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drug screening

"Synthesis, antiviral and cytotoxic activity of novel terpenyl hybrid molecules prepared by click chemistry" (2018) Pertino, M.W.; Petrera, E.; Edith Alché, L.; Schmeda-Hirschmann, G. Molecules. 23(6)

"First Steps towards the Pharmaceutical Development of Ovules Containing Lactobacillus Strains: Viability and Antimicrobial Activity as Basic First Parameters in Vaginal Formulations" (2018) Camilletti, A.L.; Ruíz, F.O.; Pascual, L.M.; Barberis, I.L. AAPS PharmSciTech. 19(2):886-895

"Synthesis and activity evaluation of a series of cholanamides as modulators of the liver X receptors" (2018) Martínez, M.D.;Ghini, A.A.;Dansey, M.V. (...)Burton, G. Bioorganic and Medicinal Chemistry. 26(5):1092-1101

"Optimization of a Bioluminescence Resonance Energy Transfer-Based Assay for Screening of Trypanosoma cruzi Protein/Protein Interaction Inhibitors" (2018) Mild, J.G.;Fernandez, L.R.;Gayet, O. (...)Edreira, M.M. Molecular Biotechnology:1-11

"A Minimalist Approach to the Design of Complexity-Enriched Bioactive Small Molecules: Discovery of Phenanthrenoid Mimics as Antiproliferative Agents" (2018) Alonso, F.;Quezada, M.J.;Gola, G.F. (...)Ramírez, J.A. ChemMedChem. 13(16):1732-1740

"In vivo hemin conditioning targets the vascular and immunologic compartments and restrains prostate tumor development" (2017) Jaworski, F.M.;Gentilini, L.D.;Gueron, G. (...)Vazquez, E.S. Clinical Cancer Research. 23(17):5135-5148

"Antitumor effectiveness of a combined therapy with a new cucurbitacin B derivative and paclitaxel on a human lung cancer xenograft model" (2017) Marostica, L.L.;de Barros, A.L.B.;Oliveira, J. (...)Simões, C.M.O. Toxicology and Applied Pharmacology. 329:272-281

"Synthesis and in vitro antiproliferative activities of (5-aryl-1,2,4-oxadiazole-3-yl) methyl D-ribofuranosides" (2017) Avanzo, R.E.; Padrón, J.M.; D'Accorso, N.B.; Fascio, M.L. Bioorganic and Medicinal Chemistry Letters. 27(16):3674-3677

"Selenium-containing analogues of WC-9 are extremely potent inhibitors of Trypanosoma cruzi proliferation" (2017) Chao, M.N.;Storey, M.;Li, C. (...)Rodriguez, J.B. Bioorganic and Medicinal Chemistry. 25(24):6435-6449

"Phytochemical Study of the Genus Salpichroa (Solanaceae), Chemotaxonomic Considerations, and Biological Evaluation in Prostate and Breast Cancer Cells" (2017) Basso, A.V.;Leiva González, S.;Barboza, G.E. (...)Nicotra, V.E. Chemistry and Biodiversity. 14(8)

"Plant and animal aquaporins crosstalk: what can be revealed from distinct perspectives" (2017) Sutka, M.; Amodeo, G.; Ozu, M. Biophysical Reviews. 9(5):545-562

"An in vitro and in vivo evaluation of new potential trans-sialidase inhibitors of Trypanosoma cruzi predicted by a computational drug repositioning method" (2017) Lara-Ramirez, E.E.;López-Cedillo, J.C.;Nogueda-Torres, B. (...)Rivera, G. European Journal of Medicinal Chemistry. 132:249-261

"Antiviral activity of natural and synthetic β-carbolines against dengue virus" (2016) Quintana, V.M.;Piccini, L.E.;Panozzo Zénere, J.D. (...)Castilla, V. Antiviral Research. 134:26-33

"RUNX1 and FOXP3 interplay regulates expression of breast cancer related genes" (2016) Recouvreux, M.S.;Grasso, E.N.;Echeverria, P.C. (...)Rubinstein, N. Oncotarget. 7(6):6552-6565

"In vitro and in vivo antitumor activity of a novel semisynthetic derivative of cucurbitacin B" (2015) Silva, I.T.;Carvalho, A.;Lang, K.L. (...)Ludwig, S. PLoS ONE. 10(2)

