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Vicent, G.P.; Burton, G.; Ghini, A.; Lantos, C.P.; Galigniana, M.D. "Influence of calf serum on glucocorticoid-responses of certain progesterone derivatives" (1998) Journal of Steroid Biochemistry and Molecular Biology. 66(4):211-216
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Abstract:

The following in vitro glucocorticoid (GC) parameters of progesterone (P), 1-ene progesterone (ΔP), 11β-hydroxyprogesterone (HOP), 11β-1-ene progesterone (ΔHOP) and dexamethasone (Dexa) were assayed in the presence or absence of bovine calf serum (BCS): binding to thymus cytosol, dissociation of the glucocorticoid receptor (GR)-heat shock protein 90 (hsp90) complex (diss.), tyrosine aminotransferase (TAT) induction in hepatocytes and the inhibition of 3H-uridine and 35S-methionine uptake by thymocytes. Without BCS, steroids were in most cases active in this general order: Dex>ΔHOP>HOP>ΔP>P. BCS abolished all activities in P and ΔP, but left them unaltered in all other steroids, except diss. in HOP, which diminished intermediately. Binding of P, ΔP, HOP and ΔHOP to GR and CBG paralleled their in vivo activating effects on glycogen deposition. Conclusions: in this steroid series, BCS, but not CBG, inhibits GC responses of P and ΔP. 11-β hydroxylation frees those molecules from the inhibitory effects of BCS.

Registro:

Documento: Artículo
Título:Influence of calf serum on glucocorticoid-responses of certain progesterone derivatives
Autor:Vicent, G.P.; Burton, G.; Ghini, A.; Lantos, C.P.; Galigniana, M.D.
Filiación:Laboratorio de Esteroides, Depto. Quim. Biol. and PRHOM-CONICET, Universidad de Buenos Aires, Buenos Aires (1428), Argentina
Depto. de Quim. Orgánica, Fac. de Cie. Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires (1428), Argentina
Palabras clave:11beta hydroxyprogesterone; dexamethasone; glucocorticoid receptor; heat shock protein; progesterone; tyrosine aminotransferase; amino acid transport; animal cell; article; controlled study; enzyme induction; glycogen synthesis; hormone action; hormone binding; hormone receptor interaction; mouse; nonhuman; structure activity relation; thymocyte; Adrenalectomy; Animals; Blood; Cattle; Cells, Cultured; Corticosterone; Cytosol; Dexamethasone; Enzyme Induction; HSP90 Heat-Shock Proteins; Liver; Liver Glycogen; Male; Methionine; Mice; Mice, Inbred BALB C; Progesterone; Rats; Rats, Sprague-Dawley; Receptors, Glucocorticoid; Structure-Activity Relationship; Thymus Gland; Transcortin; Tyrosine Transaminase; Uridine; Animalia; Bovinae; Humulus
Año:1998
Volumen:66
Número:4
Página de inicio:211
Página de fin:216
DOI: http://dx.doi.org/10.1016/S0960-0760(98)00040-5
Título revista:Journal of Steroid Biochemistry and Molecular Biology
Título revista abreviado:J. Steroid Biochem. Mol. Biol.
ISSN:09600760
CODEN:JSBBE
CAS:Corticosterone, 50-22-6; Dexamethasone, 50-02-2; HSP90 Heat-Shock Proteins; Liver Glycogen; Methionine, 63-68-3; Progesterone, 57-83-0; Receptors, Glucocorticoid; Transcortin, 9010-38-2; Tyrosine Transaminase, EC 2.6.1.5; Uridine, 58-96-8
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09600760_v66_n4_p211_Vicent

Referencias:

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Citas:

---------- APA ----------
Vicent, G.P., Burton, G., Ghini, A., Lantos, C.P. & Galigniana, M.D. (1998) . Influence of calf serum on glucocorticoid-responses of certain progesterone derivatives. Journal of Steroid Biochemistry and Molecular Biology, 66(4), 211-216.
http://dx.doi.org/10.1016/S0960-0760(98)00040-5
---------- CHICAGO ----------
Vicent, G.P., Burton, G., Ghini, A., Lantos, C.P., Galigniana, M.D. "Influence of calf serum on glucocorticoid-responses of certain progesterone derivatives" . Journal of Steroid Biochemistry and Molecular Biology 66, no. 4 (1998) : 211-216.
http://dx.doi.org/10.1016/S0960-0760(98)00040-5
---------- MLA ----------
Vicent, G.P., Burton, G., Ghini, A., Lantos, C.P., Galigniana, M.D. "Influence of calf serum on glucocorticoid-responses of certain progesterone derivatives" . Journal of Steroid Biochemistry and Molecular Biology, vol. 66, no. 4, 1998, pp. 211-216.
http://dx.doi.org/10.1016/S0960-0760(98)00040-5
---------- VANCOUVER ----------
Vicent, G.P., Burton, G., Ghini, A., Lantos, C.P., Galigniana, M.D. Influence of calf serum on glucocorticoid-responses of certain progesterone derivatives. J. Steroid Biochem. Mol. Biol. 1998;66(4):211-216.
http://dx.doi.org/10.1016/S0960-0760(98)00040-5