Artículo

Appleyard, S.M.; Hayward, M.; Young, J.I.; Butler, A.A.; Cone, R.D.; Rubinstein, M.; Low, M.J. "A role for the endogenous opioid β-endorphin in energy homeostasis" (2003) Endocrinology. 144(5):1753-1760
Estamos trabajando para incorporar este artículo al repositorio
Consulte el artículo en la página del editor
Consulte la política de Acceso Abierto del editor

Abstract:

Proopiomelanocortin (POMC) neurons in the hypothalamus are direct targets of the adipostatic hormone leptin and contribute to energy homeostasis by integrating peripheral and central information. The melanocortin and β-endorphin neuropeptides are processed from POMC and putatively coreleased at axon terminals. Melanocortins have been shown by a combination of pharmacological and genetic methods to have inhibitory effects on appetite and body weight. In contrast, pharmacological studies have generally indicated that opioids stimulate food intake. Here we report that male mice engineered to selectively lack β-endorphin, but that retained normal melanocortin signaling, were hyperphagic and obese. Furthermore, β-endorphin mutant and wild-type mice had identical orexigenic responses to exogenous opioids and identical anorectic responses to the nonselective opioid antagonist naloxone, implicating an alternative endogenous opioid tone to β-endorphin that physiologically stimulates feeding. These genetic data indicate that β-endorphin is required for normal regulation of feeding, but, in contrast to earlier reports suggesting opposing actions of β-endorphin and melanocortins on appetite, our results suggest a more complementary interaction between the endogenously released POMC-derived peptides in the regulation of energy homeostasis.

Registro:

Documento: Artículo
Título:A role for the endogenous opioid β-endorphin in energy homeostasis
Autor:Appleyard, S.M.; Hayward, M.; Young, J.I.; Butler, A.A.; Cone, R.D.; Rubinstein, M.; Low, M.J.
Filiación:Vollum Institute, Oregon Health and Science University, Portland, OR 97239, United States
Inst. Invest. Ing. Genet. Biol. M., Dept. Physiol., Molec.,/Cell. Biol., Universidad de Buenos Aires, Buenos Aires 1428, Argentina
Vollum Institute, OR Hlth./Science University, L474, Portland, OR 97201, United States
Palabras clave:beta endorphin; leptin; melanocortin; naloxone; neuropeptide; opiate; opiate antagonist; proopiomelanocortin; beta endorphin; glucose; leptin; naloxone; narcotic antagonist; neuropeptide Y; animal experiment; animal model; animal tissue; anorexia; article; body weight; controlled study; energy balance; food intake; hyperphagia; hypothalamus; male; mouse; nerve ending; nonhuman; obesity; priority journal; animal; blood; drug effect; eating; energy metabolism; homeostasis; hyperinsulinism; hyperphagia; metabolism; mouse mutant; obesity; physiology; reference value; Animals; beta-Endorphin; Eating; Energy Metabolism; Glucose; Homeostasis; Hyperinsulinism; Hyperphagia; Leptin; Male; Mice; Mice, Knockout; Naloxone; Narcotic Antagonists; Neuropeptide Y; Obesity; Reference Values
Año:2003
Volumen:144
Número:5
Página de inicio:1753
Página de fin:1760
DOI: http://dx.doi.org/10.1210/en.2002-221096
Título revista:Endocrinology
Título revista abreviado:Endocrinology
ISSN:00137227
CODEN:ENDOA
CAS:beta endorphin, 59887-17-1; naloxone, 357-08-4, 465-65-6; opiate, 53663-61-9, 8002-76-4, 8008-60-4; proopiomelanocortin, 66796-54-1; glucose, 50-99-7, 84778-64-3; neuropeptide Y, 82785-45-3, 83589-17-7; beta-Endorphin, 60617-12-1; Glucose, 50-99-7; Leptin; Naloxone, 465-65-6; Narcotic Antagonists; Neuropeptide Y
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00137227_v144_n5_p1753_Appleyard

Referencias:

