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Abstract:

Investigation of the organic extracts of the roots of Maytenus vitis-idaea and Maytenus spinosa, collected in the province of Salta, Argentina, led to isolation of eighteen compounds belonging to several classes. From M. vitis-idaea, eight methylenequinone celastroids (1-8) were isolated, four of which (4-7) were hitherto unknown. Additionally, from M. spinosa, two known celastroids, a known celastroid dimer (9), three pentacyclic triterpenoids (10-12) and six β-dihydroagarofuran sesquiterpenoid alkaloids (13-18) were identified. Compounds 4-7 were active against six solid tumor cell lines at micromolar concentrations. © 2010 Elsevier Ltd. All rights reserved.

Registro:

Documento: Artículo
Título:Antiproliferative terpenoids and alkaloids from the roots of Maytenus vitis-idaea and Maytenus spinosa
Autor:De Almeida, M.T.R.; Ríos-Luci, C.; Padrón, J.M.; Palermo, J.A.
Filiación:Departamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón 2, 1428 Buenos Aires, Argentina
BioLab, Instituto Universitario de Bio-Orgánica Antonio González (IUBO-AG), Universidad de la Laguna, Spain
Departamento de Ciências Farmacêuticas, Universidade Federal de Santa Catarina, Campus Trindade, 88040-970 Florianópolis, SC, Brazil
Palabras clave:β-Dihydroagarofuran sesquiterpenoid alkaloids; Celastraceae; Celastroids; Maytenus spinosa; Maytenus vitis-idaea; Methylenequinone; Pentacyclic triterpenoids; alkaloid; antineoplastic agent; sesquiterpene; triterpene; Argentina; article; chemical structure; chemistry; dose response; drug screening; HeLa cell; human; isolation and purification; Maytenus; medicinal plant; nuclear magnetic resonance; plant root; Alkaloids; Antineoplastic Agents, Phytogenic; Argentina; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Hela Cells; Humans; Maytenus; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Plant Roots; Plants, Medicinal; Sesquiterpenes; Triterpenes; Celastraceae; Idaea; Maytenus; Vitaceae; Vitis
Año:2010
Volumen:71
Número:14-15
Página de inicio:1741
Página de fin:1748
DOI: http://dx.doi.org/10.1016/j.phytochem.2010.06.023
Título revista:Phytochemistry
Título revista abreviado:Phytochemistry
ISSN:00319422
CODEN:PYTCA
CAS:Alkaloids; Antineoplastic Agents, Phytogenic; Sesquiterpenes; Triterpenes
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00319422_v71_n14-15_p1741_DeAlmeida

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Citas:

---------- APA ----------
De Almeida, M.T.R., Ríos-Luci, C., Padrón, J.M. & Palermo, J.A. (2010) . Antiproliferative terpenoids and alkaloids from the roots of Maytenus vitis-idaea and Maytenus spinosa. Phytochemistry, 71(14-15), 1741-1748.
http://dx.doi.org/10.1016/j.phytochem.2010.06.023
---------- CHICAGO ----------
De Almeida, M.T.R., Ríos-Luci, C., Padrón, J.M., Palermo, J.A. "Antiproliferative terpenoids and alkaloids from the roots of Maytenus vitis-idaea and Maytenus spinosa" . Phytochemistry 71, no. 14-15 (2010) : 1741-1748.
http://dx.doi.org/10.1016/j.phytochem.2010.06.023
---------- MLA ----------
De Almeida, M.T.R., Ríos-Luci, C., Padrón, J.M., Palermo, J.A. "Antiproliferative terpenoids and alkaloids from the roots of Maytenus vitis-idaea and Maytenus spinosa" . Phytochemistry, vol. 71, no. 14-15, 2010, pp. 1741-1748.
http://dx.doi.org/10.1016/j.phytochem.2010.06.023
---------- VANCOUVER ----------
De Almeida, M.T.R., Ríos-Luci, C., Padrón, J.M., Palermo, J.A. Antiproliferative terpenoids and alkaloids from the roots of Maytenus vitis-idaea and Maytenus spinosa. Phytochemistry. 2010;71(14-15):1741-1748.
http://dx.doi.org/10.1016/j.phytochem.2010.06.023