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Abstract:

Spontaneous electrical activity generated by developing sensory cells and neurons is crucial for the maturation of neural circuits. The full maturation of mammalian auditory inner hair cells (IHCs) depends on patterns of spontaneous action potentials during a 'critical period' of development. The intrinsic spiking activity of IHCs can be modulated by inhibitory input from cholinergic efferent fibres descending from the brainstem, which transiently innervate immature IHCs. However, it remains unknown whether this transient efferent input to developing IHCs is required for their functional maturation. We used a mouse model that lacks the a9-nicotinic acetylcholine receptor subunit (a9nAChR) in IHCs and another lacking synaptotagmin-2 in the efferent terminals to remove or reduce efferent input to IHCs, respectively. We found that the efferent system is required for the developmental linearization of the Ca2p-sensitivity of vesicle fusion at IHC ribbon synapses, without affecting their general cell development. This provides the first direct evidence that the efferent system, by modulating IHC electrical activity, is required for the maturation of the IHC synaptic machinery. The central control of sensory cell development is unique among sensory systems. © 2013 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License.

Registro:

Documento: Artículo
Título:Cholinergic efferent synaptic transmission regulates the maturation of auditory hair cell ribbon synapses
Autor:Johnson, S.L.; Wedemeyer, C.; Vetter, D.E.; Adachi, R.; Holley, M.C.; Elgoyhen, A.B.; Marcotti, W.
Filiación:Department of Biomedical Science, University of Sheffield, Sheffield S10 2TN, United Kingdom
Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Dr Héctor N. Torres, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires 1428, Argentina
Department of Neurobiology and Anatomical Sciences, University of Mississippi Medical Center, Jackson, MS 39216, United States
Department of Pulmonary Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030, United States
Palabras clave:Calcium current; Cochlea; Development; Efferent system; Exocytosis; Hair cell; Chrna9 protein, mouse; nicotinic receptor; synaptotagmin II; Syt2 protein, mouse; action potential; animal; article; cochlea; genetics; hair cell; knockout mouse; motoneuron; mouse; physiology; stereocilium; synapse; synaptic transmission; Action Potentials; Animals; Cochlea; Hair Cells, Auditory, Inner; Mice; Mice, Knockout; Motor Neurons; Receptors, Nicotinic; Stereocilia; Synapses; Synaptic Transmission; Synaptotagmin II
Año:2013
Volumen:3
Número:NOV
DOI: http://dx.doi.org/10.1098/rsob.130163
Título revista:Open Biology
Título revista abreviado:Open Biol.
ISSN:20462441
CAS:Chrna9 protein, mouse; Receptors, Nicotinic; Synaptotagmin II; Syt2 protein, mouse
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_20462441_v3_nNOV_p_Johnson

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Citas:

---------- APA ----------
Johnson, S.L., Wedemeyer, C., Vetter, D.E., Adachi, R., Holley, M.C., Elgoyhen, A.B. & Marcotti, W. (2013) . Cholinergic efferent synaptic transmission regulates the maturation of auditory hair cell ribbon synapses. Open Biology, 3(NOV).
http://dx.doi.org/10.1098/rsob.130163
---------- CHICAGO ----------
Johnson, S.L., Wedemeyer, C., Vetter, D.E., Adachi, R., Holley, M.C., Elgoyhen, A.B., et al. "Cholinergic efferent synaptic transmission regulates the maturation of auditory hair cell ribbon synapses" . Open Biology 3, no. NOV (2013).
http://dx.doi.org/10.1098/rsob.130163
---------- MLA ----------
Johnson, S.L., Wedemeyer, C., Vetter, D.E., Adachi, R., Holley, M.C., Elgoyhen, A.B., et al. "Cholinergic efferent synaptic transmission regulates the maturation of auditory hair cell ribbon synapses" . Open Biology, vol. 3, no. NOV, 2013.
http://dx.doi.org/10.1098/rsob.130163
---------- VANCOUVER ----------
Johnson, S.L., Wedemeyer, C., Vetter, D.E., Adachi, R., Holley, M.C., Elgoyhen, A.B., et al. Cholinergic efferent synaptic transmission regulates the maturation of auditory hair cell ribbon synapses. Open Biol. 2013;3(NOV).
http://dx.doi.org/10.1098/rsob.130163