Artículo

Molinari, A.M.; Machado-Rada, M.Y.; Mazaira, G.I.; Erlejman, A.G.; Galigniana, M.D. "Molecular basis of mineralocorticoid receptor action in the nervous system" (2013) CNS and Neurological Disorders - Drug Targets. 12(8):1163-1174
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Abstract:

The most relevant biological action of aldosterone in epithelial tissues is the regulation of sodium reabsorption through binding to the mineralocorticoid receptor (MR). Glucocorticoids also bind with high affinity to MR, which is usually protected by the enzyme 11β-hydroxysteroid dehydrogenase. This activity prevents MR activation by cortisol despite the large prevalence of this steroid in plasma. Nonetheless, there are some aspects of the mechanism of action of MR that are not entirely explained by this competitive metabolic mechanism of protection. The picture is even more complicated in those tissues such as the nervous system where the enzyme is expressed at very low levels or is directly absent in various areas of the brain. Therefore, other cellular and molecular mechanisms must also intervene to allow specific aldosterone biological effects in the presence of overwhelming concentrations of glucocorticoids. In this article, we discuss some possible mechanisms that permit the specificity of action for each type of steroid, including those related to the recently discovered novel molecular mechanism of activation of corticosteroid receptors and the structural requirements of a given ligand to favor the mineralocorticoid action via MR. The relative contribution of these mechanisms may vary in different target cells allowing the fine tuning of cellular functions depending on the degree of cooperation between steroids, receptors, chaperones associated to receptors, and other factors. All these regulatory interactions can be altered in some pathophysiological situations, most of them related to stressing situations. © 2013 Bentham Science Publishers.

Registro:

Documento: Artículo
Título:Molecular basis of mineralocorticoid receptor action in the nervous system
Autor:Molinari, A.M.; Machado-Rada, M.Y.; Mazaira, G.I.; Erlejman, A.G.; Galigniana, M.D.
Filiación:Departamento de Química Biológica, IQUIBICEN, Universidad de Buenos Aires, Argentina
IBYME, CONICET, Buenos Aires, Argentina
Palabras clave:Aldosterone; Cortisol; Glucocorticoid receptor; Heat-shock protein of 90-kDa; Immunophilins; Mineralocorticoid receptor; Steroid conformation; Stress disorders; 11beta hydroxysteroid dehydrogenase; aldosterone; alpha fetoprotein; androgen; androgen receptor; cyclooxygenase 2; cyclosporin; ecdysone; epithelial sodium channel; estrogen; estrogen receptor; glucocorticoid; hydrocortisone; interleukin 1beta; interleukin 6; leukotriene; mineralocorticoid; mineralocorticoid receptor; oxysterol; progesterone; progesterone receptor; prostaglandin; prostaglandin E2; sex hormone binding globulin; steroid receptor; tacrolimus; thyroid hormone; tumor necrosis factor alpha; unindexed drug; vitamin D; aldosterone; glucocorticoid; mineralocorticoid receptor; protein binding; article; autoradiography; biological activity; chromatin immunoprecipitation; dimerization; DNA binding; dose response; electrolyte transport; gene mutation; hormonal regulation; human; inflammation; major depression; nervous system; nonhuman; protein phosphorylation; regulatory mechanism; signal transduction; structure activity relation; agonists; animal; chemistry; drug effects; mental stress; metabolism; nervous system; pathology; physiology; Aldosterone; Animals; Glucocorticoids; Humans; Nervous System; Protein Binding; Receptors, Mineralocorticoid; Signal Transduction; Stress, Psychological
Año:2013
Volumen:12
Número:8
Página de inicio:1163
Página de fin:1174
Título revista:CNS and Neurological Disorders - Drug Targets
Título revista abreviado:CNS Neurol. Disord. Drug Targets
ISSN:18715273
CAS:11beta hydroxysteroid dehydrogenase, 9041-46-7; aldosterone, 52-39-1, 6251-69-0; cyclosporin, 79217-60-0; hydrocortisone, 50-23-7; progesterone, 57-83-0; prostaglandin E2, 363-24-6; tacrolimus, 104987-11-3; Aldosterone; Glucocorticoids; Receptors, Mineralocorticoid
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_18715273_v12_n8_p1163_Molinari

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Citas:

---------- APA ----------
Molinari, A.M., Machado-Rada, M.Y., Mazaira, G.I., Erlejman, A.G. & Galigniana, M.D. (2013) . Molecular basis of mineralocorticoid receptor action in the nervous system. CNS and Neurological Disorders - Drug Targets, 12(8), 1163-1174.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_18715273_v12_n8_p1163_Molinari [ ]
---------- CHICAGO ----------
Molinari, A.M., Machado-Rada, M.Y., Mazaira, G.I., Erlejman, A.G., Galigniana, M.D. "Molecular basis of mineralocorticoid receptor action in the nervous system" . CNS and Neurological Disorders - Drug Targets 12, no. 8 (2013) : 1163-1174.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_18715273_v12_n8_p1163_Molinari [ ]
---------- MLA ----------
Molinari, A.M., Machado-Rada, M.Y., Mazaira, G.I., Erlejman, A.G., Galigniana, M.D. "Molecular basis of mineralocorticoid receptor action in the nervous system" . CNS and Neurological Disorders - Drug Targets, vol. 12, no. 8, 2013, pp. 1163-1174.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_18715273_v12_n8_p1163_Molinari [ ]
---------- VANCOUVER ----------
Molinari, A.M., Machado-Rada, M.Y., Mazaira, G.I., Erlejman, A.G., Galigniana, M.D. Molecular basis of mineralocorticoid receptor action in the nervous system. CNS Neurol. Disord. Drug Targets. 2013;12(8):1163-1174.
Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_18715273_v12_n8_p1163_Molinari [ ]