Artículo

Ahtiainen, P.; Rulli, S.; Pakarainen, T.; Zhang, F.-P.; Poutanen, M.; Huhtaniemi, I. "Phenotypic characterisation of mice with exaggerated and missing LH/hCG action" (2007) Molecular and Cellular Endocrinology. 260-262:255-263
El editor solo permite decargar el artículo en su versión post-print desde el repositorio. Por favor, si usted posee dicha versión, enviela a
Consulte el artículo en la página del editor
Consulte la política de Acceso Abierto del editor

Abstract:

In order to study the physiology and pathophysiology of gonadotrophin action, we have produced transgenic (TG) mice overexpressing human chorionic gonadotrophin (hCG) α and β subunits (hCG+ mice) and knockout (KO) mice for the luteinising hormone receptor (LHR; LuRKO mice). The two extremes in LH function, i.e. strong LH/hCG stimulation and total blockade of this action, confirm numerous earlier concepts about LH function, but they also reveal new aspects about gonadal function during excessive LH production and in the absence of this trophic stimulus. The purpose of this review is to summarise the key findings on these two genetically modified mouse models. © 2006 Elsevier Ireland Ltd. All rights reserved.

Registro:

Documento: Artículo
Título:Phenotypic characterisation of mice with exaggerated and missing LH/hCG action
Autor:Ahtiainen, P.; Rulli, S.; Pakarainen, T.; Zhang, F.-P.; Poutanen, M.; Huhtaniemi, I.
Filiación:Department of Physiology, University of Turku, Kiinamyllynkatu 10, 20520 Turku, Finland
Institute of Biology and Experimental Medicine, CONICET, Vuelta de Obligado 2490, 1428 Buenos Aires, Argentina
Department of Physiology, University of Helsinki, Biomedicum, Haartmaninkatu 8, 00014 Helsinki, Finland
Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Campus, Du Cane Road, London, W12 0NN, United Kingdom
Palabras clave:Knockout; Luteinising hormone; Luteinising hormone receptor; Luteoma; Ovary; Pituitary gland; Prolactinoma; Testis; Transgenic; Tumorigenesis; chorionic gonadotropin; luteinizing hormone; dimerization; gene function; gene targeting; genomics; nonhuman; phenotype; priority journal; receptor binding; review; signal transduction; Animals; Chorionic Gonadotropin; Gene Expression; Genitalia; Humans; Luteinizing Hormone; Mice; Mice, Knockout; Phenotype
Año:2007
Volumen:260-262
Página de inicio:255
Página de fin:263
DOI: http://dx.doi.org/10.1016/j.mce.2005.11.047
Título revista:Molecular and Cellular Endocrinology
Título revista abreviado:Mol. Cell. Endocrinol.
ISSN:03037207
CODEN:MCEND
CAS:chorionic gonadotropin, 9002-61-3; luteinizing hormone, 39341-83-8, 9002-67-9; Chorionic Gonadotropin; Luteinizing Hormone, 9002-67-9
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03037207_v260-262_n_p255_Ahtiainen

Referencias:

