Artículo

Vetter, D.E.; Liberman, M.C.; Mann, J.; Barhanin, J.; Boulter, J.; Brown, M.C.; Saffiote-Kolman, J.; Heinemann, S.F.; Elgoyhen, A.B. "Role of α9 nicotinic ACh receptor subunits in the development and function of cochlear efferent innervation" (1999) Neuron. 23(1):93-103
Estamos trabajando para incorporar este artículo al repositorio
Consulte el artículo en la página del editor
Consulte la política de Acceso Abierto del editor

Abstract:

Cochlear outer hair cells (OHCs) express α9 nACh receptors and are contacted by descending, predominately cholinergic, efferent fibers originating in the CNS. Mice carrying a null mutation for the nACh α9 gene were produced to investigate its role(s) in auditory processing and development of hair cell innervation. In α9 knockout mice, most OHCs were innervated by one large terminal instead of multiple smaller terminals as in wild types, suggesting a role for the nACh α9 subunit in development of mature synaptic connections. α9 knockout mice also failed to show suppression of cochlear responses (compound action potentials, distortion product otoacoustic emissions) during efferent fiber activation, demonstrating the key role α9 receptors play in mediating the only known effects of the olivocochlear system.

Registro:

Documento: Artículo
Título:Role of α9 nicotinic ACh receptor subunits in the development and function of cochlear efferent innervation
Autor:Vetter, D.E.; Liberman, M.C.; Mann, J.; Barhanin, J.; Boulter, J.; Brown, M.C.; Saffiote-Kolman, J.; Heinemann, S.F.; Elgoyhen, A.B.
Filiación:Salk Inst. for Biological Studies, La Jolla, CA 92037, United States
Eaton-Peabody Laboratory, Department of Otology/Laryngology, Harvard Medical School, Boston, MA 02114, United States
Beckman Res. Inst. City Hope, Duarte, CA 92010, United States
Ctr. Natl. de la Rech. Sci., Inst. de Pharmacol. Molec. et Cell., Sophia Antipolis 06560 Valbonne, France
Dept. Psychiat./Biobehavioral Sci., Univ. of California, Los Angeles, Los Angeles, CA 90095, United States
Inst. de Invest. en Ingenieria, Genetica y Biologia Molec., CONICET-UBA, Buenos Aires 1428, Argentina
Palabras clave:nicotinic receptor; receptor subunit; nicotinic receptor; animal tissue; article; cell maturation; cell structure; cochlea; controlled study; Corti organ; distortion product otoacoustic emission; efferent nerve; gene structure; gene targeting; hair cell; knockout mouse; male; nonhuman; nucleotide sequence; parasympathetic innervation; priority journal; animal; cytology; genetics; growth, development and aging; innervation; mouse; mouse mutant; olivary nucleus; physiology; Animals; Cochlea; Efferent Pathways; Hair Cells, Outer; Mice; Mice, Knockout; Olivary Nucleus; Receptors, Nicotinic
Año:1999
Volumen:23
Número:1
Página de inicio:93
Página de fin:103
DOI: http://dx.doi.org/10.1016/S0896-6273(00)80756-4
Título revista:Neuron
Título revista abreviado:Neuron
ISSN:08966273
CODEN:NERNE
CAS:Receptors, Nicotinic
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08966273_v23_n1_p93_Vetter

Referencias:

