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Mice, Knockout
74
"Dendritic Cells Exposed to Triiodothyronine Deliver Pro-Inflammatory Signals and Amplify IL-17-Driven Immune Responses" (2019) Alamino, V.A.;Montesinos, M.D.M.;Soler, M.F. (...)Pellizas, C.G. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 52(2):354-367
"Positive regulation of raphe serotonin neurons by serotonin 2B receptors" (2018) Belmer, A.;Quentin, E.;Diaz, S.L. (...)Maroteaux, L. Neuropsychopharmacology. 43(7):1623-1632
"Targeting galectin-1 inhibits pancreatic cancer progression by modulating tumor–stroma crosstalk" (2018) Orozco, C.A.;Martinez-Bosch, N.;Guerrero, P.E. (...)Navarro, P. Proceedings of the National Academy of Sciences of the United States of America. 115(16):E3769-E3778
"Inducible ablation of dopamine D2 receptors in adult mice impairs locomotion, motor skill learning and leads to severe parkinsonism" (2017) Bello, E.P.;Casas-Cordero, R.;Galiñanes, G.L. (...)Rubinstein, M. Molecular Psychiatry. 22(4):595-604
"Proteomic and functional analysis identifies galectin-1 as a novel regulatory component of the cytotoxic granule machinery" (2017) Clemente, T.;Vieira, N.J.;Cerliani, J.P. (...)Amarante-Mendes, G.P. Cell death & disease. 8(12):e3176
"Mdm2 promotes Cdc25C protein degradation and delays cell cycle progression through the G2/M phase" (2017) Giono, L.E.;Resnick-Silverman, L.;Carvajal, L.A. (...)Manfredi, J.J. Oncogene. 36(49):6762-6773
"The Role of Heterotypic DENV-specific CD8+ T Lymphocytes in an Immunocompetent Mouse Model of Secondary Dengue Virus Infection" (2017) Talarico, L.B.;Batalle, J.P.;Byrne, A.B. (...)Polack, F.P. EBioMedicine. 20:202-216
"Modulation of GABA release from the thalamic reticular nucleus by cocaine and caffeine: Role of serotonin receptors" (2016) Goitia, B.;Rivero-Echeto, M.C.;Weisstaub, N.V. (...)Urbano, F.J. Journal of Neurochemistry. 136(3):526-535
"Chronic hyperprolactinemia evoked by disruption of lactotrope dopamine d2 receptors impacts on liver and adipocyte genes related to glucose and insulin balance" (2016) Luque, G.M.;Lopez-Vicchi, F.;María Ornstein, A. (...)Becu-Villalobos, D. American Journal of Physiology - Endocrinology and Metabolism. 311(6):E974-E988
"Hypothalamic POMC deficiency improves glucose tolerance despite insulin resistance by increasing Glycosuria" (2016) Chhabra, K.H.;Adams, J.M.;Fagel, B. (...)Low, M.J. Diabetes. 65(3):660-672
"Essential function of the transcription factor Rax in the early patterning of the mammalian hypothalamus" (2016) Orquera, D.P.;Nasif, S.;Low, M.J. (...)de Souza, F.S.J. Developmental Biology. 416(1):212-224
"Dopamine Regulation of Lateral Inhibition between Striatal Neurons Gates the Stimulant Actions of Cocaine" (2016) Dobbs, L.K.;Kaplan, A.R.;Lemos, J.C. (...)Alvarez, V.A. Neuron. 90(5):1100-1113
"Fertilization defects in sperm from Cysteine-rich secretory protein 2 (Crisp2) knockout mice: Implications for fertility disorders" (2016) Brukman, N.G.;Miyata, H.;Torres, P. (...)Cuasnicú, P.S. Molecular Human Reproduction. 22(4):240-251
"Trypanosoma cruzi infection imparts a regulatory program in dendritic cells and T cells via galectin-1-dependent mechanisms" (2015) Poncini, C.V.;Ilarregui, J.M.;Batalla, E.I. (...)Rabinovich, G.A. Journal of Immunology. 195(7):3311-3324
"Islet 1 specifies the identity of hypothalamic melanocortin neurons and is critical for normal food intake and adiposity in adulthood" (2015) Nasif, S.;De Souza, F.S.J.;González, L.E. (...)Rubinstein, M. Proceedings of the National Academy of Sciences of the United States of America. 112(15):E1861-E1870
"The galectin-1-glycan axis controls sperm fertilizing capacity by regulating sperm motility and membrane hyperpolarization" (2015) Vasen, G.;Battistone, M.A.;Croci, D.O. (...)Cuasnicú, P.S. FASEB Journal. 29(10):4189-4200
