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Abstract:

The crab Chasmagnathus granulatus reacts to a shadow passing overhead (a danger stimulus) with an escape response that habituates quickly and for at least 5 days. Recently, it has been reported that cycloheximide (CY) disrupts this long-term habituation and the corresponding context memory. In the present article, experiments with CY and an inhibitor of RNA synthesis, actinomycin-D (ACT), were parallelly conducted. An injection of CY (20 μg) or ACT (0.62 μg) reduced the incorporation of [14C]-aminoacid into cerebral plus thoracic ganglia by 80% for 2 h and 59.7% for 1 h, respectively, but no inhibition was found at 24 h. Both ACT (0.62 μg) and CY (20 μg) administered immediately after training (15 trials with the danger stimulus) impaired either long-term habituation or context memory when tested at 24 h. Because ACT and CY have in common only their direct or indirect inhibitory effect on protein synthesis, this finding is considered as an additional evidence that long-term memory in Chasmagnathus requires de novo protein synthesis. However, pretraining ACT or CY impaired context memory at 24 h but not long-term habituation. Such a disparity is explained by an unspecific attenuating effect upon the response, attributed to drug × training interaction. Neither ACT nor CY affected short-term habituation.

Registro:

Documento: Artículo
Título:Inhibitors of protein and RNA synthesis block context memory and long-term habituation in the crab chasmagnathus
Autor:Pedreira, M.E.; Dimant, B.; Maldonado, H.
Filiación:Lab. Fisiol. Comportamiento Anim., Fac. de Ciencias Exactas y Naturales, Buenos Aires University, (1428) Buenos Aires, Argentina
Palabras clave:Actinomycin-D; Antibiotics; Arthropoda; Crab; Cycloheximide; Habituation; Memory; Arthropoda; Chasmagnathus; Chasmagnathus granulata; Decapoda (Crustacea); Animalia; Arthropoda; Chasmagnathus; Chasmagnathus granulata; Decapoda (Crustacea); cycloheximide; dactinomycin; protein synthesis inhibitor; animal experiment; article; controlled study; crab; drug effect; drug screening; habituation; long term memory; male; nonhuman; priority journal; protein synthesis inhibition; rna synthesis; Amino Acids; Amnesia; Animals; Brachyura; Cycloheximide; Dactinomycin; Depression, Chemical; Escape Reaction; Ganglia, Invertebrate; Habituation, Psychophysiologic; Male; Memory; Protein Synthesis Inhibitors; RNA, Messenger
Año:1996
Volumen:54
Número:3
Página de inicio:611
Página de fin:617
DOI: http://dx.doi.org/10.1016/0091-3057(95)02206-6
Título revista:Pharmacology Biochemistry and Behavior
Título revista abreviado:Pharmacol. Biochem. Behav.
ISSN:00913057
CODEN:PBBHA
CAS:Amino Acids; Cycloheximide, 66-81-9; Dactinomycin, 50-76-0; Protein Synthesis Inhibitors; RNA, Messenger
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00913057_v54_n3_p611_Pedreira

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Citas:

---------- APA ----------
Pedreira, M.E., Dimant, B. & Maldonado, H. (1996) . Inhibitors of protein and RNA synthesis block context memory and long-term habituation in the crab chasmagnathus. Pharmacology Biochemistry and Behavior, 54(3), 611-617.
http://dx.doi.org/10.1016/0091-3057(95)02206-6
---------- CHICAGO ----------
Pedreira, M.E., Dimant, B., Maldonado, H. "Inhibitors of protein and RNA synthesis block context memory and long-term habituation in the crab chasmagnathus" . Pharmacology Biochemistry and Behavior 54, no. 3 (1996) : 611-617.
http://dx.doi.org/10.1016/0091-3057(95)02206-6
---------- MLA ----------
Pedreira, M.E., Dimant, B., Maldonado, H. "Inhibitors of protein and RNA synthesis block context memory and long-term habituation in the crab chasmagnathus" . Pharmacology Biochemistry and Behavior, vol. 54, no. 3, 1996, pp. 611-617.
http://dx.doi.org/10.1016/0091-3057(95)02206-6
---------- VANCOUVER ----------
Pedreira, M.E., Dimant, B., Maldonado, H. Inhibitors of protein and RNA synthesis block context memory and long-term habituation in the crab chasmagnathus. Pharmacol. Biochem. Behav. 1996;54(3):611-617.
http://dx.doi.org/10.1016/0091-3057(95)02206-6