  • Abel, M.H., Wootton, A.N., Wilkins, V., Huhtaniemi, I., Knight, P.G., Charlton, H.M., The effect of a null mutation in the follicle-stimulating hormone receptor gene on mouse reproduction (2000) Endocrinology, 141, pp. 1795-1803
  • Ahtiainen, P., Rulli, S.B., Shariatmadari, R., Pelliniemi, L.J., Toppari, J., Poutanen, M., Huhtaniemi, I.T., Fetal but not adult Leydig cells are susceptible to adenoma formation in response to persistently high hCG level: a study on hCG overexpressing transgenic mice (2005) Oncogene, 24, pp. 7301-7309
  • Allan, C.M., Haywood, M., Swaraj, S., Spaliviero, J., Koch, A., Jimenez, M., Poutanen, M., Handelsman, D.J., A novel transgenic model to characterize the specific effects of follicle-stimulating hormone on gonadal physiology in the absence of luteinizing hormone actions (2001) Endocrinology, 142, pp. 2213-2220
  • Apaja, P.M., Harju, K.T., Aatsinki, J.T., Petaja-Repo, U.E., Rajaniemi, H.J., Identification and structural characterization of the neuronal luteinizing hormone receptor associated with sensory systems (2004) J. Biol. Chem., 279, pp. 1899-1906
  • Chudgar, D., Lei, Z., Rao, C.V., Orthotopic transplantation of LH receptor knockout and wild-type ovaries (2005) Life Sci., 77, pp. 2656-2662
  • Delbaere, A., Smits, G., De Leener, A., Costagliola, S., Vassart, G., Understanding ovarian hyperstimulation syndrome (2005) Endocrine, 26, pp. 285-290
  • Dierich, A., Sairam, M.R., Monaco, L., Fimia, G.M., Gansmuller, A., LeMeur, M., Sassone-Corsi, P., Impairing follicle-stimulating hormone (FSH) signaling in vivo: targeted disruption of the FSH receptor leads to aberrant gametogenesis and hormonal imbalance (1998) Proc. Natl. Acad. Sci. U.S.A., 95, pp. 13612-13617
  • El-Gehani, F., Tena-Sempere, M., Huhtaniemi, I., Vasoactive intestinal peptide is an important endocrine regulatory factor of fetal rat testicular steroidogenesis (1998) Endocrinology, 139, pp. 1474-1480
  • El-Gehani, F., Tena-Sempere, M., Huhtaniemi, I., Evidence that pituitary adenylate cyclase-activating polypeptide is a potent regulator of fetal rat testicular steroidogenesis (2000) Biol. Reprod., 63, pp. 1482-1489
  • El-Gehani, F., Tena-Sempere, M., Ruskoaho, H., Huhtaniemi, I., Natriuretic peptides stimulate steroidogenesis in the fetal rat testis (2001) Biol. Reprod., 65, pp. 595-600
  • El-Gehani, F., Zhang, F.P., Pakarinen, P., Rannikko, A., Huhtaniemi, I., Gonadotropin-independent regulation of steroidogenesis in the fetal rat testis (1998) Biol. Reprod., 58, pp. 116-123
  • Fazleabas, A.T., Donnelly, K.M., Srinivasan, S., Fortman, J.D., Miller, J.B., Modulation of the baboon (Papio anubis) uterine endometrium by chorionic gonadotrophin during the period of uterine receptivity (1999) Proc. Natl. Acad. Sci. U.S.A., 96, pp. 2543-2548
  • Fields, M.J., Shemesh, M., Extragonadal luteinizing hormone receptors in the reproductive tract of domestic animals (2004) Biol. Reprod., 71, pp. 1412-1418
  • Filicori, M., Fazleabas, A.T., Huhtaniemi, I., Licht, P., Rao, C.V., Tesarik, J., Zygmunt, M., Novel concepts of human chorionic gonadotropin; reproductive system interactions and potentials in the management of infertility (2005) Fertil. Steril., 84, pp. 275-284
  • Galway, A.B., Lapolt, P.S., Tsafriri, A., Dargan, C.M., Boime, I., Hsueh, A.J., Recombinant follicle-stimulating hormone induces ovulation and tissue plasminogen activator expression in hypophysectomized rats (1990) Endocrinology, 127, pp. 3023-3028
  • Haider, S.G., Servos, G., Ultracytochemistry of 3beta-hydroxysteroid dehydrogenase in Leydig cell precursors and vascular endothelial cells of the postnatal rat testis (1998) Anat. Embryol. (Berl.), 198, pp. 101-110
  • Huhtaniemi, I., Fetal testis-a very special endocrine organ (1994) Eur. J. Endocrinol., 130, pp. 25-31
  • Kamischke, A., Nieschlag, E., Progress towards hormonal male contraception (2004) Trends Pharmacol. Sci., 25, pp. 49-57
  • Kendall, S.K., Samuelson, L.C., Saunders, T.L., Wood, R.I., Camper, S.A., Targeted disruption of the pituitary glycoprotein hormone alpha-subunit produces hypogonadal and hypothyroid mice (1995) Genes Dev., 9, pp. 2007-2019
  • Kumar, T.R., Palapattu, G., Wang, P., Woodruff, T.K., Boime, I., Byrne, M.C., Matzuk, M.M., Transgenic models to study gonadotropin function: the role of follicle-stimulating hormone in gonadal growth and tumorigenesis (1999) Mol. Endocrinol., 13, pp. 851-865
  • Kumar, T.R., Wang, Y., Lu, N., Matzuk, M.M., Follicle stimulating hormone is required for ovarian follicle maturation but not male fertility (1997) Nat. Genet., 15, pp. 201-204
  • Lei, Z.M., Mishra, S., Zou, W., Xu, B., Foltz, M., Li, X., Rao, C.V., Targeted disruption of luteinizing hormone/human chorionic gonadotropin receptor gene (2001) Mol. Endocrinol., 15, pp. 184-200
  • Lin, D.X., Lei, Z.M., Li, X., Rao, Ch.V., Targeted disruption of LH receptor gene revealed the importance of uterine LH signaling (2005) Mol. Cell Endocrinol., 234, pp. 105-116
  • Liu, G., Duranteau, L., Carel, J.C., Monroe, J., Doyle, D.A., Shenker, A., Leydig-cell tumors caused by an activating mutation of the gene encoding the luteinizing hormone receptor (1999) N. Engl. J. Med., 341, pp. 1731-1736
  • Ma, X., Dong, Y., Matzuk, M.M., Kumar, T.R., Targeted disruption of luteinizing hormone beta-subunit leads to hypogonadism, defects in gonadal steroidogenesis, and infertility (2004) Proc. Natl. Acad. Sci. U.S.A., 101, pp. 17294-17299
  • Matzuk, M.M., DeMayo, F.J., Handsell, L.A., Kumar, T.R., Overexpression of human choropinic gonadotropin causes multiple reproductive defects in transgenic mice (2003) Biol. Reprod., 69, pp. 338-346
  • Meehan, T.P., Harmon, B.G., Overcast, M.E., Yu, K.K., Camper, S.A., Puett, D., Narayan, P., Gonadal defects and hormonal alterations in transgenic mice expressing a single chain human chorionic gonadotropin-lutropin receptor complex (2005) J. Mol. Endocrinol., 34, pp. 489-503