  • Aschoff, A., Ostwald, J., Different origins of cochlear efferents in some bat species, rats, and guinea pigs (1987) J. Comp. Neurol., 264, pp. 56-72
  • Aschoff, A., Ostwald, J., Distribution of cochlear efferents and olivo-collicular neurons in the brainstem of rat and guinea pig. A double labeling study with fluorescent tracers (1988) Exp. Brain Res., 71, pp. 241-251
  • Aschoff, A., Muller, M., Ott, H., Origin of cochlea efferents in some gerbil species. A comparative anatomical study with fluorescent tracers (1988) Exp. Brain Res., 71, pp. 252-261
  • Balice-Gordon, R.J., Lichtmann, J.W., Long-term synapse loss induced by focal blockade of postsynaptic receptors (1994) Nature, 372, pp. 519-524
  • Bobbin, R.P., Konishi, T., Action of cholinergic and anticholinergic drugs at the crossed olivocochlear bundle-hair cell junction (1974) Acta Otolaryngol. (Stockh.), 77, pp. 56-65
  • Brown, M.C., Nuttall, A.L., Efferent control of cochlear inner hair cell responses in the guinea-pig (1984) J. Physiol. (Lond.), 354, pp. 625-646
  • Brown, M.C., Nuttall, A.L., Masta, R.I., Intracellular recordings from cochlear inner hair cells: Effects of stimulation of the crossed olivocochlear efferents (1983) Science, 222, pp. 69-72
  • Campbell, J.P., Henson, M.M., Olivocochlear neurons in the brainstem of the mouse (1988) Hear. Res., 35, pp. 271-274
  • Chomczynski, P., Sacchi, N., Single-step method of RNA isolation by acid guanidinium thiocyanate-pheol-chloroform extraction (1987) Anal. Biochem., 162, pp. 156-159
  • Cody, A.R., Johnstone, B.M., Acoustically evoked activity of single efferent neurons in the guinea pig cochlea (1982) J. Acoust. Soc. Am., 72, pp. 280-282
  • Dallos, P., He, D., Lin, X., Sziklai, I., Mehta, S., Evans, B., Acetylcholine, outer hair cell electromotility, and the cochlear amplifier (1997) J. Neurosci., 17, pp. 2212-2226
  • Desmedt, J., Auditory-evoked potentials from cochlea to cortex as influenced by activation of the efferent olivocochlear bundle (1962) J. Acoust. Soc. Am., 34, pp. 1478-1496
  • Desmedt, J., Monaco, P., Mode of action of the efferent olivo-cochlear bundle on the inner ear (1961) Nature, 192, pp. 1263-1265
  • Elgoyhen, A.B., Johnson, D.S., Boulter, J., Vetter, D.E., Heinemann, S., Alpha 9: An acetylcholine receptor with novel pharmacological properties expressed in rat cochlear hair cells (1994) Cell, 79, pp. 705-715
  • Emmerling, M.R., Sobkowicz, H.M., Levenick, C.V., Scott, G.L., Slapnick, S.M., Rose, J.E., Biochemical and morphological differentiation of acetylcholinesterase-positive efferent fibers in the mouse cochlea (1990) J. Electron Microsc. Tech., 15, pp. 123-143
  • Erostegui, C., Norris, C.H., Bobbin, R.P., In vitro pharmacologic characterization of a cholinergic receptor on outer hair cells (1994) Hear. Res., 74, pp. 135-147
  • Eybalin, M., Neurotransmitters and neuromodulators of the mammalian cochlea (1993) Physiol. Rev., 73, pp. 309-373
  • Fex, J., Adams, J.C., Alpha-bungarotoxin blocks reversibly cholinergic inhibition in the cochlea (1978) Brain Res., 159, pp. 440-444
  • Folsom, R., Owsley, R., N1 action potentials in humans. Influence of simultaneous contralateral stimulation (1987) Acta Otolaryngol. (Stockh.), 103, pp. 262-265
  • Fredette, B., Rutishauser, U., Landmesser, L., Regulation and activity-dependence of N-cadherin, NCAM isoforms, and polysialic acid on chick myotubes during development (1993) J. Cell Biol., 123, pp. 1867-1888
  • Fritzsch, B., Nichols, D.H., Dil reveals a prenatal arrival of efferents at the differentiating otocyst of mice (1993) Hear. Res., 65, pp. 51-60
  • Fuchs, P.A., Murrow, B.W., A novel cholinergic receptor mediates inhibition of chick cochlear hair cells (1992) Proc. R. Soc. Lond. B Biol. Sci., 248, pp. 35-40
  • Galambos, R., Suppresion of auditory nerve activity by stimulation of efferent fibers to the cochlea (1956) J. Neurophysiol., 19, pp. 424-437
  • Ginzberg, R.D., Morest, D.K., Fine structure of cochlear innervation in the cat (1984) Hear. Res., 14, pp. 109-127
  • Glowatzki, E., Wild, K., Brändle, U., Fakler, G., Fakler, B., Zenner, H.-P., Ruppersberg, J.P., Cell-specific expression of the a9 n-ACh receptor subunit in auditory hair cells revealed by single cell RT-PCR (1995) Proc. R. Soc. Lond. B, 262, pp. 141-147