  • Elmquist, J.K., Maratos-Flier, E., Saper, C.B., Flier, J.S., Unraveling the central nervous system pathways underlying responses to leptin (1998) Nat Neurosci, 1, pp. 445-450
  • Kalra, S.P., Dube, M.G., Pu, S., Xu, B., Horvath, T.L., Kalra, P.S., Interacting appetite-regulating pathways in the hypothalamic regulation of body weight (1999) Endocr Rev, 20, pp. 68-100
  • Cowley, M.A., Smart, J.L., Rubinstein, M., Cerdan, M.G., Diano, S., Horvath, T.L., Cone, R.D., Low, M.J., Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus (2001) Nature, 411, pp. 480-484
  • Flier, J., Maratos-Flier, E., Energy homeostasis and body weight (2000) Curr Biol, 10, pp. R215-R217
  • Schwartz, M.W., Woods, S.C., Porte D., Jr., Seeley, R.J., Baskin, D.G., Central nervous system control of food intake (2000) Nature, 404, pp. 661-671
  • Castro, M.G., Morrison, E., Post-translational processing of proopiomelanocortin in the pituitary and in the brain (1997) Crit Rev Neurobiol, 11, pp. 35-57
  • Yeo, G.S., Farooqi, I.S., Challis, B.G., Jackson, R.S., O'Rahilly, S., The role of melanocortin signalling in the control of body weight: Evidence from human and murine genetic models (2000) Q J Med, 93, pp. 7-14
  • Huszar, D., Lynch, C.A., Fairchild-Huntress, V., Dunmore, J.H., Fang, Q., Berkemeier, L.R., Gu, W., Lee, F., Targeted disruption of the melanocortin-4 receptor results in obesity in mice (1997) Cell, 88, pp. 131-141
  • Fan, W., Boston, B.A., Kesterson, R.A., Hruby, V.J., Cone, R.D., Role of melanocortinergic neurons in feeding and the agouti obesity syndrome (1997) Nature, 385, pp. 165-168
  • Butler, A.A., Kesterson, R.A., Khong, K., Cullen, M.J., Pelleymounter, M.A., Dekoning, J., Baetscher, M., Cone, R.D., A unique metabolic syndrome causes obesity in the melanocortin-3 receptor-deficient mouse (2000) Endocrinology, 141, pp. 3518-3521
  • Chen, A.S., Marsh, D.J., Trumbauer, M.E., Frazier, E.G., Guan, X.M., Yu, H., Rosenblum, C.I., Van Der Ploeg, L.H., Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass (2000) Nat Genet, 26, pp. 97-102
  • Glass, M.J., Billington, C.J., Levine, A.S., Opioids and food intake: Distributed functional neural pathways? (1999) Neuropeptides, 33, pp. 360-368
  • Kalra, S.P., Horvath, T.L., Neuroendocrine interactions between galanin, opioids, and neuropeptide Y in the control of reproduction and appetite (1998) Ann NY Acad Sci, 863, pp. 236-240
  • Kieffer, B.L., Recent advances in molecular recognition and signal transduction of active peptides: Receptors for opioid peptides (1995) Cell Mol Neurobiol, 15, pp. 615-635
  • Rubinstein, M., Mogil, J.S., Japon, M., Chan, E.C., Allen, R.G., Low, M.J., Absence of opioid stress-induced analgesia in mice lacking β-endorphin by site-directed mutagenesis (1996) Proc Natl Acad Sci USA, 93, pp. 3995-4000
  • Young, J.I., Otero, V., Cerdan, M.G., Falzone, T.L., Chan, E.C., Low, M.J., Rubinstein, M., Authentic cell-specific and developmentally regulated expression of pro-opiomelanocortin genomic fragments in hypothalamic and hindbrain neurons of transgenic mice (1998) J Neurosci, 18, pp. 6631-6640
  • Rubinstein, M., Mortrud, M., Liu, B., Low, M.J., Rat and mouse proopiomelanocortin gene sequences target tissue-specific expression to the pituitary gland but not to the hypothalamus of transgenic mice (1993) Neuroendocrinology, 58, pp. 373-380
  • Dave, J.R., Rubinstein, N., Eskay, R.L., Evidence that β-endorphin binds to specific receptors in rat peripheral tissues and stimulates the adenylate cyclase-adenosine 3′,5′-monophosphate system (1985) Endocrinology, 117, pp. 1389-1396
  • Grahame, N.J., Low, M.J., Cunningham, C.L., Intravenous self-administration of ethanol in β-endorphin-deficient mice (1998) Alcohol Clin Exp Res, 22, pp. 1093-1098
  • Ramabadran, K., Bansinath, M., Glucose homeostasis and endogenous opioid peptides (1990) Int J Clin Pharmacol Ther Toxicol, 28, pp. 89-98
  • Fulghesu, A.M., Ciampelli, M., Guido, M., Murgia, F., Caruso, A., Mancuso, S., Lanzone, A., Role of opioid tone in the pathophysiology of hyperinsulinemia and insulin resistance in polycystic ovarian disease (1998) Metabolism, 47, pp. 158-162
  • Dawson R., Jr., Naloxone-induced suppression of food intake is potentiated by neonatal administration of monosodium glutamate to mice (1983) Neurobehav Toxicol Teratol, 5, pp. 523-526
  • Brown, D.R., Holtzman, S.G., Suppression of deprivation-induced food and water intake in rats and mice by naloxone (1979) Pharmacol Biochem Behav, 11, pp. 567-573
  • Hayward, M.D., Low, M.J., The effect of naloxone on operant behavior for food reinforcers in DBA/2 mice (2001) Brain Res Bull, 56, pp. 537-543
  • Rudski, J.M., Grace, M., Kuskowski, M.A., Billington, C.J., Levine, A.S., Behavioral effects of naloxone on neuropeptide Y-induced feeding (1996) Pharmacol Biochem Behav, 54, pp. 771-777
  • Thornhill, J.A., Taylor, B., Marshall, W., Parent, K., Central, as well as peripheral naloxone administration suppresses feeding in food-deprived Sprague-Dawley and genetically obese (Zucker) rats (1982) Physiol Behav, 29, pp. 841-846
  • Levine, A.S., Weldon, D.T., Grace, M., Cleary, J.P., Billington, C.J., Naloxone blocks that portion of feeding driven by sweet taste in food-restricted rats (1995) Am J Physiol, 268, pp. R248-R252
  • Gee, C.E., Chen, C.L., Roberts, J.L., Thompson, R., Watson, S.J., Identification of proopiomelanocortin neurones in rat hypothalamus by in situ cDNA-mRNA hybridization (1983) Nature, 306, pp. 374-376
  • Banks, W.A., Kastin, A.J., Peptide transport systems for opiates across the blood-brain barrier (1990) Am J Physiol, 259, pp. E1-E10
  • Levine, A.S., Billington, C.J., Opioids Are they regulators of feeding? (1989) Ann NY Acad Sci, 575, pp. 209-219
  • De Zwaan, M., Mitchell, J.E., Opiate antagonists and eating behavior in humans: A review (1992) J Clin Pharmacol, 32, pp. 1060-1072
  • Hayward, M.D., Pintar, J.E., Low, M.J., Selective reward deficit in mice lacking β-endorphin and enkephalin (2002) J Neurosci, 22, pp. 8251-8258
  • Silva, R.M., Hadjimarkou, M.M., Rossi, G.C., Pasternak, G.W., Bodnar, R.J., Beta-endorphin-induced feeding: Pharmacological characterization using selective opioid antagonists and antisense probes in rats (2001) J Pharmacol Exp Ther, 297, pp. 590-596
  • Mogil, J.S., Grisel, J.E., Hayward, M.D., Bales, J.R., Rubinstein, M., Belknap, J.K., Low, M.J., Disparate spinal and supraspinal opioid antinociceptive responses in β-endorphin-deficient mutant mice (2000) Neuroscience, 101, pp. 709-717
  • Slugg, R.M., Hayward, M.D., Ronnekleiv, O.K., Low, M.J., Kelly, M.J., Effect of the μ-opioid agonist DAMGO on medial basal hypothalamic neurons in β-endorphin knockout mice (2000) Neuroendocrinology, 72, pp. 208-217
  • Govoni, S., Yang, H.Y., Sex differences in the content of β-endorphin and enkephalin-like peptides in the pituitary of obese (ob/ob) mice (1981) J Neurochem, 36, pp. 1829-1833
  • Krzanowska, E.K., Bodnar, R.J., Analysis of sex and gonadectomy differences in β-endorphin antinociception elicited from the ventrolateral periaqueductal gray in rats (2000) Eur J Pharmacol, 392, pp. 157-161
  • Krzanowska, E., Bodnar, R.J., Sex differences in locomotor activity following β-endorphin in the ventrolateral periaqueductal gray (2000) Physiol Behav, 68, pp. 595-598
  • Islam, A.K., Beczkowska, I.W., Bodnar, R.J., Interactions among aging, gender, and gonadectomy effects upon naloxone hypophagia in rats (1993) Physiol Behav, 54, pp. 981-992

