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118
"Frustration, function and folding"
(2018) Ferreiro, D.U.; Komives, E.A.; Wolynes, P.G. Current Opinion in Structural Biology. 48:68-73
"Determining the virus life-cycle stage blocked by an antiviral"
(2018) Sepúlveda, C.S.; García, C.C.; Damonte, E.B. Methods in Molecular Biology. 1604:371-392
"Oxidation at C-16 enhances butyrylcholinesterase inhibition in lupane triterpenoids"
(2018) Castro, M.J.; Richmond, V.; Faraoni, M.B.; Murray, A.P. Bioorganic Chemistry. 79:301-309
"Synthesis, molecular docking and biological evaluation of novel phthaloyl derivatives of 3-amino-3-aryl propionic acids as inhibitors of Trypanosoma cruzi trans-sialidase"
(2018) Kashif, M.;Chacón-Vargas, K.F.;López-Cedillo, J.C. (
...
)Rivera, G. European Journal of Medicinal Chemistry. 156:252-268
"Isolation and Antifouling Activity of Azulene Derivatives from the Antarctic Gorgonian Acanthogorgia laxa"
(2018) Patiño Cano, L.P.;Quintana Manfredi, R.;Pérez, M. (
...
)Palermo, J.A. Chemistry and Biodiversity. 15(1)
"Structural and mechanistic comparison of the Cyclopropane Mycolic Acid Synthases (CMAS) protein family of Mycobacterium tuberculosis"
(2018) Defelipe, L.A.; Osman, F.; Marti, M.A.; Turjanski, A.G. Biochemical and Biophysical Research Communications. 498(2):288-295
"Structural and mechanistic comparison of the Cyclopropane Mycolic Acid Synthases (CMAS) protein family of Mycobacterium tuberculosis"
(2018) Defelipe, L.A.; Osman, F.; Marti, M.A.; Turjanski, A.G. Biochemical and Biophysical Research Communications. 498(2):288-295
"A Minimalist Approach to the Design of Complexity-Enriched Bioactive Small Molecules: Discovery of Phenanthrenoid Mimics as Antiproliferative Agents"
(2018) Alonso, F.;Quezada, M.J.;Gola, G.F. (
...
)Ramírez, J.A. ChemMedChem. 13(16):1732-1740
"Chemoenzymatic synthesis of new derivatives of glycyrrhetinic acid with antiviral activity. Molecular docking study"
(2018) Zígolo, M.A.;Salinas, M.;Alché, L. (
...
)Liñares, G.G. Bioorganic Chemistry. 78:210-219
"Synthesis and in vitro antiproliferative activities of (5-aryl-1,2,4-oxadiazole-3-yl) methyl D-ribofuranosides"
(2017) Avanzo, R.E.; Padrón, J.M.; D'Accorso, N.B.; Fascio, M.L. Bioorganic and Medicinal Chemistry Letters. 27(16):3674-3677
"Evolved distal tail carbohydrate binding modules of Lactobacillus phage J-1: a novel type of anti-receptor widespread among lactic acid bacteria phages"
(2017) Dieterle, M.-E.;Spinelli, S.;Sadovskaya, I. (
...
)Cambillau, C. Molecular Microbiology. 104(4):608-620
"Selenium-containing analogues of WC-9 are extremely potent inhibitors of Trypanosoma cruzi proliferation"
(2017) Chao, M.N.;Storey, M.;Li, C. (
...
)Rodriguez, J.B. Bioorganic and Medicinal Chemistry. 25(24):6435-6449
"Differential contribution of subunit interfaces to α9α10 nicotinic acetylcholine receptor function"
(2017) Boffi, J.C.;Marcovich, I.;Gill-Thind, J.K. (
...
)Elgoyhen, A.B. Molecular Pharmacology. 91(3):250-262
"Synthesis and cytotoxicity evaluation of A-ring derivatives of cycloartanone"
(2017) Zambrano, E.E.;Casas, A.G.;Di Venosa, G.M. (
...
)Palermo, J.A. Phytochemistry Letters. 21:200-205
"An in vitro and in vivo evaluation of new potential trans-sialidase inhibitors of Trypanosoma cruzi predicted by a computational drug repositioning method"
(2017) Lara-Ramirez, E.E.;López-Cedillo, J.C.;Nogueda-Torres, B. (
...