  • Guinan J.J., Jr., Warr, W.B., Norris, B.E., Differential olivocochlear projections from lateral versus medial zones of the superior olivary complex (1983) J. Comp. Neurol., 221, pp. 358-370
  • Hashimoto, S., Kimura, R.S., Takasaka, T., Computer- Aided three-dimensional reconstruction of the inner hair cells and their nerve endings in the guinea pig cochlea (1990) Acta Otolaryngol. (Stockh.), 109, pp. 228-234
  • Heinz, R., Stiles, P., May, B., Effects of bilateral olivocochlear lesions on vowel formant discrimination in cats (1998) Hear. Res., 116, pp. 10-20
  • Hiel, H., Elgoyhen, A., Drescher, D., Morley, B., Expression of nicotinic acetylcholine receptor mRNA in the adult rat peripheral vestibular system (1996) Brain Res., 738, pp. 347-352
  • Holst, B., Vanderklish, P., Krushel, L., Zhou, W., Langdon, R., McWhirter, J., Edelman, G., Crossin, K., Allosteric modulation of AMPA-type glutamate receptors increases activity of the promoter for the neural cell adhesion molecule, NCAM (1998) Proc. Natl. Acad. Sci. USA, 95, pp. 2597-2602
  • Housley, G.D., Ashmore, J.F., Direct measurement of the action of acetylcholine on isolated outer hair cells of the guinea pig cochlea (1991) Proc. R. Soc. Lond. B Biol. Sci., 244, pp. 161-167
  • Klinke, R., Galley, N., Efferent innervation of vestibular and auditory receptors (1974) Physiol. Rev., 54, pp. 316-357
  • Königen, F., Stewart, C.L., Simple screening procedure to detect gene targeting events in embryonic stem cells (1993) Methods Enzymol., 225, pp. 878-890
  • Kujawa, S.G., Glattke, T.J., Fallon, M., Bobbin, R.P., Intracochlear application of acetylcholine alters sound-induced mechanical events within the cochlear partition (1992) Hear. Res., 61, pp. 106-116
  • Kujawa, S.G., Glattke, T.J., Fallon, M., Bobbin, R.P., Contralateral sound suppresses distortion product otoacoustic emissions through cholinergic mechanisms (1993) Hear. Res., 68, pp. 97-106
  • Kujawa, S.G., Glattke, T.J., Fallon, M., Bobbin, R.P., A nicotinic-like receptor mediates suppression of distortion product otoacoustic emissions by contralateral sound (1994) Hear. Res., 74, pp. 122-134
  • Lauder, J.M., Neurotransmitters as growth regulatory signals: Role of receptors and second messengers (1993) Trends Neurosci., 16, pp. 233-240
  • Li, Y., Erzurumlu, R.S., Chen, C., Jhaveri, S., Tonegawa, S., Whisker-related neuronal patterns fail to develop in the trigeminal brainstem nuclei of NMDAR1 knockout mice (1994) Cell, 76, pp. 427-437
  • Liberman, M.C., Rapid assessment of sound-evoked olivocochlear feedback: Suppression of compound action potentials by contralateral sound (1989) Hear. Res., 38, pp. 47-56
  • Liberman, M.C., The olivocochlear efferent bundle and susceptibility of the inner ear to acoustic injury (1991) J. Neurophysiol., 65, pp. 123-132
  • Lipton, S.A., Frosch, M.P., Phillips, M.D., Tauck, D.L., Aizenman, D.L., Nicotinic antagonists enhance process outgrowth by rat retinal ganglion cells in culture (1988) Science, 239, pp. 1293-1296
  • Lonsbury-Martin, B.L., Martin, G.K., Whitehead, M.L., Distortion product otoacoustic emissions (1997) Otoacoustic Emissions: Clinical Applications, pp. 83-109. , M.S. Robinette and T.J. Glattke, eds. (New York: Thieme)
  • Luo, L., Bennett, T., Jung, H.H., Ryan, A.F., Developmental expression of a9 acetylcholine receptor mRNA in the rat cochlea and vestibular inner ear (1998) J. Comp. Neurol., 393, pp. 320-331
  • Mattson, M.P., Neurotransmitters in the regulation of neuronal cytoarchitecture (1988) Brain Res. Brain Res. Rev., 13, pp. 179-212
  • May, B., McQuone, S., Effects of bilateral olivocochlear efferent lesions on pure-tone intensity discrimination in cats (1995) Aud. Neurosci., 1, pp. 385-400
  • Morley, B., Li, H., Hiel, H., Drescher, D., Elgoyhen, A., Identification of the subunits of the nicotinic cholinergic receptors in the rat cochlea using RT-PCR and in situ hybridization (1998) Brain Res. Mol. Brain Res., 53, pp. 78-87
  • Mountain, D.C., Changes in endolymphatic potential and crossed olivocochlear bundle stimulation alter cochlear mechanics (1980) Science, 210, pp. 71-72
  • Mountain, D.C., Geisler, C.D., Hubbard, A.E., Stimulation of efferents alters the cochlear microphonic and the sound-induced resistance changes measured in scale media of the guinea pig (1980) Hear. Res., 3, pp. 231-240
  • Murugasu, E., Russell, I., The effect of efferent stimulation on basilar membrane displacement in the basal turn of the guinea pig cochlea (1996) J. Neurosci., 16, pp. 325-332