"Aryloxyethyl thiocyanates are potent growth inhibitors of Trypanosoma cruzi and Toxoplasma gondii" (2015) Chao, M.N.;Matiuzzi, C.E.;Storey, M. (...)Rodriguez, J.B. ChemMedChem. 10(6):1094-1108

"Prostate cancer cell-stromal cell crosstalk via FGFR1 mediates antitumor activity of dovitinib in bone metastases" (2014) Wan, X.;Corn, P.G.;Yang, J. (...)Navone, N.M. Science Translational Medicine. 6(252)

"Synthesis and cytotoxic evaluation of four new 6E-hydroximinosteroids" (2014) Richmond, V.;Careaga, V.P.;Sacca, P. (...)Maier, M.S. Steroids. 84:7-10

"QSAR on antiproliferative naphthoquinones based on a conformation- independent approach" (2014) Duchowicz, P.R.;Bennardi, D.O.;Bacelo, D.E. (...)Misico, R.I. European Journal of Medicinal Chemistry. 77:176-184

"OTX008, a selective small-molecule inhibitor of galectin-1, downregulates cancer cell proliferation, invasion and tumour angiogenesis" (2014) Astorgues-Xerri, L. European journal of cancer (Oxford, England : 1990). 50(14):2463-2477

"Synthesis and biological evaluation of salpichrolide analogs as antiestrogenic agents" (2014) Sonego, J.M.;Rivero, E.M.;Gargiulo, L. (...)Burton, G. European Journal of Medicinal Chemistry. 82:233-241

"Preclinical development of novel Rac1-GEF signaling inhibitors using a rational design approach in highly aggressive breast cancer cell lines" (2014) Cardama, G.A.;Comin, M.J.;Hornos, L. (...)Menna, P.L. Anti-Cancer Agents in Medicinal Chemistry. 14(6):840-851

"New insights into molecular recognition of 1,1-bisphosphonic acids by farnesyl diphosphate synthase" (2014) Ferrer-Casal, M.;Li, C.;Galizzi, M. (...)Rodriguez, J.B. Bioorganic and Medicinal Chemistry. 22(1):398-405

"Antiprotozoan lead discovery by aligning dry and wet screening: Prediction, synthesis, and biological assay of novel quinoxalinones" (2014) Martins Alho, M.A.;Marrero-Ponce, Y.;Barigye, S.J. (...)Arán, V.J. Bioorganic and Medicinal Chemistry. 22(5):1568-1585

"Prostate tumor growth is impaired by CtBP1 depletion in high-fat diet-fed mice" (2014) Moiola, C.P.;Luca, P.D.;Zalazar, F. (...)De Siervi, A. Clinical Cancer Research. 20(15):4086-4095

"Synthesis and biological evaluation of novel substituted pyrrolo[1,2-a] quinoxaline derivatives as inhibitors of the human protein kinase CK2" (2013) Guillon, J.;Le Borgne, M.;Rimbault, C. (...)Jose, J. European Journal of Medicinal Chemistry. 65:205-222

"Chemical constituents and biological activity of euglena gracilis extracts" (2013) Tolivia, A.; Conforti, V.; Córdoba, O.; Flores, L. Journal of Pharmacy Research. 7(3):209-214

"Synthesis and acetylcholinesterase inhibitory activity of polyhydroxylated sulfated steroids: Structure/activity studies" (2013) Richmond, V.; Murray, A.P.; Maier, M.S. Steroids. 78(11):1141-1147

"Design, synthesis and biological evaluation of WC-9 analogs as antiparasitic agents" (2013) Elicio, P.D.;Chao, M.N.;Galizzi, M. (...)Rodriguez, J.B. European Journal of Medicinal Chemistry. 69:480-489

"Antitumor activity of histamine and clozapine in a mouse experimental model of human melanoma" (2013) Massari, N.A.;Medina, V.A.;Cricco, G.P. (...)Rivera, E.S. Journal of Dermatological Science. 72(3):252-262

"Design, synthesis and biological evaluation of sulfur-containing 1,1-bisphosphonic acids as antiparasitic agents" (2013) Recher, M.;Barboza, A.P.;Li, Z.-H. (...)Rodriguez, J.B. European Journal of Medicinal Chemistry. 60:431-440

