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Abstract:

Diverse classes of sulfated polysaccharides obtained from the red seaweeds (Rhodophyta) Grateloupia indica, Scinaia hatei and Gracilaria corticata, the brown seaweeds (Phaeophyta) Stoechospermum marginatum and Cystoseira indica and the green seaweed (Chlorophyta) Caulerpa racemosa were assayed for antiviral activity against the four serotypes of dengue virus (DENV). DENV-2 was the most susceptible serotype to all polysulfates, with inhibitory concentration 50% values in the range 0.12-20. μg/mL. The antiviral potency of the sulfated polysaccharides depended on the sulfate content, the position of sulfate group, the sugar composition, and the molar mass. Independently of the sugar composition, the antiviral effect was mainly exerted during DENV-2 adsorption and internalization. © 2012 Elsevier B.V.

Registro:

Documento: Artículo
Título:Antiviral activity against dengue virus of diverse classes of algal sulfated polysaccharides
Autor:Pujol, C.A.; Ray, S.; Ray, B.; Damonte, E.B.
Filiación:Laboratorio de Virología, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón 2, Piso 4, Ciudad Universitaria, 1428 Buenos Aires, Argentina
Natural Products Laboratory, Department of Chemistry, University of Burdwan, WB 713 104, India
Palabras clave:Algal sulfated polysaccharides; Antiviral activity; Dengue virus; Sugar composition; algal extract; antivirus agent; dextran sulfate; ds 8000; fucan sulfate; galactan; galactan sulfate; heparin; hot water; polysaccharide sulfate; unclassified drug; xylomannan sulfate; animal cell; antiviral activity; antiviral susceptibility; article; brown alga; carbohydrate analysis; Caulerpa racemosa; cell viability; Cystoseira indica; dengue; Dengue virus; Dengue virus 1; Dengue virus 2; Dengue virus 3; Dengue virus 4; drug cytotoxicity; drug determination; drug efficacy; drug isolation; drug potency; drug structure; Gracilaria corticata; Grateloupia indica; green alga; IC 50; in vitro study; infection control; molecular weight; nonhuman; red alga; Scinaia hatei; Stoechospermum marginatum; structure activity relation; Vero cell; virus attachment; virus entry; virus inhibition; Animals; Antiviral Agents; Cercopithecus aethiops; Chlorophyta; Dengue Virus; Phaeophyta; Polysaccharides; Rhodophyta; Sulfates; Vero Cells; algae; Caulerpa racemosa; Chlorophyta; Cystoseira indica; Dengue virus; Gracilaria corticata; Grateloupia; Phaeophyceae; Rhodophyta; Scinaia; Stoechospermum marginatum
Año:2012
Volumen:51
Número:4
Página de inicio:412
Página de fin:416
DOI: http://dx.doi.org/10.1016/j.ijbiomac.2012.05.028
Título revista:International Journal of Biological Macromolecules
Título revista abreviado:Int. J. Biol. Macromol.
ISSN:01418130
CODEN:IJBMD
CAS:dextran sulfate, 9011-18-1, 9042-14-2; galactan, 39300-87-3, 9037-55-2; heparin, 37187-54-5, 8057-48-5, 8065-01-8, 9005-48-5; polysaccharide sulfate, 79933-28-1; Antiviral Agents; Polysaccharides; Sulfates
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01418130_v51_n4_p412_Pujol

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Citas:

---------- APA ----------
Pujol, C.A., Ray, S., Ray, B. & Damonte, E.B. (2012) . Antiviral activity against dengue virus of diverse classes of algal sulfated polysaccharides. International Journal of Biological Macromolecules, 51(4), 412-416.
http://dx.doi.org/10.1016/j.ijbiomac.2012.05.028
---------- CHICAGO ----------
Pujol, C.A., Ray, S., Ray, B., Damonte, E.B. "Antiviral activity against dengue virus of diverse classes of algal sulfated polysaccharides" . International Journal of Biological Macromolecules 51, no. 4 (2012) : 412-416.
http://dx.doi.org/10.1016/j.ijbiomac.2012.05.028
---------- MLA ----------
Pujol, C.A., Ray, S., Ray, B., Damonte, E.B. "Antiviral activity against dengue virus of diverse classes of algal sulfated polysaccharides" . International Journal of Biological Macromolecules, vol. 51, no. 4, 2012, pp. 412-416.
http://dx.doi.org/10.1016/j.ijbiomac.2012.05.028
---------- VANCOUVER ----------
Pujol, C.A., Ray, S., Ray, B., Damonte, E.B. Antiviral activity against dengue virus of diverse classes of algal sulfated polysaccharides. Int. J. Biol. Macromol. 2012;51(4):412-416.
http://dx.doi.org/10.1016/j.ijbiomac.2012.05.028