Artículo

Cepeda, C.; Hurst, R.S.; Altemus, K.L.; Flores-Hernández, J.; Calvert, C.R.; Jokel, E.S.; Grandy, D.K.; Low, M.J.; Rubinstein, M.; Ariano, M.A.; Levine, M.S. "Facilitated glutamatergic transmission in the striatum of D2 dopamine receptor-deficient mice" (2001) Journal of Neurophysiology. 85(2):659-670
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Abstract:

Dopamine (DA) receptors play an important role in the modulation of excitability and the responsiveness of neurons to activation of excitatory amino acid receptors in the striatum. In the present study, we utilized mice with genetic deletion of D2 or D4 DA receptors and their wild-type (WT) controls to examine if the absence of either receptor subtype affects striatal excitatory synaptic activity. Immunocytochemical analysis verified the absence of D2 or D4 protein expression in the striatum of receptor-deficient mutant animals. Sharp electrode current- and whole cell patch voltage-clamp recordings were obtained from slices of receptor-deficient and WT mice. Basic membrane properties were similar in D2 and D4 receptor-deficient mutants and their respective WT controls. In current-clamp recordings in WT animals, very little low-amplitude spontaneous synaptic activity was observed. The frequency of these spontaneous events was increased slightly in D2 receptor-deficient mice. In addition, large-amplitude depolarizations were observed in a subset of neurons from only the D2 receptor-deficient mutants. Bath application of the K+ channel blocker 4-aminopyridine (100 μM) and bicuculline methiodide (10 μM, to block synaptic activity due to activation of GABAA receptors) markedly increased spontaneous synaptic activity in receptor-deficient mutants and WTs. Under these conditions, D2 receptor-deficient mice displayed significantly more excitatory synaptic activity than their WT controls, while there was no difference between D4 receptor-deficient mice and their controls. In voltage-clamp recordings, there was an increase in frequency of spontaneous glutamate receptor-mediated inward currents without a change in mean amplitude in D2 receptor-deficient mutants. In WT mice, activation of D2 family receptors with quinpirole decreased spontaneous excitatory events and conversely sulpiride, a D2 receptor antagonist, increased activity. In D2 receptor-deficient mice, sulpiride had very little net effect. Morphologically, a subpopulation of medium-sized spiny neurons from D2 receptor-deficient mice displayed decreased dendritic spines compared with cells from WT mice. These results provide evidence that D2 receptors play an important role in the regulation of glutamate receptor-mediated activity in the corticostriatal or thalamostriatal pathway. These receptors may function as gatekeepers of glutamate release or of its subsequent effects and thus may protect striatal neurons from excessive excitation.

Registro:

Documento: Artículo
Título:Facilitated glutamatergic transmission in the striatum of D2 dopamine receptor-deficient mice
Autor:Cepeda, C.; Hurst, R.S.; Altemus, K.L.; Flores-Hernández, J.; Calvert, C.R.; Jokel, E.S.; Grandy, D.K.; Low, M.J.; Rubinstein, M.; Ariano, M.A.; Levine, M.S.
Filiación:Mental Retardation Research Center, University of California, Los Angeles, CA 90095, United States
Department of Cell and Developmental Biology, Oregon Health Sciences University, Portland, OR 97201, United States
Vollum Institute, Oregon Health Sciences University, Portland, OR 97201, United States
Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Consejo Nacional de Investigaciones Científicas y Técnicas, Universidad de Buenos Aires, 1428 Buenos Aires, Argentina
Department of Neuroscience, Chicago Medical School, North Chicago, IL 60064, United States
Palabras clave:4 aminopyridine; bicuculline methiodide; dopamine 2 receptor; dopamine 4 receptor; glutamate receptor; quinpirole; receptor subtype; sulpiride; animal tissue; article; controlled study; corpus striatum; dendritic spine; depolarization; immunocytochemistry; mouse; nerve cell stimulation; neurotransmission; nonhuman; priority journal; synapse; voltage clamp; 4-Aminopyridine; Animals; Corpus Striatum; Dopamine; Electrophysiology; Glutamic Acid; Immunohistochemistry; Membranes; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Receptors, Dopamine D2; Synapses; Synaptic Transmission
Año:2001
Volumen:85
Número:2
Página de inicio:659
Página de fin:670
Título revista:Journal of Neurophysiology
Título revista abreviado:J. Neurophysiol.
