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Abstract:

The zinc finger proteins have fascinated many research groups because of their modular assembly, broad range of biological functions and more recently because they are attractive targets for antiviral therapy. The zinc finger domain is a very stable structural element whose hallmark is the coordination of a zinc ion by several amino acid residues, usually cysteines and histidines. These structural motifs are associated with protein-nucleic acid recognition as well as protein-protein interactions. The biological function of the zinc finger proteins is strongly dependent on the zinc ion, which assure integrity and stability. Thus, the disruption of critical zinc finger viral proteins represents a fundamentally new approach to inhibit viral replication in the absence of mutations leading to drug resistance phenotypes. This review summarizes the drug design and potential therapeutic applications of viral zinc fingers disrupting agents for the control of viral diseases. © 2007 Bentham Science Publishers Ltd.

Registro:

Documento: Artículo
Título:Zn finger containing proteins as targets for the control of viral infections
Autor:García, C.C.; Damonte, E.B.
Filiación:Laboratorio de Virologia, Departamento de Química Biológica, Universidad de Buenos Aires, Pabellón 2, 1428 Buenos Aires, Argentina
Palabras clave:Antiviral; Arenavirus; Human immunodeficiency virus; Oxiding compounds; Structural domains; Zinc fingers; 1 (2 guanidine)phenyldisulfide; 1,1 dioxide 1,2 dithiane 4,5 diol; 3 nitrosobenzamide; 4,4' dithiomorpholine; aldrithiol 2; antiinfective agent; antiretrovirus agent; antivirus agent; azo compound; azoformamide; benzamide derivative; cysteine; disulfide; fatty acid binding protein; guanine nucleotide exchange factor; histidine; influenza vaccine; n [2 (5 pyridiniovaleroylthio)benzoyl]sulfacetamide bromide; n ethylmaleimide; nsc 20625; nsc 624151; nsc 65239; nucleocapsid protein; promyelocytic leukemia protein; protein E6; proteinase inhibitor; ribavirin; RNA directed DNA polymerase inhibitor; transcription factor GATA 1; transcription factor IIIA; unclassified drug; unindexed drug; zinc finger protein; zinc ion; acquired immune deficiency syndrome; amino acid sequence; antiviral activity; clinical trial; condyloma; drug design; drug efficacy; drug screening; drug selectivity; drug structure; drug targeting; drug treatment failure; Friend leukemia; highly active antiretroviral therapy; human; Human immunodeficiency virus 1; Human immunodeficiency virus infection; infection control; influenza; influenza vaccination; Lassa fever; nonhuman; Papilloma virus; phenotype; plasma transfusion; protein domain; protein function; protein motif; protein protein interaction; Retrovirus; review; verruca plantaris; virus hemorrhagic fever; virus infection; virus infectivity; virus inhibition; virus mutation; virus replication; virus resistance; Antiviral Agents; Drug Delivery Systems; Drug Design; Drug Resistance, Viral; Humans; Viral Proteins; Virus Diseases; Virus Replication; Zinc; Zinc Fingers
Año:2007
Volumen:7
Número:3
Página de inicio:204
Página de fin:212
DOI: http://dx.doi.org/10.2174/187152607782110004
Título revista:Infectious Disorders - Drug Targets
Título revista abreviado:Infect. Disord. Drug Targets
ISSN:18715265
CAS:azoformamide, 123-77-3; cysteine, 4371-52-2, 52-89-1, 52-90-4; disulfide, 16734-12-6; histidine, 645-35-2, 7006-35-1, 71-00-1; n ethylmaleimide, 128-53-0; proteinase inhibitor, 37205-61-1; ribavirin, 36791-04-5; transcription factor GATA 1, 125267-48-3; zinc ion, 23713-49-7; Antiviral Agents; Viral Proteins; Zinc, 7440-66-6
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_18715265_v7_n3_p204_Garcia

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Citas:

---------- APA ----------
García, C.C. & Damonte, E.B. (2007) . Zn finger containing proteins as targets for the control of viral infections. Infectious Disorders - Drug Targets, 7(3), 204-212.
http://dx.doi.org/10.2174/187152607782110004
---------- CHICAGO ----------
García, C.C., Damonte, E.B. "Zn finger containing proteins as targets for the control of viral infections" . Infectious Disorders - Drug Targets 7, no. 3 (2007) : 204-212.
http://dx.doi.org/10.2174/187152607782110004
---------- MLA ----------
García, C.C., Damonte, E.B. "Zn finger containing proteins as targets for the control of viral infections" . Infectious Disorders - Drug Targets, vol. 7, no. 3, 2007, pp. 204-212.
http://dx.doi.org/10.2174/187152607782110004
---------- VANCOUVER ----------
García, C.C., Damonte, E.B. Zn finger containing proteins as targets for the control of viral infections. Infect. Disord. Drug Targets. 2007;7(3):204-212.
http://dx.doi.org/10.2174/187152607782110004