc..

Registro:

Documento: Artículo
Título:Regulatory Circuits Mediated by Lectin-Glycan Interactions in Autoimmunity and Cancer
Autor:Rabinovich, G.; Croci, D.O.
Filiación:Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental (IBYME), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), C1428 Buenos Aires, Argentina
Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, C1428 Buenos Aires, Argentina
Palabras clave:carcinoembryonic antigen related cell adhesion molecule 1; CD22 antigen; cytotoxic T lymphocyte antigen 4; dectin 1; galectin; glycan; glycosidase; glycosyltransferase; immunoglobulin; interleukin 10; interleukin 12; interleukin 6; lectin; mitogen activated protein kinase; protein tyrosine kinase; tumor necrosis factor receptor 1; antigen presenting cell; autoimmune disease; autoimmunity; carbohydrate synthesis; cell death; cell migration; cell survival; cytokine production; endocytosis; enzyme activation; glycosylation; immune response; immunocompetent cell; immunological tolerance; inflammation; lymphocyte activation; neoplasm; priority journal; protein interaction; protein motif; protein phosphorylation; protein structure; regulatory mechanism; regulatory T lymphocyte; review; Animals; Antigen-Presenting Cells; Autoimmunity; Cell Death; Humans; Immune Tolerance; Inflammation; Lectins; Lymphocyte Activation; Mice; Models, Immunological; Neoplasms; Polysaccharides; Signal Transduction; T-Lymphocytes
Año:2012
Volumen:36
Número:3
Página de inicio:322
Página de fin:335
DOI: http://dx.doi.org/10.1016/j.immuni.2012.03.004
Título revista:Immunity
Título revista abreviado:Immunity
ISSN:10747613
CODEN:IUNIE
CAS:glycosidase, 9032-92-2; glycosyltransferase, 9033-07-2; immunoglobulin, 9007-83-4; interleukin 12, 138415-13-1; mitogen activated protein kinase, 142243-02-5; protein tyrosine kinase, 80449-02-1; Lectins; Polysaccharides
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10747613_v36_n3_p322_Rabinovich

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Citas:

---------- APA ----------
Rabinovich, G. & Croci, D.O. (2012) . Regulatory Circuits Mediated by Lectin-Glycan Interactions in Autoimmunity and Cancer. Immunity, 36(3), 322-335.
http://dx.doi.org/10.1016/j.immuni.2012.03.004
---------- CHICAGO ----------
Rabinovich, G., Croci, D.O. "Regulatory Circuits Mediated by Lectin-Glycan Interactions in Autoimmunity and Cancer" . Immunity 36, no. 3 (2012) : 322-335.
http://dx.doi.org/10.1016/j.immuni.2012.03.004
---------- MLA ----------
Rabinovich, G., Croci, D.O. "Regulatory Circuits Mediated by Lectin-Glycan Interactions in Autoimmunity and Cancer" . Immunity, vol. 36, no. 3, 2012, pp. 322-335.
http://dx.doi.org/10.1016/j.immuni.2012.03.004
---------- VANCOUVER ----------
Rabinovich, G., Croci, D.O. Regulatory Circuits Mediated by Lectin-Glycan Interactions in Autoimmunity and Cancer. Immunity. 2012;36(3):322-335.
http://dx.doi.org/10.1016/j.immuni.2012.03.004