Abstract:
The neuregulin receptor tyrosine kinase Erb-b4, initially linked to early cardiac development, is shown here to play a critical role in adult cardiac function. In wild-type mice, Erb-b4 protein localized to Z lines and to intercalated disks, suggesting a role in subcellular and intercellular communications of cardiomyocytes. Conditional inactivation of erb-b4 in ventricular muscle cells led to a severe dilated cardiomyopathy, characterized by thinned ventricular walls with eccentric hypertrophy, reduced contractility, and delayed conduction. This cardiac dysfunction may account for premature death in adult erb-b4-knockout mice. This study establishes a critical role for Erb-b4 in the maintenance of normal postnatal cardiac structure and function. Copyright © 2005 the American Physiological Society.
Registro:
Documento: |
Artículo
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Título: | Dilated cardiomyopathy in Erb-b4-deficient ventricular muscle |
Autor: | García-Rivello, H.; Taranda, J.; Said, M.; Cabeza-Meckert, P.; Vila-Petroff, M.; Scaglione, J.; Ghio, S.; Chen, J.; Lai, C.; Laguens, R.P.; Lloyd, K.C.; Hertig, C.M. |
Filiación: | Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Buenos Aires, Argentina Centro de Investigaciones Cardiovasculares, Universidad de la Plata, La Plata, Argentina División de Patología, Universidad Favaloro, Buenos Aires, Argentina Medical School, University of California San Diego, San Diego, CA, United States Scripps Research Institute, San Diego, CA, United States Center for Comparative Medicine, University of California Davis, Davis, CA, United States Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, INGEBI, Vuelta de Obligado 2490, 1428 Buenos Aires, Argentina
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Palabras clave: | Conditional knockout; erb-b2; Heart; Mouse; Neuregulin; actin; atrial natriuretic factor; brain natriuretic peptide; cre recombinase; epidermal growth factor receptor 4; indo 1; myosin light chain; animal experiment; animal model; animal tissue; article; cell communication; cellular distribution; congestive cardiomyopathy; controlled study; electrocardiography; female; gene inactivation; gene targeting; heart development; heart muscle cell; heart muscle contractility; heart ventricle hypertrophy; heterozygosity; histochemistry; immunofluorescence; knockout mouse; mouse; nick end labeling; nonhuman; priority journal; reverse transcription polymerase chain reaction; Western blotting; wild type; Animals; Cardiomegaly; Cardiomyopathy, Dilated; Disease Models, Animal; Female; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardial Contraction; Myocardium; Receptor, Epidermal Growth Factor; Signal Transduction |
Año: | 2005
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Volumen: | 289
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Número: | 3 58-3
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Página de inicio: | H1153
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Página de fin: | H1160
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DOI: |
http://dx.doi.org/10.1152/ajpheart.00048.2005 |
Título revista: | American Journal of Physiology - Heart and Circulatory Physiology
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Título revista abreviado: | Am. J. Physiol. Heart Circ. Physiol.
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ISSN: | 03636135
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CODEN: | AJPPD
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CAS: | atrial natriuretic factor, 85637-73-6; brain natriuretic peptide, 114471-18-0; indo 1, 96314-96-4; ERBB4 protein, EC 2.7.1.112; Receptor, Epidermal Growth Factor, EC 2.7.1.112
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03636135_v289_n358-3_pH1153_GarciaRivello |
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Citas:
---------- APA ----------
García-Rivello, H., Taranda, J., Said, M., Cabeza-Meckert, P., Vila-Petroff, M., Scaglione, J., Ghio, S.,..., Hertig, C.M.
(2005)
. Dilated cardiomyopathy in Erb-b4-deficient ventricular muscle. American Journal of Physiology - Heart and Circulatory Physiology, 289(3 58-3), H1153-H1160.
http://dx.doi.org/10.1152/ajpheart.00048.2005---------- CHICAGO ----------
García-Rivello, H., Taranda, J., Said, M., Cabeza-Meckert, P., Vila-Petroff, M., Scaglione, J., et al.
"Dilated cardiomyopathy in Erb-b4-deficient ventricular muscle"
. American Journal of Physiology - Heart and Circulatory Physiology 289, no. 3 58-3
(2005) : H1153-H1160.
http://dx.doi.org/10.1152/ajpheart.00048.2005---------- MLA ----------
García-Rivello, H., Taranda, J., Said, M., Cabeza-Meckert, P., Vila-Petroff, M., Scaglione, J., et al.
"Dilated cardiomyopathy in Erb-b4-deficient ventricular muscle"
. American Journal of Physiology - Heart and Circulatory Physiology, vol. 289, no. 3 58-3, 2005, pp. H1153-H1160.
http://dx.doi.org/10.1152/ajpheart.00048.2005---------- VANCOUVER ----------
García-Rivello, H., Taranda, J., Said, M., Cabeza-Meckert, P., Vila-Petroff, M., Scaglione, J., et al. Dilated cardiomyopathy in Erb-b4-deficient ventricular muscle. Am. J. Physiol. Heart Circ. Physiol. 2005;289(3 58-3):H1153-H1160.
http://dx.doi.org/10.1152/ajpheart.00048.2005