)Rivera, G. European Journal of Medicinal Chemistry. 132:249-261
"Inferring repeat-protein energetics from evolutionary information"
(2017) Espada, R.;Parra, R.G.;Mora, T. (
...
)Ferreiro, D.U. PLoS Computational Biology. 13(6)
"Antiparasitic activity of sulfur- and fluorine-containing bisphosphonates against trypanosomatids and apicomplexan parasites"
(2017) Galaka, T.;Casal, M.F.;Storey, M. (
...
)Rodriguez, J.B. Molecules. 22(1)
"Evolutionary and Functional Relationships in the Truncated Hemoglobin Family"
(2016) Bustamante, J.P.;Radusky, L.;Boechi, L. (
...
)Martí, M.A. PLoS Computational Biology. 12(1)
"Structural and functional characterization of a cold-adapted stand-alone TPM domain reveals a relationship between dynamics and phosphatase activity"
(2016) Pellizza, L.A.;Smal, C.;Ithuralde, R.E. (
...
)Arán, M. FEBS Journal. 283(23):4370-4385
"Polyhydroxylated sulfated steroids derived from 5α-cholestanes as antiviral agents against herpes simplex virus"
(2016) Pujol, C.A.;Sepúlveda, C.S.;Richmond, V. (
...
)Damonte, E.B. Archives of Virology. 161(7):1993-1999
"Structure-based activity prediction of CYP21A2 stability variants: A survey of available gene variations"
(2016) Bruque, C.D.;Delea, M.;Fernández, C.S. (
...
)Dain, L. Scientific Reports. 6
"WC-9 a lead drug with great prospects for American trypanosomiasis and toxoplasmosis"
(2016) Rodriguez, J.B. Mini-Reviews in Medicinal Chemistry. 16(15):1195-1200
"Immunotoxicity of commercial-mixed glyphosate in broad snouted caiman (Caiman latirostris)"
(2016) Siroski, P.A.;Poletta, G.L.;Latorre, M.A. (
...
)Mudry, M.D. Chemico-Biological Interactions. 244:64-70
"Structural Plasticity in Globins: Role of Protein Dynamics in Defining Ligand Migration Pathways"
(2016) Estarellas, C.;Capece, L.;Seira, C. (
...
)Christov C.Z. Advances in Protein Chemistry and Structural Biology. 105:59-80
"Structural Study of a Flexible Active Site Loop in Human Indoleamine 2,3-Dioxygenase and Its Functional Implications"
(2016) Álvarez, L.;Lewis-Ballester, A.;Roitberg, A. (
...
)Capece, L. Biochemistry. 55(19):2785-2793
"Structure-activity relationship of hybrids of Cinchona alkaloids and bile acids with in vitro antiplasmodial and antitrypanosomal activities"
(2015) Leverrier, A.;Bero, J.;Cabrera, J. (
...
)Palermo, J.A. European Journal of Medicinal Chemistry. 100(1):10-17
"Structure-activity relationship of hybrids of Cinchona alkaloids and bile acids with in vitro antiplasmodial and antitrypanosomal activities"
(2015) Leverrier, A.;Bero, J.;Cabrera, J. (
...
)Palermo, J.A. European Journal of Medicinal Chemistry. 100(1):10-17
"Exploring the molecular basis of neurosteroid binding to the β3 homopentameric GABAA receptor"
(2015) Alvarez, L.D.; Estrin, D.A. Journal of Steroid Biochemistry and Molecular Biology. 154:159-167
"Enzymatic synthesis of bile acid derivatives and biological evaluation against Trypanosoma cruzi"
(2015) García Liñares, G.;Antonela Zígolo, M.;Simonetti, L. (
...
)Baldessari, A. Bioorganic and Medicinal Chemistry. 23(15):4804-4814
"Exploring the molecular basis of action of ring D aromatic steroidal antiestrogens"
(2015) Alvarez, L.D.; Veleiro, A.S.; Burton, G. Proteins: Structure, Function and Bioinformatics. 83(7):1297-1306
"A novel missense mutation in the HSD3B2 gene, underlying nonsalt-wasting congenital adrenal hyperplasia. new insight into the structure-function relationships of 3β-hydroxysteroid dehidrogenase type II"
(2015) Baquedano, M.S.;Ciaccio, M.;Marino, R. (
...
