Artículo

García-Rivello, H.; Taranda, J.; Said, M.; Cabeza-Meckert, P.; Vila-Petroff, M.; Scaglione, J.; Ghio, S.; Chen, J.; Lai, C.; Laguens, R.P.; Lloyd, K.C.; Hertig, C.M. "Dilated cardiomyopathy in Erb-b4-deficient ventricular muscle" (2005) American Journal of Physiology - Heart and Circulatory Physiology. 289(3 58-3):H1153-H1160
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Abstract:

The neuregulin receptor tyrosine kinase Erb-b4, initially linked to early cardiac development, is shown here to play a critical role in adult cardiac function. In wild-type mice, Erb-b4 protein localized to Z lines and to intercalated disks, suggesting a role in subcellular and intercellular communications of cardiomyocytes. Conditional inactivation of erb-b4 in ventricular muscle cells led to a severe dilated cardiomyopathy, characterized by thinned ventricular walls with eccentric hypertrophy, reduced contractility, and delayed conduction. This cardiac dysfunction may account for premature death in adult erb-b4-knockout mice. This study establishes a critical role for Erb-b4 in the maintenance of normal postnatal cardiac structure and function. Copyright © 2005 the American Physiological Society.

Registro:

Documento: Artículo
Título:Dilated cardiomyopathy in Erb-b4-deficient ventricular muscle
Autor:García-Rivello, H.; Taranda, J.; Said, M.; Cabeza-Meckert, P.; Vila-Petroff, M.; Scaglione, J.; Ghio, S.; Chen, J.; Lai, C.; Laguens, R.P.; Lloyd, K.C.; Hertig, C.M.
Filiación:Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Buenos Aires, Argentina
Centro de Investigaciones Cardiovasculares, Universidad de la Plata, La Plata, Argentina
División de Patología, Universidad Favaloro, Buenos Aires, Argentina
Medical School, University of California San Diego, San Diego, CA, United States
Scripps Research Institute, San Diego, CA, United States
Center for Comparative Medicine, University of California Davis, Davis, CA, United States
Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, INGEBI, Vuelta de Obligado 2490, 1428 Buenos Aires, Argentina
Palabras clave:Conditional knockout; erb-b2; Heart; Mouse; Neuregulin; actin; atrial natriuretic factor; brain natriuretic peptide; cre recombinase; epidermal growth factor receptor 4; indo 1; myosin light chain; animal experiment; animal model; animal tissue; article; cell communication; cellular distribution; congestive cardiomyopathy; controlled study; electrocardiography; female; gene inactivation; gene targeting; heart development; heart muscle cell; heart muscle contractility; heart ventricle hypertrophy; heterozygosity; histochemistry; immunofluorescence; knockout mouse; mouse; nick end labeling; nonhuman; priority journal; reverse transcription polymerase chain reaction; Western blotting; wild type; Animals; Cardiomegaly; Cardiomyopathy, Dilated; Disease Models, Animal; Female; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardial Contraction; Myocardium; Receptor, Epidermal Growth Factor; Signal Transduction
Año:2005
Volumen:289
Número:3 58-3
Página de inicio:H1153
Página de fin:H1160
DOI: http://dx.doi.org/10.1152/ajpheart.00048.2005
Título revista:American Journal of Physiology - Heart and Circulatory Physiology
Título revista abreviado:Am. J. Physiol. Heart Circ. Physiol.
ISSN:03636135
CODEN:AJPPD
CAS:atrial natriuretic factor, 85637-73-6; brain natriuretic peptide, 114471-18-0; indo 1, 96314-96-4; ERBB4 protein, EC 2.7.1.112; Receptor, Epidermal Growth Factor, EC 2.7.1.112
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03636135_v289_n358-3_pH1153_GarciaRivello

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Citas:

---------- APA ----------
García-Rivello, H., Taranda, J., Said, M., Cabeza-Meckert, P., Vila-Petroff, M., Scaglione, J., Ghio, S.,..., Hertig, C.M. (2005) . Dilated cardiomyopathy in Erb-b4-deficient ventricular muscle. American Journal of Physiology - Heart and Circulatory Physiology, 289(3 58-3), H1153-H1160.
http://dx.doi.org/10.1152/ajpheart.00048.2005
---------- CHICAGO ----------
García-Rivello, H., Taranda, J., Said, M., Cabeza-Meckert, P., Vila-Petroff, M., Scaglione, J., et al. "Dilated cardiomyopathy in Erb-b4-deficient ventricular muscle" . American Journal of Physiology - Heart and Circulatory Physiology 289, no. 3 58-3 (2005) : H1153-H1160.
http://dx.doi.org/10.1152/ajpheart.00048.2005
---------- MLA ----------
García-Rivello, H., Taranda, J., Said, M., Cabeza-Meckert, P., Vila-Petroff, M., Scaglione, J., et al. "Dilated cardiomyopathy in Erb-b4-deficient ventricular muscle" . American Journal of Physiology - Heart and Circulatory Physiology, vol. 289, no. 3 58-3, 2005, pp. H1153-H1160.
http://dx.doi.org/10.1152/ajpheart.00048.2005
---------- VANCOUVER ----------
García-Rivello, H., Taranda, J., Said, M., Cabeza-Meckert, P., Vila-Petroff, M., Scaglione, J., et al. Dilated cardiomyopathy in Erb-b4-deficient ventricular muscle. Am. J. Physiol. Heart Circ. Physiol. 2005;289(3 58-3):H1153-H1160.
http://dx.doi.org/10.1152/ajpheart.00048.2005