  • O'Shaughnessy, P.J., Fleming, L.M., Jackson, G., Hochgeschwender, U., Reed, P., Baker, P.J., Adrenocorticotropic hormone directly stimulates testosterone production by the fetal and neonatal mouse testis (2003) Endocrinology, 144, pp. 3279-3284
  • Pakarainen, T., Zhang, F.P., Makela, S., Poutanen, M., Huhtaniemi, I., Testosterone replacement therapy induces spermatogenesis and partially restores fertility in luteinizing hormone receptor knockout mice (2005) Endocrinology, 146, pp. 596-606
  • Pakarainen, T., Zhang, F.P., Poutanen, M., Huhtaniemi, I., Fertility in luteinizing hormone receptor-knockout mice after wild-type ovary transplantation demonstrates redundancy of extragonadal luteinizing hormone action (2005) J. Clin. Invest., 115, pp. 1862-1868
  • Pakarinen, P., Kimura, S., El-Gehani, F., Pelliniemi, L.J., Huhtaniemi, I., Pituitary hormones are not required for sexual differentiation of male mice: phenotype of the T/ebp/Nkx2.1 null mutant mice (2002) Endocrinology, 143, pp. 4477-4482
  • Park, J.Y., Su, Y.Q., Ariga, M., Law, E., Jin, S.L., Conti, M., EGF-like growth factors as mediators of LH action in the ovulatory follicle (2004) Science, 303, pp. 682-684
  • Plant, T.M., Marshall, G.R., The functional significance of FSH in spermatogenesis and the control of its secretion in male primates (2001) Endocr. Rev., 22, pp. 764-786
  • Rao, C.V., Multiple novel roles of luteinizing hormone (2001) Fertil. Steril., 76, pp. 1097-1100
  • Richter-Unruh, A., Wessels, H.T., Menken, U., Bergmann, M., Schmittmann-Ohters, K., Schaper, J., Tappeser, S., Hauffa, B.P., Male LH-independent sexual precocity in a 3.5-year-old boy caused by a somatic activating mutation of the LH receptor in a Leydig cell tumor (2002) J. Clin. Endocrinol. Metab., 87, pp. 1052-1056
  • Risma, K.A., Clay, C.M., Nett, T.M., Wagner, T., Yun, J., Nilson, J.H., Targeted overexpression of luteinizing hormone in transgenic mice leads to infertility, polycystic ovaries, and ovarian tumors (1995) Proc. Natl. Acad. Sci. U.S.A., 92, pp. 1322-1326
  • Rulli, S.B., Ahtiainen, P., Makela, S., Toppari, J., Poutanen, M., Huhtaniemi, I., Elevated steroidogenesis, defective reproductive organs, and infertility in transgenic male mice overexpressing human chorionic gonadotropin (2003) Endocrinology, 144, pp. 4980-4990
  • Rulli, S.B., Kuorelahti, A., Karaer, O., Pelliniemi, L.J., Poutanen, M., Huhtaniemi, I., Reproductive disturbances, pituitary lactotrope adenomas, and mammary gland tumors in transgenic female mice producing high levels of human chorionic gonadotropin (2002) Endocrinology, 143, pp. 4084-4095
  • Shemesh, M., Actions of gonadotrophins on the uterus (2001) Reproduction, 121, pp. 835-842
  • Shemesh, M., Mizrachi, D., Gurevich, M., Stram, Y., Shore, L.S., Fields, M.J., Functional importance of bovine myometrial and vascular LH receptors and cervical FSH receptors (2001) Semin. Reprod. Med., 19, pp. 87-96
  • Strauss, B.L., Pittman, R., Pixley, M.R., Boime, I., Expression of the beta subunit of chorionic gonadotropin in transgenic mice (1994) J. Biol. Chem., 269, pp. 4968-4973
  • Tapanainen, J.S., Lapolt, P.S., Perlas, E., Hsueh, A.J., Induction of ovarian follicle luteinization by recombinant follicle-stimulating hormone (1993) Endocrinology, 133, pp. 2875-2880
  • Themmen, A.P.N., Huhtaniemi, I.T., Mutations of gonadotropins and gonadotropin receptors: elucidating the physiology and pathophysiology of pituitary-gonadal function (2000) Endocr. Rev., 21, pp. 551-583
  • Urizar, E., Montanelli, L., Loy, T., Bonomi, M., Swillens, S., Gales, C., Bouvier, M., Costagliola, S., Glycoprotein hormone receptors: link between receptor homodimerization and negative cooperativity (2005) Embo J., 24, pp. 1954-1964
  • Valdes-Socin, H., Salvi, R., Daly, A.F., Gaillard, R.C., Quatresooz, P., Tebeu, P.M., Pralong, F.P., Beckers, A., Hypogonadism in a patient with a mutation in the luteinizing hormone beta-subunit gene (2004) N. Engl. J. Med., 351, pp. 2619-2625
  • Weiss, J., Axelrod, L., Whitcomb, R.W., Harris, P.E., Crowley, W.F., Jameson, J.L., Hypogonadism caused by a single amino acid substitution in the beta subunit of luteinizing hormone (1992) N. Engl. J. Med., 326, pp. 179-183
  • Yarram, S.J., Perry, M.J., Christopher, T.J., Westby, K., Brown, N.L., Lamminen, T., Rulli, S.B., Mansell, J.P., Luteinizing hormone receptor knockout (LuRKO) mice and transgenic human chorionic gonadotropin (hCG)-overexpressing mice (hCG alphabeta+) have bone phenotypes (2003) Endocrinology, 144, pp. 3555-3564
  • Zhang, F.P., Pakarainen, T., Poutanen, M., Toppari, J., Huhtaniemi, I., The low gonadotropin-independent constitutive production of testicular testosterone is sufficient to maintain spermatogenesis (2003) Proc. Natl. Acad. Sci. U.S.A., 100, pp. 13692-13697
  • Zhang, F.P., Pakarainen, T., Zhu, F., Poutanen, M., Huhtaniemi, I., Molecular characterization of postnatal development of testicular steroidogenesis in luteinizing hormone receptor knockout mice (2004) Endocrinology, 145, pp. 1453-1463
  • Zhang, F.P., Poutanen, M., Wilbertz, J., Huhtaniemi, I., Normal prenatal but arrested postnatal sexual development of luteinizing hormone receptor knockout (LuRKO) mice (2001) Mol. Endocrinol., 15, pp. 172-183
  • Zhang, M., Shi, H., Segaloff, D.L., Van Voorhis, B.J., Expression and localization of luteinizing hormone receptor in the female mouse reproductive tract (2001) Biol. Reprod., 64, pp. 179-187
  • Ziecik, A.J., Stanchev, P.D., Tilton, J.E., Evidence for the presence of luteinizing hormone/human chorionic gonadotropin-binding sites in the porcine uterus (1986) Endocrinology, 119, pp. 1159-1163

