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Abstract:

Studies on structure-activity relationships were carried out to characterize the response specificity of the benzoic acid cell of the female of the moth Bombyx mori by means of single sensillum electrophysiological recordings. We demonstrated that this cell type responds best to a natural key substance (benzoic acid) and has similar response profiles for less effective compounds, including various halogen substitutes of benzoic acid, benzaldehyde and other derivates of the key compound. Using different halogen substitutes (F, Cl, Br, I), we showed that the cellular response decreases with increasing atomic size of the substitute and that halogen substitutes were most effective in the meta-position. Thus, m-fluor benzoic acid was even more effective than benzoic acid. These results indicate that a critical feature of the stimulus molecule is the inductive effect generated by the halogen substitutes. Increasing the atomic size of the halogen substitute impairs the recognition of the molecule by the receptor cell, possibly due to steric effects. Decreasing the electron density in the aromatic ring improves the receptor response. The benzoic acid receptor cell can be considered as specialist despite not being involved in pheromone detection as it responds maximally to a key substance and has similar response profiles for less effective compounds. © Springer-Verlag 2004.

Registro:

Documento: Artículo
Título:The antennal benzoic acid receptor cell of the female silk moth Bombyx mori L.: Structure-activity relationship studies with halogen substitutes
Autor:Sanchez, M.G.D.B.; Kaissling, K.-E.
Filiación:Lab. de Fisiologia de Insectos, FCEyN, Ciudad Universitaria, 1428 Buenos Aires, Argentina
Max-Planck-Inst. F. V., 82319 Seewiesen/Starnberg, Germany
Ctr. de Rech. Sur la Cogn. Animale, Université Paul-Sabatier, CNRS, 118, route de Narbonne, 31062 Toulouse Cedex 04, France
Palabras clave:Benzoic acid; Bombyx mori; Olfaction; Olfactory receptor cell; Structure-activity relationships; benzoic acid; halogen; action potential; animal; article; chemistry; chemoreceptor; comparative study; dose response; drug effect; female; physiology; silkworm; structure activity relation; Action Potentials; Animals; Benzoic Acid; Bombyx; Chemoreceptors; Dose-Response Relationship, Drug; Female; Halogens; Structure-Activity Relationship
Año:2005
Volumen:191
Número:2
Página de inicio:189
Página de fin:196
DOI: http://dx.doi.org/10.1007/s00359-004-0588-2
Título revista:Journal of Comparative Physiology A: Neuroethology, Sensory, Neural, and Behavioral Physiology
Título revista abreviado:J. Comp. Physiol. A Neuroethol. Sens. Neural. Behav. Physiol.
ISSN:03407594
CODEN:JCPAD
CAS:benzoic acid, 532-32-1, 582-25-2, 65-85-0, 766-76-7; Benzoic Acid, 65-85-0; Halogens
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03407594_v191_n2_p189_Sanchez

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Citas:

---------- APA ----------
Sanchez, M.G.D.B. & Kaissling, K.-E. (2005) . The antennal benzoic acid receptor cell of the female silk moth Bombyx mori L.: Structure-activity relationship studies with halogen substitutes. Journal of Comparative Physiology A: Neuroethology, Sensory, Neural, and Behavioral Physiology, 191(2), 189-196.
http://dx.doi.org/10.1007/s00359-004-0588-2
---------- CHICAGO ----------
Sanchez, M.G.D.B., Kaissling, K.-E. "The antennal benzoic acid receptor cell of the female silk moth Bombyx mori L.: Structure-activity relationship studies with halogen substitutes" . Journal of Comparative Physiology A: Neuroethology, Sensory, Neural, and Behavioral Physiology 191, no. 2 (2005) : 189-196.
http://dx.doi.org/10.1007/s00359-004-0588-2
---------- MLA ----------
Sanchez, M.G.D.B., Kaissling, K.-E. "The antennal benzoic acid receptor cell of the female silk moth Bombyx mori L.: Structure-activity relationship studies with halogen substitutes" . Journal of Comparative Physiology A: Neuroethology, Sensory, Neural, and Behavioral Physiology, vol. 191, no. 2, 2005, pp. 189-196.
http://dx.doi.org/10.1007/s00359-004-0588-2
---------- VANCOUVER ----------
Sanchez, M.G.D.B., Kaissling, K.-E. The antennal benzoic acid receptor cell of the female silk moth Bombyx mori L.: Structure-activity relationship studies with halogen substitutes. J. Comp. Physiol. A Neuroethol. Sens. Neural. Behav. Physiol. 2005;191(2):189-196.
http://dx.doi.org/10.1007/s00359-004-0588-2