"Dual roles of endogenous and exogenous galectin-1 in the control of testicular immunopathology" (2015) Pérez, C.V.;Gómez, L.G.;Gualdoni, G.S. (...)Guazzone, V.A. Scientific Reports. 5
"Loss of Feedback Inhibition via D2 Autoreceptors Enhances Acquisition of Cocaine Taking and Reactivity to Drug-Paired Cues" (2015) Holroyd, K.B.;Adrover, M.F.;Fuino, R.L. (...)Alvarez, V.A. Neuropsychopharmacology. 40(6):1495-1509
"Galectin-1 Prevents Infection and Damage Induced by Trypanosoma cruzi on Cardiac Cells" (2015) Benatar, A.F.;García, G.A.;Bua, J. (...)Gómez, K.A. PLoS Neglected Tropical Diseases. 9(10)
"Selective disruption of dopamine D2 receptors in pituitary lactotropes increases body weight and adiposity in female mice" (2014) Millan, M.I.P.;Luque, G.M.;Ramirez, M.C. (...)Becu-Villalobos, D. Endocrinology. 155(3):829-839
"H2S and NO cooperatively regulate vascular tone by activating a neuroendocrine HNO-TRPA1-CGRP signalling pathway" (2014) Eberhardt, M.;Dux, M.;Namer, B. (...)Filipovic, M.R. Nature Communications. 5
"Acid-sensing ion channels 1a (ASIC1a) inhibit neuromuscular transmission in female mice" (2014) Urbano, F.J.;Lino, N.G.;González-Inchauspe, C.M.F. (...)Uchitel, O.D. American Journal of Physiology - Cell Physiology. 306(4):C396-C406
"Sex differences in the pituitary transforming growth factor-β1 system: Studies in a model of resistant prolactinomas" (2013) Recouvreux, M.V.;Lapyckyj, L.;Camilletti, M.A. (...)Díaz-Torga, G. Endocrinology. 154(11):4192-4205
"Kinetics of extracellular ATP in mastoparan 7-activated human erythrocytes" (2013) Leal Denis, M.F.;Incicco, J.J.;Espelt, M.V. (...)Schwarzbaum, P.J. Biochimica et Biophysica Acta - General Subjects. 1830(10):4692-4707
"Cholinergic efferent synaptic transmission regulates the maturation of auditory hair cell ribbon synapses" (2013) Johnson, S.L.;Wedemeyer, C.;Vetter, D.E. (...)Marcotti, W. Open Biology. 3(NOV)
"Galectin-3 negatively regulates the frequency and function of CD4 + CD25 + Foxp3 + regulatory T cells and influences the course of Leishmania major infection" (2013) Fermino, M.L.;Dias, F.C.;Lopes, C.D. (...)Bernardes, E.S. European Journal of Immunology. 43(7):1806-1817
"Endogenous galectin-3 controls experimental malaria in a species-specific manner" (2012) Toscano, M.A.;Tongren, J.E.;De Souza, J.B. (...)Rabinovich, G.A. Parasite Immunology. 34(7):383-387
"Disrupting galectin-1 interactions with N-glycans suppresses hypoxia-driven angiogenesis and tumorigenesis in Kaposi's sarcoma" (2012) Croci, D.O.;Salatino, M.;Rubinstein, N. (...)Rabinovich, G.A. Journal of Experimental Medicine. 209(11):1985-2000
"Progesterone receptors: A key for neuroprotection in experimental stroke" (2012) Liu, A.;Margaill, I.;Zhang, S. (...)Guennoun, R. Endocrinology. 153(8):3747-3757
"Hippocampal SPARC regulates depression-related behavior" (2012) Campolongo, M.;Benedetti, L.;Podhajcer, O.L. (...)Depino, A.M. Genes, Brain and Behavior. 11(8):966-976
"Galectin-1 Deactivates Classically Activated Microglia and Protects from Inflammation-Induced Neurodegeneration" (2012) Starossom, S.;Mascanfroni, I.;Imitola, J. (...)Rabinovich, G. Immunity. 37(2):249-263
"Obesity-programmed mice are rescued by early genetic intervention" (2012) Bumaschny, V.F.;Yamashita, M.;Casas-Cordero, R. (...)Low, M.J. Journal of Clinical Investigation. 122(11):4203-4212
"The glycan-binding protein galectin-1 controls survival of epithelial cells along the crypt-villus axis of small intestine" (2011) Muglia, C.;Mercer, N.;Toscano, M.A. (...)Docena, G.H. Cell Death and Disease. 2(5)
"Amyotrophic lateral sclerosis-immunoglobulins selectively interact with neuromuscular junctions expressing P/Q-type calcium channels" (2011) Gonzalez, L.E.;Kotler, M.L.;Vattino, L.G. (...)Uchitel, O.D. Journal of Neurochemistry. 119(4):826-838