Citas:

---------- APA ----------
Ahtiainen, P., Rulli, S., Pakarainen, T., Zhang, F.-P., Poutanen, M. & Huhtaniemi, I. (2007) . Phenotypic characterisation of mice with exaggerated and missing LH/hCG action. Molecular and Cellular Endocrinology, 260-262, 255-263.
http://dx.doi.org/10.1016/j.mce.2005.11.047
---------- CHICAGO ----------
Ahtiainen, P., Rulli, S., Pakarainen, T., Zhang, F.-P., Poutanen, M., Huhtaniemi, I. "Phenotypic characterisation of mice with exaggerated and missing LH/hCG action" . Molecular and Cellular Endocrinology 260-262 (2007) : 255-263.
http://dx.doi.org/10.1016/j.mce.2005.11.047
---------- MLA ----------
Ahtiainen, P., Rulli, S., Pakarainen, T., Zhang, F.-P., Poutanen, M., Huhtaniemi, I. "Phenotypic characterisation of mice with exaggerated and missing LH/hCG action" . Molecular and Cellular Endocrinology, vol. 260-262, 2007, pp. 255-263.
http://dx.doi.org/10.1016/j.mce.2005.11.047
---------- VANCOUVER ----------
Ahtiainen, P., Rulli, S., Pakarainen, T., Zhang, F.-P., Poutanen, M., Huhtaniemi, I. Phenotypic characterisation of mice with exaggerated and missing LH/hCG action. Mol. Cell. Endocrinol. 2007;260-262:255-263.
http://dx.doi.org/10.1016/j.mce.2005.11.047