)Belgorosky, A. The Journal of clinical endocrinology and metabolism. 100(1):E191-E196
"Recovery study of cholinesterases and neurotoxic signs in the non-target freshwater invertebrate Chilina gibbosa after an acute exposure to an environmental concentration of azinphos-methyl"
(2015) Cossi, P.F.; Beverly, B.; Carlos, L.; Kristoff, G. Aquatic Toxicology. 167:248-256
"A novel missense mutation in the HSD3B2 gene, underlying nonsalt-wasting congenital adrenal hyperplasia. New insight into the structurefunction relationships of 3βhydroxysteroid dehidrogenase type II"
(2015) Baquedano, M.S.;Ciaccio, M.;Marino, R. (
...
)Belgorosky, A. Journal of Clinical Endocrinology and Metabolism. 100(1):E191-E196
"A novel missense mutation in the HSD3B2 gene, underlying nonsalt-wasting congenital adrenal hyperplasia. New insight into the structurefunction relationships of 3βhydroxysteroid dehidrogenase type II"
(2015) Baquedano, M.S.;Ciaccio, M.;Marino, R. (
...
)Belgorosky, A. Journal of Clinical Endocrinology and Metabolism. 100(1):E191-E196
"Structural basis of redox-dependent modulation of galectin-1 dynamics and function"
(2014) Guardia, C.M.;Caramelo, J.J.;Trujillo, M. (
...
)Rabinovich, G.A. Glycobiology. 24(5):428-441
"Multivariate SAR and QSAR of cucurbitacin derivatives as cytotoxic compounds in a human lung adenocarcinoma cell line"
(2014) Lang, K.L.;Silva, I.T.;Machado, V.R. (
...
)De Melo, E.B. Journal of Molecular Graphics and Modelling. 48:70-79
"Synthesis and cholinesterase inhibition of cativic acid derivatives"
(2014) Alza, N.P.;Richmond, V.;Baier, C.J. (
...
)Murray, A.P. Bioorganic and Medicinal Chemistry. 22(15):3838-3849
"QSAR on antiproliferative naphthoquinones based on a conformation- independent approach"
(2014) Duchowicz, P.R.;Bennardi, D.O.;Bacelo, D.E. (
...
)Misico, R.I. European Journal of Medicinal Chemistry. 77:176-184
"Synthesis and biological evaluation of salpichrolide analogs as antiestrogenic agents"
(2014) Sonego, J.M.;Rivero, E.M.;Gargiulo, L. (
...
)Burton, G. European Journal of Medicinal Chemistry. 82:233-241
"Preclinical development of novel Rac1-GEF signaling inhibitors using a rational design approach in highly aggressive breast cancer cell lines"
(2014) Cardama, G.A.;Comin, M.J.;Hornos, L. (
...
)Menna, P.L. Anti-Cancer Agents in Medicinal Chemistry. 14(6):840-851
"Preparation, anticholinesterase activity and molecular docking of new lupane derivatives"
(2014) Castro, M.J.;Richmond, V.;Romero, C. (
...
)Murray, A.P. Bioorganic and Medicinal Chemistry. 22(13):3341-3350
"Antiprotozoan lead discovery by aligning dry and wet screening: Prediction, synthesis, and biological assay of novel quinoxalinones"
(2014) Martins Alho, M.A.;Marrero-Ponce, Y.;Barigye, S.J. (
...
)Arán, V.J. Bioorganic and Medicinal Chemistry. 22(5):1568-1585
"Multicomponent synthesis of 4,4-dimethyl sterol analogues and their effect on eukaryotic cells"
(2014) Alonso, F.;Cirigliano, A.M.;Dávola, M.E. (
...
)Ramírez, J.A. Steroids. 84:1-6
"Organization of columnar inputs in the third optic ganglion of a highly visual crab"
(2014) Bengochea, M.; Berón de Astrada, M. Journal of Physiology Paris. 108(2-3):61-70
"Molecular basis of mineralocorticoid receptor action in the nervous system"
(2013) Molinari, A.M.;Machado-Rada, M.Y.;Mazaira, G.I. (
...
