Artículo

Siroski, P.A.; Poletta, G.L.; Latorre, M.A.; Merchant, M.E.; Ortega, H.H.; Mudry, M.D. "Immunotoxicity of commercial-mixed glyphosate in broad snouted caiman (Caiman latirostris)" (2016) Chemico-Biological Interactions. 244:64-70
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Abstract:

The expansion and intensification of agriculture during the past 50 years is unprecedented, and thus environmental problems have been triggered at different scales. These transformations have caused the loss of habitat and biodiversity, and disruption of the structure and functioning of ecosystems. As a result of the expansion of the agricultural frontier in the recent past, many areas of the natural geographic distribution of the local wildlife, among them crocodilians and particularly the broad snouted caiman (Caiman latirostris), are being exposed to contaminants. The present study was designed to evaluate the effect of commercially-mixed glyphosate (RU) on some parameters of the immune system of C. latirostris. Two groups of caimans were exposed for two months to different concentrations of RU recommended for its application in the field, while one group was maintained as an unexposed control. The RU concentration was progressively decreased through the exposure period to simulate glyphosate degradation in water. After exposure, total and differential white blood cell (WBC), and complement system activity (CS) were determined. In addition, the animals were injected with a solution of lipopolysaccharide (LPS) from Escherichia coli to trigger an immune response and evaluate the parameters associated with it. The results showed that an effect of the herbicide on CS was observed, as animals exposed to RU showed a lower CS activity than animals from the negative control (NC) but not in total WBC. In the case of leukocyte population counts, differences were only found for heterophils and lymphocytes. © 2015 Published by Elsevier Ireland Ltd.

Registro:

Documento: Artículo
Título:Immunotoxicity of commercial-mixed glyphosate in broad snouted caiman (Caiman latirostris)
Autor:Siroski, P.A.; Poletta, G.L.; Latorre, M.A.; Merchant, M.E.; Ortega, H.H.; Mudry, M.D.
Filiación:Proyecto Yacaré - Laboratorio de Zoología Aplicada: Anexo Vertebrados, Facultad de Humanidades y Ciencias, Universidad Nacional del Litoral, UNL, Ministerio de Aguas, Servicios Públicos y Medio Ambiente, Av. Arist obulo del Valle 8700, Santa Fe, C.P. 3000, Argentina
Instituto de Ciencias Veterinarias del Litoral, UNL-CONICET, Esperanza, Santa Fe, Argentina
Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina
Cátedra de Toxicología, Farmacología y Bioquímica Legal, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina
Department of Chemistry, McNeese State University, Lake Charles, LA, United States
Grupo Investigación Biología Evolutiva (GIBE), IEGEBA-DEGE, CONICET-UBA, FCEyN, Universidad de Buenos Aires, Buenos Aires, Argentina
Palabras clave:Broad snouted caiman; Complement system; Glyphosate; Immunotoxicity; White blood cell; glyphosate; herbicide; lipopolysaccharide; glycine; glyphosate; herbicide; lipopolysaccharide; animal experiment; Article; biodiversity; caiman; Caiman latirostris; complement system; controlled study; crocodilian; degradation; ecosystem; environmental exposure; Escherichia coli; geographic distribution; habitat; immune response; immune system; immunity; immunotoxicity; innate immunity; leukocyte; leukocyte count; lymphocyte; nonhuman; wildlife; analogs and derivatives; animal; dose response; drug effects; immunology; structure activity relation; Alligators and Crocodiles; Animals; Dose-Response Relationship, Drug; Escherichia coli; Glycine; Herbicides; Leukocytes; Lipopolysaccharides; Structure-Activity Relationship
Año:2016
Volumen:244
Página de inicio:64
Página de fin:70
DOI: http://dx.doi.org/10.1016/j.cbi.2015.11.031
Título revista:Chemico-Biological Interactions
Título revista abreviado:Chem.-Biol. Interact.
ISSN:00092797
CODEN:CBINA
CAS:glyphosate, 1071-83-6; glycine, 56-40-6, 6000-43-7, 6000-44-8; Glycine; glyphosate; Herbicides; Lipopolysaccharides
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00092797_v244_n_p64_Siroski

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Citas:

---------- APA ----------
Siroski, P.A., Poletta, G.L., Latorre, M.A., Merchant, M.E., Ortega, H.H. & Mudry, M.D. (2016) . Immunotoxicity of commercial-mixed glyphosate in broad snouted caiman (Caiman latirostris). Chemico-Biological Interactions, 244, 64-70.
http://dx.doi.org/10.1016/j.cbi.2015.11.031
---------- CHICAGO ----------
Siroski, P.A., Poletta, G.L., Latorre, M.A., Merchant, M.E., Ortega, H.H., Mudry, M.D. "Immunotoxicity of commercial-mixed glyphosate in broad snouted caiman (Caiman latirostris)" . Chemico-Biological Interactions 244 (2016) : 64-70.
http://dx.doi.org/10.1016/j.cbi.2015.11.031
---------- MLA ----------
Siroski, P.A., Poletta, G.L., Latorre, M.A., Merchant, M.E., Ortega, H.H., Mudry, M.D. "Immunotoxicity of commercial-mixed glyphosate in broad snouted caiman (Caiman latirostris)" . Chemico-Biological Interactions, vol. 244, 2016, pp. 64-70.
http://dx.doi.org/10.1016/j.cbi.2015.11.031
---------- VANCOUVER ----------
Siroski, P.A., Poletta, G.L., Latorre, M.A., Merchant, M.E., Ortega, H.H., Mudry, M.D. Immunotoxicity of commercial-mixed glyphosate in broad snouted caiman (Caiman latirostris). Chem.-Biol. Interact. 2016;244:64-70.
http://dx.doi.org/10.1016/j.cbi.2015.11.031