Artículo
Gil, R.R.; Misico, R.I.; Sotes, I.R.; Oberti, J.C.; Veleiro, A.S.; Burton, G. "16-hydroxylated withanolides from Exodeconus maritimus" (1997) Journal of Natural Products. 60(6):568-572
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Abstract:
In addition to the known compounds withanolide A (4), withanone (5), and NIC-3 (6), three 16-hydroxylated withanolides were isolated from Exodeconus maritimus. The new withanolides were identified as 6α,7α-epoxy-5α,16β- dihydroxy-1-oxowitha-2,17(20),24-trienolide (exodeconolide A, 1), 6α,7α- epoxy-5α,16α-dihydroxy-l-oxowitha-2,17(20),24-trienolide (exodeconolide B, 2), and 6α7α-epoxy-5α,16α,17α-trihydroxy-1-oxowitha-2, 24-dienolide (exodeconolide C, 3), by a combination of spectroscopic (1D and 2D NMR, MS) and chemical methods with the aid of molecular modeling.
Registro:
| Documento: | Artículo |
| Título: | 16-hydroxylated withanolides from Exodeconus maritimus |
| Autor: | Gil, R.R.; Misico, R.I.; Sotes, I.R.; Oberti, J.C.; Veleiro, A.S.; Burton, G. |
| Filiación: | Depto. de Quim. Organ. and IMBIV, Facultad de Ciencias Químicas, Univ. Nacional de Córdoba, Agenda Postal 4-CC 61, 5000 Córdoba, Argentina Depto. de Quim. Orgánica, Fac. de Ciencias Exactas y Naturales, Universidad de Buenos Aires, 1428 Buenos Aires, Argentina |
| Palabras clave: | exodeconolide a; exodeconolide b; exodeconolide c; nic 3; unclassified drug; withanolide; withanolide a; withanone; antiinflammatory activity; antimicrobial activity; antineoplastic activity; article; defense mechanism; drug isolation; drug structure; immunomodulation; mass spectrometry; nuclear magnetic resonance; phytochemistry; species differentiation; structure activity relation; taxonomy; Exodeconus maritimus |
| Año: | 1997 |
| Volumen: | 60 |
| Número: | 6 |
| Página de inicio: | 568 |
| Página de fin: | 572 |
| DOI: | http://dx.doi.org/10.1021/np970048z |
| Título revista: | Journal of Natural Products |
| Título revista abreviado: | J. NAT. PROD. |
| ISSN: | 01633864 |
| CODEN: | JNPRD |
| CAS: | withanolide, 40326-62-3 |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01633864_v60_n6_p568_Gil |
Referencias:
- Axelius, B., (1994) Plants System. Evol., 193, pp. 153-172
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- Kirson, I., Glotter, E., Lavie, D., (1971) J. Chem. Soc. (C), pp. 2032-2044
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- Kirson, I., Glotter, E., Lavie, D., Abraham, A., (1971) J. Chem. Soc. (C), pp. 2032-2044
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- See, for example, Kirson et. al. in reference 7; Pelletier, S.W., Chokshi, H.P., Desai, H.K., (1986) J. Nat. Prod., 49, pp. 892-900
Citas:
---------- APA ----------
Gil, R.R., Misico, R.I., Sotes, I.R., Oberti, J.C., Veleiro, A.S. & Burton, G. (1997) . 16-hydroxylated withanolides from Exodeconus maritimus. Journal of Natural Products, 60(6), 568-572.http://dx.doi.org/10.1021/np970048z
---------- CHICAGO ----------
Gil, R.R., Misico, R.I., Sotes, I.R., Oberti, J.C., Veleiro, A.S., Burton, G. "16-hydroxylated withanolides from Exodeconus maritimus" . Journal of Natural Products 60, no. 6 (1997) : 568-572.http://dx.doi.org/10.1021/np970048z
---------- MLA ----------
Gil, R.R., Misico, R.I., Sotes, I.R., Oberti, J.C., Veleiro, A.S., Burton, G. "16-hydroxylated withanolides from Exodeconus maritimus" . Journal of Natural Products, vol. 60, no. 6, 1997, pp. 568-572.http://dx.doi.org/10.1021/np970048z
---------- VANCOUVER ----------
Gil, R.R., Misico, R.I., Sotes, I.R., Oberti, J.C., Veleiro, A.S., Burton, G. 16-hydroxylated withanolides from Exodeconus maritimus. J. NAT. PROD. 1997;60(6):568-572.http://dx.doi.org/10.1021/np970048z