)Galigniana, M.D. CNS and Neurological Disorders - Drug Targets. 12(8):1163-1174
"Synthesis and acetylcholinesterase inhibitory activity of polyhydroxylated sulfated steroids: Structure/activity studies"
(2013) Richmond, V.; Murray, A.P.; Maier, M.S. Steroids. 78(11):1141-1147
"Coordination of peroxide to the CuM center of peptidylglycine α-hydroxylating monooxygenase (PHM): Structural and computational study"
(2013) Rudzka, K.;Moreno, D.M.;Eipper, B. (
...
)Amzel, L.M. Journal of Biological Inorganic Chemistry. 18(2):223-232
"The key role of water in the dioxygenase function of Escherichia coli flavohemoglobin"
(2013) Ferreiro, D.N.; Boechi, L.; Estrin, D.A.; Martí, M.A. Journal of Inorganic Biochemistry. 119:75-84
"Alterations of fibrin network structure mediated by dermatan sulfate"
(2013) Lauricella, A.M.; Castañon, M.M.; Kordich, L.C.; Quintana, I.L. Journal of Thrombosis and Thrombolysis. 35(2):257-263
"In Silico Structural and Functional Characterization of the RSUME Splice Variants"
(2013) Gerez, J.;Fuertes, M.;Tedesco, L. (
...
)Arzt, E. PLoS ONE. 8(2)
"Synthesis of 6-azaprogesterone and 19-hydroxy-6-azasteroids"
(2013) Martínez, M.D.;Edelsztein, V.C.;Durán, F.J. (
...
)Burton, G. Steroids. 78(1):34-37
"Synthesis and cytotoxic activity evaluation of dihydrocucurbitacin B and cucurbitacin B derivatives"
(2012) Lang, K.L.;Silva, I.T.;Zimmermann, L.A. (
...
)Durán, F.J. Bioorganic and Medicinal Chemistry. 20(9):3016-3030
"Functional characterization of residues involved in redox modulation of maize photosynthetic NADP-Malic enzyme activity"
(2012) Alvarez, C.E.;Detarsio, E.;Moreno, S. (
...
)Drincovich, M.F. Plant and Cell Physiology. 53(6):1144-1153
"An anionic synthetic sugar containing 6-SO3-NAcGlc mimics the sulfated cruzipain epitope that plays a central role in immune recognition"
(2012) Couto, A.S.;Soprano, L.L.;Landoni, M. (
...
)Duschak, V.G. FEBS Journal. 279(19):3665-3679
"Sequence Evolution of the Intrinsically Disordered and Globular Domains of a Model Viral Oncoprotein"
(2012) Chemes, L.B.;Glavina, J.;Alonso, L.G. (
...
)Sánchez, I.E. PLoS ONE. 7(10)
"Antiviral activity against dengue virus of diverse classes of algal sulfated polysaccharides"
(2012) Pujol, C.A.; Ray, S.; Ray, B.; Damonte, E.B. International Journal of Biological Macromolecules. 51(4):412-416
"Design, synthesis, calorimetry, and crystallographic analysis of 2-alkylaminoethyl-1,1-bisphosphonates as inhibitors of trypanosoma cruzi farnesyl diphosphate synthase"
(2012) Aripirala, S.;Szajnman, S.H.;Jakoncic, J. (
...
)Amzel, L.M. Journal of Medicinal Chemistry. 55(14):6445-6454
"Biological activity and ligand binding mode to the progesterone receptor of A-homo analogues of progesterone"
(2011) Alvarez, L.D.;Dansey, M.V.;Martí, M.A. (
...
)Burton, G. Bioorganic and Medicinal Chemistry. 19(5):1683-1691
"Inhibitory effect of quercetin on matrix metalloproteinase 9 activity Molecular mechanism and structure-activity relationship of the flavonoid-enzyme interaction"
(2010) Saragusti, A.C.;Ortega, M.G.;Cabrera, J.L. (
...
