Artículo

Tomiyama, K.; McNamara, F.N.; Clifford, J.J.; Kinsella, A.; Drago, J.; Fuchs, S.; Grandy, D.K.; Low, M.J.; Rubinstein, M.; Tighe, O.; Croke, D.T.; Koshikawa, N.; Waddington, J.L. "Comparative Phenotypic Resolution of Spontaneous, D2-Like and D1-Like Agonist-Induced Orofacial Movement Topographies in Congenic Mutants with Dopamine D2 vs. D3 Receptor "Knockout"" (2004) Synapse. 51(1):71-81
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Abstract:

Using a novel system, the role of D2-like dopamine receptors in distinct topographies of orofacial movement was assessed in mutant mice with congenic D2 vs. D3 receptor knockout, and compared with findings in D1A mutants. Under spontaneous conditions, D2 mutants evidenced increased vertical jaw movements and unaltered horizontal jaw movements, with reductions in tongue protrusions and incisor chattering; in D3 mutants, only incisor chattering was reduced. Given previous evidence that D1A mutants show reduced horizontal but not vertical jaw movements, this indicates that apparent oppositional D 1-like:D2-like interactions in the regulation of composited jaw movements may in fact reflect the independent actions of D 2 receptors to inhibit vertical jaw movements and of D1A receptors to facilitate horizontal jaw movements. Effects of the D 2-like agonist RU 24213 to exert greater reduction in horizontal than in vertical jaw movements were not altered prominently in either D 2 or D3 mutants. The D1-like agonists A 68930 and SK&F 83959 induced vertical jaw movements, tongue protrusions, and incisor chattering; induction of tongue protrusions by A 68930 was reduced in D2 mutants. D2 receptors exert topographically specific regulation of orofacial movements in a manner distinct from their D 1A counterparts, while D3 receptors exert only minor regulation of such movements. © 2003 Wiley-Liss, Inc.

Registro:

Documento: Artículo
Título:Comparative Phenotypic Resolution of Spontaneous, D2-Like and D1-Like Agonist-Induced Orofacial Movement Topographies in Congenic Mutants with Dopamine D2 vs. D3 Receptor "Knockout"
Autor:Tomiyama, K.; McNamara, F.N.; Clifford, J.J.; Kinsella, A.; Drago, J.; Fuchs, S.; Grandy, D.K.; Low, M.J.; Rubinstein, M.; Tighe, O.; Croke, D.T.; Koshikawa, N.; Waddington, J.L.
Filiación:Department of Clinical Pharmacology, Inst. of Biopharmaceutical Sciences, Royal College of Surgeons in Ireland, St Stephen's Green, Dublin 2, Ireland
Department of Pharmacology, Dental Research Centre, Nihon University School of Dentistry, Tokyo 101-8310, Japan
School of Mathematics, Dublin Institute of Technology, Dublin 8, Ireland
Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel
Dept. of Physiology and Pharmacology, Oregon Health Sciences University, Portland, OR 97201, United States
Vollum Institute, Oregon Health Sciences University, Portland, OR 97201, United States
Inst. Invest. Ing. Genet./Biol. Mol., Universidad de Buenos Aires, Buenos Aires 1428, Argentina
Department of Biochemistry, Inst. of Biopharmaceutical Sciences, Royal College of Surgeons in Ireland, St Stephen's Green, Dublin 2, Ireland
Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, St Stephen's Green, Dublin 2, Ireland
Palabras clave:Behavioural phenotype; D 3 knockout; D2 knockout; Dopamine receptors; Orofacial movements; 1 aminomethyl 5,6 dihydroxy 3 phenylisochroman; 6 chloro 2,3,4,5 tetrahydro 7,8 dihydroxy 3 methyl 1 (3 methylphenyl) 1h 3 benzazepine; dopamine 1 receptor; dopamine 2 receptor; dopamine 3 receptor; n (3 hydroxyphenethyl) n (phenethyl)propylamine; animal behavior; animal experiment; article; controlled study; dopaminergic system; face; female; jaw movement; knockout mouse; male; motor control; mouse; mouth; nonhuman; phenotype; priority journal; Animals; Dopamine Agonists; Face; Female; Male; Mice; Mice, Congenic; Mice, Inbred C57BL; Mice, Knockout; Movement; Mutation; Phenotype; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Dopamine D3
Año:2004
Volumen:51
Número:1
Página de inicio:71
Página de fin:81
DOI: http://dx.doi.org/10.1002/syn.10284
Título revista:Synapse
Título revista abreviado:Synapse
ISSN:08874476
CODEN:SYNAE
CAS:1 aminomethyl 5,6 dihydroxy 3 phenylisochroman, 130465-45-1; 6 chloro 2,3,4,5 tetrahydro 7,8 dihydroxy 3 methyl 1 (3 methylphenyl) 1h 3 benzazepine, 80751-85-5; n (3 hydroxyphenethyl) n (phenethyl)propylamine, 67383-44-2; Dopamine Agonists; Drd3 protein, mouse; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Dopamine D3
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08874476_v51_n1_p71_Tomiyama

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Citas:

---------- APA ----------
Tomiyama, K., McNamara, F.N., Clifford, J.J., Kinsella, A., Drago, J., Fuchs, S., Grandy, D.K.,..., Waddington, J.L. (2004) . Comparative Phenotypic Resolution of Spontaneous, D2-Like and D1-Like Agonist-Induced Orofacial Movement Topographies in Congenic Mutants with Dopamine D2 vs. D3 Receptor "Knockout". Synapse, 51(1), 71-81.
http://dx.doi.org/10.1002/syn.10284
---------- CHICAGO ----------
Tomiyama, K., McNamara, F.N., Clifford, J.J., Kinsella, A., Drago, J., Fuchs, S., et al. "Comparative Phenotypic Resolution of Spontaneous, D2-Like and D1-Like Agonist-Induced Orofacial Movement Topographies in Congenic Mutants with Dopamine D2 vs. D3 Receptor "Knockout"" . Synapse 51, no. 1 (2004) : 71-81.
http://dx.doi.org/10.1002/syn.10284
---------- MLA ----------
Tomiyama, K., McNamara, F.N., Clifford, J.J., Kinsella, A., Drago, J., Fuchs, S., et al. "Comparative Phenotypic Resolution of Spontaneous, D2-Like and D1-Like Agonist-Induced Orofacial Movement Topographies in Congenic Mutants with Dopamine D2 vs. D3 Receptor "Knockout"" . Synapse, vol. 51, no. 1, 2004, pp. 71-81.
http://dx.doi.org/10.1002/syn.10284
---------- VANCOUVER ----------
Tomiyama, K., McNamara, F.N., Clifford, J.J., Kinsella, A., Drago, J., Fuchs, S., et al. Comparative Phenotypic Resolution of Spontaneous, D2-Like and D1-Like Agonist-Induced Orofacial Movement Topographies in Congenic Mutants with Dopamine D2 vs. D3 Receptor "Knockout". Synapse. 2004;51(1):71-81.
http://dx.doi.org/10.1002/syn.10284