"Synthesis and cytotoxic activity evaluation of dihydrocucurbitacin B and cucurbitacin B derivatives" (2012) Lang, K.L.;Silva, I.T.;Zimmermann, L.A. (...)Durán, F.J. Bioorganic and Medicinal Chemistry. 20(9):3016-3030

"Anti-infective pregnane steroid from the octocoral Carijoa riisei collected in South Brazil" (2012) de Almeida, M.T.R.;Tonini, M.L.;Guimarães, T.R. (...)Schenkel, E.P. Latin American Journal of Pharmacy. 31(10):1489-1495

"Chemoenzymatic synthesis and biological evaluation of 2- and 3-hydroxypyridine derivatives against Leishmania mexicana" (2012) García Liñares, G.; Parraud, G.; Labriola, C.; Baldessari, A. Bioorganic and Medicinal Chemistry. 20(15):4614-4624

"In vitro antiviral activity of dehydroepiandrosterone, 17 synthetic analogs and ERK modulators against herpes simplex virus type 1" (2012) Torres, N.I.;Castilla, V.;Bruttomesso, A.C. (...)Wachsman, M.B. Antiviral Research. 95(1):37-48

"Argentinean Andean propolis associated with the medicinal plant Larrea nitida Cav. (Zygophyllaceae). HPLC-MS and GC-MS characterization and antifungal activity" (2011) Agüero, M.B.;Svetaz, L.;Sánchez, M. (...)Tapia, A. Food and Chemical Toxicology. 49(9):1970-1978

"Synthesis and biological evaluation of new 2-alkylaminoethyl-1,1- bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl diphosphate synthase" (2011) Rosso, V.S.;Szajnman, S.H.;Malayil, L. (...)Rodriguez, J.B. Bioorganic and Medicinal Chemistry. 19(7):2211-2217

"Antiproliferative terpenoids and alkaloids from the roots of Maytenus vitis-idaea and Maytenus spinosa" (2010) De Almeida, M.T.R.; Ríos-Luci, C.; Padrón, J.M.; Palermo, J.A. Phytochemistry. 71(14-15):1741-1748

"Cytotoxic terpenoids from Nardophyllum bryoides" (2010) Sánchez, M.;Mazzuca, M.;Veloso, M.J. (...)Palermo, J.A. Phytochemistry. 71(11-12):1395-1399

"Synthesis and biological evaluation of N-thia-carba-thymidine as an antiherpetic agent" (2010) Elhalem, E.; Pujol, C.A.; Damonte, E.B.; Rodriguez, J.B. Tetrahedron. 66(18):3332-3340

"Screening of one-bead-one-peptide combinatorial library using red fluorescent dyes. Presence of positive and false positive beads" (2009) Marani, M.M.;Ceron, M.C.M.;Giudicessi, S.L. (...)Camperi, S.A. Journal of Combinatorial Chemistry. 11(1):146-150

"Antiproliferative, cytotoxic and hemolytic activities of a triterpene glycoside from Psolus patagonicus and its desulfated analog" (2009) Careaga, V.P.;Bueno, C.;Muniain, C. (...)Maier, M.S. Chemotherapy. 55(1):60-68

"Discovery of novel trichomonacidals using LDA-driven QSAR models and bond-based bilinear indices as molecular descriptors" (2009) Rivera-Barroto, O.M.;Marrero-Ponce, Y.;Meneses-Marcel, A. (...)Vogel, C. QSAR and Combinatorial Science. 28(1):9-26

"Synthesis and GABAA receptor activity of 2,19-sulfamoyl analogues of allopregnanolone" (2009) Durán, F.J.;Edelsztein, V.C.;Ghini, A.A. (...)Burton, G. Bioorganic and Medicinal Chemistry. 17(18):6526-6533

"An antifungal tetrapeptide from the culture of Penicillium canescens" (2009) Bertinetti, B.V.; Peña, N.I.; Cabrera, G.M. Chemistry and Biodiversity. 6(8):1178-1184

"Synthesis and evaluation of 1,1′-hydrocarbylenebis(indazol-3-ols) as potential antimalarial drugs" (2009) Alho, M.M.;García-Sánchez, R.N.;Nogal-Ruiz, J.J. (...)Arán, V.J. ChemMedChem. 4(1):78-87

