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Abstract:

The effects of reproductive hormones on pineal serotonin (5-HT) metabolism were examined in castrated rats. Castration of males but not of females increased 5-HT content, whereas follicle-stimulating hormone (FSH) and luteinizing hormone (LH) augmented, and testosterone (T) decreased, pineal 5-HT concentration of orchidectomized rats. In males castration slowed the rate of decline of pineal amine concentration following the injection of p-chlorophenylalanine (PCPA). The administration of T, FSH or LH brought about significant acceleration of pineal 5-HT turnover rate. In spayed rats estradiol treatment decreased 5-HT decline following PCPA. Pineal monoamine oxidase (MAO) activity type B (assaying by using β-phenylethylamine as substrate) was increased by T injection whereas estradiol diminished MAO type A activity (assaying by using 5-HT as substrate). The administration of prolactin to castrated male rats resulted in depression of both types of MAO activity while LH and FSH reduced the activity of MAO type B. The injection of T to rats subjected to superior cervical ganglionectomy counteracted partially the depressed pineal 5-HT levels caused by surgical manipulation. LH or FSH also augmented pineal 5-HT concentration in ganglion-ectomized rats. Bilateral decentralization of ganglia abolished hormone effects on amine levels. These results offer additional support to previous observations indicating that the pineal gland and its innervating sympathetic neurons are effector tissues for reproductive hormones. © 1979 S. Karger AG, Basel.

Registro:

Documento: Artículo
Título:Effects of castration and reproductive hormones on pineal serotonin metabolism in rats
Autor:Vacas, M.I.; Cardinal, D.P.
Filiación:Centro de Estudios Farmacológicos, de Principios Naturales (CEFAPRIN), Consejo Nacional de Invesligacioncs Cientifícas y Técnicas, Buenos Aires, Argentina
Palabras clave:Estradiol; FSH; LH; Pineal gland; Prolactin; Serotonin metabolism; Superior cervical ganglion; Testosterone; amine oxidase (flavin containing); estradiol; fenclonine; follitropin; gonadotropin; luteinizing hormone; prolactin; radioisotope; steroid hormone; testosterone; animal experiment; castration; central nervous system; drug comparison; drug screening; endocrine system; female genital system; gonadectomy; male genital system; phenethylamine c 14; pineal body; rat; serotonin c 14; sex; superior cervical ganglionectomy; Animal; Castration; Comparative Study; Estradiol; Female; Fenclonine; Follicle Stimulating Hormone; Ganglia, Autonomic; Gonadotropins, Pituitary; Luteinizing Hormone; Male; Monoamine Oxidase; Pineal Gland; Prolactin; Rats; Serotonin; Testosterone
Año:1979
Volumen:28
Número:3
Página de inicio:187
Página de fin:195
DOI: http://dx.doi.org/10.1159/000122861
Título revista:Neuroendocrinology
Título revista abreviado:Neuroendocrinology
ISSN:00283835
CAS:amine oxidase (flavin containing), 37255-42-8, 9001-66-5, 9059-11-4; estradiol, 50-28-2; fenclonine, 1991-78-2, 7424-00-2; follitropin, 9002-68-0; gonadotropin, 63231-54-9; luteinizing hormone, 39341-83-8, 9002-67-9; prolactin, 12585-34-1, 50647-00-2, 9002-62-4; testosterone, 58-22-0; Estradiol, 50-28-2; Fenclonine, 7424-00-2; Follicle Stimulating Hormone, 9002-68-0; Gonadotropins, Pituitary; Luteinizing Hormone, 9002-67-9; Monoamine Oxidase, EC 1.4.3.4; Prolactin, 9002-62-4; Serotonin, 50-67-9; Testosterone, 57-85-2
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00283835_v28_n3_p187_Vacas

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Citas:

---------- APA ----------
Vacas, M.I. & Cardinal, D.P. (1979) . Effects of castration and reproductive hormones on pineal serotonin metabolism in rats. Neuroendocrinology, 28(3), 187-195.
http://dx.doi.org/10.1159/000122861
---------- CHICAGO ----------
Vacas, M.I., Cardinal, D.P. "Effects of castration and reproductive hormones on pineal serotonin metabolism in rats" . Neuroendocrinology 28, no. 3 (1979) : 187-195.
http://dx.doi.org/10.1159/000122861
---------- MLA ----------
Vacas, M.I., Cardinal, D.P. "Effects of castration and reproductive hormones on pineal serotonin metabolism in rats" . Neuroendocrinology, vol. 28, no. 3, 1979, pp. 187-195.
http://dx.doi.org/10.1159/000122861
---------- VANCOUVER ----------
Vacas, M.I., Cardinal, D.P. Effects of castration and reproductive hormones on pineal serotonin metabolism in rats. Neuroendocrinology. 1979;28(3):187-195.
http://dx.doi.org/10.1159/000122861