)Chiabrando, G.A. European Journal of Pharmacology. 644(1-3):138-145
"Antiproliferative activity of synthetic naphthoquinones related to lapachol. First synthesis of 5-hydroxylapachol"
(2010) Bonifazi, E.L.;Ríos-Luci, C.;León, L.G. (
...
)Misico, R.I. Bioorganic and Medicinal Chemistry. 18(7):2621-2630
"Xylans from Scinaia hatei: Structural features, sulfation and anti-HSV activity"
(2010) Mandal, P.;Pujol, C.A.;Damonte, E.B. (
...
)Ray, B. International Journal of Biological Macromolecules. 46(2):173-178
"Synthesis and biological evaluation of N-thia-carba-thymidine as an antiherpetic agent"
(2010) Elhalem, E.; Pujol, C.A.; Damonte, E.B.; Rodriguez, J.B. Tetrahedron. 66(18):3332-3340
"Insights on glucocorticoid receptor activity modulation through the binding of rigid steroids"
(2010) Presman, D.M.;Alvarez, L.D.;Levi, V. (
...
)Pecci, A. PLoS ONE. 5(10)
"Overview of anticoagulant activity of sulfated polysaccharides from seaweeds in relation to their structures, focusing on those of green seaweeds"
(2010) Ciancia, M.; Quintana, I.; Cerezo, A.S. Current Medicinal Chemistry. 17(23):2503-2529
"Sulfated xylomannans from the red seaweed Sebdenia polydactyla: Structural features, chemical modification and antiviral activity"
(2009) Ghosh, T.;Pujol, C.A.;Damonte, E.B. (
...
)Ray, B. Antiviral Chemistry and Chemotherapy. 19(6):235-242
"Antiproliferative, cytotoxic and hemolytic activities of a triterpene glycoside from Psolus patagonicus and its desulfated analog"
(2009) Careaga, V.P.;Bueno, C.;Muniain, C. (
...
)Maier, M.S. Chemotherapy. 55(1):60-68
"New lead compounds in the search for pure antiglucocorticoids and the dissociation of antiglucocorticoid effects"
(2009) Pecci, A.;Alvarez, L.D.;Veleiro, A.S. (
...
)Burton, G. Journal of Steroid Biochemistry and Molecular Biology. 113(3-5):155-162
"Allopregnanolone (3α-Hydroxy-5α-pregnan-20-one) derivatives with a polar chain in position 16α: Synthesis and activity"
(2009) Slavíková, B.;Krištofíková, Z.;Chodounská, H. (
...
)Kasal, A. Journal of Medicinal Chemistry. 52(7):2119-2125
"Structure-activity relationships of neuroactive steroids acting on the GABAA receptor"
(2009) Veleiro, A.S.; Burton, G. Current Medicinal Chemistry. 16(4):455-472
"Role of pre-A motif in nitric oxide scavenging by truncated hemoglobin, HbN, of Mycobacterium tuberculosis"
(2009) Lama, A.;Pawaria, S.;Bidon-Chanal, A. (
...
)Dikshit, K.L. Journal of Biological Chemistry. 284(21):14457-14468
"Synthesis and GABAA receptor activity of 2,19-sulfamoyl analogues of allopregnanolone"
(2009) Durán, F.J.;Edelsztein, V.C.;Ghini, A.A. (
...
)Burton, G. Bioorganic and Medicinal Chemistry. 17(18):6526-6533
"Synthesis of pentopyranosyl-containing thiodisaccharides. Inhibitory activity against β-glycosidases"
(2009) Cagnoni, A.J.; Uhrig, M.L.; Varela, O. Bioorganic and Medicinal Chemistry. 17(17):6203-6212
"Cruzipain, the major cysteine protease of Trypanosoma cruzi: A sulfated glycoprotein antigen as relevant candidate for vaccine development and drug target. A review"
(2009) Duschak, V.G.; Couto, A.S. Current Medicinal Chemistry. 16(24):3174-3202
"Synthesis and antiviral activity of azoles obtained from carbohydrates"
(2008) Barradas, J.S.;Errea, M.I.;D'Accorso, N.B. (
...
)Damonte, E.B. Carbohydrate Research. 343(14):2468-2474
"Hemisuccinate of 21-hydroxy-6,19-epoxyprogesterone: A tissue-specific modulator of the glucocorticoid receptor"
(2008) Álvarez, L.D.;Martí, M.A.;Veleiro, A.S. (
...