ISSN:00223077
CODEN:JONEA
CAS:4-Aminopyridine, 504-24-5; Dopamine, 51-61-6; Glutamic Acid, 56-86-0; Receptors, Dopamine D2
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00223077_v85_n2_p659_Cepeda

Referencias:

  • Altemus, K.L., Cepeda, C., Liu, J.C., Hurst, R.S., Ariano, M.A., Low, M.J., Rubenstein, M., Levine, M.S., D2 and D4 dopamine receptors modulate neurotransmitter release: Electrophysiological evidence from receptor-deficient mutant mice (1998) Soc Neurosci Abstr, 24, p. 1643
  • Arbuthnott, G.W., Brown, J.R., MacLeod, N.K., Mitchell, R., Wright, A.K., The action of dopamine on synaptic transmission through the striatum (1987), pp. 71-81. , Neurotransmitter Interactions in the Basal Ganglia, edited by Sandler M, Feuerstein C, and Scatton B. New York: Raven; Ariano, M.A., Wang, J., Noblett, K.L., Larson, E.R., Sibley, D.R., Cellular distribution of the rat D4 dopamine receptor protein in the CNS using anti-receptor antisera (1997) Brain Res, 752, pp. 26-34
  • Baik, J.H., Picetti, R., Saiardi, A., Thiriet, G., Dierich, A., Depaulis, A., Le Meur, M., Borrelli, E., Parkinsonian-like locomotor impairment in mice lacking dopamine D2 receptors (1995) Nature, 377, pp. 424-428
  • Bargas, J., Ayala, G.X., Hernandez, E., Galarraga, E., Ca2+-channels involved in neostriatal glutamatergic transmission (1998) Brain Res Bull, 45, pp. 521-524
  • Berkowicz, D.A., Trombley, P.Q., Dopaminergic modulation at the olfactory nerve synapse (2000) Brain Res, 855, pp. 90-99
  • Boulay, D., Depoortere, R., Oblin, A., Sanger, D.J., Schoemaker, H., Perrault, G., Haloperidol-induced catalepsy is absent in dopamine D(2), but maintained in dopamine D(3) receptor knock-out mice (2000) Eur J Pharmacol, 391, pp. 63-73
  • Brown, J.R., Arbuthnott, G.W., The electrophysiology of dopamine (D2) receptors: A study of the actions of dopamine on corticostriatal transmission (1983) Neuroscience, 10, pp. 349-355
  • Calabresi, P., Benedetti, M., Mercuri, N.B., Bernardi, G., Endogenous dopamine and dopaminergic agonists modulate synaptic excitation in neostriatum: Intracellular studies from naive and catecholamine-depleted rats (1988) Neuroscience, 27, pp. 145-157
  • Calabresi, P., Centonze, D., Gubellini, P., Marfia, G.A., Pisani, A., Sancesario, G., Bernardi, G., Synaptic transmission in the striatum: From plasticity to neurodegeneration (2000) Prog Neurobiol, 61, pp. 231-265
  • Calabresi, P., Mercuri, N., Sancesario, G., Bernardi, G., Electrophysiology of dopamine-denervated striatal neurons (1993) Brain, 116, pp. 433-452
  • Calabresi, P., Mercuri, N., Stanzione, P., Stefani, A., Bernardi, G., Intracellular studies on the dopamine-induced firing inhibition of neostriatal neurons in vitro: Evidence for D1 receptor involvement (1987) Neuroscience, 20, pp. 757-771
  • Calabresi, P., Misgeld, U., Dodt, H.U., Intrinsic membrane properties of neostriatal neurons can account for their low level of spontaneous activity (1987) Neuroscience, 20, pp. 293-303
  • Calabresi, P., Pisani, A., Centonze, D., Bernardi, G., Synaptic plasticity and physiological interactions between dopamine and glutamate in the striatum (1997) Neurosci Biobehav Rev, 21, pp. 519-523
  • Calabresi, P., Pisani, A., Mercuri, N.B., Bernardi, G., The corticostriatal projection: From synaptic plasticity to dysfunctions of the basal ganglia (1996) Trends Neurosci, 19, pp. 19-24
