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Abstract:

Twelve Salpichroa taxa have been phytochemically analyzed. From the aerial parts of S. scandens, four known salpichrolides A, C, I, S, and an unreported withanolide named salpichrolide V (1), were isolated. In S. dependens, S. gayi, S. glandulosa subsp. glandulosa, S. glandulosa subps. weddellii, S. leucantha, S. micrantha, S. microloba, S. proboscidea, S. ramosissima, S. tristis var. tristis, and S. weberbauerii, no withanolides were found. The chemical content of ca. 85% of the Salpichroa taxa is in agreement with molecular studies, which suggest that Salpichroa and Jaborosa, a genus considered morphologically close to Salpichroa, are distant in the systematic of the Solanoideae subfamily. Moreover, the in vitro cytotoxic activity of a set of natural salpichrolides and derivatives was examined against two prostate carcinoma cell lines (PC3 and LNCaP) and two human breast cancer cell lines (MCF-7 and T47D). Several compounds showed moderate activity (IC50 = 64.91 – 29.97 μm). © 2017 Wiley-VHCA AG, Zurich, Switzerland

Registro:

Documento: Artículo
Título:Phytochemical Study of the Genus Salpichroa (Solanaceae), Chemotaxonomic Considerations, and Biological Evaluation in Prostate and Breast Cancer Cells
Autor:Basso, A.V.; Leiva González, S.; Barboza, G.E.; Careaga, V.P.; Calvo, J.C.; Sacca, P.A.; Nicotra, V.E.
Filiación:Facultad de Ciencias Químicas, Instituto Multidisciplinario de Biología Vegetal (IMBIV-CONICET), Universidad Nacional de Córdoba, CC 495, Córdoba, 5000, Argentina
Museo de Historia Natural, Universidad Privada Antenor Orrego, Trujillo, CC 1075, Peru
Departamento de Química Orgánica, Unidad de Microanálisis y Métodos Físicos Aplicados a la Química Orgánica (UMYMFOR-CONICET), Facultad de Ciencias, Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria S/N Piso: 3, Ciudad Autónoma de Buenos Aires, C1428EHA, Argentina
Instituto de Biología y Medicina Experimental (IBYME-CONICET), Vuelta de Obligado 2490, Ciudad Autónoma de Buenos Aires, C1428ADN, Argentina
Palabras clave:Chemotaxonomic markers; Cytotoxic activities; Salpichroa; Structure elucidation; Withanolides; 2,3 dihydrosalpicrolide b; antineoplastic agent; doxorubicin; plant medicinal product; salpichrolide a; salpichrolide c; salpichrolide d; salpichrolide g; salpichrolide m; salpichrolide s; salpichrolide t; salpichrolide v; unclassified drug; plant medicinal product; antineoplastic activity; Article; breast cancer; cancer cell; cancer chemotherapy; cell density; chemotaxonomy; column chromatography; comparative study; controlled study; cytotoxicity; drug isolation; heteronuclear multiple bond correlation; heteronuclear single quantum coherence; human; human cell; in vitro study; nuclear Overhauser effect; prostate carcinoma; proton nuclear magnetic resonance; Salpichroa; Salpichroa dependens; Salpichroa gayi; Salpichroa glandulosa; Salpichroa leucantha; Salpichroa micrantha; Salpichroa microloba; Salpichroa proboscidea; Salpichroa ramosissima; Salpichroa scandens; Salpichroa tristis; Salpichroa weberbauerii; Solanaceae; thin layer chromatography; ultraviolet spectrophotometry; breast tumor; cell survival; chemistry; drug effects; drug screening; female; isolation and purification; male; MCF-7 cell line; metabolism; pathology; prostate tumor; Solanaceae; tumor cell line; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Chromatography, Thin Layer; Drug Screening Assays, Antitumor; Female; Humans; Male; MCF-7 Cells; Phytochemicals; Prostatic Neoplasms; Solanaceae
Año:2017
Volumen:14
Número:8
DOI: http://dx.doi.org/10.1002/cbdv.201700118
Título revista:Chemistry and Biodiversity
Título revista abreviado:Chem. Biodiversity
ISSN:16121872
CODEN:CBHIA
CAS:doxorubicin, 23214-92-8, 25316-40-9; Phytochemicals
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_16121872_v14_n8_p_Basso

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Citas:

---------- APA ----------
Basso, A.V., Leiva González, S., Barboza, G.E., Careaga, V.P., Calvo, J.C., Sacca, P.A. & Nicotra, V.E. (2017) . Phytochemical Study of the Genus Salpichroa (Solanaceae), Chemotaxonomic Considerations, and Biological Evaluation in Prostate and Breast Cancer Cells. Chemistry and Biodiversity, 14(8).
http://dx.doi.org/10.1002/cbdv.201700118
---------- CHICAGO ----------
Basso, A.V., Leiva González, S., Barboza, G.E., Careaga, V.P., Calvo, J.C., Sacca, P.A., et al. "Phytochemical Study of the Genus Salpichroa (Solanaceae), Chemotaxonomic Considerations, and Biological Evaluation in Prostate and Breast Cancer Cells" . Chemistry and Biodiversity 14, no. 8 (2017).
http://dx.doi.org/10.1002/cbdv.201700118
---------- MLA ----------
Basso, A.V., Leiva González, S., Barboza, G.E., Careaga, V.P., Calvo, J.C., Sacca, P.A., et al. "Phytochemical Study of the Genus Salpichroa (Solanaceae), Chemotaxonomic Considerations, and Biological Evaluation in Prostate and Breast Cancer Cells" . Chemistry and Biodiversity, vol. 14, no. 8, 2017.
http://dx.doi.org/10.1002/cbdv.201700118
---------- VANCOUVER ----------
Basso, A.V., Leiva González, S., Barboza, G.E., Careaga, V.P., Calvo, J.C., Sacca, P.A., et al. Phytochemical Study of the Genus Salpichroa (Solanaceae), Chemotaxonomic Considerations, and Biological Evaluation in Prostate and Breast Cancer Cells. Chem. Biodiversity. 2017;14(8).
http://dx.doi.org/10.1002/cbdv.201700118