"New acridinone derivative with trypanocidal activity" (2008) Pardo Andreu, G.L.;Inada, N.M.;Pellón, R.F. (...)Vercesi, A.E. International Journal of Antimicrobial Agents. 31(5):502-504

"Synthesis and evaluation of N-substituted acridones as antiviral agents against haemorrhagic fever viruses" (2008) Sepúlveda, C.S.;Fascio, M.L.;Mazzucco, M.B. (...)Damonte, E.B. Antiviral Chemistry and Chemotherapy. 19(1):41-47

"Synthesis and biological evaluation of 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl diphosphate synthase" (2008) Szajnman, S.H.;García Liñares, G.E.;Li, Z.-H. (...)Rodriguez, J.B. Bioorganic and Medicinal Chemistry. 16(6):3283-3290

"Chemical structure and antiviral activity of the sulfated heterorhamnan isolated from the green seaweed Gayralia oxysperma" (2008) Cassolato, J.E.F.;Noseda, M.D.;Pujol, C.A. (...)Duarte, M.E.R. Carbohydrate Research. 343(18):3085-3095

"The Gα12/13 family of heterotrimeric G proteins and the small GTPase RhoA link the Kaposi sarcoma-associated herpes virus G protein-coupled receptor to heme oxygenase-1 expression and tumorigenesis" (2007) Martín, M.J.;Tanos, T.;García, A.B. (...)Marinissen, M.J. Journal of Biological Chemistry. 282(47):34510-34524

"Zn finger containing proteins as targets for the control of viral infections" (2007) García, C.C.; Damonte, E.B. Infectious Disorders - Drug Targets. 7(3):204-212

"Antioxidant and antimicrobial activities of rosemary extracts linked to their polyphenol composition" (2006) Moreno, S.; Scheyer, T.; Romano, C.S.; Vojnov, A.A. Free Radical Research. 40(2):223-231

"Nucleoside phosphorylases" (2006) Lewkowicz, E.S.; Iribarren, A.M. Current Organic Chemistry. 10(11):1197-1215

"Evaluation of chemical and antiviral properties of essential oils from South American plants" (2005) Duschatzky, C.B.;Possetto, M.L.;Talarico, L.B. (...)Damonte, E.B. Antiviral Chemistry and Chemotherapy. 16(4):247-251

"Toxicogenetic evaluation of metronidazole in the treatment of women infected with Trichomonas vaginalis" (2004) Carballo, M.A.; Palermo, A.M.; Mudry, M.D. Annals of Tropical Medicine and Parasitology. 98(2):139-147

"Anti-Trypanosoma cruzi Activity of Green Tea (Camellia sinensis) Catechins" (2004) Paveto, C.;Güida, M.C.;Esteva, M.I. (...)Torres, H.N. Antimicrobial Agents and Chemotherapy. 48(1):69-74

"Anti-herpes simplex virus activity of sulfated galactans from the red seaweeds Gymnogongrus griffithsiae and Cryptonemia crenulata" (2004) Talarico, L.B.;Zibetti, R.G.M.;Faria, P.C.S. (...)Damonte, E.B. International Journal of Biological Macromolecules. 34(1-2):63-71

"Synthesis and antiviral activity of sulfated and acetylated derivatives of 2β,3α-dihydroxy-5α-cholestane" (2003) Garrido Santos, G.A.;Murray, A.P.;Pujol, C.A. (...)Maier, M.S. Steroids. 68(2):125-132

"Virucidal Activity of Essential Oils from Aromatic Plants of San Luis, Argentina" (2003) García, C.C.;Talarico, L.;Almeida, N. (...)Damonte, E.B. Phytotherapy Research. 17(9):1073-1075

"Synthesis and biological evaluation of glutathione-like tripeptidesagainstTrypanosoma cruzi" (2003) Ravaschino, E.L.; Docampo, R.; Rodriguez, J.B. Arkivoc. 2003(10):298-313

"Evaluation of the antiviral activity against junin virus of macrocyclic trichothecenes produced by the hypocrealean epibiont of Baccharis coridifolia" (2002) García, C.C.;Rosso, M.L.;Bertoni, M.D. (...)Damonte, E.B. Planta Medica. 68(3):209-212

"Spectrofluorimetric assay for the photodegradation products of alprazolam" (2002) Nudelman, N.S.; Gallardo Cabrera, C. Journal of Pharmaceutical and Biomedical Analysis. 30(3):887-893

