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Murer, M.G.; Dziewczapolski, G.; Salin, P.; Vila, M.; Tseng, K.Y.; Ruberg, M.; Rubinstein, M.; Kelly, M.A.; Grandy, D.K.; Low, M.J.; Hirsch, E.; Raisman-Vozari, R.; Gershanik, O. "The indirect basal ganglia pathway in dopamine D2 receptor-deficient mice" (2000) Neuroscience. 99(4):643-650
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Abstract:

Recent pathophysiological models of basal ganglia function in Parkinson's disease predict that specific neurochemical changes in the indirect pathway would follow the lack of stimulation of D2 dopamine receptors. Post mortem studies of the basal ganglia in genetically modified mice lacking functional copies of the D2 dopamine receptor gene allowed us to test these predictions. When compared with their congenic N5 wild-type siblings, mice lacking D2 receptors show an increased expression of enkephalin messenger RNA in the striatum, and an increased activity and expression of cytochrome oxidase I in the subthalamic nucleus, as expected. In addition, D2 receptor-deficient mice display a reduced expression of glutamate decarboxylase-67 messenger RNA in the globus pallidus, as the basal ganglia model predicts. This reduction contrasts with the lack of change or increase in glutamate decarboxylase-67 messenger RNA expression found in animals depleted of dopamine after lesions of the mesostriatal dopaminergic system. Furthermore, D2 receptor-deficient mice show a significant decrease in substance P messenger RNA expression in the striatonigral neurons which form the direct pathway. Finally, glutamate decarboxylase-67 messenger RNA expression in the basal ganglia output nuclei was not affected by mutations in the D2 receptor gene, a fact that could probably be related to the absence of a parkinsonian locomotor phenotype in D2 receptor-deficient mice. In summary, these findings provide compelling evidence demonstrating that the lack of endogenous stimulation of D2 receptors is sufficient to produce subthalamic nucleus hyperactivity, as assessed by cytochrome oxidase I histochemistry and messenger RNA expression, and strongly suggest the existence of interactions between the basal ganglia direct and indirect pathways. (C) 2000 IBRO.

Registro:

Documento: Artículo
Título:The indirect basal ganglia pathway in dopamine D2 receptor-deficient mice
Autor:Murer, M.G.; Dziewczapolski, G.; Salin, P.; Vila, M.; Tseng, K.Y.; Ruberg, M.; Rubinstein, M.; Kelly, M.A.; Grandy, D.K.; Low, M.J.; Hirsch, E.; Raisman-Vozari, R.; Gershanik, O.
Filiación:INSERM U289, Hop. de la Salpêtrière, Paris, France
Depto. de Fisiol. Y Biofísica, Fac. Med., Univ. Buenos Aires, 1121, Buenos Aires, Argentina
ININFA, CONICET, Buenos Aires, Argentina
UPR9013, CNRS, Marseille, France
INGEBI, CONICET Depto. Cie. Biol., FCEYN, U., Buenos Aires, Argentina
Vollum Institute, Oregon Health Sciences University, Portland, OR, United States
Dept. of Physiology and Pharmacology, Oregon Health Sciences University, Portland, OR, United States
Palabras clave:Globus pallidus; Parkinson's disease; Striatum; Substantia nigra; Subthalamic nucleus; cytochrome c oxidase; dopamine 2 receptor; glutamate decarboxylase; messenger RNA; substance P; animal tissue; article; basal ganglion; controlled study; corpus striatum; enzyme activity; gene mutation; globus pallidus; mouse; neuromodulation; nonhuman; Parkinson disease; priority journal; protein expression; receptor gene; substantia nigra; subthalamic nucleus; Animals; Electron Transport Complex IV; Female; Gene Expression; Globus Pallidus; Glutamate Decarboxylase; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neostriatum; Neural Pathways; Neurons; Parkinson Disease; Phenotype; Receptors, Dopamine D2; RNA, Messenger; Substance P; Substantia Nigra; Subthalamic Nucleus
Año:2000
Volumen:99
Número:4
Página de inicio:643
Página de fin:650
DOI: http://dx.doi.org/10.1016/S0306-4522(00)00223-2
Título revista:Neuroscience
Título revista abreviado:Neuroscience
ISSN:03064522
CODEN:NRSCD
CAS:Electron Transport Complex IV, EC 1.9.3.1; Glutamate Decarboxylase, EC 4.1.1.15; Receptors, Dopamine D2; RNA, Messenger; Substance P, 33507-63-0
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03064522_v99_n4_p643_Murer

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Citas:

---------- APA ----------
Murer, M.G., Dziewczapolski, G., Salin, P., Vila, M., Tseng, K.Y., Ruberg, M., Rubinstein, M.,..., Gershanik, O. (2000) . The indirect basal ganglia pathway in dopamine D2 receptor-deficient mice. Neuroscience, 99(4), 643-650.
http://dx.doi.org/10.1016/S0306-4522(00)00223-2
---------- CHICAGO ----------
Murer, M.G., Dziewczapolski, G., Salin, P., Vila, M., Tseng, K.Y., Ruberg, M., et al. "The indirect basal ganglia pathway in dopamine D2 receptor-deficient mice" . Neuroscience 99, no. 4 (2000) : 643-650.
http://dx.doi.org/10.1016/S0306-4522(00)00223-2
---------- MLA ----------
Murer, M.G., Dziewczapolski, G., Salin, P., Vila, M., Tseng, K.Y., Ruberg, M., et al. "The indirect basal ganglia pathway in dopamine D2 receptor-deficient mice" . Neuroscience, vol. 99, no. 4, 2000, pp. 643-650.
http://dx.doi.org/10.1016/S0306-4522(00)00223-2
---------- VANCOUVER ----------
Murer, M.G., Dziewczapolski, G., Salin, P., Vila, M., Tseng, K.Y., Ruberg, M., et al. The indirect basal ganglia pathway in dopamine D2 receptor-deficient mice. Neuroscience. 2000;99(4):643-650.
http://dx.doi.org/10.1016/S0306-4522(00)00223-2