Abstract:
A new tetrapeptide D-Phe-L-Val-D-Val-L-Tyr (1), along with three known diketopiperazines and pseurotin A, were isolated from the culture of Penicillium canescens, collected from pollen from beehives, in a screening for new antimicrobial products from unexplored sources. The structure of the tetrapeptide, which exhibits antifungal activity comparable with that of the commercial product benomyl against the soybean phytopathogen Fusarium virguliforme, was determined by spectroscopic (2D-NMR, and MS and MS/MS) and chemical methods, and the sequence was confirmed by comparison with authentic synthetic isomeric peptides. © 2009 Verlag Helvetica Chimica Acta AG.
Registro:
Documento: |
Artículo
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Título: | An antifungal tetrapeptide from the culture of Penicillium canescens |
Autor: | Bertinetti, B.V.; Peña, N.I.; Cabrera, G.M. |
Filiación: | Departamento de Química Orgánica Y UMYMFOR, Universidad de Buenos Aires, Ciudad Universitaria, (1428), Buenos Aires, Argentina Departamento de Biología, FCEyN, UNMdP, Mar del Plata, Argentina
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Palabras clave: | benomyl; dextro phenylalanylvalyl dextro valyltyrosine; tetrapeptide; unclassified drug; antifungal activity; antimicrobial activity; article; Bacillus subtilis; Colletotrichum; controlled study; drug identification; drug inhibition; drug isolation; drug screening; drug structure; Fusarium; Fusarium lateritium; Fusarium virguliforme; nonhuman; nuclear magnetic resonance; Penicillium; Penicillium canescens; pollen; Antifungal Agents; Fusarium; Nuclear Magnetic Resonance, Biomolecular; Oligopeptides; Penicillium; Tandem Mass Spectrometry; Fusarium virguliforme; Glycine max; Penicillium canescens |
Año: | 2009
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Volumen: | 6
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Número: | 8
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Página de inicio: | 1178
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Página de fin: | 1184
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DOI: |
http://dx.doi.org/10.1002/cbdv.200800336 |
Título revista: | Chemistry and Biodiversity
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Título revista abreviado: | Chem. Biodiversity
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ISSN: | 16121872
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CAS: | benomyl, 17804-35-2; Antifungal Agents; Oligopeptides; phenylalanyl-valyl-valyl-tyrosine
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_16121872_v6_n8_p1178_Bertinetti |
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Citas:
---------- APA ----------
Bertinetti, B.V., Peña, N.I. & Cabrera, G.M.
(2009)
. An antifungal tetrapeptide from the culture of Penicillium canescens. Chemistry and Biodiversity, 6(8), 1178-1184.
http://dx.doi.org/10.1002/cbdv.200800336---------- CHICAGO ----------
Bertinetti, B.V., Peña, N.I., Cabrera, G.M.
"An antifungal tetrapeptide from the culture of Penicillium canescens"
. Chemistry and Biodiversity 6, no. 8
(2009) : 1178-1184.
http://dx.doi.org/10.1002/cbdv.200800336---------- MLA ----------
Bertinetti, B.V., Peña, N.I., Cabrera, G.M.
"An antifungal tetrapeptide from the culture of Penicillium canescens"
. Chemistry and Biodiversity, vol. 6, no. 8, 2009, pp. 1178-1184.
http://dx.doi.org/10.1002/cbdv.200800336---------- VANCOUVER ----------
Bertinetti, B.V., Peña, N.I., Cabrera, G.M. An antifungal tetrapeptide from the culture of Penicillium canescens. Chem. Biodiversity. 2009;6(8):1178-1184.
http://dx.doi.org/10.1002/cbdv.200800336