Citas:

---------- APA ----------
Appleyard, S.M., Hayward, M., Young, J.I., Butler, A.A., Cone, R.D., Rubinstein, M. & Low, M.J. (2003) . A role for the endogenous opioid β-endorphin in energy homeostasis. Endocrinology, 144(5), 1753-1760.
http://dx.doi.org/10.1210/en.2002-221096
---------- CHICAGO ----------
Appleyard, S.M., Hayward, M., Young, J.I., Butler, A.A., Cone, R.D., Rubinstein, M., et al. "A role for the endogenous opioid β-endorphin in energy homeostasis" . Endocrinology 144, no. 5 (2003) : 1753-1760.
http://dx.doi.org/10.1210/en.2002-221096
---------- MLA ----------
Appleyard, S.M., Hayward, M., Young, J.I., Butler, A.A., Cone, R.D., Rubinstein, M., et al. "A role for the endogenous opioid β-endorphin in energy homeostasis" . Endocrinology, vol. 144, no. 5, 2003, pp. 1753-1760.
http://dx.doi.org/10.1210/en.2002-221096
---------- VANCOUVER ----------
Appleyard, S.M., Hayward, M., Young, J.I., Butler, A.A., Cone, R.D., Rubinstein, M., et al. A role for the endogenous opioid β-endorphin in energy homeostasis. Endocrinology. 2003;144(5):1753-1760.
http://dx.doi.org/10.1210/en.2002-221096