Artículo

Fernández Do Porto, D.A.; Jurado, J.O.; Pasquinelli, V.; Alvarez, I.B.; Aspera, R.H.; Musella, R.M.; García, V.E. "CD137 differentially regulates innate and adaptive immunity against Mycobacterium tuberculosis" (2012) Immunology and Cell Biology. 90(4):449-456
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Abstract:

Protective immunity against Mycobacterium tuberculosis is primarily mediated by the interaction of antigen-specific T cells and antigen presenting cells, which often depends on the interplay of cytokines produced by these cells. Costimulatory signals represent a complex network of receptor-ligand interactions that qualitatively and quantitatively influence immune responses. Thus, here we investigated the function of CD137 and CD137L, molecules known to have a central role in immune regulation, during human tuberculosis (TB). We demonstrated that M. tuberculosis antigen stimulation increased both CD137 and CD137L expression on monocytes and NK cells from TB patients and healthy donors, but only up-regulated CD137 on T lymphocytes. Blockage of the CD137 pathway enhanced the levels of interferon (IFN)-γ and tumor necrosis factor (TNF)-α produced by monocytes and NK against M. tuberculosis. In contrast, CD137 blockage significantly decreased the specific degranulation of CD8 + T cells and the percentage of specific IFN-γ and TNF-α producing lymphocytes against the pathogen. Furthermore, inhibition of the CD137 pathway markedly increased T-cell apoptosis. Taken together, our results demonstrate that CD137:CD137L interactions regulate the innate and adaptive immune response of the host against M. tuberculosis. © 2012 Australasian Society for Immunology Inc. All rights reserved.

Registro:

Documento: Artículo
Título:CD137 differentially regulates innate and adaptive immunity against Mycobacterium tuberculosis
Autor:Fernández Do Porto, D.A.; Jurado, J.O.; Pasquinelli, V.; Alvarez, I.B.; Aspera, R.H.; Musella, R.M.; García, V.E.
Filiación:Department of Biological Chemistry, University of Buenos Aires, School of Sciences, Intendente Güiraldes 2160, 1428, Capital Federal, Buenos Aires C1428EGA, Argentina
División de Tisioneumonología, Hospital FJ Muñiz, Buenos Aires, Argentina
Palabras clave:CD137; cytokines; monocytes; NK cells; T cells; tuberculosis; CD137 antigen; CD137 ligand; gamma interferon; tumor necrosis factor alpha; adaptive immunity; adult; apoptosis; article; CD8+ T lymphocyte; cell expansion; cell proliferation; cell survival; clinical article; controlled study; cytokine production; degranulation; female; human; human cell; human tissue; immunoregulation; innate immunity; lung tuberculosis; male; monocyte; Mycobacterium tuberculosis; natural killer cell; nonhuman; protein expression; protein protein interaction; T lymphocyte; upregulation; 4-1BB Ligand; Adaptive Immunity; Antigens, CD137; Cells, Cultured; Humans; Immunity, Innate; Killer Cells, Natural; Mycobacterium tuberculosis; T-Lymphocytes; Tuberculosis; Mycobacterium tuberculosis
Año:2012
Volumen:90
Número:4
Página de inicio:449
Página de fin:456
DOI: http://dx.doi.org/10.1038/icb.2011.63
Título revista:Immunology and Cell Biology
Título revista abreviado:Immunol. Cell Biol.
ISSN:08189641
CODEN:ICBIE
CAS:gamma interferon, 82115-62-6; 4-1BB Ligand; Antigens, CD137; TNFSF9 protein, human
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08189641_v90_n4_p449_FernandezDoPorto

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Citas:

---------- APA ----------
Fernández Do Porto, D.A., Jurado, J.O., Pasquinelli, V., Alvarez, I.B., Aspera, R.H., Musella, R.M. & García, V.E. (2012) . CD137 differentially regulates innate and adaptive immunity against Mycobacterium tuberculosis. Immunology and Cell Biology, 90(4), 449-456.
http://dx.doi.org/10.1038/icb.2011.63
---------- CHICAGO ----------
Fernández Do Porto, D.A., Jurado, J.O., Pasquinelli, V., Alvarez, I.B., Aspera, R.H., Musella, R.M., et al. "CD137 differentially regulates innate and adaptive immunity against Mycobacterium tuberculosis" . Immunology and Cell Biology 90, no. 4 (2012) : 449-456.
http://dx.doi.org/10.1038/icb.2011.63
---------- MLA ----------
Fernández Do Porto, D.A., Jurado, J.O., Pasquinelli, V., Alvarez, I.B., Aspera, R.H., Musella, R.M., et al. "CD137 differentially regulates innate and adaptive immunity against Mycobacterium tuberculosis" . Immunology and Cell Biology, vol. 90, no. 4, 2012, pp. 449-456.
http://dx.doi.org/10.1038/icb.2011.63
---------- VANCOUVER ----------
Fernández Do Porto, D.A., Jurado, J.O., Pasquinelli, V., Alvarez, I.B., Aspera, R.H., Musella, R.M., et al. CD137 differentially regulates innate and adaptive immunity against Mycobacterium tuberculosis. Immunol. Cell Biol. 2012;90(4):449-456.
http://dx.doi.org/10.1038/icb.2011.63