  • Oatman, L., Role of visual attention on auditory evoked potentials in unanesthesized cats (1971) Exp. Neurol., 32, pp. 341-356
  • Probst, R., Lonsbury-Martin, B.L., Martin, G.K., A review of otoacoustic emissions (1991) J. Acoust. Soc. Am., 89, pp. 2027-2067
  • Puria, S., Guinan J.J., Jr., Liberman, M., Olivocochlear reflex assays: Effects of contralateral sound on compound action potentials versus ear-canal distortion products (1996) J. Acoust. Soc. Am., 99, pp. 500-507
  • Rasmussen, G.L., An efferent cochlear bundle (1942) Anat. Rec., 82, p. 441
  • Rasmussen, G.L., The olivary peduncle and other fiber projections of the superior olivary complex (1946) J. Comp. Neurol., 84, pp. 141-219
  • Rasmussen, G.L., Descending, or "feed-back" connections of the auditory system of the cat (1955) Am. J. Physiol., 183, p. 653
  • Robertson, D., Brainstem location of efferent neurones projecting to the guinea pig cochlea (1985) Hear. Res., 20, pp. 79-84
  • Ruggero, M.A., Robles, L., Rich, N.C., Recio, A., Basilar membrane responses to two-tone and broadband stimuli (1992) Philos. Trans. R. Soc. Lond. B Biol. Sci., 336, pp. 307-314. , discussion 314-135
  • Scharf, B., Quigley, S., Aoki, C., Peachey, N., Reeves, A., Focused auditory attention and frequency selectivity (1987) Percept. Psychophys., 42, pp. 215-223
  • Scharf, B., Magnan, J., Collet, L., Ulmer, E., Chays, A., On the role of the olivocochlear bundle in hearing: A case study (1994) Hear. Res., 75, pp. 11-26
  • Siegel, J.H., Kim, D.O., Efferent neural control of cochlear mechanics? olivocochlear bundle stimulation affects cochlear biomechanical nonlinearity (1982) Hear. Res., 6, pp. 171-182
  • Slepecky, N., Structure of the mammalian cochlea. In (1996) The Cochlea, pp. 44-129. , P. Dallos, A.N. Popper, and R.R. Fay, eds. (New York: Springer)
  • Sobkowicz, H., The development of innervation in the organ of corti. In (1992) Development of the Auditory and Vestibular Systems, 2, pp. 59-100. , R. Romand, ed. (New York: Eisevier Science Publishers)
  • Sridhar, T., Liberman, M., Brown, M., Sewell, W., A novel cholinergic "slow effect" of efferent stimulation on cochlear potentials in the guinea pig (1995) J. Neurosci., 15, pp. 3667-3678
  • Stewart, C.L., Production of chimeras between embryonic stem cells and embryos (1993) Methods Enzymol., 225, pp. 823-855
  • Szabo, P., Mann, J.R., Expression and methylation of imprinted genes during in vitro differentiation of mouse parthenogenetic and androgenetic stem cell lines (1994) Development, 120, pp. 1651-1660
  • Thompson, G.C., Thompson, A.M., Olivocochlear neurons in the squirrel monkey brainstem (1986) J. Comp. Neurol., 254, pp. 246-258
  • Ulfendahl, M., Mechanical responses of the mammalian cochlea (1997) Prog. Neurobiol., 53, pp. 331-380
  • Vetter, D.E., Mann, J.R., Wangemann, P., Liu, J., McLaughlin, K.J., Lesage, F., Marcus, D.C., Barhanin, J., Inner ear defects induced by null mutation of the isk gene (1996) Neuron, 17, pp. 1251-1264
  • Walsh, E., McGee, J., McFadden, S., Liberman, M., Long-term effects of sectioning the olivocochlear bundle in neonatal cats (1998) J. Neurosci., 18, pp. 3859-3869
  • Warren, E.H.D., Liberman, M.C., Effects of contralateral sound on auditory-nerve responses. II. Dependence on stimulus variables (1989) Hear. Res., 37, pp. 105-121
  • White, J.S., Warr, W.B., The dual origins of the olivocochlear bundle in the albino rat (1983) J. Comp. Neurol., 219, pp. 203-214
  • Whitlon, D.S., Rutishauser, U.S., NCAM in the organ of Corti of the developing mouse (1990) J. Neurocytol., 19, pp. 970-977
  • Whitlon, D.S., Zhang, X., Polysialic acid in the cochlea of the developing mouse (1997) Int. J. Dev. Neurosci., 15, pp. 657-669
  • Wiederhold, M.L., Kiang, N.Y., Effects of electric stimulation of the crossed olivocochlear bundle on single auditory-nerve fibers in the cat (1970) J. Acoust. Soc. Am., 48, pp. 950-965
  • Winslow, R.L., Sachs, M.B., Single-tone intensity discrimination based on auditory-nerve rate responses in backgrounds of quiet, noise, and with stimulation of the crossed olivocochlear bundle (1988) Hear. Res., 35, pp. 165-189
  • Xie, D.H., Henson, M.M., Henson O.W., Jr., Ache-staining of type II ganglion cells, processes and terminals in the cochlea of the mustached bat (1994) Hear. Res., 75, pp. 61-66