)Burton, G. ChemMedChem. 3(12):1869-1877
"Comparative rates of sialylation by recombinant trans-sialidase and inhibitor properties of synthetic oligosaccharides from Trypanosoma cruzi mucins-containing galactofuranose and galactopyranose"
(2007) Agustí, R.;Giorgi, M.E.;Mendoza, V.M. (
...
)de Lederkremer, R.M. Bioorganic and Medicinal Chemistry. 15(7):2611-2616
"Current status and progress made in malaria chemotherapy"
(2007) Liñares, G.E.G.; Rodriguez, J.B. Current Medicinal Chemistry. 14(3):289-314
"Syntheses of immunomodulating androstanes and stigmastanes: Comparison of their TNF-α inhibitory activity"
(2007) Ramírez, J.A.;Bruttomesso, A.C.;Michelini, F.M. (
...
)Galagovsky, L.R. Bioorganic and Medicinal Chemistry. 15(24):7538-7544
"Identification of regions critically affecting kinetics and allosteric regulation of the Escherichia coli ADP-glucose pyrophosphorylase by modeling and pentapeptide-scanning mutagenesis"
(2007) Ballicora, M.A.;Erben, E.D.;Yazaki, T. (
...
)Preiss, J. Journal of Bacteriology. 189(14):5325-5333
"Sperm protein "DE" mediates gamete fusion through an evolutionarily conserved site of the CRISP family"
(2006) Ellerman, D.A.;Cohen, D.J.;Da Ros, V.G. (
...
)Cuasnicú, P.S. Developmental Biology. 297(1):228-237
"Nucleoside phosphorylases"
(2006) Lewkowicz, E.S.; Iribarren, A.M. Current Organic Chemistry. 10(11):1197-1215
"The antennal benzoic acid receptor cell of the female silk moth Bombyx mori L.: Structure-activity relationship studies with halogen substitutes"
(2005) Sanchez, M.G.D.B.; Kaissling, K.-E. Journal of Comparative Physiology A: Neuroethology, Sensory, Neural, and Behavioral Physiology. 191(2):189-196
"Molecular mechanism of activation and nuclear translocation of the mineralocorticoid receptor upon binding of pregnanesteroids"
(2004) Galigniana, M.D.;Pilipuk, G.P.;Kanelakis, K.C. (
...
)Lantos, C.P. Molecular and Cellular Endocrinology. 217(1-2):167-179
"The structure of the agaran sulfate from Acanthophora spicifera (Rhodomelaceae, Ceramiales) and its antiviral activity. Relation between structure and antiviral activity in agarans"
(2004) Duarte, M.E.R.;Cauduro, J.P.;Noseda, D.G. (
...
)Cerezo, A.S. Carbohydrate Research. 339(2):335-347
"Antiviral activity of natural and synthetic brassinosteroids"
(2004) Wachsman, M.B.;Ramírez, J.A.;Talarico, L.B. (
...
)Coto, C.E. Current Medicinal Chemistry: Anti-Infective Agents. 3(2):163-179
"Structural and functional complexity of the humoral response against the Trypanosoma cruzi ribosomal P2β protein in patients with chronic Chagas' heart disease"
(2004) Mahler, E.; Hoebeke, J.; Levin, M.J. Clinical and Experimental Immunology. 136(3):527-534
"Oxido-bridged neurosteroid analogues. Synthesis of 2,19-oxido-allopregnanolone"
(2003) Eduardo, S.L.; Ghini, A.A.; Burton, G. Arkivoc. 2003(10):468-476
"Synthesis and isolation of chloro-β-carbolines obtained by chlorination of β-carboline alkaloids in solution and in solid state"
(2003) Ponce, M.A.; Tarzi, O.I.; Erra-Balsells, R. Journal of Heterocyclic Chemistry. 40(3):419-426
"Inhibitory effect of thiosemicarbazone derivatives on Junin virus replication in vitro"
(2003) García, C.C.;Brousse, B.N.;Carlucci, M.J. (
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)Damonte, E.B. Antiviral Chemistry and Chemotherapy. 14(2):99-105
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