  • Calabresi, P., Saiardi, A., Pisani, A., Baik, J.H., Centonze, D., Mercuri, N.B., Bernardi, G., Borrelli, E., Abnormal synaptic plasticity in the striatum of mice lacking dopamine D2 receptors (1997) J Neurosci, 17, pp. 4536-4544
  • Cepeda, C., Buchwald, N.A., Levine, M.S., Neuromodulatory actions of dopamine in the neostriatum are dependent upon the excitatory amino acid receptor subtypes activated (1993) Proc Natl Acad Sci USA, 90, pp. 9576-9580
  • Cepeda, C., Colwell, C.S., Itri, J.N., Chandler, S.H., Levine, M.S., Dopaminergic modulation of NMDA-induced whole cell currents in neostriatal neurons in slices: Contribution of calcium conductances (1998) J Neurophysiol, 79, pp. 82-94
  • Cepeda, C., Colwell, C.S., Itri, J.N., Gruen, E., Levine, M.S., Dopaminergic modulation of early signs of excitotoxicity in visualized rat neostriatal neurons (1998) Eur J Neurosci, 10, pp. 3491-3497
  • Cepeda, C., Levine, M.S., Dopamine and N-methyl-D-aspartate receptor interactions in the neostriatum (1998) Dev Neurosci, 20, pp. 1-18
  • Cepeda, C., Walsh, J.P., Hull, C.D., Howard, S.G., Buchwald, N.A., Levine, M.S., Dye-coupling in the neostriatum of the rat. I. Modulation by dopamine-depleting lesions (1989) Synapse, 4, pp. 229-237
  • Cepeda, C., Walsh, J.P., Peacock, W., Buchwald, N.A., Levine, M.S., Neurophysiological, pharmacological and morphological properties of human caudate neurons recorded in vitro (1994) Neuroscience, 59, pp. 89-103
  • Civelli, O., Bunzow, J.R., Grandy, D.K., Zhou, Q.Y., Van Tol, H.H., Molecular biology of the dopamine receptors (1991) Eur J Pharmacol, 207, pp. 277-286
  • Clifford, J.J., Usiello, A., Vallone, D., Kinsella, A., Borrelli, E., Waddington, J.L., Topographical evaluation of behavioural phenotype in a line of mice with targeted gene deletion of the D2 dopamine receptor (2000) Neuropharmacology, 39, pp. 382-390
  • Crawley, J.N., Belknap, J.K., Collins, A., Crabbe, J.C., Frankel, W., Henderson, N., Hitzemann, R.J., Paylor, R., Behavioral phenotypes of inbred mouse strains: Implications and recommendations for molecular studies (1997) Psychopharmacology, 132, pp. 107-124
  • Creese, I., Fraser, C.M., Receptor biochemistry and methodology (1997), 8, pp. 1-125. , Dopamine Receptors, edited by Creese I and Fraser CM. New York: Liss; Dickinson, S.D., Sabeti, J., Larson, G.A., Giardina, K., Rubinstein, M., Kelly, M.A., Grandy, D.K., Zahniser, N.R., Dopamine D2 receptor-deficient mice exhibit decreased dopamine transporter function but no changes in dopamine release in dorsal striatum (1999) J Neurochem, 72, pp. 148-156
  • Dudel, J., Kuffler, S.W., Presynaptic inhibition at the crayfish neuromuscular junction (1961) J Physiol (Lond), 155, pp. 543-562
  • Fisher, R.S., Levine, M.S., Sibley, D.R., Ariano, M.A., D2 dopamine receptor protein location: Golgi impregnation-gold toned and ultrastructural analysis of the rat neostriatum (1994) J Neurosci Res, 38, pp. 551-564
  • Flores-Hernández, J., Cepeda, C., Fienberg, A.A., Greengard, P., Levine, M.S., Multiple pathways are involved in the enhancement of NMDA responses by activation of dopamine D1 receptors in neostriatal neurons (1999) Soc Neurosci Abstr, 25, p. 1156
  • Flores-Hernández, J., Galarraga, E., Bargas, J., Dopamine selects glutamatergic inputs to neostriatal neurons (1997) Synapse, 25, pp. 185-195
  • Flores-Hernández, J., Galarraga, E., Pineda, J.C., Bargas, J., Patterns of excitatory and inhibitory synaptic transmission in the rat neostriatum as revealed by 4-AP (1994) J Neurophysiol, 72, pp. 2246-2256