"P/Q-type calcium channel ablation in a mice glycinergic synapse mediated by multiple types of Ca 2+ channels alters transmitter release and short term plasticity" (2011) Giugovaz-Tropper, B.;González-Inchauspe, C.;Di Guilmi, M.N. (...)Uchitel, O.D. Neuroscience. 192:219-230
"Inhibitory effects of antivascular endothelial growth factor strategies in experimental dopamine-resistant prolactinomas" (2011) Luque, G.M.;Perez-Millán, M.I.;Ornstein, A.M. (...)Becu-Villalobos, D. Journal of Pharmacology and Experimental Therapeutics. 337(3):766-774
"Cocaine supersensitivity and enhanced motivation for reward in mice lacking dopamine D2 autoreceptors" (2011) Bello, E.P.;Mateo, Y.;Gelman, D.M. (...)Rubinstein, M. Nature Neuroscience. 14(8):1033-1038
"Disruption of the dopamine D2 receptor impairs insulin secretion and causes glucose intolerance" (2010) García-Tornadú, I.;Ornstein, A.M.;Chamson-Reig, A. (...)Becu-Villalobos, D. Endocrinology. 151(4):1441-1450
"New insights into the endocrine and metabolic roles of dopamine D2 receptors gained from the Drd2-/- mouse" (2010) Garcia-Tornadú, I.;Perez-Millan, M.I.;Recouvreux, V. (...)Becu-Villalobos, D. Neuroendocrinology. 92(4):207-214
"Dynamic conformational changes in the FERM domain of FAK are involved in focal-adhesion behavior during cell spreading and motility" (2009) Papusheva, E.;de Queiroz, F.M.;Dalous, J. (...)Bunt, G. Journal of Cell Science. 122(5):656-666
"Reward-seeking and discrimination deficits displayed by hypodopaminergic mice are prevented in mice lacking dopamine D4 receptors" (2009) Nemirovsky, S.I.; Avale, M.E.; Brunner, D.; Rubinstein, M. Synapse. 63(11):991-997
"Hypothalamic orexin, OX1, αMSH, NPY and MCRs expression in dopaminergic D2R knockout mice" (2009) García-Tornadú, I.;Díaz-Torga, G.;Risso, G.S. (...)Becu-Villalobos, D. Neuropeptides. 43(4):267-274
"Tssk6 is required for Izumo relocalization and gamete fusion in the mouse" (2009) Sosnik, J.;Miranda, P.V.;Spiridonov, N.A. (...)Visconti, P.E. Journal of Cell Science. 122(15):2741-2749
"Differential gene expression in models of pituitary prolactin-producing tumoral cells" (2009) Giacomini, D.;Haedo, M.;Gerez, J. (...)Arzt, E. Hormone Research. 71(SUPPL2):88-94
"Role of dopamine D1-like receptors in methamphetamine locomotor responses of D2 receptor knockout mice" (2008) Kelly, M.A.; Low, M.J.; Rubinstein, M.; Phillips, T.J. Genes, Brain and Behavior. 7(5):568-577
"Altered synaptic synchrony in motor nerve terminals lacking P/Q-calcium channels" (2008) Depetris, R.S.; Nudler, S.I.; Uchitel, O.D.; Urbano, F.J. Synapse. 62(6):466-471
"P/Q Ca2+ channels are functionally coupled to exocytosis of the immediately releasable pool in mouse chromaffin cells" (2008) Álvarez, Y.D.; Ibañez, L.I.; Uchitel, O.D.; Marengo, F.D. Cell Calcium. 43(2):155-164
"Fibroblast growth factor-2 in hyperplastic pituitaries of D2R knockout female mice" (2007) Cristina, C.;Díaz-Torga, G.;Góngora, A. (...)Becu-Villalobos, D. American Journal of Physiology - Endocrinology and Metabolism. 293(5):E1341-E1351
"Genes involved in the balance between neuronal survival and death during inflammation" (2007) Glezer, I.;Chernomoretz, A.;David, S. (...)Rivest, S. PLoS ONE. 2(3)
"Phenotypic characterisation of mice with exaggerated and missing LH/hCG action" (2007) Ahtiainen, P.;Rulli, S.;Pakarainen, T. (...)Huhtaniemi, I. Molecular and Cellular Endocrinology. 260-262:255-263
"PTTG expression in different experimental and human prolactinomas in relation to dopaminergic control of lactotropes" (2007) Cristina, C.;Díaz-Torga, G.S.;Goya, R.G. (...)Becu-Villalobos, D. Molecular Cancer. 6
"The α10 nicotinic acetylcholine receptor subunit is required for normal synaptic function and integrity of the olivocochlear system" (2007) Vetter, D.E.;Katz, E.;Maison, S.F. (...)Boulter, J. Proceedings of the National Academy of Sciences of the United States of America. 104(51):20594-20599
