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Abstract:

Twelve polyhydroxylated sulfated steroids synthesized from a 5α-cholestane skeleton with different substitutions in C-2, C-3 and C-6 were evaluated for cytotoxicity and antiviral activity against herpes simplex virus (HSV) by a virus plaque reduction assay. Four compounds elicited a selective inhibitory effect against HSV. The disodium salt of 2β,3α-dihydroxy-6E-hydroximine-5α-cholestane-2,3-disulfate, named compound 7, was the most effective inhibitor of HSV-1, HSV-2 and pseudorabies virus (PrV) strains, including acyclovir-resistant variants, in human and monkey cell lines. Preliminary mechanistic studies demonstrated that compound 7 did not affect the initial steps of virus entry but inhibited a subsequent event in the infection process of HSV. © 2016, Springer-Verlag Wien.

Registro:

Documento: Artículo
Título:Polyhydroxylated sulfated steroids derived from 5α-cholestanes as antiviral agents against herpes simplex virus
Autor:Pujol, C.A.; Sepúlveda, C.S.; Richmond, V.; Maier, M.S.; Damonte, E.B.
Filiación:Laboratorio de Virología, Departamento de Química Biológica- IQUIBICEN (CONICET-UBA), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellón 2, Piso 4, Buenos Aires, 1428, Argentina
Departamento de Química Orgánica- UMYMFOR (CONICET-UBA), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellón 2, Piso 3, Buenos Aires, 1428, Argentina
Palabras clave:5α-Cholestanes; Antiviral activity; Herpes simplex virus; Polyhydroxylated sulfated steroids; antivirus agent; cholestane derivative; steroid; animal; cell line; chemical structure; chemistry; drug effects; genital herpes; herpes simplex; Herpes simplex virus 1; Herpes simplex virus 2; human; physiology; structure activity relation; virology; virus entry; Animals; Antiviral Agents; Cell Line; Cholestanes; Herpes Genitalis; Herpes Simplex; Herpesvirus 1, Human; Herpesvirus 2, Human; Humans; Molecular Structure; Steroids; Structure-Activity Relationship; Virus Internalization
Año:2016
Volumen:161
Número:7
Página de inicio:1993
Página de fin:1999
DOI: http://dx.doi.org/10.1007/s00705-016-2867-y
Título revista:Archives of Virology
Título revista abreviado:Arch. Virol.
ISSN:03048608
CODEN:ARVID
CAS:Antiviral Agents; Cholestanes; Steroids
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03048608_v161_n7_p1993_Pujol

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Citas:

---------- APA ----------
Pujol, C.A., Sepúlveda, C.S., Richmond, V., Maier, M.S. & Damonte, E.B. (2016) . Polyhydroxylated sulfated steroids derived from 5α-cholestanes as antiviral agents against herpes simplex virus. Archives of Virology, 161(7), 1993-1999.
http://dx.doi.org/10.1007/s00705-016-2867-y
---------- CHICAGO ----------
Pujol, C.A., Sepúlveda, C.S., Richmond, V., Maier, M.S., Damonte, E.B. "Polyhydroxylated sulfated steroids derived from 5α-cholestanes as antiviral agents against herpes simplex virus" . Archives of Virology 161, no. 7 (2016) : 1993-1999.
http://dx.doi.org/10.1007/s00705-016-2867-y
---------- MLA ----------
Pujol, C.A., Sepúlveda, C.S., Richmond, V., Maier, M.S., Damonte, E.B. "Polyhydroxylated sulfated steroids derived from 5α-cholestanes as antiviral agents against herpes simplex virus" . Archives of Virology, vol. 161, no. 7, 2016, pp. 1993-1999.
http://dx.doi.org/10.1007/s00705-016-2867-y
---------- VANCOUVER ----------
Pujol, C.A., Sepúlveda, C.S., Richmond, V., Maier, M.S., Damonte, E.B. Polyhydroxylated sulfated steroids derived from 5α-cholestanes as antiviral agents against herpes simplex virus. Arch. Virol. 2016;161(7):1993-1999.
http://dx.doi.org/10.1007/s00705-016-2867-y