  • Galarraga, E., Bargas, J., Martinez-Fong, D., Aceves, J., Spontaneous synaptic potentials in dopamine-denervated neostriatal neurons (1987) Neurosci Lett, 81, pp. 351-355
  • Garau, L., Govoni, S., Stefanini, E., Trabucchi, M., Spano, P.F., Dopamine receptors: Pharmacological and anatomical evidences indicate that two distinct dopamine receptor populations are present in rat striatum (1978) Life Sci, 23, pp. 1745-1750
  • Garcia-Muñoz, M., Young, S.J., Groves, P.M., Terminal excitability of the corticostriatal pathway. I. Regulation by dopamine receptor stimulation (1991) Brain Res, 551, pp. 195-206
  • Godukhin, O.V., Zharivoka, A.D., Budantsev, A.Y., Role of presynaptic dopamine receptors in regulation of the glutamatergic neurotransmission in rat neostriatum (1984) Neuroscience, 12, pp. 377-383
  • Hersch, S.M., Ciliax, B.J., Gutekunst, C.A., Rees, H.D., Heilman, C.J., Yung, K.K., Bolam, J.P., Levey, A.I., Electron microscopic analysis of D1 and D2 dopamine receptor proteins in the dorsal striatum and their synaptic relationships with motor corticostriatal afferents (1995) J Neurosci, 15, pp. 5222-5237
  • Holsboer, F., Transgenic mouse models: New tools for psychiatric research (1997) Neuroscientist, 3, pp. 328-336
  • Hsu, K.S., Huang, C.C., Yang, C.H., Gean, P.W., Presynaptic D2 dopaminergic receptors mediate inhibition of excitatory synaptic transmission in rat neostriatum (1995) Brain Res, 690, pp. 264-268
  • Jiang, Z.G., North, R.A., Membrane properties and synaptic responses of rat striatal neurones in vitro (1991) J Physiol (Lond), 443, pp. 533-553
  • Joyce, J.N., Marshall, J.F., Quantitative autoradiography of dopamine D2 sites in rat caudate-putamen: Localization to intrinsic neurons and not to neocortical afferents (1987) Neuroscience, 20, pp. 773-795
  • Kelly, M.A., Rubinstein, M., Asa, S.L., Zhang, G., Saez, C., Bunzow, J.R., Allen, R.G., Low, M.J., Pituitary lactotroph hyperplasia and chronic hyperprolactinemia in dopamine D2 receptor-deficient mice (1997) Neuron, 19, pp. 103-113
  • Kelly, M.A., Rubinstein, M., Phillips, T.J., Lessov, C.N., Burkhart-Kasch, S., Zhang, G., Bunzow, J.R., Low, M.J., Locomotor activity in D2 dopamine receptor-deficient mice is determined by gene dosage, genetic background, and developmental adaptations (1998) J Neurosci, 18, pp. 3470-3479
  • Kita, H., Armstrong, W., A biotin-containing compound N-(2-aminoethyl)biotinamide for intracellular labeling and neuronal tracing studies: Comparison with biocytin (1991) J Neurosci Methods, 37, pp. 141-150
  • Koga, E., Momiyama, T., Presynaptic dopamine D2-like receptors inhibit excitatory transmission onto rat ventral tegmental dopaminergic neurones (2000) J Physiol (Lond), 523, pp. 163-173
  • Konradi, C., Cepeda, C., Levine, M.S., Dopamine-glutamate interactions Handb Exp Pharmacol, , In press
  • Kornhuber, J., Kornhuber, M.E., Presynaptic dopaminergic modulation of cortical input to the striatum (1986) Life Sci, 39, pp. 699-674
  • Levine, M.S., Altemus, K.L., Cepeda, C., Cromwell, H.C., Crawford, C., Ariano, M.A., Drago, J., Westphal, H., Modulatory actions of dopamine on NMDA receptor-mediated responses are reduced in D1A-deficient mutant mice (1996) J Neurosci, 16, pp. 5870-5882