"GH in the dwarf dopaminergic D2 receptor knockout mouse: Somatotrope population, GH release, and responsiveness to GH-releasing factors and somatostatin" (2006) García-Tornadú, I.;Rubinstein, M.;Gaylinn, B.D. (...)Becu-Villalobos, D. Journal of Endocrinology. 190(3):611-619
"Dopaminergic D2 receptor knockout mouse: An animal model of prolactinoma" (2006) Cristina, C.;García-Tornadú, I.;Díaz-Torga, G. (...)Bronstein M. Frontiers of Hormone Research. 35:50-63
"Genetically modified mouse models in studies of luteinising hormone action" (2006) Huhtaniemi, I.;Ahtiainen, P.;Pakarainen, T. (...)Poutanen, M. Molecular and Cellular Endocrinology. 252(1-2):126-135
"Increased pituitary vascular endothelial growth factor-A in dopaminergic D2 receptor knockout female mice" (2005) Cristina, C.;Díaz-Torga, G.;Baldi, A. (...)Becú-Villalobos, D. Endocrinology. 146(7):2952-2962
"A polar mechanism coordinates different regions of alternative splicing within a single gene" (2005) Fededa, J.P.;Petrillo, E.;Gelfand, M.S. (...)Kornblihtt, A.R. Molecular Cell. 19(3):393-404
"Dilated cardiomyopathy in Erb-b4-deficient ventricular muscle" (2005) García-Rivello, H.;Taranda, J.;Said, M. (...)Hertig, C.M. American Journal of Physiology - Heart and Circulatory Physiology. 289(3 58-3):H1153-H1160
"Functional compensation of P/Q by N-type channels blocks short-term plasticity at the calyx of Held presynaptic terminal" (2004) González Inchauspe, C.; Martini, F.J.; Forsythe, I.D.; Uchitel, O.D. Journal of Neuroscience. 24(46):10379-10383
"A role for the endogenous opioid β-endorphin in energy homeostasis" (2003) Appleyard, S.M.;Hayward, M.;Young, J.I. (...)Low, M.J. Endocrinology. 144(5):1753-1760
"Altered properties of quantal neurotransmitter release at endplates of mice lacking P/Q-type Ca2+ channels" (2003) Urbano, F.J.;Piedras-Rentería, E.S.;Jun, K. (...)Tsien, R.W. Proceedings of the National Academy of Sciences of the United States of America. 100(6):3491-3496
"Increased splenocyte proliferative response and cytokine production in β-endorphin-deficient mice" (2002) Refojo, D.;Kovalovsky, D.;Young, J.I. (...)Arzt, E. Journal of Neuroimmunology. 131(1-2):126-134
"Dysfunctional light-evoked regulation of cAMP in photoreceptors and abnormal retinal adaptation in mice lacking dopamine D4 receptors" (2002) Nir, I.;Harrison, J.M.;Haque, R. (...)Iuvone, P.M. Journal of Neuroscience. 22(6):2063-2073
"Cocaine-induced locomotor activity and cocaine discrimination in dopamine D2 receptor mutant mice" (2002) Chausmer, A.L.;Elmer, G.I.;Rubinstein, M. (...)Katz, J.L. Psychopharmacology. 163(1):54-61
"Absence of dopamine D4 receptors results in enhanced reactivity to unconditioned, but not conditioned, fear" (2002) Falzone, T.L.;Gelman, D.M.;Young, J.I. (...)Rubinstein, M. European Journal of Neuroscience. 15(1):158-164
"The role of the D2 dopamine receptor (D2R) in A2A adenosine receptor (A2AR)-mediated behavioral and cellular responses as revealed by A2A and D2 receptor knockout mice" (2001) Chen, J.-F.;Moratalla, R.;Impagnatiello, F. (...)Schwarzschild, M.A. Proceedings of the National Academy of Sciences of the United States of America. 98(4):1970-1975
"Facilitated glutamatergic transmission in the striatum of D2 dopamine receptor-deficient mice" (2001) Cepeda, C.;Hurst, R.S.;Altemus, K.L. (...)Levine, M.S. Journal of Neurophysiology. 85(2):659-670
"The indirect basal ganglia pathway in dopamine D2 receptor-deficient mice" (2000) Murer, M.G.;Dziewczapolski, G.;Salin, P. (...)Gershanik, O. Neuroscience. 99(4):643-650
"The dopamine D 2 , but not D 3 or D 4 , receptor subtype is essential for the disruption of prepulse inhibition produced by amphetamine in mice" (1999) Ralph, R.J.;Varty, G.B.;Kelly, M.A. (...)Geyer, M.A. Journal of Neuroscience. 19(11):4627-4633
"Role of α9 nicotinic ACh receptor subunits in the development and function of cochlear efferent innervation" (1999) Vetter, D.E.;Liberman, M.C.;Mann, J. (...)Elgoyhen, A.B. Neuron. 23(1):93-103