Citas:

---------- APA ----------
Vetter, D.E., Liberman, M.C., Mann, J., Barhanin, J., Boulter, J., Brown, M.C., Saffiote-Kolman, J.,..., Elgoyhen, A.B. (1999) . Role of α9 nicotinic ACh receptor subunits in the development and function of cochlear efferent innervation. Neuron, 23(1), 93-103.
http://dx.doi.org/10.1016/S0896-6273(00)80756-4
---------- CHICAGO ----------
Vetter, D.E., Liberman, M.C., Mann, J., Barhanin, J., Boulter, J., Brown, M.C., et al. "Role of α9 nicotinic ACh receptor subunits in the development and function of cochlear efferent innervation" . Neuron 23, no. 1 (1999) : 93-103.
http://dx.doi.org/10.1016/S0896-6273(00)80756-4
---------- MLA ----------
Vetter, D.E., Liberman, M.C., Mann, J., Barhanin, J., Boulter, J., Brown, M.C., et al. "Role of α9 nicotinic ACh receptor subunits in the development and function of cochlear efferent innervation" . Neuron, vol. 23, no. 1, 1999, pp. 93-103.
http://dx.doi.org/10.1016/S0896-6273(00)80756-4
---------- VANCOUVER ----------
Vetter, D.E., Liberman, M.C., Mann, J., Barhanin, J., Boulter, J., Brown, M.C., et al. Role of α9 nicotinic ACh receptor subunits in the development and function of cochlear efferent innervation. Neuron. 1999;23(1):93-103.
http://dx.doi.org/10.1016/S0896-6273(00)80756-4