  • Levine, M.S., Cepeda, C., Dopamine modulation of responses mediated by excitatory amino acids in the neostriatum (1998) Adv Pharmacol, 42, pp. 724-729
  • Levine, M.S., Li, Z., Cepeda, C., Cromwell, H.C., Altemus, K.L., Neuromodulatory actions of dopamine on synaptically-evoked neostriatal responses in slices (1996) Synapse, 24, pp. 65-78
  • Lovinger, D.M., Merritt, A., Reyes, D., Involvement of N- and non-N-type calcium channels in synaptic transmission at corticostriatal synapses (1994) Neuroscience, 62, pp. 31-40
  • Maura, G., Carbone, R., Raiteri, M., Aspartate-releasing nerve terminals in rat striatum possess D-2 dopamine receptors mediating inhibition of release (1989) J Pharmacol Exp Ther, 251, pp. 1142-1146
  • Maura, G., Giardi, A., Raiteri, M., Release-regulating D-2 dopamine receptors are located on striatal glutamatergic nerve terminals (1988) J Pharmacol Exp Ther, 247, pp. 680-684
  • McVittie, L.D., Ariano, M.A., Sibley, D.R., Characterization of anti-peptide antibodies for the localization of D2 dopamine receptors in rat striatum (1991) Proc Natl Acad Sci USA, 88, pp. 1441-1445
  • Mercuri, N.B., Bernardi, G., Calabresi, P., Cotugno, A., Levi, G., Stanzione, P., Dopamine decreases cell excitability in rat striatal neurons by pre- and postsynaptic mechanisms (1985) Brain Res, 358, pp. 110-121
  • Mercuri, N.B., Saiardi, A., Bonci, A., Picetti, R., Calabresi, P., Bernardi, G., Borrelli, E., Loss of autoreceptor function in dopaminergic neurons from dopamine D2 receptor deficient mice (1997) Neuroscience, 79, pp. 323-327
  • Mitchell, P.R., Doggett, N.S., Modulation of striatal [3H]-glutamic acid release by dopaminergic drugs (1980) Life Sci, 26, pp. 2073-2081
  • Miyazaki, T., Lacey, M.G., Presynaptic inhibition by dopamine of a discrete component of GABA release in rat substantia nigra pars reticulata (1998) J Physiol (Lond), 513, pp. 805-817
  • Murer, M.G., Dziewczapolski, G., Salin, P., Vial, M., Tseng, K.Y., Ruberg, M., Rubinstein, M., Gershanik, O., The indirect basal ganglia pathway in dopamine D2 receptor-deficient mice (2000) Neuroscience, 99, pp. 643-650
  • Pich, E.M., Epping-Jordan, M.P., Transgenic mice in drug dependence (1998) Ann Med, 30, pp. 390-396
  • Ralph, R.J., Varty, G.B., Kelly, M.A., Wang, Y.M., Caron, M.G., Rubinstein, M., Grandy, D.K., Geyer, M.A., The dopamine D2, but not D3 or D4, receptor subtype is essential for the disruption of prepulse inhibition produced by amphetamine in mice (1999) J Neurosci, 19, pp. 4627-4633
  • Rowlands, G.F., Roberts, P.J., Activation of dopamine receptors inhibits calcium-dependent glutamate release from cortico-striatal terminals in vitro (1980) Eur J Pharmacol, 62, pp. 241-242
  • Rubinstein, M., Phillips, T.J., Bunzow, J.R., Falzone, T.L., Dziewczapolski, G., Zhang, G., Fang, Y., Grandy, D.K., Mice lacking dopamine D4 receptors are supersensitive to ethanol, cocaine, and methamphetamine (1997) Cell, 90, pp. 991-1001
  • Ruteki, P.A., Lebeda, F.J., Johnston, D., 4-aminopyridine produces epileptiform activity in hippocampus and enhances synaptic excitation and inhibition (1987) J Neurophysiol, 57, pp. 1911-1924
  • Saiardi, A., Abdel Samad, T., Picetti, R., Bozzi, Y., Baik, J.H., Borrelli, E., The physiological role of dopamine D2 receptors in signal transduction and behavior (1998) Adv Pharmacol, 42, pp. 521-524
  • Schultz, W., Depletion of dopamine in the striatum as an experimental model of Parkinsonism: Direct effects and adaptive mechanisms (1982) Prog Neurobiol, 18, pp. 121-166
