Artículo

Sassetti, B.; Vizcargüénaga, M.I.; Zanaro, N.L.; Silva, M.V.; Kordich, L.; Florentini, L.; Diaz, M.; Vitacco, M.; Sanchez Avalos, J.C. "Hemolytic uremic syndrome in children: Platelet aggregation and membrane glycoproteins" (1999) Journal of Pediatric Hematology/Oncology. 21(2):123-128
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Abstract:

Purpose: Several mechanisms have been proposed to explain the fibrin- platelet thrombosis at the microcirculation level in the different clinical conditions of hemolytic uremic syndrome (HUS). The relationships between platelet structure and function during the first 4 weeks of evolution of the disease were studied to understand the mechanism of platelet alteration. Patients and Methods: Coagulation parameters, platelet counts, and aggregation were studied in 49 children, and membrane glycoproteins (GPs) in 20 of the 49 children (mean age, 17 months) with HUS (Group 2) were studied during the first 4 weeks of evolution of the disease. Results: No disseminated intravascular coagulation was found in patients with recurrent or persistent thrombocytopenia. Platelet aggregation was sequentially performed during the first weeks of evolution. All patients had a functional decrease in the acute period of HUS. Platelet GPs GPIb, GPIIbIIIa, GPIIb, and GPIIIa were evaluated. GPIIbIIIa complex presented low level and never reached normal values during the first 4 weeks of disease. Conclusions: Platelet alterations are probably caused by multiple mechanisms: 'exhausted' platelets, structural membrane alterations caused by arginine-glycine- aspartic peptide blockade, or diminished or nonfunctional membrane GPIb and GPIIbIIIa complexes.

Registro:

Documento: Artículo
Título:Hemolytic uremic syndrome in children: Platelet aggregation and membrane glycoproteins
Autor:Sassetti, B.; Vizcargüénaga, M.I.; Zanaro, N.L.; Silva, M.V.; Kordich, L.; Florentini, L.; Diaz, M.; Vitacco, M.; Sanchez Avalos, J.C.
Filiación:Depto. de Quim. Biológica, Fac. de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Hemostasia, Argentina
Hospital Privado Güemes, Hemostasia, Argentina
Hospital J.P. Garrahan, Nefrología, Argentina
Hosp. de Clinicas, J. de S. Martin, Universidad de Buenos Aires, Buenos Aires, Argentina
Fac. de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellon II 4 P, 1428-Buenos Aires, Argentina
Palabras clave:Children; Glycoproteins; GPIIbIIIa; HUS; Platelets; Uremic hemolytic syndrome; fibrinogen receptor; glycoprotein; glycoprotein Ib; glycoprotein IIb; membrane protein; very late activation antigen 2; article; clinical article; controlled study; female; hemolytic uremic syndrome; human; human cell; human tissue; infant; male; molecular dynamics; pathophysiology; preschool child; priority journal; protein expression; structure activity relation; thrombocyte aggregation; thrombocyte count; Bacterial Toxins; Blood Coagulation Factors; Blood Proteins; Child, Preschool; Diarrhea, Infantile; Dysentery, Bacillary; Endothelium, Vascular; Escherichia coli Infections; Female; Hemolytic-Uremic Syndrome; Humans; Infant; Male; Microcirculation; Platelet Aggregation; Platelet Count; Platelet Membrane Glycoproteins; Shiga-Like Toxin I; Spleen; Thrombophilia; Trihexosylceramides
Año:1999
Volumen:21
Número:2
Página de inicio:123
Página de fin:128
DOI: http://dx.doi.org/10.1097/00043426-199903000-00008
Título revista:Journal of Pediatric Hematology/Oncology
Título revista abreviado:J. Pediatr. Hematol. Oncol.
ISSN:10774114
CODEN:JPHOF
CAS:Bacterial Toxins; Blood Coagulation Factors; Blood Proteins; globotriaosylceramide, 71965-57-6; Platelet Membrane Glycoproteins; Shiga-Like Toxin I; Trihexosylceramides
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10774114_v21_n2_p123_Sassetti

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Citas:

---------- APA ----------
Sassetti, B., Vizcargüénaga, M.I., Zanaro, N.L., Silva, M.V., Kordich, L., Florentini, L., Diaz, M.,..., Sanchez Avalos, J.C. (1999) . Hemolytic uremic syndrome in children: Platelet aggregation and membrane glycoproteins. Journal of Pediatric Hematology/Oncology, 21(2), 123-128.
http://dx.doi.org/10.1097/00043426-199903000-00008
---------- CHICAGO ----------
Sassetti, B., Vizcargüénaga, M.I., Zanaro, N.L., Silva, M.V., Kordich, L., Florentini, L., et al. "Hemolytic uremic syndrome in children: Platelet aggregation and membrane glycoproteins" . Journal of Pediatric Hematology/Oncology 21, no. 2 (1999) : 123-128.
http://dx.doi.org/10.1097/00043426-199903000-00008
---------- MLA ----------
Sassetti, B., Vizcargüénaga, M.I., Zanaro, N.L., Silva, M.V., Kordich, L., Florentini, L., et al. "Hemolytic uremic syndrome in children: Platelet aggregation and membrane glycoproteins" . Journal of Pediatric Hematology/Oncology, vol. 21, no. 2, 1999, pp. 123-128.
http://dx.doi.org/10.1097/00043426-199903000-00008
---------- VANCOUVER ----------
Sassetti, B., Vizcargüénaga, M.I., Zanaro, N.L., Silva, M.V., Kordich, L., Florentini, L., et al. Hemolytic uremic syndrome in children: Platelet aggregation and membrane glycoproteins. J. Pediatr. Hematol. Oncol. 1999;21(2):123-128.
http://dx.doi.org/10.1097/00043426-199903000-00008