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Abstract:

Background: Many viruses display affinity for cell surface heparan sulfate proteoglycans with biological relevance in virus entry. This raises the possibility of the application of sulfated polysaccharides in antiviral therapy. Methods: In this study, we analysed polysaccharide fractions isolated from Sebdenia polydactyla. Results: The purified xylomannan sulfate and its further sulfated derivatives showed strong activity against herpes simplex virus type-1 (HSV-1). Their 50% inhibitory concentration values were in the range 0.35-2.8 μg/ ml and they lacked cytotoxicity at concentrations up to 1,000 μg/ml. The major polysaccharide, which had 0.6 sulfate groups per monomer unit and an apparent molecular mass of 150 kDa, contained a backbone of α-(1→3)- linked D-mannopyranosyl residues substituted at position 6 with a single stub of β-d-xylopyranosyl residues. Conclusions: The degree of sulfation seemed to play an important role because desulfation and/or further sulfation of the isolated macromolecules largely influenced their in vitro anti-HSV-1 activity. ©2009 International Medical Press.

Registro:

Documento: Artículo
Título:Sulfated xylomannans from the red seaweed Sebdenia polydactyla: Structural features, chemical modification and antiviral activity
Autor:Ghosh, T.; Pujol, C.A.; Damonte, E.B.; Sinha, S.; Ray, B.
Filiación:Natural Products Laboratory, Department of Chemistry, University of Burdwan, West Bengal, India
Departamento de Química Biológica, Facultad de Ciencias Exactas Y Naturales UBA, Ciudad Universitaria-Pabellón II, Buenos Aires, Argentina
Palabras clave:monomer; polysaccharide; unclassified drug; xylomannan derivative; animal cell; antiviral activity; article; chemical modification; drug cytotoxicity; drug isolation; drug selectivity; Herpes simplex virus 1; IC 50; in vitro study; macromolecule; molecular weight; nonhuman; priority journal; seaweed; Sebdenia polydactyla; structure activity relation; sulfation
Año:2009
Volumen:19
Número:6
Página de inicio:235
Página de fin:242
DOI: http://dx.doi.org/10.1177/095632020901900603
Título revista:Antiviral Chemistry and Chemotherapy
Título revista abreviado:Antiviral Chem. Chemother.
ISSN:09563202
CODEN:ACCHE
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09563202_v19_n6_p235_Ghosh

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Citas:

---------- APA ----------
Ghosh, T., Pujol, C.A., Damonte, E.B., Sinha, S. & Ray, B. (2009) . Sulfated xylomannans from the red seaweed Sebdenia polydactyla: Structural features, chemical modification and antiviral activity. Antiviral Chemistry and Chemotherapy, 19(6), 235-242.
http://dx.doi.org/10.1177/095632020901900603
---------- CHICAGO ----------
Ghosh, T., Pujol, C.A., Damonte, E.B., Sinha, S., Ray, B. "Sulfated xylomannans from the red seaweed Sebdenia polydactyla: Structural features, chemical modification and antiviral activity" . Antiviral Chemistry and Chemotherapy 19, no. 6 (2009) : 235-242.
http://dx.doi.org/10.1177/095632020901900603
---------- MLA ----------
Ghosh, T., Pujol, C.A., Damonte, E.B., Sinha, S., Ray, B. "Sulfated xylomannans from the red seaweed Sebdenia polydactyla: Structural features, chemical modification and antiviral activity" . Antiviral Chemistry and Chemotherapy, vol. 19, no. 6, 2009, pp. 235-242.
http://dx.doi.org/10.1177/095632020901900603
---------- VANCOUVER ----------
Ghosh, T., Pujol, C.A., Damonte, E.B., Sinha, S., Ray, B. Sulfated xylomannans from the red seaweed Sebdenia polydactyla: Structural features, chemical modification and antiviral activity. Antiviral Chem. Chemother. 2009;19(6):235-242.
http://dx.doi.org/10.1177/095632020901900603