  • Schwarcz, R., Creese, I., Coyle, J.T., Snyder, S.H., Dopamine receptors localized on cerebral cortical afferents to rat corpus striatum (1978) Nature, 271, pp. 766-768
  • Sesack, S.R., Aoki, C., Pickel, V.M., Ultrastructural localization of D2 receptor-like immunoreactivity in midbrain dopamine neurons and their striatal targets (1994) J Neurosci, 14, pp. 88-106
  • Shoji, Y., Delfs, J., Williams, J.T., Presynaptic inhibition of GABA(B)-mediated synaptic potentials in the ventral tegmental area during morphine withdrawal (1999) J Neurosci, 19, pp. 2347-2355
  • Sibley, D.R., Monsma F.J., Jr., Molecular biology of dopamine receptors (1992) Trends Pharmacol Sci, 13, pp. 61-69
  • Sulzer, D., Joyce, M.P., Lin, L., Geldwert, D., Haber, S.N., Hattori, T., Rayport, S., Dopamine neurons make glutamatergic synapses in vitro (1998) J Neurosci, 18, pp. 4588-4602
  • Takahashi, T., Forsythe, I.D., Tsujimoto, T., Barnes-Davies, M., Onodera, K., Presynaptic calcium current modulation by a metabotropic glutamate receptor (1996) Science, 274, pp. 594-597
  • Tarazi, F.I., Campbell, A., Yeghiayan, S.K., Baldessarini, R.J., Localization of dopamine receptor subtypes in corpus striatum and nucleus accumbens septi of rat brain: Comparison of D1-, D2- and D4-like receptors (1998) Neuroscience, 83, pp. 169-176
  • Thesleff, S., Aminopyridines and synaptic transmission (1980) Neuroscience, 5, pp. 1413-1419
  • Trugman, J.M., Geary, W.A., Wooten, G.F., Localization of D-2 dopamine receptors to intrinsic striatal neurones by quantitative autoradiography (1986) Nature, 323, pp. 267-269
  • Wilson, C.J., Kawaguchi, Y., The origins of two-state spontaneous membrane potential fluctuations of neostriatal spiny neurons (1996) J Neurosci, 16, pp. 2397-2410
  • Yamamoto, B.K., Davy, S., Dopaminergic modulation of glutamate release in striatum as measured by microdialysis (1992) J Neurochem, 58, pp. 1736-1742

Citas:

---------- APA ----------
Cepeda, C., Hurst, R.S., Altemus, K.L., Flores-Hernández, J., Calvert, C.R., Jokel, E.S., Grandy, D.K.,..., Levine, M.S. (2001) . Facilitated glutamatergic transmission in the striatum of D2 dopamine receptor-deficient mice. Journal of Neurophysiology, 85(2), 659-670.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00223077_v85_n2_p659_Cepeda [ ]
---------- CHICAGO ----------
Cepeda, C., Hurst, R.S., Altemus, K.L., Flores-Hernández, J., Calvert, C.R., Jokel, E.S., et al. "Facilitated glutamatergic transmission in the striatum of D2 dopamine receptor-deficient mice" . Journal of Neurophysiology 85, no. 2 (2001) : 659-670.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00223077_v85_n2_p659_Cepeda [ ]
---------- MLA ----------
Cepeda, C., Hurst, R.S., Altemus, K.L., Flores-Hernández, J., Calvert, C.R., Jokel, E.S., et al. "Facilitated glutamatergic transmission in the striatum of D2 dopamine receptor-deficient mice" . Journal of Neurophysiology, vol. 85, no. 2, 2001, pp. 659-670.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00223077_v85_n2_p659_Cepeda [ ]
---------- VANCOUVER ----------
Cepeda, C., Hurst, R.S., Altemus, K.L., Flores-Hernández, J., Calvert, C.R., Jokel, E.S., et al. Facilitated glutamatergic transmission in the striatum of D2 dopamine receptor-deficient mice. J. Neurophysiol. 2001;85(2):659-670.
Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00223077_v85_n2_p659_Cepeda [ ]