"Synthesis of β-D-galactofuranosyl nucleoside analogues. A new type of β-D-galactofuranosidase inhibitor" (2001) Marino, C.; Herczegh, P.; De Lederkremer, R.M. Carbohydrate Research. 333(2):123-128

"Antiviral activity of an acidic polysaccharides fraction extracted from Cedrela tubiflora leaves" (2001) Craig, M.I.; Benencia, F.; Coulombié, F.C. Fitoterapia. 72(2):113-119

"Bioactive metabolites produced by fungi cultures" (2000) Levy, L.M.; Cabrera, G.M.; Wright, J.E.; Seldes, A.M. Molecules. 5(3):354-355

"Sensitivity of trypanosomatid protozoa to DFMO and metabolic turnover of ornithine decarboxylase" (2000) Carrillo, C.;Cejas, S.;Cortés, M. (...)Algranati, I.D. Biochemical and Biophysical Research Communications. 279(2):663-668

"Effect of crude extracts from melia azedarach L. on the multiplication of chlamydias in different cellular systems " (1999) Venier, M.;Wachsman, M.;Rodriguez Fermepin, M. (...)De Torres, R. Revista Argentina de Microbiologia. 31(SUPPL 1):24-26

"Structure-activity relationship of new growth inhibitors of Trypanosoma cruzi" (1998) Cinque, G.M.;Szajnman, S.H.;Zhong, L. (...)Gros, E.G. Journal of Medicinal Chemistry. 41(9):1540-1554

"Preclinical toxicology of bisphosphonates " (1997) Mondelo, N.;Peluffo, V.A.;Parma, M.D. (...)Montuori, E. Medicina. 57(SUPPL 1):93-100

"Inhibitors of protein and RNA synthesis block context memory and long-term habituation in the crab chasmagnathus" (1996) Pedreira, M.E.; Dimant, B.; Maldonado, H. Pharmacology Biochemistry and Behavior. 54(3):611-617

"Hydroperoxycycloartanes from tillandsia recurvata" (1995) Cabrera, G.M.; Seldes, A.M. Journal of Natural Products. 58(12):1920-1924

"Determination of the antiviral activity of a naturally occurring sulfated xylomannan under various experimental conditions " (1995) Pujol, C.A.; Coto, C.E.; Damonte, E.B. Revista Argentina de microbiología. 27(2):91-98

"Antitumor and cytotoxic screen of 5,6,7-trisubstituted flavones from Gomphrena martiana" (1994) Pomilio, A.B.; Rutty Solá, G.A.; Mayer, A.M.S.; Rumi, L.S. Journal of Ethnopharmacology. 44(1):25-33

"Antitumor screening of Gomphrena species" (1991) Pomilio, A.B.; Buschi, C.A.; Rutty Sola, G.A.; Rumi, L.S. Fitoterapia. 62(6):511-514

"Detection of drug effects on neurons: Protein synthesis inhibition by low doses of amphetamine" (1989) Berninsone, P.M.; Bruses, J.L.; Azcurra, J.M. Methods and Findings in Experimental and Clinical Pharmacology. 11(4):249-253

"Effect of sulfation on the biological activity of β-(1→3)-glucans from the tree fungus Cyttaria harioti Fischer" (1989) Fernandez Cirelli, A.;Covian, J.A.;Ohno, N. (...)Yadomae, T. Carbohydrate Research. 190(2):329-337

"Antimicrobial screening of some Argentine higher plants. Part II" (1986) Tomesi, C.N.; Viale, A.A.; Buschi, C.A. Fitoterapia. 57(1):46-50

"Antifungal product from algal origin" (1983) Accorinti, J. Revue Internationale d'Oceanographie Medicale. 72:45-53

"Effects of castration and reproductive hormones on pineal serotonin metabolism in rats" (1979) Vacas, M.I.; Cardinal, D.P. Neuroendocrinology. 28(3):187-195

"Factors underlying the variable inotropic effect of ouabain on isolated rat atria. Changes in contractile frequency and adrenergic mechanisms" (1979) GIMENO, A.L.; STERIN‐BORDA, L.; BORDA, E.S.; GIMENO, M.F. Journal of Pharmacy and Pharmacology. 31(1):545-550